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Results for gbx2

Z-value: 1.32

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Transcription factors associated with gbx2

Gene Symbol Gene ID Gene Info
gbx2
ENSDARG00000002933 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gbx2dr10_dc_chr6_+_15904220_15904239-0.765.7e-04Click!

Activity profile of gbx2 motif

Sorted Z-values of gbx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of gbx2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_6442588 7.05 ENSDART00000137879
zgc:162969
zgc:162969
chr21_-_32747592 5.45

chr1_-_18118467 4.12 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr19_-_10411573 3.63 ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr24_-_26915897 3.34 ENSDART00000142864
stag1b
stromal antigen 1b
chr7_+_45747622 3.26 ENSDART00000163991
ccne1
cyclin E1
chr14_+_50010976 3.22 ENSDART00000171955
CR855307.1
ENSDARG00000099628
chr5_-_19619115 2.88 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr7_+_45747395 2.84 ENSDART00000163991
ccne1
cyclin E1
chr14_-_49777408 2.77 ENSDART00000166463
cnot6b
CCR4-NOT transcription complex, subunit 6b
chr15_-_16241412 2.56 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr5_-_19619201 2.48 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr1_+_18118735 2.34 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
KN149710v1_+_38638 2.29

chr8_+_23083842 2.22 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr25_-_26399777 2.09 ENSDART00000140643
commd4
COMM domain containing 4
chr14_+_23420053 2.09 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr6_+_3556296 2.08 ENSDART00000041627
ssb
Sjogren syndrome antigen B (autoantigen La)
chr11_-_12174576 1.99 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr17_+_24300451 1.99 ENSDART00000064083
otx1b
orthodenticle homeobox 1b
chr11_-_6442547 1.97 ENSDART00000137879
zgc:162969
zgc:162969
chr7_+_59371957 1.86 ENSDART00000125570
trmt44
tRNA methyltransferase 44 homolog (S. cerevisiae)
chr6_-_42371527 1.85 ENSDART00000039868
usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr15_+_35076414 1.82 ENSDART00000165210
zgc:66024
zgc:66024
chr11_-_6442490 1.82 ENSDART00000137879
zgc:162969
zgc:162969
chr19_-_10411518 1.75 ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr24_-_32668102 1.71 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr20_+_54404987 1.71 ENSDART00000099338
actr10
ARP10 actin related protein 10 homolog
chr20_-_7079663 1.70 ENSDART00000040793
sirt5
sirtuin 5
chr19_-_25565317 1.65 ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr8_+_23084130 1.65 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr21_-_32747544 1.62

chr20_-_7079412 1.54 ENSDART00000040793
sirt5
sirtuin 5
chr22_-_9832436 1.50

chr15_-_16241500 1.47 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr24_-_26915972 1.45 ENSDART00000142864
stag1b
stromal antigen 1b
chr22_+_17803347 1.44 ENSDART00000136016
hapln4
hyaluronan and proteoglycan link protein 4
chr20_-_7079949 1.37 ENSDART00000040793
sirt5
sirtuin 5
chr10_-_14971565 1.32 ENSDART00000147653
smad2
SMAD family member 2
chr19_-_10411878 1.23 ENSDART00000136653
ccdc106b
coiled-coil domain containing 106b
chr8_-_17974364 1.19 ENSDART00000133666
acot11b
acyl-CoA thioesterase 11b
chr24_-_33915389 1.15 ENSDART00000079202
abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr8_-_17974316 1.15 ENSDART00000122730
acot11b
acyl-CoA thioesterase 11b
chr22_-_9832520 1.14

chr2_+_42077559 1.14 ENSDART00000023208
ENSDARG00000014209
ENSDARG00000014209
chr5_-_62982537 1.08 ENSDART00000111403
ciz1b
cdkn1a interacting zinc finger protein 1b
chr8_-_50151276 1.05

chr15_+_34584015 1.03

chr16_+_30393572 1.02

chr5_-_62982637 1.02 ENSDART00000111403
ciz1b
cdkn1a interacting zinc finger protein 1b
chr17_+_24300332 0.98 ENSDART00000064083
otx1b
orthodenticle homeobox 1b
chr20_-_7079708 0.97 ENSDART00000040793
sirt5
sirtuin 5
chr19_-_25564720 0.92 ENSDART00000148432
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr14_+_50011161 0.89 ENSDART00000171955
CR855307.1
ENSDARG00000099628
chr23_+_4315077 0.83 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr18_+_31078854 0.74 ENSDART00000164585
ENSDART00000159316
mvda
mevalonate (diphospho) decarboxylase a
chr11_-_29520809 0.74 ENSDART00000079117
plekha3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr5_+_38225036 0.73 ENSDART00000076835
mrpl1
mitochondrial ribosomal protein L1
chr10_-_14971401 0.69 ENSDART00000044756
ENSDART00000128579
smad2
SMAD family member 2
chr20_+_54404819 0.62 ENSDART00000099338
actr10
ARP10 actin related protein 10 homolog
chr21_-_32747483 0.58

chr2_-_53797678 0.54 ENSDART00000057053
im:7138239
im:7138239
chr16_-_26982451 0.52 ENSDART00000078119
ino80c
INO80 complex subunit C
chr2_-_53797472 0.51 ENSDART00000057053
im:7138239
im:7138239
chr25_+_14153652 0.50

chr16_-_22378805 0.47 ENSDART00000124718
aqp10a
aquaporin 10a
chr8_+_23083870 0.46 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr6_-_1638631 0.45 ENSDART00000087039
ENSDARG00000015563
ENSDARG00000015563
chr7_-_45747162 0.42 ENSDART00000172591
zgc:162297
zgc:162297
chr24_+_33916364 0.41 ENSDART00000136040
atg9b
autophagy related 9B
chr3_+_22386709 0.38

chr11_+_16082265 0.37 ENSDART00000081035
slc25a26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr16_-_36085222 0.37 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr18_+_15964146 0.36

chr13_-_199651 0.36 ENSDART00000165165
ddx21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr6_-_42371446 0.34 ENSDART00000039868
usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr2_-_53797503 0.34 ENSDART00000057053
im:7138239
im:7138239
chr13_-_33545295 0.34 ENSDART00000020350
snx5
sorting nexin 5
chr5_-_25133456 0.33 ENSDART00000051566
zgc:101016
zgc:101016
chr15_+_44514665 0.32

chr7_-_45747112 0.30 ENSDART00000172591
zgc:162297
zgc:162297
chr6_-_1638559 0.22 ENSDART00000087039
ENSDARG00000015563
ENSDARG00000015563
chr18_+_7680416 0.16 ENSDART00000132369
rabl2
RAB, member of RAS oncogene family-like 2
chr2_+_35612974 0.15 ENSDART00000098734
cacybp
calcyclin binding protein
chr7_-_33413478 0.11 ENSDART00000130553
tle3b
transducin-like enhancer of split 3b
chr17_+_41313762 0.10 ENSDART00000128482
fosl2
fos-like antigen 2
chr14_-_33010712 0.05 ENSDART00000010019
upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr22_+_2074020 0.04 ENSDART00000106540
znf1161
zinc finger protein 1161
chr25_-_20426215 0.04

chr11_-_12174627 0.03 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr19_-_42759922 0.01

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) protein demalonylation(GO:0036046) peptidyl-lysine demalonylation(GO:0036047) protein desuccinylation(GO:0036048) peptidyl-lysine desuccinylation(GO:0036049) protein deglutarylation(GO:0061698)
0.5 2.3 GO:0032289 central nervous system myelin formation(GO:0032289)
0.3 4.3 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.3 2.0 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 0.7 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 1.5 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 0.7 GO:0035627 ceramide transport(GO:0035627)
0.1 2.0 GO:0043171 peptide catabolic process(GO:0043171)
0.1 6.1 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.1 4.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 2.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.4 GO:0044805 late nucleophagy(GO:0044805)
0.1 1.9 GO:0030488 tRNA methylation(GO:0030488)
0.1 2.1 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 0.1 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.0 2.3 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.8 GO:0051051 negative regulation of transport(GO:0051051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.4 4.8 GO:0008278 cohesin complex(GO:0008278)
0.2 2.3 GO:0005869 dynactin complex(GO:0005869)
0.2 2.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 11.1 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0036055 protein-malonyllysine demalonylase activity(GO:0036054) protein-succinyllysine desuccinylase activity(GO:0036055) protein-glutaryllysine deglutarylase activity(GO:0061697)
0.6 1.9 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.6 2.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.5 4.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 2.1 GO:0050699 WW domain binding(GO:0050699)
0.2 2.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.7 GO:1902388 ceramide transporter activity(GO:0035620) sphingolipid transporter activity(GO:0046624) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.2 0.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.1 2.0 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 6.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.4 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0034452 dynactin binding(GO:0034452)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.5 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 4.8 GO:0003682 chromatin binding(GO:0003682)
0.0 1.2 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 2.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation