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Results for hmx2_hmx3a
Z-value: 2.42
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Transcription factors associated with hmx2_hmx3a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hmx3a | dr10_dc_chr17_-_21773194_21773214 | -0.81 | 1.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of hmx2_hmx3a
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_868378 Show fit | 9.18 |
|
|
|
| chr17_+_50622734 Show fit | 8.13 |
ENSDART00000049464
|
fermitin family member 2 |
|
| chr24_-_9857510 Show fit | 8.09 |
ENSDART00000136274
|
si:ch211-146l10.7 |
|
| chr17_-_45021393 Show fit | 7.79 |
|
|
|
| chr23_+_46000362 Show fit | 6.67 |
ENSDART00000023944
|
lamin L3 |
|
| chr22_-_20670164 Show fit | 5.98 |
ENSDART00000169077
|
oogenesis-related gene |
|
| chr21_+_6289363 Show fit | 5.92 |
ENSDART00000138600
|
si:ch211-225g23.1 |
|
| chr16_+_28946580 Show fit | 5.58 |
ENSDART00000146525
|
chromatin target of PRMT1b |
|
| chr24_+_23571714 Show fit | 5.54 |
ENSDART00000080332
|
COP9 signalosome subunit 5 |
|
| chr24_-_9874069 Show fit | 5.49 |
ENSDART00000176344
|
si:ch211-146l10.7 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 17.0 | GO:0031111 | negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) |
| 1.1 | 12.3 | GO:0032776 | DNA methylation on cytosine(GO:0032776) |
| 1.7 | 10.1 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 1.2 | 8.6 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 8.4 | GO:0006310 | DNA recombination(GO:0006310) |
| 0.6 | 6.4 | GO:0019896 | axonal transport of mitochondrion(GO:0019896) |
| 0.8 | 6.0 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 5.7 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.1 | 5.5 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.2 | 5.2 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 17.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.8 | 10.1 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 8.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 8.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 7.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 6.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 6.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 5.7 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 1.8 | 5.5 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.5 | 5.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 17.0 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 2.0 | 10.1 | GO:0070551 | endoribonuclease activity, cleaving siRNA-paired mRNA(GO:0070551) |
| 0.5 | 9.6 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 1.1 | 8.6 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 7.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 7.0 | GO:0030295 | kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295) |
| 0.5 | 6.4 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 6.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.0 | 6.0 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.5 | 5.8 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.5 | 7.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 4.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.7 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 3.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 2.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 2.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 1.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.4 | 7.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.4 | 5.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 4.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 3.9 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 3.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.5 | 3.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.9 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.7 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.3 | 2.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |