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Results for hmx1+hmx3b

Z-value: 0.22

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Transcription factors associated with hmx1+hmx3b

Gene Symbol Gene ID Gene Info
hmx1
ENSDARG00000095651 H6 family homeobox 1
hmx3b
ENSDARG00000096716 H6 family homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx1dr10_dc_chr1_-_40211790_402117950.332.2e-01Click!

Activity profile of hmx1+hmx3b motif

Sorted Z-values of hmx1+hmx3b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx1+hmx3b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_23172938 0.46 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr20_+_31366832 0.37 ENSDART00000133353
apobb.1
apolipoprotein Bb, tandem duplicate 1
chr7_+_42124857 0.34 ENSDART00000004120
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr6_-_41087828 0.31 ENSDART00000028217
srsf3a
serine/arginine-rich splicing factor 3a
chr14_+_14262816 0.29 ENSDART00000164749
pcdh20
protocadherin 20
chr20_+_22321303 0.27 ENSDART00000049204
kdr
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr21_-_39239757 0.25

chr13_+_30743690 0.24 ENSDART00000134809
ercc6
excision repair cross-complementation group 6
chr1_-_37990863 0.17 ENSDART00000132402
gpm6ab
glycoprotein M6Ab
chr4_+_13932849 0.17 ENSDART00000141742
pphln1
periphilin 1
chr3_+_39514598 0.17 ENSDART00000156038
epn2
epsin 2
chr7_-_17129072 0.16

chr12_+_2412047 0.16 ENSDART00000112032
ARHGAP22 (1 of many)
Rho GTPase activating protein 22
chr6_-_37444807 0.15 ENSDART00000138351
cth
cystathionase (cystathionine gamma-lyase)
chr15_+_29183251 0.15 ENSDART00000153609
capns1b
calpain, small subunit 1 b
chr12_+_24221087 0.15 ENSDART00000088178
nrxn1a
neurexin 1a
chr23_+_13106555 0.14

chr5_-_41672394 0.14 ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr13_+_46487890 0.13

chr1_+_21037251 0.12

chr4_-_26262761 0.11 ENSDART00000176623
BX957270.2
ENSDARG00000107325
chr9_+_50670635 0.11 ENSDART00000179475
CABZ01083707.1
ENSDARG00000107278
chr22_-_5683909 0.11 ENSDART00000138507
CU459089.1
ENSDARG00000077631
chr18_+_9213713 0.11 ENSDART00000127469
ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr20_-_23526954 0.11 ENSDART00000004625
zar1
zygote arrest 1
chr25_-_13737344 0.10

chr17_+_10437343 0.10 ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr17_+_45892751 0.10

chr22_+_16266827 0.10 ENSDART00000170960
dbt
dihydrolipoamide branched chain transacylase E2
chr16_-_6450531 0.08 ENSDART00000060550
ENSDART00000145663
ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr22_-_5683814 0.08 ENSDART00000138507
CU459089.1
ENSDARG00000077631
chr21_+_21870019 0.08 ENSDART00000016916
gria4b
glutamate receptor, ionotropic, AMPA 4b
chr20_+_28958586 0.08 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr25_+_17493675 0.08 ENSDART00000167750
vac14
vac14 homolog (S. cerevisiae)
chr17_-_52735250 0.08

chr20_-_23527004 0.07 ENSDART00000004625
zar1
zygote arrest 1
chr24_+_40292617 0.07

chr4_-_70948610 0.07 ENSDART00000174299
CABZ01054394.2
ENSDARG00000098324
chr1_-_37990935 0.07 ENSDART00000132402
gpm6ab
glycoprotein M6Ab
chr23_-_28367816 0.06 ENSDART00000003548
znf385a
zinc finger protein 385A
chr3_-_3589844 0.06 ENSDART00000140482
ENSDARG00000079723
ENSDARG00000079723
chr24_-_12836986 0.05 ENSDART00000133166
dcaf11
ddb1 and cul4 associated factor 11
chr13_-_36785295 0.04 ENSDART00000167154
trim9
tripartite motif containing 9
chr10_-_39210658 0.04 ENSDART00000150193
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr13_-_29290894 0.04 ENSDART00000150228
chata
choline O-acetyltransferase a
chr5_+_36431824 0.04 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr8_+_23172960 0.04 ENSDART00000028946
tpd52l2a
tumor protein D52-like 2a
chr4_-_18752965 0.04 ENSDART00000145747
atxn10
ataxin 10
chr11_-_18081944 0.03 ENSDART00000113468
CABZ01112215.1
ENSDARG00000079534
chr6_+_20266345 0.03 ENSDART00000020333
rae1
ribonucleic acid export 1
chr13_+_15084591 0.03 ENSDART00000133041
pank2
pantothenate kinase 2
chr17_-_52735615 0.03

chr9_+_50609926 0.02 ENSDART00000098687
GRB14
growth factor receptor bound protein 14
chr1_-_37991246 0.02 ENSDART00000128794
gpm6ab
glycoprotein M6Ab
chr6_+_11445617 0.01 ENSDART00000151447
ENSDART00000151618
calcrlb
calcitonin receptor-like b
chr10_-_39211281 0.01 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr19_-_6503643 0.01

chr4_+_13932693 0.01 ENSDART00000142466
pphln1
periphilin 1
chr16_-_28333633 0.01 ENSDART00000121671
si:dkey-12j5.1
si:dkey-12j5.1
chr17_+_25828037 0.00

chr9_+_50670606 0.00 ENSDART00000179475
CABZ01083707.1
ENSDARG00000107278
chr19_-_35286400 0.00 ENSDART00000016057
ctnnal1
catenin (cadherin-associated protein), alpha-like 1
chr5_-_66441778 0.00 ENSDART00000168245
rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr18_+_17503828 0.00 ENSDART00000161827
si:dkey-102f14.5
si:dkey-102f14.5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.0 0.2 GO:0019344 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.0 0.1 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0035924 cellular response to vascular endothelial growth factor stimulus(GO:0035924)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042627 chylomicron(GO:0042627)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.0 0.2 GO:0030669 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.0 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions