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Results for egr4

Z-value: 1.26

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Transcription factors associated with egr4

Gene Symbol Gene ID Gene Info
egr4
ENSDARG00000077799 early growth response 4

Activity profile of egr4 motif

Sorted Z-values of egr4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of egr4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_35060298 3.84 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr12_+_30389706 3.28

chr16_+_27680365 3.15 ENSDART00000005625
glipr2l
GLI pathogenesis-related 2, like
chr13_+_35799681 3.11 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr14_+_14850200 2.92 ENSDART00000167966
zgc:158852
zgc:158852
chr16_-_47446494 2.85 ENSDART00000032188
si:dkey-256h2.1
si:dkey-256h2.1
chr6_+_48188448 2.78

chr6_+_48188313 2.75

chr14_-_35060332 2.61 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr13_+_35799602 2.61 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr17_+_46403915 2.49 ENSDART00000154499
si:dkey-206p8.1
si:dkey-206p8.1
chr3_-_5157662 2.39 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
KN150034v1_+_1223 2.31

KN150034v1_+_1158 2.19

chr22_-_10562118 2.07 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr24_+_39285121 2.07

chr8_-_49227286 2.05

chr18_+_2124267 2.04

chr8_-_49227232 1.92

chr3_-_2041373 1.83 ENSDART00000146552
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr13_+_48475352 1.78 ENSDART00000165051
CU651669.1
ENSDARG00000101069
chr6_+_48188520 1.73

chr22_-_22315679 1.70 ENSDART00000033479
si:ch211-129c21.1
si:ch211-129c21.1
chr16_+_53632289 1.69 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr13_-_31267459 1.61 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr2_-_57502821 1.57

chr2_+_38959335 1.48 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr6_+_48188549 1.47

chr2_-_57502700 1.46

chr13_-_31267133 1.41 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr19_-_48327666 1.38

chr16_+_53632152 1.36 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr11_+_12662209 1.33 ENSDART00000054837
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr14_-_38549466 1.30 ENSDART00000035779
zgc:101583
zgc:101583
chr5_-_23192997 1.27 ENSDART00000167629
rnf128a
ring finger protein 128a
chr19_+_26807634 1.21

chr22_-_9809500 1.20

chr22_-_11024649 1.18 ENSDART00000105823
ENSDART00000159995
insrb
insulin receptor b
chr11_-_36425176 1.17 ENSDART00000156166
CR457444.1
ENSDARG00000096865
chr3_+_29338315 1.15 ENSDART00000103592
fam83fa
family with sequence similarity 83, member Fa
chr3_+_22853476 1.11 ENSDART00000043190
lsm12a
LSM12 homolog a
chr2_+_17042235 1.08 ENSDART00000017852
ubxn7
UBX domain protein 7
chr12_-_7604946 1.08 ENSDART00000126712
ccdc6b
coiled-coil domain containing 6b
chr11_-_3240247 1.07 ENSDART00000036581
cdk2
cyclin-dependent kinase 2
chr1_-_9789386 1.06 ENSDART00000040116
tnrc5
trinucleotide repeat containing 5
chr13_+_35799851 1.04 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr5_-_23192934 1.02 ENSDART00000021462
rnf128a
ring finger protein 128a
chr8_+_23144448 1.01 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr21_-_43402921 0.99 ENSDART00000166530
ccni2
cyclin I family, member 2
chr18_+_20493237 0.99 ENSDART00000128139
kbtbd4
kelch repeat and BTB (POZ) domain containing 4
chr3_-_45358502 0.96 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr13_-_31267513 0.96 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr20_-_36510718 0.93

chr11_+_12662507 0.92 ENSDART00000135761
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr20_-_10077762 0.89 ENSDART00000134439
znf770
zinc finger protein 770
chr22_-_22315810 0.84 ENSDART00000033479
si:ch211-129c21.1
si:ch211-129c21.1
chr19_-_25842574 0.84 ENSDART00000036854
glcci1
glucocorticoid induced 1
chr5_+_2472901 0.84 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr16_+_19223683 0.80 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr8_-_44617200 0.77 ENSDART00000063396
bag4
BCL2-associated athanogene 4
chr5_+_61279071 0.76 ENSDART00000168808
si:dkeyp-117b8.4
si:dkeyp-117b8.4
chr7_-_44623926 0.75 ENSDART00000073735
rrad
Ras-related associated with diabetes
chr18_+_8943793 0.71 ENSDART00000144247
si:dkey-5i3.5
si:dkey-5i3.5
chr15_+_12127861 0.70

chr7_+_41060622 0.67 ENSDART00000160143
garem
GRB2 associated, regulator of MAPK1
chr3_-_5318147 0.66 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr18_+_2124217 0.66

chr16_+_53632229 0.64 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr6_+_48188609 0.61

chr19_+_5562075 0.58 ENSDART00000148794
jupb
junction plakoglobin b
chr12_-_7604882 0.56 ENSDART00000126219
ccdc6b
coiled-coil domain containing 6b
chr22_-_3165441 0.56 ENSDART00000158009
lonp1
lon peptidase 1, mitochondrial
chr3_+_34690574 0.55

chr13_+_11741597 0.50

chr18_+_20493291 0.49 ENSDART00000100668
kbtbd4
kelch repeat and BTB (POZ) domain containing 4
chr15_+_14925529 0.48 ENSDART00000166250
CR936977.2
ENSDARG00000103638
chr5_+_61278798 0.45 ENSDART00000168808
si:dkeyp-117b8.4
si:dkeyp-117b8.4
chr8_-_49227143 0.42

chr18_-_45620179 0.38 ENSDART00000163794
ENSDART00000146543
wt1b
wilms tumor 1b
chr22_+_10683985 0.35 ENSDART00000063207
ENSDART00000122349
hiat1b
hippocampus abundant transcript 1b
chr15_+_9318502 0.32 ENSDART00000133588
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr5_-_43219303 0.29 ENSDART00000022481
mccc2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr22_+_12773735 0.28 ENSDART00000005720
stat1a
signal transducer and activator of transcription 1a
chr13_+_48191437 0.27 ENSDART00000053332
FOXN2 (1 of many)
forkhead box N2
chr20_-_16366248 0.26

chr16_-_40558536 0.25 ENSDART00000075718
ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr7_+_41060426 0.23 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr5_+_61278989 0.23 ENSDART00000168808
si:dkeyp-117b8.4
si:dkeyp-117b8.4
chr10_+_19597171 0.22 ENSDART00000063810
ENSDART00000063806
atp6v1b2
ATPase, H+ transporting, lysosomal, V1 subunit B2
chr17_+_26736073 0.19 ENSDART00000163886
larp1b
La ribonucleoprotein domain family, member 1B
chr11_+_12662284 0.19 ENSDART00000054837
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr22_-_20695416 0.15 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr1_+_11608323 0.14 ENSDART00000164045
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr20_-_16366304 0.10

chr21_+_6107404 0.09 ENSDART00000150301
fnbp1b
formin binding protein 1b
chr3_-_5318012 0.08 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr8_+_53919318 0.08

chr6_-_18019342 0.07 ENSDART00000154941
ten1
TEN1 CST complex subunit
chr8_-_53584884 0.04

chr13_-_36483866 0.03

chr21_+_6107190 0.01 ENSDART00000161647
fnbp1b
formin binding protein 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:1990379 maintenance of blood-brain barrier(GO:0035633) lysophospholipid transport(GO:0051977) lipid transport across blood brain barrier(GO:1990379)
0.9 6.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.6 2.5 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.6 3.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.4 2.5 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.3 0.9 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.2 1.0 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.7 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 2.4 GO:0071482 cellular response to light stimulus(GO:0071482)
0.1 1.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 1.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.1 0.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 3.3 GO:0006096 glycolytic process(GO:0006096)
0.1 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0006552 leucine catabolic process(GO:0006552)
0.0 1.1 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.3 GO:0060337 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.4 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 1.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.8 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0090316 positive regulation of intracellular protein transport(GO:0090316)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.3 GO:1905202 methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.1 6.4 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.1 3.7 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 0.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase II, core complex(GO:0005665) DNA-directed RNA polymerase I complex(GO:0005736)
0.0 2.4 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 2.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 2.3 GO:0005770 late endosome(GO:0005770)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0051978 lysophospholipid transporter activity(GO:0051978)
0.7 4.0 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.4 2.5 GO:0071253 connexin binding(GO:0071253)
0.3 1.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 3.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.2 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 6.4 GO:0017069 snRNA binding(GO:0017069)
0.1 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679) cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.1 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism