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Results for eomesa+eomesb

Z-value: 0.52

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Transcription factors associated with eomesa+eomesb

Gene Symbol Gene ID Gene Info
eomesa
ENSDARG00000006640 eomesodermin homolog a
eomesb
ENSDARG00000104243 eomesodermin homolog b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
eomesadr10_dc_chr19_-_867262_867279-0.458.1e-02Click!

Activity profile of eomesa+eomesb motif

Sorted Z-values of eomesa+eomesb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa+eomesb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_44006939 1.70

chr22_-_36721626 0.73 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr22_+_25113293 0.72 ENSDART00000171851
si:ch211-226h8.4
si:ch211-226h8.4
chr7_+_23782982 0.64

chr1_-_55072271 0.61 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr11_+_18823629 0.60

chr13_+_7607232 0.55

KN149861v1_-_5655 0.54

chr16_+_4825665 0.52

chr11_-_1524107 0.48 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr22_-_18519706 0.44 ENSDART00000132156
cirbpb
cold inducible RNA binding protein b
chr22_+_25156826 0.39 ENSDART00000140670
ENSDART00000105308
si:ch211-226h8.4
si:ch211-226h8.4
chr10_-_25246786 0.38 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr22_+_25734113 0.37 ENSDART00000136334
si:ch211-250e5.16
si:ch211-250e5.16
chr5_-_15971338 0.37 ENSDART00000110437
piwil2
piwi-like RNA-mediated gene silencing 2
chr17_+_23534953 0.37 ENSDART00000135814
pank1a
pantothenate kinase 1a
chr16_+_25192196 0.35 ENSDART00000033211
zgc:66448
zgc:66448
chr2_+_2977250 0.35

chr8_-_43151763 0.35 ENSDART00000134801
ccdc92
coiled-coil domain containing 92
chr1_-_39297624 0.35 ENSDART00000165373
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr16_+_24046996 0.34

chr11_+_18823762 0.33

chr6_-_34951317 0.32

chr1_-_39297686 0.31 ENSDART00000165373
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr5_+_61656465 0.31 ENSDART00000130177
ENSDART00000050879
pho
phoenix
chr5_-_41044841 0.31 ENSDART00000051092
riok2
RIO kinase 2 (yeast)
chr17_-_27030048 0.29 ENSDART00000050018
cnksr1
connector enhancer of kinase suppressor of Ras 1
chr17_-_33463210 0.27 ENSDART00000135218
ccdc28a
coiled-coil domain containing 28A
chr22_+_25754857 0.27 ENSDART00000174421
AL929192.1
ENSDARG00000106684
chr8_+_25988813 0.26 ENSDART00000058100
xpc
xeroderma pigmentosum, complementation group C
chr18_+_3435932 0.26

chr6_-_34951155 0.23

chr22_+_25755073 0.23 ENSDART00000174421
AL929192.1
ENSDARG00000106684
chr11_+_18856937 0.23

chr19_+_40439358 0.21 ENSDART00000123647
sfpq
splicing factor proline/glutamine-rich
chr10_+_6339177 0.21 ENSDART00000160813
tpm2
tropomyosin 2 (beta)
chr2_+_2976671 0.21 ENSDART00000081976
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr5_+_30436723 0.21 ENSDART00000141463
zzef1
zinc finger, ZZ-type with EF hand domain 1
chr2_+_22936475 0.20 ENSDART00000126891
ENSDART00000130603
sept2
septin 2
chr10_+_42841562 0.20

chr1_-_55072375 0.20 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr22_+_25754948 0.18 ENSDART00000174421
AL929192.1
ENSDARG00000106684
chr12_+_35855929 0.16

chr16_+_4825019 0.16 ENSDART00000167665
LIN28A
lin-28 homolog A
chr10_+_6339059 0.16 ENSDART00000160813
tpm2
tropomyosin 2 (beta)
chr4_-_11604184 0.16 ENSDART00000170136
net1
neuroepithelial cell transforming 1
chr12_-_17302222 0.15 ENSDART00000079144
ptenb
phosphatase and tensin homolog B
chr12_-_622463 0.15 ENSDART00000158563
wu:fj29h11
wu:fj29h11
chr22_-_4867538 0.14 ENSDART00000081801
ncl1
nicalin
KN149861v1_-_5543 0.14

chr11_-_40239946 0.14 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr7_+_30222432 0.14 ENSDART00000027466
fam63b
family with sequence similarity 63, member B
chr15_-_45522055 0.14 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr10_+_6338988 0.14 ENSDART00000160813
tpm2
tropomyosin 2 (beta)
chr22_-_18520332 0.14

chr18_+_50921419 0.14 ENSDART00000058468
ENSDART00000008696
cttn
cortactin
KN150593v1_+_10332 0.13

chr3_-_44113070 0.12 ENSDART00000160717
znf750
zinc finger protein 750
chr7_-_14835871 0.12 ENSDART00000172489
CU280645.1
ENSDARG00000098326
chr5_-_41045017 0.12 ENSDART00000051092
riok2
RIO kinase 2 (yeast)
chr6_-_34951506 0.12

chr17_-_33463482 0.11 ENSDART00000164064
ccdc28a
coiled-coil domain containing 28A
chr9_-_24013313 0.11 ENSDART00000059209
wdfy2
WD repeat and FYVE domain containing 2
chr8_-_43151611 0.11 ENSDART00000134801
ccdc92
coiled-coil domain containing 92
chr9_-_12913920 0.11 ENSDART00000122799
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr11_-_40464213 0.11 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr3_+_36941624 0.11 ENSDART00000125611
retreg3
reticulophagy regulator family member 3
chr22_-_18520027 0.11 ENSDART00000132156
cirbpb
cold inducible RNA binding protein b
chr25_-_23485520 0.11 ENSDART00000149107
nap1l4a
nucleosome assembly protein 1-like 4a
chr17_+_23535117 0.08 ENSDART00000135814
pank1a
pantothenate kinase 1a
chr2_+_2976973 0.08 ENSDART00000163587
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr3_+_62116865 0.08 ENSDART00000112428
iqck
IQ motif containing K
chr20_-_7594437 0.06

chr5_-_41044810 0.05 ENSDART00000051092
riok2
RIO kinase 2 (yeast)
chr21_-_14719281 0.05 ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr24_-_55232 0.04

chr17_-_29295450 0.04 ENSDART00000133668
tecpr2
tectonin beta-propeller repeat containing 2
chr24_-_36307897 0.03 ENSDART00000154395
esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr11_-_40464253 0.02 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr8_-_47855945 0.02 ENSDART00000145429
si:dkeyp-104h9.5
si:dkeyp-104h9.5
chr11_+_14254556 0.02 ENSDART00000102518
si:ch211-262i1.5
si:ch211-262i1.5
chr24_-_36307855 0.01 ENSDART00000111891
esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr8_-_19167286 0.00 ENSDART00000161646
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr1_-_55072064 0.00 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.1 0.3 GO:0070655 mechanosensory epithelium regeneration(GO:0070655) mechanoreceptor differentiation involved in mechanosensory epithelium regeneration(GO:0070656) neuromast regeneration(GO:0070657) neuromast hair cell differentiation involved in neuromast regeneration(GO:0070658)
0.1 0.3 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.1 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.2 GO:0021547 midbrain-hindbrain boundary initiation(GO:0021547)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.8 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071546 pi-body(GO:0071546)
0.0 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034584 piRNA binding(GO:0034584)
0.1 0.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse