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Results for gata1b+gata2a
Z-value: 3.21
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Transcription factors associated with gata1b+gata2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gata2a | dr10_dc_chr11_-_3846064_3846121 | 0.88 | 8.0e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of gata1b+gata2a
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_25157675 Show fit | 12.48 |
ENSDART00000136984
|
fatty acid binding protein 2, intestinal |
|
| chr23_+_7445760 Show fit | 10.92 |
ENSDART00000012194
|
GATA binding protein 5 |
|
| chr7_-_50827308 Show fit | 10.68 |
ENSDART00000121574
|
collagen, type IV, alpha 6 |
|
| chr20_+_15653121 Show fit | 10.22 |
ENSDART00000152702
|
jun proto-oncogene |
|
| chr25_+_21732255 Show fit | 10.14 |
ENSDART00000027393
|
creatine kinase, mitochondrial 1 |
|
| chr15_+_19902697 Show fit | 9.77 |
ENSDART00000101204
|
activated leukocyte cell adhesion molecule b |
|
| chr10_+_10843384 Show fit | 8.78 |
ENSDART00000130283
|
alpha-1-microglobulin/bikunin precursor |
|
| chr13_+_2774422 Show fit | 8.54 |
ENSDART00000162362
|
wu:fj16a03 |
|
| chr1_+_29054033 Show fit | 8.13 |
ENSDART00000054066
|
zic family member 2 (odd-paired homolog, Drosophila) b |
|
| chr11_-_28367271 Show fit | 7.21 |
ENSDART00000065853
|
dehydrogenase/reductase (SDR family) member 3b |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0033993 | response to lipid(GO:0033993) |
| 1.1 | 11.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 2.7 | 10.9 | GO:0048618 | post-embryonic morphogenesis(GO:0009886) post-embryonic foregut morphogenesis(GO:0048618) |
| 2.7 | 10.7 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 1.5 | 10.7 | GO:0001773 | myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028) |
| 0.6 | 10.7 | GO:0071711 | basement membrane organization(GO:0071711) |
| 1.3 | 10.1 | GO:0046314 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.2 | 10.0 | GO:0033334 | fin morphogenesis(GO:0033334) |
| 1.4 | 9.8 | GO:0021885 | forebrain cell migration(GO:0021885) |
| 0.2 | 9.2 | GO:1902668 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 20.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 14.5 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 14.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 11.1 | GO:0005811 | lipid particle(GO:0005811) |
| 2.7 | 10.7 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 0.3 | 10.7 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 10.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 9.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 8.2 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.4 | 19.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 17.1 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 1.1 | 12.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 12.3 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.1 | 12.2 | GO:0042802 | identical protein binding(GO:0042802) |
| 1.1 | 11.6 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 1.9 | 11.1 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.2 | 10.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.3 | 10.1 | GO:0016775 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 11.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 10.7 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 10.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 1.1 | 9.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.9 | 7.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 6.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.5 | 6.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 5.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 5.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.3 | 10.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 10.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.1 | 9.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.0 | 7.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 6.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 6.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 5.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 5.5 | REACTOME AQUAPORIN MEDIATED TRANSPORT | Genes involved in Aquaporin-mediated transport |
| 0.1 | 5.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |