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Results for elf2a+elf2b
Z-value: 3.33
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Transcription factors associated with elf2a+elf2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| elf2b | dr10_dc_chr1_-_13302745_13302847 | -0.86 | 2.4e-05 | Click! |
| elf2a | dr10_dc_chr14_-_47083485_47083555 | -0.85 | 3.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of elf2a+elf2b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| KN150623v1_+_258 Show fit | 9.00 |
|
|
|
| chr21_+_20360180 Show fit | 7.42 |
ENSDART00000003299
|
ENSDARG00000025174 |
|
| chr16_+_36794614 Show fit | 7.34 |
ENSDART00000139069
|
2,4-dienoyl CoA reductase 1, mitochondrial |
|
| chr14_-_880799 Show fit | 7.17 |
ENSDART00000031992
|
regulator of G protein signaling 14a |
|
| chr23_-_27123433 Show fit | 7.10 |
ENSDART00000142324
ENSDART00000133249 |
ENSDARG00000025766 |
|
| chr9_+_8387050 Show fit | 6.69 |
ENSDART00000136847
|
si:dkey-90l23.2 |
|
| chr8_+_52456064 Show fit | 6.63 |
ENSDART00000012758
|
zgc:77112 |
|
| chr22_-_38321005 Show fit | 6.35 |
ENSDART00000015117
|
ELAV like neuron-specific RNA binding protein 2 |
|
| chr5_+_3567992 Show fit | 5.85 |
ENSDART00000129329
|
RPA interacting protein |
|
| chr3_+_32285237 Show fit | 5.32 |
ENSDART00000157324
|
proline rich Gla (G-carboxyglutamic acid) 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.3 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 16.7 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.2 | 13.8 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 13.4 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.2 | 13.0 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.3 | 12.6 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.8 | 11.4 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 1.4 | 11.1 | GO:0032447 | protein urmylation(GO:0032447) |
| 0.4 | 10.7 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.4 | 9.9 | GO:1903845 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.2 | 17.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 14.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.4 | 12.6 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.3 | 11.3 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 11.2 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.3 | 11.1 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.2 | 11.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 9.8 | GO:0005769 | early endosome(GO:0005769) |
| 1.5 | 8.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 50.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 25.7 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 20.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.7 | 19.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.8 | 12.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 11.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 11.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 10.9 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.6 | 10.3 | GO:0004407 | histone deacetylase activity(GO:0004407) NAD-dependent histone deacetylase activity(GO:0017136) |
| 0.1 | 10.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.4 | 14.5 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.6 | 10.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 1.0 | 8.9 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.8 | 8.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 8.6 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 7.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 6.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.3 | 6.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.4 | 5.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.6 | 11.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.5 | 9.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.3 | 8.9 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.5 | 7.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 7.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 7.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 7.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.3 | 7.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.7 | 6.6 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |