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Results for foxo3a

Z-value: 0.43

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Transcription factors associated with foxo3a

Gene Symbol Gene ID Gene Info
foxo3a
ENSDARG00000023058 forkhead box O3A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo3adr10_dc_chr17_+_6635602_6635627-0.665.0e-03Click!

Activity profile of foxo3a motif

Sorted Z-values of foxo3a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo3a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_-_9992898 1.01 ENSDART00000080664
ACTC1
zgc:86709
chr14_-_36037883 0.92 ENSDART00000173006
gpm6aa
glycoprotein M6Aa
chr8_+_7740132 0.81 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr25_-_30845998 0.73 ENSDART00000027661
myod1
myogenic differentiation 1
chr6_-_14821305 0.72

chr9_-_13383818 0.68 ENSDART00000084055
fzd7a
frizzled class receptor 7a
chr7_-_28425307 0.64 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr7_-_38288929 0.62

chr4_-_6800721 0.53 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr11_+_26371444 0.53 ENSDART00000042322
map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr21_+_10775209 0.52

chr3_+_23567458 0.51 ENSDART00000078466
hoxb3a
homeobox B3a
chr8_-_24991984 0.51 ENSDART00000078795
ahcyl1
adenosylhomocysteinase-like 1
chr9_+_25117850 0.50

chr24_-_2316745 0.49 ENSDART00000138432
cul2
cullin 2
chr15_-_25592228 0.49 ENSDART00000157498
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr3_+_23580269 0.46 ENSDART00000151584
hoxb4a
homeobox B4a
chr4_-_22751641 0.45 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
kmt2e
lysine (K)-specific methyltransferase 2E
chr12_+_16403743 0.45 ENSDART00000058665
kif20bb
kinesin family member 20Bb
chr7_-_28339836 0.44 ENSDART00000054366
scube2
signal peptide, CUB domain, EGF-like 2
chr18_+_26916897 0.43 ENSDART00000050230
tspan3a
tetraspanin 3a
chr20_-_35568169 0.43 ENSDART00000153402
pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr11_+_6809190 0.43 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr16_-_1736470 0.42 ENSDART00000124660
ascc3
activating signal cointegrator 1 complex subunit 3
chr11_-_1792616 0.40

chr9_+_24089828 0.39 ENSDART00000127859
trim63b
tripartite motif containing 63b
chr13_+_24703802 0.39 ENSDART00000101274
zgc:153981
zgc:153981
chr7_+_47014195 0.38 ENSDART00000114669
dpy19l3
dpy-19-like 3 (C. elegans)
chr10_+_42761097 0.38 ENSDART00000075259
fgfr1b
fibroblast growth factor receptor 1b
chr15_-_4537178 0.38 ENSDART00000155619
ENSDART00000128602
tfdp2
transcription factor Dp-2
chr15_-_17074107 0.38 ENSDART00000156768
hip1
huntingtin interacting protein 1
chr7_-_18295101 0.37 ENSDART00000173969
rgs12a
regulator of G protein signaling 12a
chr5_-_68439806 0.36 ENSDART00000168213
mat2ab
methionine adenosyltransferase II, alpha b
chr14_-_8975187 0.35 ENSDART00000054693
asb12b
ankyrin repeat and SOCS box-containing 12b
chr20_-_47680305 0.35 ENSDART00000023058
efhc1
EF-hand domain (C-terminal) containing 1
chr16_-_42011213 0.35 ENSDART00000111956
gramd1a
GRAM domain containing 1A
chr2_+_9263844 0.35 ENSDART00000028906
pigk
phosphatidylinositol glycan anchor biosynthesis, class K
chr25_+_13566205 0.35 ENSDART00000008989
ccdc113
coiled-coil domain containing 113
chr15_-_17074348 0.34 ENSDART00000156768
hip1
huntingtin interacting protein 1
chr6_+_7309023 0.34 ENSDART00000160128
erbb3a
erb-b2 receptor tyrosine kinase 3a
chr1_-_10423289 0.34

chr18_-_38235232 0.32 ENSDART00000114224
si:dkey-10o6.2
si:dkey-10o6.2
chr23_+_40070965 0.32 ENSDART00000166539
fyco1a
FYVE and coiled-coil domain containing 1a
chr3_+_27477793 0.32

chr23_+_33457343 0.31 ENSDART00000114423
rapgef3
Rap guanine nucleotide exchange factor (GEF) 3
chr11_-_37921642 0.30

chr7_-_28278286 0.30 ENSDART00000113313
st5
suppression of tumorigenicity 5
chr23_-_4175790 0.30 ENSDART00000109807
ENSDARG00000076299
ENSDARG00000076299
chr6_-_18733424 0.30 ENSDART00000151578
tns1a
tensin 1a
chr20_+_19175518 0.29

chr25_-_3345176 0.28 ENSDART00000029067
hbp1
HMG-box transcription factor 1
chr12_-_13848616 0.28 ENSDART00000110503
adam11
ADAM metallopeptidase domain 11
chr6_-_9329917 0.27 ENSDART00000151470
map3k2
mitogen-activated protein kinase kinase kinase 2
chr25_+_2909562 0.26 ENSDART00000149360
mpi
mannose phosphate isomerase
chr4_-_14927871 0.26 ENSDART00000110199
prdm4
PR domain containing 4
chr24_-_24859334 0.24 ENSDART00000080997
zdhhc20b
zinc finger, DHHC-type containing 20b
chr8_+_49582361 0.24 ENSDART00000108613
rasef
RAS and EF-hand domain containing
chr14_-_49951676 0.23 ENSDART00000021736
scocb
short coiled-coil protein b
chr14_+_32586048 0.23 ENSDART00000139159
lnx2b
ligand of numb-protein X 2b
chr1_-_5796394 0.23 ENSDART00000109356
klf7a
Kruppel-like factor 7a
chr13_+_35509853 0.23 ENSDART00000148481
thbs2a
thrombospondin 2a
chr9_-_10561062 0.23 ENSDART00000175269
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr15_+_42393715 0.23

chr5_-_54026450 0.23 ENSDART00000159009
spag8
sperm associated antigen 8
chr10_-_36690119 0.22 ENSDART00000077161
rsf1b.1
remodeling and spacing factor 1b, tandem duplicate 1
chr7_+_25778546 0.22 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr17_+_44666606 0.22 ENSDART00000155096
tmem63c
transmembrane protein 63C
chr3_-_23580055 0.21

chr15_+_25700036 0.21 ENSDART00000135409
ENSDART00000162240
tsr1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
chr8_-_3974357 0.21 ENSDART00000163754
ENSDART00000169474
mtmr3
myotubularin related protein 3
chr23_-_12223878 0.21 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr8_+_7739964 0.21 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr14_-_25301744 0.20 ENSDART00000131886
slc25a48
solute carrier family 25, member 48
chr13_+_42476309 0.20 ENSDART00000133388
mlh1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr12_+_34662699 0.19 ENSDART00000153097
slc38a10
solute carrier family 38, member 10
chr15_+_30276801 0.18 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr13_-_42274486 0.17 ENSDART00000043069
march5
membrane-associated ring finger (C3HC4) 5
chr12_-_22387786 0.16 ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr1_-_29885008 0.16 ENSDART00000018827
dachc
dachshund c
chr25_-_10992022 0.15 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr21_-_22441376 0.14

chr24_+_39314937 0.14 ENSDART00000129371
CABZ01072827.1
ENSDARG00000087471
chr17_-_610651 0.14

chr22_+_37696217 0.14 ENSDART00000007346
psmd1
proteasome 26S subunit, non-ATPase 1
chr4_+_17364740 0.14 ENSDART00000136299
nup37
nucleoporin 37
chr9_-_13383708 0.13 ENSDART00000084055
fzd7a
frizzled class receptor 7a
chr20_-_23526954 0.13 ENSDART00000004625
zar1
zygote arrest 1
chr12_-_48278273 0.13

chr3_+_23580216 0.13 ENSDART00000151584
hoxb4a
homeobox B4a
chr14_-_33704021 0.13 ENSDART00000149396
ENSDART00000123607
cyfip2
cytoplasmic FMR1 interacting protein 2
chr3_+_27655753 0.12 ENSDART00000086994
nat15
N-acetyltransferase 15 (GCN5-related, putative)
chr24_+_6649249 0.11

chr23_-_33753634 0.11 ENSDART00000138416
tfcp2
transcription factor CP2
chr10_+_29763134 0.11

chr15_+_16961487 0.10 ENSDART00000154679
ypel2b
yippee-like 2b
chr3_+_52861409 0.10 ENSDART00000115117
brd4
bromodomain containing 4
chr25_-_18153381 0.10 ENSDART00000067312
si:dkey-106n21.1
si:dkey-106n21.1
chr12_-_19063851 0.10 ENSDART00000153343
zc3h7b
zinc finger CCCH-type containing 7B
chr17_-_26849495 0.09 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr25_-_35668179 0.09 ENSDART00000122559
ENSDART00000012944
amfr
autocrine motility factor receptor, E3 ubiquitin protein ligase a
chr21_-_41859818 0.08 ENSDART00000139698
endou2
endonuclease, polyU-specific 2
chr13_+_24703728 0.08 ENSDART00000101274
zgc:153981
zgc:153981
chr5_-_4507692 0.08 ENSDART00000067600
zbtb43
zinc finger and BTB domain containing 43
chr9_+_13258378 0.08 ENSDART00000141705
ENSDART00000154879
carf
calcium responsive transcription factor
chr5_-_51351827 0.07 ENSDART00000097194
serinc5
serine incorporator 5
chr24_-_39749565 0.06 ENSDART00000142522
fam234a
family with sequence similarity 234, member A
chr10_-_6587490 0.06 ENSDART00000163788
ENSDART00000171833
chd1
chromodomain helicase DNA binding protein 1
chr23_-_17524325 0.06 ENSDART00000104680
tpd52l2b
tumor protein D52-like 2b
chr25_-_7585373 0.06 ENSDART00000157076
prdm11
PR domain containing 11
chr9_-_12913920 0.06 ENSDART00000122799
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr12_+_27122352 0.05 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr10_-_6587323 0.05 ENSDART00000163788
ENSDART00000171833
chd1
chromodomain helicase DNA binding protein 1
chr6_-_54118302 0.05 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr24_-_32110851 0.04 ENSDART00000159034
rsu1
Ras suppressor protein 1
chr9_+_13258490 0.04 ENSDART00000141705
carf
calcium responsive transcription factor
chr18_+_27119086 0.04 ENSDART00000086094
plekha7a
pleckstrin homology domain containing, family A member 7a
chr5_-_19942216 0.04 ENSDART00000051607
ISCU (1 of many)
iron-sulfur cluster assembly enzyme
chr14_-_32838287 0.04

chr8_+_21192955 0.04 ENSDART00000129210
cry1ba
cryptochrome circadian clock 1ba
chr1_+_44113645 0.03

chr16_+_36794641 0.03 ENSDART00000139069
decr1
2,4-dienoyl CoA reductase 1, mitochondrial
chr5_+_36010448 0.03 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr3_-_19913881 0.03 ENSDART00000126915
ubtf
upstream binding transcription factor, RNA polymerase I
chr10_-_8238422 0.03 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr7_-_32562435 0.03 ENSDART00000099872
ENSDART00000099871
ENSDART00000147554
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr18_-_40923017 0.02 ENSDART00000098878
polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr19_-_13045465 0.02 ENSDART00000128975
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr3_-_13396181 0.01 ENSDART00000159647
amdhd2
amidohydrolase domain containing 2
chr1_+_45148094 0.01 ENSDART00000048191
map2k7
mitogen-activated protein kinase kinase 7
chr24_-_24999348 0.01 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr25_+_26962541 0.01 ENSDART00000115139
pot1
protection of telomeres 1 homolog
chr5_-_66671163 0.00 ENSDART00000144092
mlxip
MLX interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070445 peripheral nervous system myelin maintenance(GO:0032287) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 0.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 1.0 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.2 0.8 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 0.4 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976)
0.1 0.3 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.4 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.1 0.4 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.4 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:0071554 cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554) chondrocyte morphogenesis(GO:0090171)
0.0 0.4 GO:0042694 muscle cell fate specification(GO:0042694)
0.0 0.1 GO:0051311 chiasma assembly(GO:0051026) meiotic metaphase plate congression(GO:0051311)
0.0 0.1 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.0 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.5 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0001964 startle response(GO:0001964)
0.0 0.0 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0 0.2 GO:0051181 cofactor transport(GO:0051181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.1 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.7 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0016801 hydrolase activity, acting on ether bonds(GO:0016801)
0.1 0.4 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.0 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
0.0 0.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins