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Results for ebf3a-1+si:ch211-51e8.2

Z-value: 0.79

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Transcription factors associated with ebf3a-1+si:ch211-51e8.2

Gene Symbol Gene ID Gene Info
si_ch211-51e8.2
ENSDARG00000092635 si_ch211-51e8.2
ebf3a
ENSDARG00000099849 EBF transcription factor 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ebf1adr10_dc_chr14_+_34683602_346836730.925.4e-07Click!

Activity profile of ebf3a-1+si:ch211-51e8.2 motif

Sorted Z-values of ebf3a-1+si:ch211-51e8.2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-1+si:ch211-51e8.2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_32752138 3.20 ENSDART00000052383
cd81a
CD81 molecule a
chr22_+_11726312 3.00 ENSDART00000155366
krt96
keratin 96
chr16_-_9978112 2.79 ENSDART00000149312
ncalda
neurocalcin delta a
chr8_-_985673 2.66 ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr17_-_45383925 2.41

chr25_+_30746445 2.40 ENSDART00000156916
lsp1
lymphocyte-specific protein 1
chr19_+_20183210 2.04 ENSDART00000164968
hoxa4a
homeobox A4a
chr22_+_11745592 1.97 ENSDART00000140272
krt96
keratin 96
chr25_+_25358457 1.96 ENSDART00000112330
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr21_-_15833030 1.85 ENSDART00000080693
lhx5
LIM homeobox 5
chr4_-_76594677 1.75 ENSDART00000049170
zgc:85975
zgc:85975
chr24_-_23797468 1.70 ENSDART00000080810
arxa
aristaless related homeobox a
chr21_+_26352675 1.67 ENSDART00000077197
tmsb
thymosin, beta
chr11_-_22966274 1.66 ENSDART00000003646
optc
opticin
chr13_+_11913290 1.57 ENSDART00000079398
gng2
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_36853345 1.57 ENSDART00000172074
NINJ1
ninjurin 1
chr2_+_57136624 1.54 ENSDART00000159912
ENSDARG00000105208
ENSDARG00000105208
chr14_-_21662462 1.50 ENSDART00000021417
p2rx3a
purinergic receptor P2X, ligand-gated ion channel, 3a
chr10_-_31619761 1.49 ENSDART00000023575
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr7_+_25649559 1.44 ENSDART00000026295
arrb2b
arrestin, beta 2b
chr6_+_54703206 1.38 ENSDART00000074605
pkp1b
plakophilin 1b
chr4_+_8637319 1.30

chr12_-_26314881 1.29 ENSDART00000178687
myoz1b
myozenin 1b
chr3_+_48362748 1.26 ENSDART00000157199
mkl2b
MKL/myocardin-like 2b
chr7_-_52283383 1.25 ENSDART00000165649
tcf12
transcription factor 12
chr2_-_23516930 1.24 ENSDART00000165355
prrx1a
paired related homeobox 1a
chr5_-_28090077 1.19

chr22_+_11745657 1.17 ENSDART00000140272
krt96
keratin 96
chr6_+_2849460 1.16

chr2_-_20490037 1.14 ENSDART00000160388
FQ377605.1
ENSDARG00000101927
chr15_-_4154407 1.12 ENSDART00000090624
lpar6a
lysophosphatidic acid receptor 6a
chr8_-_15144533 1.10 ENSDART00000138855
bcar3
breast cancer anti-estrogen resistance 3
chr8_+_39525254 1.05

chr2_-_23517033 1.02 ENSDART00000041365
prrx1a
paired related homeobox 1a
chr18_+_37291448 0.99 ENSDART00000132749
tmem123
transmembrane protein 123
chr20_+_30948175 0.97

chr15_-_31635737 0.96 ENSDART00000156047
hmgb1b
high mobility group box 1b
chr10_+_35478939 0.94 ENSDART00000147303
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr4_-_16356071 0.91 ENSDART00000079521
kera
keratocan
chr8_-_27496134 0.90 ENSDART00000134879
si:ch211-254n4.3
si:ch211-254n4.3
chr21_+_10663517 0.89 ENSDART00000074833
rx3
retinal homeobox gene 3
chr2_+_22839514 0.89 ENSDART00000167915
lrrc8da
leucine rich repeat containing 8 family, member Da
chr15_-_24934442 0.89 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr13_+_28723589 0.85

chr20_+_38298893 0.85 ENSDART00000022694
ehd3
EH-domain containing 3
chr4_-_76594399 0.84 ENSDART00000049170
zgc:85975
zgc:85975
chr13_+_28574593 0.82 ENSDART00000126845
ldb1a
LIM domain binding 1a
chr19_+_11061965 0.82 ENSDART00000142975
si:ch1073-70f20.1
si:ch1073-70f20.1
chr16_-_31835463 0.81 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr1_-_11707288 0.81 ENSDART00000134708
sclt1
sodium channel and clathrin linker 1
chr22_+_11726429 0.79 ENSDART00000155366
krt96
keratin 96
chr3_-_30027552 0.79 ENSDART00000103502
si:ch211-152f23.5
si:ch211-152f23.5
chr20_+_30979286 0.78

chr13_-_40190349 0.78 ENSDART00000009343
pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr12_+_30245620 0.78 ENSDART00000153116
ENSDART00000152900
ENSDARG00000020224
ENSDARG00000020224
chr6_+_42478185 0.76 ENSDART00000150226
mst1ra
macrophage stimulating 1 receptor a
chr5_-_5338903 0.74 ENSDART00000112856
ENSDARG00000078362
ENSDARG00000078362
chr20_-_25839801 0.73

chr7_+_39139248 0.69 ENSDART00000165594
CT030188.1
ENSDARG00000099385
chr20_-_23539928 0.69 ENSDART00000022887
slc10a4
solute carrier family 10, member 4
chr8_+_24276667 0.68

chr21_-_9863186 0.67 ENSDART00000170710
arhgap24
Rho GTPase activating protein 24
chr1_-_46292847 0.66 ENSDART00000125032
pknox1.2
pbx/knotted 1 homeobox 1.2
chr20_+_38298755 0.65 ENSDART00000022694
ehd3
EH-domain containing 3
chr8_+_24276581 0.64

chr19_-_46396376 0.64

chr25_-_29245587 0.61

chr15_+_24077452 0.60

chr24_-_26594117 0.59 ENSDART00000124580
pld1b
phospholipase D1b
chr4_+_27141061 0.59 ENSDART00000145083
brd1a
bromodomain containing 1a
chr7_-_18302231 0.59 ENSDART00000108938
msantd1
Myb/SANT-like DNA-binding domain containing 1
chr12_-_425381 0.58 ENSDART00000083827
hs3st3l
heparan sulfate (glucosamine) 3-O-sulfotransferase 3-like
chr10_-_27087472 0.55 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr24_-_26594053 0.54 ENSDART00000124580
pld1b
phospholipase D1b
chr11_-_38278666 0.53

chr12_+_34662699 0.53 ENSDART00000153097
slc38a10
solute carrier family 38, member 10
chr16_-_7310925 0.50 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr3_+_52901602 0.49 ENSDART00000114343
brd4
bromodomain containing 4
chr20_+_27121126 0.49 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr23_-_36319185 0.49 ENSDART00000139328
znf740b
zinc finger protein 740b
chr18_+_6692267 0.49

chr21_-_9863071 0.48 ENSDART00000170710
arhgap24
Rho GTPase activating protein 24
chr7_-_41209891 0.48 ENSDART00000174300
smarcd3b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr20_+_230164 0.46 ENSDART00000002661
lama4
laminin, alpha 4
chr10_-_17383380 0.45

chr17_-_120568 0.45

chr14_+_41519751 0.42 ENSDART00000173264
slc7a11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr16_-_25691856 0.42 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr3_+_12132746 0.41

chr6_-_8029184 0.41 ENSDART00000091628
ccdc151
coiled-coil domain containing 151
chr2_-_23516991 0.40 ENSDART00000165355
prrx1a
paired related homeobox 1a
chr17_+_24421150 0.39 ENSDART00000168926
mdh1ab
malate dehydrogenase 1Ab, NAD (soluble)
chr13_-_47510290 0.39 ENSDART00000121817
fbln7
fibulin 7
chr17_-_120755 0.35

chr11_+_2211050 0.34 ENSDART00000123944
hoxc13b
homeobox C13b
chr10_-_17383466 0.34

chr17_-_20538582 0.33

chr4_+_15820977 0.32 ENSDART00000101613
lrguk
leucine-rich repeats and guanylate kinase domain containing
chr5_-_63912962 0.31

chr1_-_52869817 0.31 ENSDART00000162025
ENSDART00000100788
commd1
copper metabolism (Murr1) domain containing 1
chr16_+_40396454 0.30 ENSDART00000121711
BX072576.2
ENSDARG00000090181
chr17_+_33862300 0.28

chr24_-_23797593 0.28 ENSDART00000080810
arxa
aristaless related homeobox a
chr4_-_72835088 0.24 ENSDART00000174361
ptprb
protein tyrosine phosphatase, receptor type, b
chr7_+_60746590 0.23 ENSDART00000115355
nwd2
NACHT and WD repeat domain containing 2
chr25_-_17406938 0.23 ENSDART00000061726
trim35-40
tripartite motif containing 35-40
chr8_-_17692185 0.23

chr15_+_2495106 0.23

chr2_-_23516868 0.23 ENSDART00000165355
prrx1a
paired related homeobox 1a
chr20_-_48255596 0.22 ENSDART00000031167
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr14_+_10795333 0.22

chr25_-_23977017 0.21 ENSDART00000040410
th
tyrosine hydroxylase
chr22_-_27274035 0.20 ENSDART00000153589
si:dkey-16m19.1
si:dkey-16m19.1
chr12_+_45515755 0.18 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
si:ch73-111m19.2
chr5_-_32861219 0.18 ENSDART00000162290
ENSDARG00000060631
ENSDARG00000060631
chr16_-_45888127 0.18 ENSDART00000027013
ENSDART00000128068
ntrk1
neurotrophic tyrosine kinase, receptor, type 1
chr7_+_34216359 0.18 ENSDART00000173854
cln6a
CLN6, transmembrane ER protein a
chr12_+_5283561 0.17

chr3_-_19847002 0.17

chr12_+_6161471 0.16 ENSDART00000163828
BX248126.1
ENSDARG00000096552
chr3_-_55397643 0.15 ENSDART00000176127
axin2
axin 2 (conductin, axil)
chr22_-_2828572 0.12

chr25_+_29245654 0.12 ENSDART00000073478
brd1b
bromodomain containing 1b
chr16_-_42857240 0.10

chr7_+_39183037 0.10 ENSDART00000173520
tnnt3b
troponin T type 3b (skeletal, fast)
chr24_+_25649220 0.09 ENSDART00000109809
sh3kbp1
SH3-domain kinase binding protein 1
chr7_+_44265618 0.08 ENSDART00000171690
ENSDART00000161949
CT027744.2
ENSDARG00000102431
chr1_-_58183299 0.07 ENSDART00000166615
dnm2b
dynamin 2b
chr5_-_32860888 0.06 ENSDART00000085636
ENSDARG00000060631
ENSDARG00000060631
chr3_-_55397592 0.06 ENSDART00000176127
axin2
axin 2 (conductin, axil)
chr15_+_28335293 0.06 ENSDART00000152536
myo1cb
myosin Ic, paralog b
chr1_-_53465275 0.05

chr12_-_31369772 0.04 ENSDART00000066578
tectb
tectorin beta
chr4_-_16356247 0.02 ENSDART00000079521
kera
keratocan
chr23_-_16765933 0.01 ENSDART00000046784
fkbp1ab
FK506 binding protein 1Ab

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0086066 atrial cardiac muscle cell action potential(GO:0086014) cell-cell signaling involved in cardiac conduction(GO:0086019) atrial cardiac muscle cell to AV node cell signaling(GO:0086026) cell communication involved in cardiac conduction(GO:0086065) atrial cardiac muscle cell to AV node cell communication(GO:0086066)
0.6 1.7 GO:0019731 antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.5 2.0 GO:0003322 pancreatic A cell development(GO:0003322)
0.5 1.4 GO:0002031 G-protein coupled receptor internalization(GO:0002031) regulation of protein binding(GO:0043393)
0.4 1.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.4 2.5 GO:0048769 sarcomerogenesis(GO:0048769)
0.3 0.9 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.3 0.9 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.3 1.5 GO:0033198 response to ATP(GO:0033198)
0.2 1.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 1.1 GO:0035313 negative regulation of Rac protein signal transduction(GO:0035021) wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.2 0.6 GO:0051701 interaction with host(GO:0051701)
0.2 1.1 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.2 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.2 1.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.5 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 0.5 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.1 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.1 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 0.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.3 GO:2000009 negative regulation of sodium ion transmembrane transport(GO:1902306) regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.1 0.2 GO:0009713 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.1 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.7 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 1.6 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 1.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 2.0 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.9 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884) neurotransmitter receptor internalization(GO:0099590)
0.0 0.7 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0031430 M band(GO:0031430)
0.1 1.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 1.5 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.5 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.1 6.9 GO:0005882 intermediate filament(GO:0005882)
0.1 1.4 GO:0030057 desmosome(GO:0030057)
0.1 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 0.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 1.9 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.3 1.1 GO:0004630 phospholipase D activity(GO:0004630)
0.3 1.5 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) extracellular ATP-gated cation channel activity(GO:0004931) nucleotide receptor activity(GO:0016502) ATP-gated ion channel activity(GO:0035381)
0.2 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.2 2.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.0 7.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 1.4 GO:0001664 G-protein coupled receptor binding(GO:0001664)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 1.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 2.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling