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Results for fosaa+fosab+fosl1a_nfya_nfyal
Z-value: 5.34
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Transcription factors associated with fosaa+fosab+fosl1a_nfya_nfyal
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000015355 | FOS-like antigen 1a | |
| ENSDARG00000031683 | v-fos FBJ murine osteosarcoma viral oncogene homolog Ab | |
| ENSDARG00000040135 | v-fos FBJ murine osteosarcoma viral oncogene homolog Aa | |
| ENSDARG00000042004 | nuclear transcription factor Y, alpha | |
| ENSDARG00000001621 | nuclear transcription factor Y, alpha, like |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfyal | dr10_dc_chr8_-_25015215_25015329 | 0.86 | 2.4e-05 | Click! |
| nfya | dr10_dc_chr11_-_36017572_36017661 | -0.77 | 4.7e-04 | Click! |
| fosab | dr10_dc_chr20_-_46650719_46650720 | -0.66 | 5.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosaa+fosab+fosl1a_nfya_nfyal
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| KN149735v1_-_1679 Show fit | 34.95 |
|
|
|
| chr1_-_32914487 Show fit | 19.59 |
ENSDART00000015547
|
claudin g |
|
| chr8_-_2557556 Show fit | 13.07 |
ENSDART00000140033
|
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a |
|
| chr12_-_1435708 Show fit | 12.13 |
|
|
|
| chr16_+_39209567 Show fit | 11.03 |
ENSDART00000121756
|
syntabulin (syntaxin-interacting) |
|
| chr13_-_50150732 Show fit | 10.25 |
ENSDART00000083857
|
cyclin J |
|
| chr21_+_3732973 Show fit | 9.92 |
ENSDART00000170653
|
dolichyldiphosphatase 1 |
|
| chr3_+_1398333 Show fit | 9.72 |
ENSDART00000031823
|
TRIO and F-actin binding protein b |
|
| chr7_+_30355221 Show fit | 9.55 |
ENSDART00000173533
ENSDART00000052541 |
cyclin B2 |
|
| chr7_-_33414221 Show fit | 9.31 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.0 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 1.5 | 21.3 | GO:0007032 | endosome organization(GO:0007032) |
| 1.0 | 19.1 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.4 | 18.8 | GO:0009060 | aerobic respiration(GO:0009060) |
| 2.5 | 17.5 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.8 | 17.2 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 4.2 | 16.9 | GO:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235) negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 1.2 | 16.9 | GO:0035306 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.4 | 16.6 | GO:0001878 | response to yeast(GO:0001878) |
| 0.4 | 16.5 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 44.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 35.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 25.7 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 25.5 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.0 | 22.4 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.5 | 21.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 20.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 19.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 3.7 | 18.6 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 18.1 | GO:0016604 | nuclear body(GO:0016604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 41.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 35.7 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.5 | 29.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 23.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 20.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 19.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 18.3 | GO:0005347 | ATP transmembrane transporter activity(GO:0005347) |
| 0.7 | 17.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.0 | 14.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 1.1 | 13.8 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 62.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 40.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 2.1 | 19.0 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.6 | 17.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 15.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.9 | 13.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 11.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 11.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.7 | 9.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 8.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 28.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.7 | 26.1 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.1 | 24.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 22.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 2.4 | 16.5 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.3 | 16.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.3 | 15.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.9 | 14.9 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.3 | 14.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.8 | 14.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |