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Results for en2a+en2b_gbx1_en1b_emx1

Z-value: 1.64

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Transcription factors associated with en2a+en2b_gbx1_en1b_emx1

Gene Symbol Gene ID Gene Info
en2a
ENSDARG00000026599 engrailed homeobox 2a
en2b
ENSDARG00000038868 engrailed homeobox 2b
gbx1
ENSDARG00000071418 gastrulation brain homeobox 1
en1b
ENSDARG00000098730 engrailed homeobox 1b
emx1
ENSDARG00000039569 empty spiracles homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gbx1dr10_dc_chr24_+_34227202_34227285-0.911.4e-06Click!
en2bdr10_dc_chr2_+_29992879_29992897-0.871.2e-05Click!
emx1dr10_dc_chr13_+_14873339_14873426-0.783.6e-04Click!
en2adr10_dc_chr7_-_40713381_40713426-0.774.6e-04Click!
en1bdr10_dc_chr1_+_6995893_6995939-0.765.7e-04Click!

Activity profile of en2a+en2b_gbx1_en1b_emx1 motif

Sorted Z-values of en2a+en2b_gbx1_en1b_emx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of en2a+en2b_gbx1_en1b_emx1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_25740782 15.97 ENSDART00000021620
cldnd
claudin d
chr8_-_23759076 10.93 ENSDART00000145894
zgc:195245
zgc:195245
chr11_-_6442588 9.77 ENSDART00000137879
zgc:162969
zgc:162969
chr24_-_14446593 9.26

chr18_-_40718244 9.24 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr10_-_34971985 8.69 ENSDART00000141201
ccna1
cyclin A1
chr10_-_21404605 7.87 ENSDART00000125167
avd
avidin
chr10_-_34058331 7.86 ENSDART00000046599
zar1l
zygote arrest 1-like
chr11_-_44539778 7.86 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr1_-_54570813 7.66 ENSDART00000098615
nanos3
nanos homolog 3
chr17_+_16038358 7.36 ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr23_-_35691369 6.03 ENSDART00000142369
mfsd5
major facilitator superfamily domain containing 5
chr14_+_34150130 6.01 ENSDART00000132193
ENSDART00000141058
wnt8a
BX927327.1
wingless-type MMTV integration site family, member 8a
ENSDARG00000105311
KN150266v1_-_68652 5.98

chr20_-_23527234 5.97 ENSDART00000004625
zar1
zygote arrest 1
chr17_+_16038103 5.48 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
KN150456v1_-_19515 5.46 ENSDART00000168786
h1m
linker histone H1M
chr10_-_44713495 5.36 ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr2_+_6341404 5.30 ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr16_+_42567707 5.25 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr24_+_19270877 5.25

KN150699v1_-_15078 5.20 ENSDART00000159861
ENSDARG00000098739
ENSDARG00000098739
chr11_+_37371675 5.17 ENSDART00000140502
sh2d5
SH2 domain containing 5
chr23_+_2786407 5.08 ENSDART00000066086
zgc:114123
zgc:114123
chr24_+_8702288 5.07 ENSDART00000114810
sycp2l
synaptonemal complex protein 2-like
chr11_-_1524107 4.96 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr10_-_34971926 4.67 ENSDART00000141201
ccna1
cyclin A1
KN149710v1_+_38638 4.59

chr22_+_4035577 4.50 ENSDART00000170620
ctxn1
cortexin 1
chr13_-_18564182 4.47 ENSDART00000176809
sfxn3
sideroflexin 3
chr23_+_43868027 4.39 ENSDART00000112598
ENSDART00000169576
otud4
OTU deubiquitinase 4
chr9_-_35824470 4.25 ENSDART00000140356
zp2l1
zona pellucida glycoprotein 2, like 1
chr18_-_43890836 4.21 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr23_-_33692244 4.12

chr24_+_1110206 4.03 ENSDART00000152063
BX005461.1
ENSDARG00000096447
chr24_+_12689711 3.94 ENSDART00000114762
nanog
nanog homeobox
chr19_-_18664720 3.93 ENSDART00000108627
snx10a
sorting nexin 10a
chr1_-_18118467 3.86 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr8_+_20108592 3.80

chr14_-_8634381 3.77 ENSDART00000129030
zgc:153681
zgc:153681
chr12_-_14104939 3.67 ENSDART00000152742
buc2l
bucky ball 2-like
chr21_-_32027717 3.67 ENSDART00000131651
ENSDARG00000073961
ENSDARG00000073961
chr6_+_18941135 3.58 ENSDART00000044519
cx44.2
connexin 44.2
chr7_+_24257251 3.49 ENSDART00000136473
ENSDARG00000079281
ENSDARG00000079281
chr10_+_6925373 3.44 ENSDART00000128866
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr22_+_17803309 3.34 ENSDART00000136016
hapln4
hyaluronan and proteoglycan link protein 4
chr13_-_37530793 3.33 ENSDART00000141295
si:dkey-188i13.11
si:dkey-188i13.11
chr12_+_46281592 3.20 ENSDART00000149326
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr2_-_38305602 3.15 ENSDART00000061677
si:ch211-14a17.6
si:ch211-14a17.6
chr20_-_14218080 3.14 ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
chr10_-_32550351 3.13 ENSDART00000129395
uvrag
UV radiation resistance associated gene
chr23_+_28396415 3.11 ENSDART00000142179
birc5b
baculoviral IAP repeat containing 5b
chr1_-_22617455 3.10 ENSDART00000137567
smim14
small integral membrane protein 14
chr5_+_29193876 3.10 ENSDART00000045410
thy1
Thy-1 cell surface antigen
chr2_-_57020663 3.09

KN150266v1_-_68620 2.99

chr11_-_44756789 2.97 ENSDART00000161712
syngr2b
synaptogyrin 2b
chr7_+_72925910 2.95 ENSDART00000175267
ENSDART00000179638
CABZ01067170.1
ENSDARG00000106453
chr5_-_14783255 2.93 ENSDART00000052712
gnb1l
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
chr5_+_6391432 2.93 ENSDART00000170564
ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr10_-_35313462 2.92 ENSDART00000139107
prr11
proline rich 11
chr20_-_6542402 2.88 ENSDART00000054653
mcm3l
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like
chr22_+_8973724 2.85 ENSDART00000106414
rnh1
ribonuclease/angiogenin inhibitor 1
chr23_-_32267833 2.78

chr10_-_44713414 2.75 ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr24_+_39630741 2.72 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr11_-_6442490 2.71 ENSDART00000137879
zgc:162969
zgc:162969
chr8_-_1833095 2.67 ENSDART00000114476
ENSDART00000091235
ENSDART00000140077
pi4kab
phosphatidylinositol 4-kinase, catalytic, alpha b
chr12_+_47448318 2.63 ENSDART00000152857
fmn2b
formin 2b
chr3_+_28729443 2.62 ENSDART00000077235
alg1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr6_-_2000017 2.61 ENSDART00000158535
vstm2l
V-set and transmembrane domain containing 2 like
chr10_+_19625897 2.58

KN149735v1_-_1679 2.57

chr15_-_16241412 2.56 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr4_-_26106485 2.55 ENSDART00000100611
si:ch211-244b2.3
si:ch211-244b2.3
chr10_+_35313772 2.49 ENSDART00000028940
styxl1
serine/threonine/tyrosine interacting-like 1
chr24_-_19573615 2.47 ENSDART00000158952
ENSDART00000109107
ENSDART00000056082
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr19_+_21209328 2.44 ENSDART00000142463
txnl4a
thioredoxin-like 4A
chr20_-_29961498 2.38 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr16_+_42567668 2.33 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr20_-_29961589 2.32 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr18_+_20571619 2.32 ENSDART00000040074
wee2
WEE1 homolog 2 (S. pombe)
chr24_+_12689887 2.31 ENSDART00000114762
nanog
nanog homeobox
chr4_+_4825461 2.27 ENSDART00000150309
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr2_-_27892824 2.26

chr12_+_46281623 2.26 ENSDART00000149326
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr13_-_37530730 2.22 ENSDART00000141295
si:dkey-188i13.11
si:dkey-188i13.11
chr5_+_36168475 2.21 ENSDART00000146854
mark4a
MAP/microtubule affinity-regulating kinase 4a
chr7_-_51497945 2.18 ENSDART00000054591
bmp15
bone morphogenetic protein 15
chr10_-_25448712 2.15 ENSDART00000140023
grik1a
glutamate receptor, ionotropic, kainate 1a
chr20_+_14218237 2.14 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr6_-_3821922 2.14 ENSDART00000171944
slc25a12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr3_+_42383724 2.14

chr11_+_30005768 2.11 ENSDART00000167618
CR790368.1
ENSDARG00000100936
chr9_+_33310981 2.09

chr3_-_29725539 2.09

chr17_+_7377230 2.08 ENSDART00000157123
shprh
SNF2 histone linker PHD RING helicase
chr12_+_46281511 2.05 ENSDART00000149326
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr7_+_20092235 2.03 ENSDART00000139274
ponzr1
plac8 onzin related protein 1
chr19_+_31998646 2.02 ENSDART00000132182
gmnn
geminin, DNA replication inhibitor
chr12_+_22552867 2.00 ENSDART00000152930
cdca9
cell division cycle associated 9
chr17_-_25630635 1.99 ENSDART00000149060
ppp1cb
protein phosphatase 1, catalytic subunit, beta isozyme
chr16_-_42105636 1.98 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr20_-_20425034 1.98 ENSDART00000152795
snapc1a
small nuclear RNA activating complex, polypeptide 1a
chr8_-_44247277 1.94

chr17_-_45021393 1.93

chr16_-_41764849 1.92 ENSDART00000084610
cep85
centrosomal protein 85
chr1_+_35253862 1.92 ENSDART00000139636
zgc:152968
zgc:152968
chr3_-_15060685 1.91 ENSDART00000037906
hirip3
HIRA interacting protein 3
chr17_+_16421892 1.90 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr5_+_37303599 1.88 ENSDART00000097754
ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr21_-_39521698 1.88 ENSDART00000020174
dynll2b
dynein, light chain, LC8-type 2b
chr19_-_5186692 1.86 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr14_-_9686650 1.86

chr7_+_20091996 1.86 ENSDART00000138786
ponzr1
plac8 onzin related protein 1
chr2_-_15656155 1.85 ENSDART00000015655
tecrl2b
trans-2,3-enoyl-CoA reductase-like 2b
chr6_+_28218420 1.84 ENSDART00000171216
ENSDART00000171377
si:ch73-14h10.2
si:ch73-14h10.2
chr14_+_23420053 1.84 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr8_+_11287550 1.83 ENSDART00000115057
tjp2b
tight junction protein 2b (zona occludens 2)
chr24_-_19573966 1.82 ENSDART00000158952
ENSDART00000109107
ENSDART00000056082
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr2_+_6341345 1.79 ENSDART00000058256
zp3b
zona pellucida glycoprotein 3b
chr9_+_18821640 1.79 ENSDART00000006514
gtf2f2b
general transcription factor IIF, polypeptide 2b
chr10_+_16078021 1.74 ENSDART00000065037
ENSDART00000124502
lmnb1
lamin B1
chr11_-_12024136 1.74 ENSDART00000111919
sp2
sp2 transcription factor
chr5_+_32687626 1.74 ENSDART00000146759
med22
mediator complex subunit 22
chr24_+_16402587 1.73 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_+_38262119 1.72 ENSDART00000042276
nxph1
neurexophilin 1
chr24_-_9838947 1.72 ENSDART00000138576
zgc:171977
zgc:171977
chr12_-_33256671 1.71 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr17_+_10582214 1.70 ENSDART00000051527
tbpl2
TATA box binding protein like 2
chr8_+_49128711 1.69 ENSDART00000079631
rad21l1
RAD21 cohesin complex component like 1
chr25_-_13394261 1.68 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr15_+_28477741 1.68 ENSDART00000057257
pitpnaa
phosphatidylinositol transfer protein, alpha a
chr8_-_32376710 1.66 ENSDART00000098850
lipg
lipase, endothelial
chr6_+_40925259 1.65 ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr11_-_44539726 1.65 ENSDART00000173360
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr2_+_37194276 1.63 ENSDART00000048277
copa
coatomer protein complex, subunit alpha
chr7_+_37818365 1.63 ENSDART00000052365
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr12_+_3632548 1.61

chr10_-_2944190 1.60 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr25_+_33486711 1.59 ENSDART00000121498
ice2
interactor of little elongator complex ELL subunit 2
chr12_+_22459177 1.57 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr12_-_33256754 1.56 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr10_-_25808063 1.53 ENSDART00000134176
postna
periostin, osteoblast specific factor a
chr24_-_14446522 1.50

chr1_+_518777 1.49 ENSDART00000109083
txnl4b
thioredoxin-like 4B
chr19_+_40558066 1.49 ENSDART00000049968
si:ch211-173p18.3
si:ch211-173p18.3
chr24_-_34794538 1.49 ENSDART00000171009
ENSDART00000170046
ctnna1
catenin (cadherin-associated protein), alpha 1
chr14_+_23419864 1.47 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr19_+_42657913 1.47 ENSDART00000131574
ENSDART00000135436
jtb
jumping translocation breakpoint
chr8_-_21039978 1.45 ENSDART00000137606
ENSDART00000146532
zgc:112962
zgc:112962
chr6_-_37766424 1.45 ENSDART00000149722
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr14_-_33605295 1.43 ENSDART00000168546
zdhhc24
zinc finger, DHHC-type containing 24
chr17_+_10582044 1.43 ENSDART00000051527
tbpl2
TATA box binding protein like 2
chr18_-_49291686 1.42 ENSDART00000174038
si:zfos-464b6.2
si:zfos-464b6.2
chr14_+_43357313 1.42

chr24_-_24999240 1.41 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr8_-_21110262 1.41 ENSDART00000143192
cpt2
carnitine palmitoyltransferase 2
chr19_-_8849482 1.40 ENSDART00000170416
si:ch73-350k19.1
si:ch73-350k19.1
chr13_-_10214396 1.40 ENSDART00000132231
AL929457.1
ENSDARG00000095483
chr2_+_10209233 1.39 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr14_-_14353451 1.39 ENSDART00000170355
ENSDART00000159888
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr1_+_18118735 1.38 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr19_-_33264349 1.37

chr3_-_26052785 1.37 ENSDART00000147517
si:ch211-11k18.4
si:ch211-11k18.4
chr3_+_38497816 1.37

chr16_+_47283253 1.37 ENSDART00000062507
ica1
islet cell autoantigen 1
chr18_+_20571460 1.36 ENSDART00000151990
wee2
WEE1 homolog 2 (S. pombe)
chr20_+_27188382 1.36 ENSDART00000062094
tmem251
transmembrane protein 251
chr19_-_20819477 1.36 ENSDART00000151356
dazl
deleted in azoospermia-like
chr22_+_25734113 1.35 ENSDART00000136334
si:ch211-250e5.16
si:ch211-250e5.16
chr3_-_15060501 1.33 ENSDART00000037906
hirip3
HIRA interacting protein 3
chr15_+_6462447 1.33 ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr15_-_25164321 1.32 ENSDART00000154628
fam101b
family with sequence similarity 101, member B
chr20_+_37023072 1.32 ENSDART00000155058
CR388421.1
ENSDARG00000096706
chr12_+_33257120 1.31

chr25_-_9889107 1.29 ENSDART00000137407
AL929493.1
ENSDARG00000093575
chr5_+_19429620 1.29 ENSDART00000088819
ankrd13a
ankyrin repeat domain 13A
chr16_-_24727689 1.29 ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr2_+_55065658 1.29

chr24_-_36721857 1.28

chr11_+_23799984 1.28

chr2_+_42923652 1.28 ENSDART00000168318
BX005083.1
ENSDARG00000097562
chr24_-_14447519 1.25

chr12_-_26943743 1.25

chr11_+_12754166 1.24 ENSDART00000123445
ENSDART00000163364
ENSDART00000066122
rtel1
regulator of telomere elongation helicase 1
chr12_-_33257026 1.24 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr9_-_32348003 1.24 ENSDART00000037182
ankrd44
ankyrin repeat domain 44
chr9_-_32347822 1.24 ENSDART00000037182
ankrd44
ankyrin repeat domain 44
chr8_+_45326435 1.24 ENSDART00000134161
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr1_-_17000212 1.22 ENSDART00000146258
cfap97
cilia and flagella associated protein 97
chr19_+_15536640 1.21 ENSDART00000098970
lin28a
lin-28 homolog A (C. elegans)
chr20_-_14218236 1.21 ENSDART00000168434
si:ch211-223m11.2
si:ch211-223m11.2
chr2_+_3115593 1.20 ENSDART00000160715
pik3r3a
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr10_+_516924 1.19 ENSDART00000128275
npffr1l3
neuropeptide FF receptor 1 like 3
chr23_-_2957262 1.19 ENSDART00000165955
zhx3
zinc fingers and homeoboxes 3
chr14_+_8634323 1.18 ENSDART00000159920
rps6kal
ribosomal protein S6 kinase a, like
chr19_+_1743359 1.17 ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr8_-_25015215 1.16 ENSDART00000170511
nfyal
nuclear transcription factor Y, alpha, like
chr3_-_26052601 1.15 ENSDART00000147517
si:ch211-11k18.4
si:ch211-11k18.4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0050957 equilibrioception(GO:0050957)
1.8 7.2 GO:0043622 cortical microtubule organization(GO:0043622)
1.7 6.8 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
1.3 5.1 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
1.3 6.3 GO:0060631 regulation of meiosis I(GO:0060631)
1.2 4.9 GO:0070986 left/right axis specification(GO:0070986)
1.1 4.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
1.0 3.1 GO:0051311 meiotic metaphase plate congression(GO:0051311)
0.9 3.6 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.8 2.5 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.8 13.3 GO:0060046 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.6 1.9 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 15.4 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.6 5.6 GO:0061458 gonad development(GO:0008406) reproductive structure development(GO:0048608) reproductive system development(GO:0061458)
0.5 3.9 GO:0072088 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.4 1.2 GO:0090656 t-circle formation(GO:0090656)
0.4 2.9 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.4 1.9 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 1.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 5.1 GO:0045116 protein neddylation(GO:0045116)
0.3 6.8 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.3 1.8 GO:0035264 multicellular organism growth(GO:0035264)
0.3 2.4 GO:0034063 stress granule assembly(GO:0034063)
0.3 1.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 7.1 GO:0019827 stem cell population maintenance(GO:0019827)
0.3 4.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 1.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 1.9 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.3 1.4 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.3 1.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119) mRNA pseudouridine synthesis(GO:1990481)
0.3 14.8 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 2.1 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.2 0.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 0.5 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.2 0.7 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.2 1.7 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.2 0.6 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.2 3.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 0.6 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.2 0.9 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.2 5.5 GO:0016584 nucleosome positioning(GO:0016584)
0.2 1.9 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.2 0.9 GO:1900182 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.2 1.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 3.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 3.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 0.5 GO:0031639 plasminogen activation(GO:0031639)
0.2 1.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 1.9 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 0.9 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 1.0 GO:0016572 histone phosphorylation(GO:0016572)
0.1 0.7 GO:0035627 ceramide transport(GO:0035627)
0.1 0.4 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.1 0.9 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.4 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 2.0 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.3 GO:0050435 beta-amyloid metabolic process(GO:0050435) melanocyte migration(GO:0097324)
0.1 1.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0006481 C-terminal protein methylation(GO:0006481)
0.1 5.4 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 2.7 GO:0051014 actin filament severing(GO:0051014)
0.1 1.6 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 0.8 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 3.1 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.1 1.6 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.6 GO:0031297 replication fork processing(GO:0031297)
0.1 0.3 GO:0051645 Golgi localization(GO:0051645)
0.1 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.2 GO:0090344 negative regulation of cell aging(GO:0090344)
0.1 2.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 3.3 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.3 GO:0097435 fibril organization(GO:0097435)
0.1 5.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.6 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.1 0.4 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.1 0.4 GO:0043090 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.1 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 0.7 GO:0032185 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.1 3.0 GO:0001878 response to yeast(GO:0001878)
0.1 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.5 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222) skin epidermis development(GO:0098773)
0.1 1.0 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.9 GO:0060021 palate development(GO:0060021)
0.1 0.9 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.4 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) renal absorption(GO:0070293) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 4.5 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.1 0.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.4 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.3 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.3 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.1 5.7 GO:0015698 inorganic anion transport(GO:0015698)
0.1 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.3 GO:0046098 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine metabolic process(GO:0046098) guanine biosynthetic process(GO:0046099) hypoxanthine metabolic process(GO:0046100)
0.1 0.4 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 6.0 GO:0017148 negative regulation of translation(GO:0017148)
0.1 0.6 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 0.4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.8 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 2.6 GO:0045010 actin nucleation(GO:0045010)
0.1 1.7 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.9 GO:0006825 copper ion transport(GO:0006825)
0.1 0.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 1.1 GO:0030301 cholesterol transport(GO:0030301)
0.0 0.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.2 GO:0019755 one-carbon compound transport(GO:0019755)
0.0 0.2 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441) kynurenine metabolic process(GO:0070189)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.2 GO:0008078 mesodermal cell migration(GO:0008078)
0.0 0.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 4.8 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.0 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.9 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 2.5 GO:0051225 spindle assembly(GO:0051225)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 1.1 GO:0071230 response to amino acid(GO:0043200) cellular response to amino acid stimulus(GO:0071230)
0.0 2.6 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 1.7 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.2 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 1.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 2.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.7 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.4 GO:0030719 P granule organization(GO:0030719)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.3 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.0 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 1.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0030817 regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of adenylate cyclase activity(GO:0045761)
0.0 1.5 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.2 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 2.3 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.8 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 1.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 1.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.4 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.4 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0006623 protein targeting to vacuole(GO:0006623)
0.0 0.6 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.5 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.6 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.7 GO:0021536 diencephalon development(GO:0021536)
0.0 0.4 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.6 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.3 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.2 GO:0046460 triglyceride biosynthetic process(GO:0019432) neutral lipid biosynthetic process(GO:0046460) acylglycerol biosynthetic process(GO:0046463)
0.0 0.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.1 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.0 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 1.2 GO:0045087 innate immune response(GO:0045087)
0.0 0.3 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.3 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.3 GO:0030217 T cell differentiation(GO:0030217)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.4 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.7 6.8 GO:0097189 apoptotic body(GO:0097189)
0.7 2.0 GO:0019185 snRNA-activating protein complex(GO:0019185)
0.6 1.7 GO:0034990 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.5 11.1 GO:0043186 P granule(GO:0043186)
0.5 1.4 GO:0061689 tricellular tight junction(GO:0061689)
0.4 1.8 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.4 2.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.3 4.8 GO:0005682 U5 snRNP(GO:0005682)
0.3 0.9 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 4.5 GO:0042555 MCM complex(GO:0042555)
0.2 16.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 2.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 2.4 GO:0030667 secretory granule membrane(GO:0030667)
0.2 2.1 GO:0070652 HAUS complex(GO:0070652)
0.2 1.0 GO:0097255 R2TP complex(GO:0097255)
0.2 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 3.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.0 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 0.9 GO:0000811 GINS complex(GO:0000811)
0.2 1.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 2.4 GO:0045180 basal cortex(GO:0045180)
0.2 4.3 GO:0000421 autophagosome membrane(GO:0000421)
0.2 1.1 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 1.6 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 4.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.9 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.3 GO:0000801 central element(GO:0000801)
0.1 3.4 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 8.5 GO:0000786 nucleosome(GO:0000786)
0.1 4.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 3.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 1.2 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 3.2 GO:0001726 ruffle(GO:0001726)
0.1 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 2.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 8.3 GO:0005813 centrosome(GO:0005813)
0.0 0.6 GO:0000792 heterochromatin(GO:0000792)
0.0 9.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.4 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 4.4 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 1.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 5.0 GO:0005730 nucleolus(GO:0005730)
0.0 0.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.9 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
1.6 7.9 GO:0009374 biotin binding(GO:0009374)
1.1 2.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.9 6.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.8 7.1 GO:0035804 structural constituent of egg coat(GO:0035804)
0.8 6.2 GO:0032190 acrosin binding(GO:0032190)
0.6 4.5 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.6 1.9 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.6 1.7 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.5 1.6 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.5 2.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.5 5.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 2.7 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 1.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.4 3.1 GO:0050699 WW domain binding(GO:0050699)
0.4 2.6 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.4 2.2 GO:0070698 type I activin receptor binding(GO:0070698)
0.3 9.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 1.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 1.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 3.1 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.2 1.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 15.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 1.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.2 0.6 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) CCR5 chemokine receptor binding(GO:0031730)
0.2 3.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 2.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 2.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 1.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 0.7 GO:1902387 ceramide transporter activity(GO:0035620) sphingolipid transporter activity(GO:0046624) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.2 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 2.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 0.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 1.0 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.2 3.1 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.2 1.0 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 1.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 0.5 GO:0097001 sphingolipid binding(GO:0046625) ceramide binding(GO:0097001)
0.1 0.4 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 5.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 4.9 GO:0005109 frizzled binding(GO:0005109)
0.1 1.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 6.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.5 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.4 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.1 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 24.0 GO:0042802 identical protein binding(GO:0042802)
0.1 0.6 GO:0016805 dipeptidase activity(GO:0016805)
0.1 2.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.8 GO:0043295 glutathione binding(GO:0043295)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0035197 siRNA binding(GO:0035197)
0.1 0.7 GO:0005537 mannose binding(GO:0005537)
0.1 5.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 2.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.9 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 6.3 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.3 GO:0052657 guanine phosphoribosyltransferase activity(GO:0052657)
0.1 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 2.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 6.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 1.0 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.4 GO:0019869 chloride channel regulator activity(GO:0017081) chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 0.5 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 1.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.5 GO:0015368 calcium:cation antiporter activity(GO:0015368)
0.1 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.3 GO:0045503 dynein light chain binding(GO:0045503)
0.1 2.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 4.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 5.5 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.1 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 1.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 4.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 6.9 GO:0042393 histone binding(GO:0042393)
0.0 2.1 GO:0004527 exonuclease activity(GO:0004527)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 4.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 2.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 3.5 GO:0008017 microtubule binding(GO:0008017)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 1.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.0 GO:0030623 U5 snRNA binding(GO:0030623)
0.0 1.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.2 2.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.7 PID ALK2 PATHWAY ALK2 signaling events
0.1 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 7.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.2 PID ARF 3PATHWAY Arf1 pathway
0.1 2.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 1.6 ST GA13 PATHWAY G alpha 13 Pathway
0.1 1.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.9 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID AURORA B PATHWAY Aurora B signaling
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.7 13.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 1.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 2.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 0.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 3.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 2.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.6 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.1 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.1 1.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 1.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 3.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 2.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation