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Results for gli2a+gli3

Z-value: 0.65

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Transcription factors associated with gli2a+gli3

Gene Symbol Gene ID Gene Info
gli2a
ENSDARG00000025641 GLI family zinc finger 2a
gli3
ENSDARG00000052131 GLI family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gli3dr10_dc_chr24_-_11681151_116811730.821.2e-04Click!
gli2adr10_dc_chr9_+_37331936_373320670.693.3e-03Click!

Activity profile of gli2a+gli3 motif

Sorted Z-values of gli2a+gli3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of gli2a+gli3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_54876680 2.83 ENSDART00000111585
hbbe1.3
hemoglobin, beta embryonic 1.3
chr23_+_20496283 2.45 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr23_+_28656263 2.15 ENSDART00000020296
nadl1.2
neural adhesion molecule L1.2
chr8_+_29953399 2.06 ENSDART00000149372
ENSDART00000007640
ptch1
ptch1
patched 1
patched 1
chr1_-_19152361 2.00 ENSDART00000132958
grhprb
glyoxylate reductase/hydroxypyruvate reductase b
chr2_-_34010299 1.87 ENSDART00000140910
ptch2
patched 2
chr21_-_23271127 1.69 ENSDART00000007806
zbtb16a
zinc finger and BTB domain containing 16a
chr7_-_8128948 1.62 ENSDART00000057101
aep1
aerolysin-like protein
chr8_-_47811709 1.60 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr10_+_33227967 1.50 ENSDART00000159666
myl10
myosin, light chain 10, regulatory
chr9_-_8752098 1.46

chr11_-_80746 1.44

chr12_+_42281025 1.42 ENSDART00000167324
ebf3a
early B-cell factor 3a
chr24_+_18154733 1.38 ENSDART00000140994
tpk1
thiamin pyrophosphokinase 1
chr16_-_38117896 1.37 ENSDART00000114266
plekho1b
pleckstrin homology domain containing, family O member 1b
chr22_+_38220826 1.33 ENSDART00000010537
cp
ceruloplasmin
chr4_+_5124186 1.30 ENSDART00000127874
ccnd2b
cyclin D2, b
chr20_-_39693535 1.29 ENSDART00000023531
hey2
hes-related family bHLH transcription factor with YRPW motif 2
chr10_+_18994733 1.28 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr1_+_50835265 1.28 ENSDART00000162226
meis1a
Meis homeobox 1 a
chr24_-_26138298 1.25 ENSDART00000128618
and1
actinodin1
chr15_-_35394535 1.14 ENSDART00000144153
mff
mitochondrial fission factor
chr12_-_17357133 1.09 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr12_+_27026112 1.09 ENSDART00000076154
hoxb8b
homeobox B8b
chr11_+_36983626 1.08 ENSDART00000170209
il17rc
interleukin 17 receptor C
chr9_-_46272322 1.04 ENSDART00000169682
hdac4
histone deacetylase 4
chr13_+_30673907 1.03 ENSDART00000053946
cxcl12a
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
chr5_+_32732535 1.02 ENSDART00000156913
BX927184.1
ENSDARG00000097904
chr20_+_15653121 0.98 ENSDART00000152702
jun
jun proto-oncogene
chr6_+_6967174 0.97 ENSDART00000151311
ENSDARG00000058903
ENSDARG00000058903
chr7_-_38288929 0.95

chr23_+_4475256 0.92 ENSDART00000081821
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr16_-_5006929 0.92 ENSDART00000054077
tpbgb
trophoblast glycoprotein b
chr22_+_1568413 0.91 ENSDART00000175704
si:ch211-255f4.11
si:ch211-255f4.11
chr19_-_19282688 0.88 ENSDART00000162708
ppt2
palmitoyl-protein thioesterase 2
chr9_+_8752130 0.88 ENSDART00000137813
FP103004.1
ENSDARG00000092413
chr16_-_7963894 0.87 ENSDART00000172836
CABZ01061349.1
ENSDARG00000105487
chr1_+_3674819 0.78

chr12_-_15524097 0.76

chr13_+_41998500 0.73 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr16_+_5466342 0.73 ENSDART00000160008
plecb
plectin b
chr12_-_1545172 0.73

chr20_-_28739099 0.71 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr19_-_10941519 0.71 ENSDART00000169118
ENSDART00000160599
CU855694.1
ENSDARG00000098513
chr2_-_59006559 0.69

chr10_-_1799784 0.68 ENSDART00000058627
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr8_+_47352102 0.66

chr14_-_7772 0.63 ENSDART00000054822
nkx3.2
NK3 homeobox 2
chr16_-_43090120 0.63 ENSDART00000155637
BX005234.1
ENSDARG00000097761
chr19_-_10324632 0.62 ENSDART00000148073
shisa7b
shisa family member 7
chr17_+_45931793 0.61 ENSDART00000155372
kif26ab
kinesin family member 26Ab
chr9_-_10561062 0.60 ENSDART00000175269
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr10_+_26786051 0.60 ENSDART00000100329
f9b
coagulation factor IXb
chr24_-_35486496 0.59

chr2_+_47864913 0.59

chr25_+_1773157 0.58

chr10_-_15090647 0.58 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr9_-_1983772 0.57 ENSDART00000082339
hoxd12a
homeobox D12a
chr14_-_16171165 0.57 ENSDART00000089021
canx
calnexin
chr8_-_14446883 0.55 ENSDART00000057644
lhx4
LIM homeobox 4
chr12_-_1545141 0.52

chr1_+_51712192 0.52

chr6_+_7395817 0.52 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr17_-_35004687 0.49

chr6_+_9192009 0.49 ENSDART00000022620
kalrnb
kalirin RhoGEF kinase b
chr8_+_31110356 0.48 ENSDART00000136578
syn1
synapsin I
chr21_-_38571536 0.47 ENSDART00000139178
ENSDART00000036600
slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr21_-_30378764 0.47 ENSDART00000136247
grpel2
GrpE-like 2, mitochondrial
chr25_+_32062428 0.46 ENSDART00000152326
sqrdl
sulfide quinone reductase-like (yeast)
chr5_-_71505131 0.46 ENSDART00000037691
tbx5a
T-box 5a
chr18_-_1577633 0.45

chr7_-_15164722 0.45 ENSDART00000172147
ENSDARG00000036809
ENSDARG00000036809
chr2_-_54028761 0.45 ENSDART00000178289
CABZ01050256.1
ENSDARG00000109075
chr20_+_13507202 0.44 ENSDART00000127350
enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_+_56507117 0.42 ENSDART00000154405
rac1b
ras-related C3 botulinum toxin substrate 1b (rho family, small GTP binding protein Rac1)
chr23_-_41929027 0.41 ENSDART00000131235
GMEB2
glucocorticoid modulatory element binding protein 2
chr2_-_24947660 0.41 ENSDART00000113356
ENSDART00000163038
crtc1a
CREB regulated transcription coactivator 1a
chr13_-_40600924 0.41 ENSDART00000099847
ENSDART00000057046
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr14_+_50164568 0.40 ENSDART00000084114
nsd1a
nuclear receptor binding SET domain protein 1a
KN150339v1_-_34304 0.40

chr9_+_6609374 0.39 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr9_-_8752195 0.38

chr2_+_27000558 0.38 ENSDART00000099208
asph
aspartate beta-hydroxylase
chr15_+_2590598 0.38 ENSDART00000178505
SH2B2
SH2B adaptor protein 2
chr2_-_6139895 0.37 ENSDART00000147509
si:ch211-284b7.3
si:ch211-284b7.3
chr20_+_22780756 0.34

chr18_+_20504641 0.33

chr20_+_26196386 0.33 ENSDART00000139350
syne1a
spectrin repeat containing, nuclear envelope 1a
chr22_-_11024472 0.32 ENSDART00000105823
ENSDART00000159995
insrb
insulin receptor b
chr7_+_24983985 0.31

chr24_-_38758093 0.31

chr18_+_54352 0.31 ENSDART00000097163
SLC27A2 (1 of many)
solute carrier family 27 member 2
chr13_+_41998172 0.29 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr7_-_18281871 0.28

chr13_+_41998364 0.28 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr8_+_28433869 0.27 ENSDART00000062716
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr14_+_43599635 0.27 ENSDART00000155539
CR786577.1
ENSDARG00000097875
chr9_-_11683760 0.26 ENSDART00000044314
ENSDART00000124129
itgav
integrin, alpha V
chr5_+_32732654 0.26 ENSDART00000156913
BX927184.1
ENSDARG00000097904
chr7_+_25735562 0.25 ENSDART00000112908
pelp1
proline, glutamate and leucine rich protein 1
chr16_+_37519702 0.25

chr14_-_32542387 0.22

chr24_-_25528893 0.22 ENSDART00000142351
cnksr2a
connector enhancer of kinase suppressor of Ras 2a
chr16_+_37519812 0.21

chr1_-_49144795 0.20

chr25_+_7287952 0.19 ENSDART00000170569
syt12
synaptotagmin XII
chr6_-_47928632 0.18

chr7_+_20008453 0.18 ENSDART00000012450
dvl2
dishevelled segment polarity protein 2
chr20_+_25727285 0.16 ENSDART00000143883
ppat
phosphoribosyl pyrophosphate amidotransferase
chr24_+_17190237 0.15 ENSDART00000126435
pdia4
protein disulfide isomerase family A, member 4
chr20_-_6087735 0.15 ENSDART00000145964
pum2
pumilio RNA-binding family member 2
chr17_+_45931756 0.15 ENSDART00000155372
kif26ab
kinesin family member 26Ab
chr21_+_11686197 0.15 ENSDART00000031786
glrx
glutaredoxin (thioltransferase)
chr7_+_51541162 0.14 ENSDART00000174120
si:ch211-122f10.4
si:ch211-122f10.4
chr20_-_25727347 0.12 ENSDART00000136475
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_-_11480368 0.12 ENSDART00000080762
sept7a
septin 7a
chr17_-_30958965 0.11 ENSDART00000051697
evla
Enah/Vasp-like a
chr20_+_4530154 0.10 ENSDART00000168322
tiam2b
T-cell lymphoma invasion and metastasis 2b
chr17_+_37354614 0.10

chr19_+_27094665 0.08 ENSDART00000079410
si:dkey-27c15.3
si:dkey-27c15.3
chr24_+_7799283 0.05 ENSDART00000135161
zgc:101569
zgc:101569
chr17_+_37354528 0.04

chr1_+_44971899 0.03 ENSDART00000149565
trappc5
trafficking protein particle complex 5
chr16_+_42763696 0.01 ENSDART00000023452
dpy19l1l
dpy-19-like 1, like (H. sapiens)
chr5_-_52357382 0.00 ENSDART00000157978
mrps30
mitochondrial ribosomal protein S30
chr16_+_41923717 0.00 ENSDART00000084631
scn1ba
sodium channel, voltage-gated, type I, beta a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.5 1.4 GO:0042723 thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357) thiamine-containing compound metabolic process(GO:0042723)
0.4 1.3 GO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853)
0.4 1.7 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.3 1.0 GO:0036073 perichondral ossification(GO:0036073)
0.3 1.0 GO:2000471 negative regulation of leukocyte migration(GO:0002686) regulation of hematopoietic stem cell migration(GO:2000471)
0.3 1.4 GO:1901739 regulation of myoblast fusion(GO:1901739)
0.3 2.8 GO:0015671 oxygen transport(GO:0015671)
0.2 1.1 GO:0050427 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 2.4 GO:0014823 response to activity(GO:0014823)
0.2 0.5 GO:0003294 atrial ventricular junction remodeling(GO:0003294)
0.1 0.4 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 1.3 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 0.4 GO:0055062 regulation of fat cell differentiation(GO:0045598) phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.1 1.2 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 1.3 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.5 GO:0015743 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.1 0.6 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.7 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.5 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.6 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.2 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 1.6 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.2 GO:0090177 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.7 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.3 GO:0051180 vitamin transport(GO:0051180)
0.0 0.6 GO:0007596 blood coagulation(GO:0007596) hemostasis(GO:0007599)
0.0 1.3 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 1.2 GO:0033333 fin development(GO:0033333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0005833 hemoglobin complex(GO:0005833) haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 1.6 GO:0046930 pore complex(GO:0046930)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 2.4 GO:0005861 troponin complex(GO:0005861)
0.1 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.5 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0008158 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.7 2.0 GO:0008465 glycerate dehydrogenase activity(GO:0008465)
0.4 2.8 GO:0031720 haptoglobin binding(GO:0031720)
0.3 1.6 GO:0070492 oligosaccharide binding(GO:0070492)
0.3 1.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 1.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.1 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 1.4 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 1.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 1.0 GO:0042379 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.1 0.5 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.1 1.0 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.2 GO:0004044 amidophosphoribosyltransferase activity(GO:0004044)
0.0 0.3 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 1.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 3.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 2.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo