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Results for egr3

Z-value: 0.51

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Transcription factors associated with egr3

Gene Symbol Gene ID Gene Info
egr3
ENSDARG00000089156 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr3dr10_dc_chr8_+_50738477_50738508-0.292.8e-01Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_-_47446494 1.50 ENSDART00000032188
si:dkey-256h2.1
si:dkey-256h2.1
chr7_+_45747395 1.42 ENSDART00000163991
ccne1
cyclin E1
chr13_+_35799602 1.37 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr7_+_45747622 1.33 ENSDART00000163991
ccne1
cyclin E1
chr19_-_48327666 1.28

chr13_+_35799681 1.23 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr6_+_48188448 1.16

chr3_-_5157662 1.14 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr22_+_37688839 1.09 ENSDART00000174664
ENSDART00000178200
FO704589.1
ENSDARG00000108910
chr6_+_48188313 1.03

chr23_-_31719203 1.02 ENSDART00000148122
sgk1
serum/glucocorticoid regulated kinase 1
chr17_+_46403915 0.94 ENSDART00000154499
si:dkey-206p8.1
si:dkey-206p8.1
KN150034v1_+_1223 0.91

chr9_-_55878791 0.83

chr13_+_48475352 0.81 ENSDART00000165051
CU651669.1
ENSDARG00000101069
chr15_-_14102102 0.81 ENSDART00000139068
zgc:114130
zgc:114130
chr12_-_37274632 0.78 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr13_-_36015558 0.77 ENSDART00000133072
med6
mediator complex subunit 6
chr21_-_41508736 0.75 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr22_-_10562118 0.72 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
KN150034v1_+_1158 0.72

chr6_+_48188520 0.70

chr7_+_55217087 0.68 ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr6_+_48188549 0.68

chr22_+_37689055 0.65

chr13_+_35799851 0.64 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr6_-_53391354 0.62 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr3_-_45358502 0.60 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr18_+_41559512 0.60 ENSDART00000059135
bcl7bb
B-cell CLL/lymphoma 7B, b
chr4_-_5010148 0.56 ENSDART00000154025
strip2
striatin interacting protein 2
chr15_+_46093261 0.56

chr2_+_38959335 0.52 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr5_-_6054581 0.50

chr12_-_2638179 0.44

chr7_+_41060622 0.43 ENSDART00000160143
garem
GRB2 associated, regulator of MAPK1
chr21_-_43402921 0.42 ENSDART00000166530
ccni2
cyclin I family, member 2
chr3_+_22853476 0.41 ENSDART00000043190
lsm12a
LSM12 homolog a
chr8_-_31374705 0.40 ENSDART00000162872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr2_+_17042235 0.40 ENSDART00000017852
ubxn7
UBX domain protein 7
chr9_-_55878468 0.38

chr25_+_1223427 0.38 ENSDART00000155229
rxfp3.3b
relaxin/insulin-like family peptide receptor 3.3b
chr15_+_14925529 0.38 ENSDART00000166250
CR936977.2
ENSDARG00000103638
chr5_+_2472901 0.38 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr19_-_25842574 0.37 ENSDART00000036854
glcci1
glucocorticoid induced 1
chr4_-_71945633 0.37 ENSDART00000170170
znf1015
zinc finger protein 1015
chr10_-_8764361 0.36

chr16_+_11027467 0.33 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr5_+_29231012 0.31 ENSDART00000159327
f11r.1
F11 receptor, tandem duplicate 1
chr6_+_48188609 0.30

chr13_-_36015609 0.30 ENSDART00000044115
med6
mediator complex subunit 6
chr3_-_5318147 0.24 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr5_+_29231241 0.24 ENSDART00000131687
ENSDART00000035098
f11r.1
F11 receptor, tandem duplicate 1
chr19_+_5562075 0.24 ENSDART00000148794
jupb
junction plakoglobin b
chr7_-_6228307 0.22 ENSDART00000173332
zgc:112234
zgc:112234
chr12_-_37274547 0.21 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr22_+_37688988 0.20

chr7_-_45747162 0.20 ENSDART00000172591
zgc:162297
zgc:162297
chr1_+_11608323 0.15 ENSDART00000164045
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr19_+_1298795 0.12 ENSDART00000113368
RNF5
ring finger protein 5
chr7_-_45747112 0.12 ENSDART00000172591
zgc:162297
zgc:162297
chr14_+_25866966 0.12

chr7_+_41060426 0.11 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr22_+_37688695 0.09 ENSDART00000174664
ENSDART00000178200
FO704589.1
ENSDARG00000108910
chr22_-_6287015 0.08 ENSDART00000148832
AL928685.4
ENSDARG00000095907
chr16_+_11027394 0.07 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr15_+_9318502 0.07 ENSDART00000133588
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr3_-_11657881 0.06 ENSDART00000127157
hlfa
hepatic leukemia factor a
chr11_-_2524380 0.06 ENSDART00000114079
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr7_-_6273677 0.05 ENSDART00000173419
si:ch73-368j24.1
si:ch73-368j24.1
chr21_+_6107404 0.03 ENSDART00000150301
fnbp1b
formin binding protein 1b
chr18_+_41559549 0.02 ENSDART00000059135
bcl7bb
B-cell CLL/lymphoma 7B, b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633) lysophospholipid transport(GO:0051977) lipid transport across blood brain barrier(GO:1990379)
0.2 0.9 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 0.5 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 0.5 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 0.6 GO:0071326 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 1.0 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 3.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.5 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.6 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 1.1 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 1.0 GO:0006954 inflammatory response(GO:0006954)
0.0 0.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.1 GO:0070847 core mediator complex(GO:0070847)
0.1 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0051978 lysophospholipid transporter activity(GO:0051978)
0.2 1.0 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 1.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 3.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation