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Results for glis2a+glis2b

Z-value: 0.91

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Transcription factors associated with glis2a+glis2b

Gene Symbol Gene ID Gene Info
glis2a
ENSDARG00000078388 GLIS family zinc finger 2a
glis2b
ENSDARG00000100232 GLIS family zinc finger 2b

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

Network of associatons between targets according to the STRING database.

Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_31672763 3.49 ENSDART00000028270
gfap
glial fibrillary acidic protein
chr9_-_23081250 3.24

chr7_+_57423271 3.05 ENSDART00000056466
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr16_+_4825019 3.00 ENSDART00000167665
LIN28A
lin-28 homolog A
chr7_+_18111890 2.87 ENSDART00000171606
cd248a
CD248 molecule, endosialin a
chr4_-_24310846 2.57 ENSDART00000017443
celf2
cugbp, Elav-like family member 2
chr4_-_17735989 2.54 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr10_+_44364117 2.20

chr7_+_11148688 2.15 ENSDART00000114383
mesdc1
mesoderm development candidate 1
chr15_-_22881 2.10 ENSDART00000158734
BACE1
beta-secretase 1
chr12_+_9842842 2.03 ENSDART00000055019
ndufa4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr15_-_22978 1.93 ENSDART00000158734
BACE1
beta-secretase 1
chr20_+_25441689 1.89 ENSDART00000063028
ctgfa
connective tissue growth factor a
chr9_-_6949104 1.88 ENSDART00000059092
tmem182a
transmembrane protein 182a
chr16_-_16682692 1.69 ENSDART00000059841
si:ch211-257p13.3
si:ch211-257p13.3
chr12_-_41124276 1.68 ENSDART00000172022
ENSDART00000158605
ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr13_-_508050 1.54 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr13_-_508202 1.50 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr20_-_1218693 1.47 ENSDART00000140650
ENSDART00000133216
ankrd6b
ankyrin repeat domain 6b
chr5_-_41672394 1.40 ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr23_-_17543731 1.31 ENSDART00000002398
trim101
tripartite motif containing 101
chr2_+_46428154 1.29 ENSDART00000128457
ephb1
EPH receptor B1
chr3_+_21059221 1.21 ENSDART00000078807
zgc:123295
zgc:123295
chr24_+_25326286 1.17 ENSDART00000066625
smpx
small muscle protein, X-linked
chr5_-_21497169 1.10 ENSDART00000143878
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr8_+_6989445 1.09 ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr24_+_25326233 0.99 ENSDART00000066625
smpx
small muscle protein, X-linked
chr11_+_27721622 0.94 ENSDART00000147984
alpl
alkaline phosphatase, liver/bone/kidney
KN150222v1_+_74557 0.92

chr24_-_9819862 0.91 ENSDART00000092975
vps41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr23_+_24778062 0.86

chr5_+_50432868 0.85 ENSDART00000097466
fam169aa
family with sequence similarity 169, member Aa
chr8_-_13182911 0.84 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr24_-_25545773 0.68 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr9_+_8131114 0.68

chr2_+_14039168 0.63 ENSDART00000155015
zbtb41
zinc finger and BTB domain containing 41
chr8_-_13183034 0.62 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr16_+_5339396 0.60

chr16_+_4825665 0.59

chr7_-_19390325 0.54 ENSDART00000163686
si:ch211-212k18.4
si:ch211-212k18.4
chr19_-_43358940 0.53

chr12_-_44825493 0.51 ENSDART00000016635
bccip
BRCA2 and CDKN1A interacting protein
chr9_-_2416300 0.51

chr19_-_43359483 0.48 ENSDART00000086659
cyhr1
cysteine/histidine-rich 1
chr7_+_48431214 0.48

chr23_+_24778090 0.48

chr16_-_45888127 0.40 ENSDART00000027013
ENSDART00000128068
ntrk1
neurotrophic tyrosine kinase, receptor, type 1
chr12_-_196397 0.37 ENSDART00000161178
ENSDART00000160926
dnah9
dynein, axonemal, heavy chain 9
chr17_+_23558463 0.35 ENSDART00000149281
slc16a12a
solute carrier family 16, member 12a
chr11_+_27721554 0.29 ENSDART00000131101
alpl
alkaline phosphatase, liver/bone/kidney
chr17_-_23654438 0.28 ENSDART00000122209
ptena
phosphatase and tensin homolog A
chr10_-_13158018 0.26 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr12_-_1565781 0.25 ENSDART00000170055
CABZ01073190.1
ENSDARG00000100999
chr10_+_44364064 0.24

chr12_+_31388957 0.23

chr13_-_508110 0.22 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr1_-_53465275 0.14

chr24_-_35819359 0.12 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_-_61087420 0.11

chr16_+_25891403 0.08 ENSDART00000154652
irgq1
immunity-related GTPase family, q1
chr15_+_557244 0.06 ENSDART00000154594
ENSDART00000102268
pcsk7
proprotein convertase subtilisin/kexin type 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 1.1 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2 0.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 1.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 0.4 GO:0090594 inflammatory response to wounding(GO:0090594)
0.1 2.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.3 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.1 1.5 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.3 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 1.5 GO:0048264 determination of ventral identity(GO:0048264)
0.0 1.2 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 0.5 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.4 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 2.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 1.7 GO:0007018 microtubule-based movement(GO:0007018)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0043034 costamere(GO:0043034)
0.2 0.9 GO:0030897 HOPS complex(GO:0030897)
0.2 1.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.1 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.8 2.5 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.4 3.3 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 3.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.3 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 2.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.7 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.1 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 2.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport