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Results for hmx2_hmx3a

Z-value: 2.42

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Transcription factors associated with hmx2_hmx3a

Gene Symbol Gene ID Gene Info
hmx2
ENSDARG00000070954 H6 family homeobox 2
hmx3a
ENSDARG00000070955 H6 family homeobox 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx3adr10_dc_chr17_-_21773194_21773214-0.811.2e-04Click!

Activity profile of hmx2_hmx3a motif

Sorted Z-values of hmx2_hmx3a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx2_hmx3a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_868378 9.18

chr17_+_50622734 8.13 ENSDART00000049464
fermt2
fermitin family member 2
chr24_-_9857510 8.09 ENSDART00000136274
si:ch211-146l10.7
si:ch211-146l10.7
chr17_-_45021393 7.79

chr23_+_46000362 6.67 ENSDART00000023944
lmnl3
lamin L3
chr22_-_20670164 5.98 ENSDART00000169077
org
oogenesis-related gene
chr21_+_6289363 5.92 ENSDART00000138600
si:ch211-225g23.1
si:ch211-225g23.1
chr16_+_28946580 5.58 ENSDART00000146525
chtopb
chromatin target of PRMT1b
chr24_+_23571714 5.54 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr24_-_9874069 5.49 ENSDART00000176344
si:ch211-146l10.7
si:ch211-146l10.7
chr17_+_16421892 5.04 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr20_-_34894930 5.01

chr10_-_1933874 4.91 ENSDART00000101023
tdgf1
teratocarcinoma-derived growth factor 1
chr11_+_25302044 4.85 ENSDART00000035602
cxxc1b
CXXC finger protein 1b
chr15_-_41732606 4.79 ENSDART00000059327
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr2_+_11423028 4.76 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr4_-_3184182 4.54

chr22_+_2735606 4.49 ENSDART00000133652
si:dkey-20i20.11
si:dkey-20i20.11
chr3_-_20989306 4.42

chr8_+_21405821 4.37 ENSDART00000142758
si:dkey-163f12.10
si:dkey-163f12.10
chr19_-_1571878 4.34

chr12_+_46242558 4.33 ENSDART00000167510
hid1b
HID1 domain containing b
chr16_-_24727689 4.22 ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr15_-_43996427 4.21 ENSDART00000177294
ENSDART00000177892
ENSDART00000174655
FO704909.1
ENSDARG00000106999
chr18_-_26732762 4.17 ENSDART00000142043
malt3
MALT paracaspase 3
chr11_+_25302180 4.15 ENSDART00000035602
cxxc1b
CXXC finger protein 1b
chr18_-_6896957 3.87 ENSDART00000175747
ppp6r2b
protein phosphatase 6, regulatory subunit 2b
chr15_+_21327206 3.85 ENSDART00000101000
gkup
glucuronokinase with putative uridyl pyrophosphorylase
chr22_+_2494565 3.81 ENSDART00000115348
zgc:173726
zgc:173726
chr4_+_17666992 3.80 ENSDART00000066999
ccdc53
coiled-coil domain containing 53
chr5_-_64983964 3.79 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr16_-_31834830 3.72

chr23_-_22146031 3.70 ENSDART00000054362
phc2a
polyhomeotic homolog 2a (Drosophila)
chr5_+_29791993 3.69 ENSDART00000086765
stk36
serine/threonine kinase 36 (fused homolog, Drosophila)
chr5_-_64983687 3.66 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr3_+_32278978 3.57 ENSDART00000061426
rras
related RAS viral (r-ras) oncogene homolog
chr1_-_53021646 3.51

chr7_-_24249672 3.50 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
KN150456v1_-_19515 3.49 ENSDART00000168786
h1m
linker histone H1M
chr5_-_64983812 3.48 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr2_+_5054170 3.45 ENSDART00000164626
si:ch211-162e15.3
si:ch211-162e15.3
chr24_+_1110206 3.39 ENSDART00000152063
BX005461.1
ENSDARG00000096447
chr11_+_25302072 3.32 ENSDART00000035602
cxxc1b
CXXC finger protein 1b
chr7_-_55879342 3.30 ENSDART00000098438
spg7
spastic paraplegia 7
chr8_+_45326435 3.29 ENSDART00000134161
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr16_+_39209567 3.23 ENSDART00000121756
sybu
syntabulin (syntaxin-interacting)
chr2_+_58943872 3.22 ENSDART00000158860
ENSDART00000067736
stk11
serine/threonine kinase 11
chr1_-_689420 3.21

chr5_-_64983648 3.19 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr13_+_1001437 3.18 ENSDART00000054318
wdr92
WD repeat domain 92
chr15_+_5124690 3.17 ENSDART00000101937
pgm2l1
phosphoglucomutase 2-like 1
chr2_-_37650547 3.16 ENSDART00000008302
insra
insulin receptor a
chr2_+_56534374 3.14 ENSDART00000113964
POLR2E (1 of many)
RNA polymerase II subunit E
chr15_+_5124897 3.13 ENSDART00000101937
pgm2l1
phosphoglucomutase 2-like 1
chr15_-_27845198 3.11

chr23_+_32102030 3.10 ENSDART00000145501
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr22_-_25015224 3.09 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr20_+_6545194 3.09 ENSDART00000159829
si:ch211-191a24.4
si:ch211-191a24.4
chr15_-_28636418 3.02 ENSDART00000127845
ssh2a
slingshot protein phosphatase 2a
chr21_+_18870471 2.98 ENSDART00000160185
smpd4
sphingomyelin phosphodiesterase 4
chr4_-_14193396 2.95 ENSDART00000101812
ENSDART00000143804
pus7l
pseudouridylate synthase 7-like
chr5_-_64983760 2.92 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr12_-_2834771 2.91 ENSDART00000114854
ENSDART00000163759
zdhhc16b
zinc finger, DHHC-type containing 16b
chr19_+_41894734 2.90 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
chr9_-_6861630 2.86

chr24_-_39315552 2.85

chr6_+_22049505 2.84 ENSDART00000158263
si:dkey-10p5.10
si:dkey-10p5.10
chr17_+_23710004 2.84 ENSDART00000034913
zgc:91976
zgc:91976
chr19_-_7124381 2.83 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr21_-_13589542 2.77

chr10_-_26240772 2.76 ENSDART00000131394
fhdc3
FH2 domain containing 3
chr10_-_14971565 2.75 ENSDART00000147653
smad2
SMAD family member 2
chr14_-_14440122 2.75 ENSDART00000161569
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr17_+_15666420 2.74 ENSDART00000156726
bach2a
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr11_-_22450582 2.72

chr2_+_49343278 2.66 ENSDART00000175147
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr24_-_9880951 2.65 ENSDART00000137250
zgc:173856
zgc:173856
chr9_+_29737843 2.65 ENSDART00000176057
rnf17
ring finger protein 17
chr21_-_35291005 2.64 ENSDART00000134780
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr8_+_21405788 2.61 ENSDART00000142758
si:dkey-163f12.10
si:dkey-163f12.10
chr16_-_31835007 2.60

chr19_+_41894863 2.59 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
chr4_-_1871246 2.56 ENSDART00000103484
gas2l3
growth arrest-specific 2 like 3
chr21_-_2292663 2.54 ENSDART00000164015
zgc:66483
zgc:66483
chr2_-_37418967 2.52 ENSDART00000015723
prkci
protein kinase C, iota
chr10_+_15066791 2.50 ENSDART00000140084
si:dkey-88l16.5
si:dkey-88l16.5
chr21_+_11686037 2.50 ENSDART00000031786
glrx
glutaredoxin (thioltransferase)
chr15_-_41732512 2.49 ENSDART00000059327
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr12_+_27613979 2.47

chr3_+_18786265 2.46 ENSDART00000141637
si:ch211-198m1.1
si:ch211-198m1.1
chr13_+_33331767 2.40 ENSDART00000177841
zgc:136302
zgc:136302
chr24_-_9874127 2.37 ENSDART00000124341
zgc:171474
zgc:171474
chr11_-_18081944 2.36 ENSDART00000113468
CABZ01112215.1
ENSDARG00000079534
chr11_-_18090243 2.35 ENSDART00000144659
zgc:173545
zgc:173545
chr6_+_40469996 2.35 ENSDART00000103868
zgc:152986
zgc:152986
chr16_-_31834774 2.33

chr21_+_6890129 2.33

chr21_-_28700679 2.32 ENSDART00000128237
ENSDART00000124826
nrg2a
neuregulin 2a
chr17_+_52526741 2.31 ENSDART00000109891
angel1
angel homolog 1 (Drosophila)
KN150289v1_-_7882 2.28

chr19_+_41895061 2.28 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
chr18_-_3430582 2.25 ENSDART00000169049
capn5a
calpain 5a
chr16_-_9939549 2.25 ENSDART00000148528
grhl2a
grainyhead-like transcription factor 2a
chr10_-_36848872 2.24

chr24_-_30929990 2.23

chr24_+_23571680 2.22 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr23_-_27768575 2.21 ENSDART00000146703
IKZF4
IKAROS family zinc finger 4
chr11_+_29295032 2.18 ENSDART00000112721
BX548000.1
ENSDARG00000079546
chr7_-_25998808 2.16 ENSDART00000079347
serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr14_+_23411927 2.15 ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr11_+_37371675 2.14 ENSDART00000140502
sh2d5
SH2 domain containing 5
chr5_+_62628554 2.13 ENSDART00000158086
si:ch73-376l24.3
si:ch73-376l24.3
chr23_+_22671069 2.12 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr21_-_28700622 2.12 ENSDART00000098696
nrg2a
neuregulin 2a
chr14_+_14850200 2.11 ENSDART00000167966
zgc:158852
zgc:158852
chr7_-_24249630 2.07 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
chr18_+_8959686 2.05 ENSDART00000145226
si:ch211-233h19.2
si:ch211-233h19.2
chr25_-_24440001 2.05 ENSDART00000156805
CR854832.1
ENSDARG00000096817
chr11_-_34314863 2.05 ENSDART00000133302
pfkfb4a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr16_-_33047066 2.04 ENSDART00000147941
ENSDART00000075218
me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr15_+_19948426 2.04 ENSDART00000054416
dyrk1ab
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b
chr16_+_40093596 2.04 ENSDART00000132457
trmt11
tRNA methyltransferase 11 homolog (S. cerevisiae)
chr12_-_33256934 2.03 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr6_+_3556296 2.03 ENSDART00000041627
ssb
Sjogren syndrome antigen B (autoantigen La)
chr11_-_15740291 2.03 ENSDART00000165836
rap1ab
RAP1A, member of RAS oncogene family b
chr17_+_23709676 2.03 ENSDART00000179026
zgc:91976
zgc:91976
chr4_-_71601845 2.02 ENSDART00000174158
CABZ01021433.1
ENSDARG00000105696
chr1_-_18118467 2.01 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr7_+_36195803 2.01 ENSDART00000138893
aktip
akt interacting protein
chr2_-_41035732 2.01 ENSDART00000123886
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr21_+_15505169 2.00 ENSDART00000011318
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr8_+_2484943 1.98 ENSDART00000101137
gle1
GLE1 RNA export mediator homolog (yeast)
chr22_+_14092247 1.98 ENSDART00000013575
bzw1a
basic leucine zipper and W2 domains 1a
chr23_+_22671035 1.97 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr3_-_26113336 1.96 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr5_-_31796734 1.96 ENSDART00000142095
fbxw2
F-box and WD repeat domain containing 2
chr18_+_18450245 1.96 ENSDART00000043843
siah1
siah E3 ubiquitin protein ligase 1
chr2_-_39026651 1.96 ENSDART00000114085
si:ch211-119o8.6
si:ch211-119o8.6
chr7_-_37908695 1.96

chr7_+_71658178 1.95

chr2_+_17027403 1.95 ENSDART00000164329
ppp1r7
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr1_+_14572155 1.95 ENSDART00000033018
pi4k2b
phosphatidylinositol 4-kinase type 2 beta
chr19_+_41894701 1.95 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
KN150307v1_+_7116 1.94

chr11_+_24548669 1.93 ENSDART00000015374
cyb5r1
cytochrome b5 reductase 1
chr2_+_37224986 1.93 ENSDART00000138952
apoda.2
apolipoprotein Da, duplicate 2
chr18_+_5707331 1.92

chr3_-_28371648 1.90 ENSDART00000150912
CR792426.1
ENSDARG00000096347
chr16_+_14075878 1.89 ENSDART00000059926
zgc:162509
zgc:162509
chr24_+_14396536 1.88 ENSDART00000135646
ngdn
neuroguidin, EIF4E binding protein
chr3_+_26113393 1.87 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr3_-_26112995 1.87 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr4_+_5839655 1.86 ENSDART00000161101
lyrm5a
LYR motif containing 5a
chr25_-_12810134 1.85 ENSDART00000165156
sept15
septin 15
chr15_-_41732567 1.83 ENSDART00000059327
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr1_-_26321129 1.83 ENSDART00000147414
cntln
centlein, centrosomal protein
chr17_-_6225136 1.82 ENSDART00000137389
ENSDART00000115389
txlnbb
taxilin beta b
chr2_-_57803431 1.82 ENSDART00000138265
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr7_+_71293928 1.81 ENSDART00000047069
tyms
thymidylate synthetase
chr21_-_30045531 1.79 ENSDART00000157307
ccnjl
cyclin J-like
chr21_+_3732973 1.79 ENSDART00000170653
dolpp1
dolichyldiphosphatase 1
chr15_+_5124616 1.78 ENSDART00000101937
pgm2l1
phosphoglucomutase 2-like 1
chr19_-_19806070 1.77 ENSDART00000165206
smarcc1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr12_-_2834814 1.76 ENSDART00000114854
ENSDART00000163759
zdhhc16b
zinc finger, DHHC-type containing 16b
chr13_+_28655188 1.75 ENSDART00000039028
nsmce4a
NSE4 homolog A, SMC5-SMC6 complex component
chr8_-_53165501 1.75 ENSDART00000135982
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr17_-_31701846 1.74 ENSDART00000136199
dtd2
D-tyrosyl-tRNA deacylase 2
chr16_-_31835083 1.73 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr10_+_42841562 1.72

chr7_+_71658255 1.71

chr20_-_53040480 1.71 ENSDART00000171177
ENSDART00000040265
tbc1d7
TBC1 domain family, member 7
chr23_-_7740761 1.70 ENSDART00000172451
plagl2
pleiomorphic adenoma gene-like 2
chr10_-_22176478 1.69

KN150702v1_+_154982 1.69 ENSDART00000163214
CABZ01076670.1
ENSDARG00000104551
chr6_-_30696540 1.69 ENSDART00000065212
ttc4
tetratricopeptide repeat domain 4
chr23_-_15234716 1.68 ENSDART00000158943
ndrg3b
ndrg family member 3b
chr23_+_22671150 1.68 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr22_-_25015473 1.68 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr3_-_20989068 1.67 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr15_+_45590082 1.67

chr24_-_38195458 1.67 ENSDART00000056381
crp2
C-reactive protein 2
chr2_-_5916299 1.66

chr3_-_26675055 1.62 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr11_-_22210506 1.62 ENSDART00000146873
tmem183a
transmembrane protein 183A
chr17_+_45754797 1.61 ENSDART00000109525
aspg
asparaginase homolog (S. cerevisiae)
chr4_+_22033615 1.60

chr11_+_17849608 1.60 ENSDART00000020283
rpusd4
RNA pseudouridylate synthase domain containing 4
chr6_+_22049537 1.60 ENSDART00000158263
si:dkey-10p5.10
si:dkey-10p5.10
chr15_+_5124820 1.57 ENSDART00000101937
pgm2l1
phosphoglucomutase 2-like 1
chr4_-_12931110 1.56 ENSDART00000013604
lemd3
LEM domain containing 3
chr9_+_38648006 1.56 ENSDART00000142512
mcm3ap
minichromosome maintenance complex component 3 associated protein
chr18_+_35153749 1.56 ENSDART00000151073
si:ch211-195m9.3
si:ch211-195m9.3
chr1_-_50395003 1.55 ENSDART00000035150
spast
spastin
chr23_-_33783345 1.54 ENSDART00000143333
pou6f1
POU class 6 homeobox 1
chr15_-_30976483 1.54 ENSDART00000112511
akap1b
A kinase (PRKA) anchor protein 1b
chr16_-_13790460 1.54 ENSDART00000047452
ube2s
ubiquitin-conjugating enzyme E2S
chr24_+_14792755 1.52 ENSDART00000091735
dok6
docking protein 6
chr21_+_11685992 1.51 ENSDART00000031786
glrx
glutaredoxin (thioltransferase)
chr5_-_18941045 1.51 ENSDART00000141268
kctd10
potassium channel tetramerization domain containing 10
chr14_+_11864388 1.50 ENSDART00000146521
rhogd
ras homolog gene family, member Gd

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 17.0 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
1.7 10.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.6 4.9 GO:0072045 convergent extension involved in nephron morphogenesis(GO:0072045)
1.2 8.6 GO:0000338 protein deneddylation(GO:0000338)
1.1 12.3 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.9 5.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.8 2.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.8 3.9 GO:0097009 energy homeostasis(GO:0097009)
0.8 6.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.7 2.2 GO:0031639 plasminogen activation(GO:0031639)
0.7 4.2 GO:0098773 ventricular trabecula myocardium morphogenesis(GO:0003222) skin epidermis development(GO:0098773)
0.6 6.4 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.6 3.6 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.5 3.7 GO:0034982 mitochondrial protein processing(GO:0034982)
0.5 1.5 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.5 2.0 GO:0051591 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 1.5 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.5 2.8 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.5 0.5 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.5 1.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 1.3 GO:0001579 medium-chain fatty acid transport(GO:0001579) temperature homeostasis(GO:0001659)
0.4 2.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.4 2.8 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.4 1.9 GO:0038171 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921) trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542)
0.4 1.8 GO:0009176 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.4 1.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 1.4 GO:0010890 regulation of sequestering of triglyceride(GO:0010889) positive regulation of sequestering of triglyceride(GO:0010890) sequestering of triglyceride(GO:0030730)
0.3 1.0 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.3 4.8 GO:0021884 forebrain neuron development(GO:0021884)
0.3 2.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.3 2.0 GO:0030576 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.3 2.0 GO:0060295 regulation of cilium beat frequency(GO:0003356) regulation of translational termination(GO:0006449) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.3 3.6 GO:0045199 maintenance of cell polarity(GO:0030011) maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.3 0.9 GO:0000967 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.3 0.9 GO:0032239 snRNA export from nucleus(GO:0006408) regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833)
0.3 4.0 GO:0007032 endosome organization(GO:0007032)
0.3 0.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 1.5 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.3 2.0 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.8 GO:0071887 leukocyte apoptotic process(GO:0071887) regulation of leukocyte apoptotic process(GO:2000106)
0.3 1.8 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.2 1.2 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.2 0.9 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 0.7 GO:0000493 box H/ACA snoRNP assembly(GO:0000493)
0.2 1.4 GO:0051601 exocyst localization(GO:0051601)
0.2 1.8 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.2 2.9 GO:0001522 pseudouridine synthesis(GO:0001522)
0.2 0.9 GO:0015809 arginine transport(GO:0015809)
0.2 1.3 GO:0000730 DNA recombinase assembly(GO:0000730)
0.2 1.3 GO:0006684 sphingomyelin metabolic process(GO:0006684)
0.2 5.2 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.6 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.2 1.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 3.6 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 2.9 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 2.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.5 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 1.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 1.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.5 GO:0043393 G-protein coupled receptor internalization(GO:0002031) regulation of protein binding(GO:0043393)
0.2 0.7 GO:0071896 protein localization to adherens junction(GO:0071896)
0.2 2.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 4.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 0.5 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.2 1.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 3.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 1.0 GO:0000012 single strand break repair(GO:0000012)
0.2 0.9 GO:0017145 stem cell division(GO:0017145)
0.2 3.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 0.8 GO:0002381 somatic recombination of immunoglobulin genes involved in immune response(GO:0002204) somatic diversification of immunoglobulins involved in immune response(GO:0002208) immunoglobulin production involved in immunoglobulin mediated immune response(GO:0002381)
0.1 4.3 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.6 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 1.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.4 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 1.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.0 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.5 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.9 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 1.2 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.9 GO:0046548 retinal rod cell development(GO:0046548)
0.1 2.0 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 1.8 GO:2000344 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 3.7 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.2 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.3 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.1 5.5 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.5 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.5 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.5 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 3.6 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 0.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.5 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.3 GO:0018008 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.1 1.8 GO:0072114 pronephros morphogenesis(GO:0072114)
0.1 1.0 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516)
0.1 1.5 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.1 3.5 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 2.0 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 3.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 0.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.0 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 3.5 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.0 GO:0000302 response to reactive oxygen species(GO:0000302)
0.1 2.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.1 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.5 GO:0072676 lymphocyte migration(GO:0072676) regulation of lymphocyte migration(GO:2000401)
0.1 1.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 1.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 1.5 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.6 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 2.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of chemotaxis(GO:0050922) negative regulation of axon guidance(GO:1902668)
0.1 0.3 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.8 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 8.4 GO:0006310 DNA recombination(GO:0006310)
0.1 0.3 GO:0045144 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177) meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.3 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.6 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 3.2 GO:0051402 neuron apoptotic process(GO:0051402)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 3.6 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 1.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.5 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.0 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 3.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.8 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.6 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 1.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.8 GO:0048634 regulation of muscle organ development(GO:0048634)
0.0 0.2 GO:0097324 melanocyte migration(GO:0097324)
0.0 2.8 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.2 GO:0060876 chondroitin sulfate biosynthetic process(GO:0030206) semicircular canal formation(GO:0060876)
0.0 0.3 GO:0090481 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 2.9 GO:0021915 neural tube development(GO:0021915)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 2.9 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 1.4 GO:0016573 histone acetylation(GO:0016573)
0.0 0.1 GO:0021501 prechordal plate formation(GO:0021501)
0.0 0.2 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.7 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 1.5 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 0.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.4 GO:0038127 ERBB signaling pathway(GO:0038127)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.2 GO:0010469 regulation of receptor activity(GO:0010469)
0.0 5.7 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.0 GO:0002693 regulation of cellular extravasation(GO:0002691) positive regulation of cellular extravasation(GO:0002693) cellular extravasation(GO:0045123) positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.0 GO:0036449 microtubule minus-end(GO:0036449)
1.8 5.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.8 10.1 GO:0005845 mRNA cap binding complex(GO:0005845)
0.5 5.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.5 1.6 GO:0070390 transcription export complex 2(GO:0070390)
0.5 5.5 GO:0008180 COP9 signalosome(GO:0008180)
0.5 0.9 GO:0034518 RNA cap binding complex(GO:0034518)
0.4 2.5 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.4 1.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.4 2.0 GO:0070695 FHF complex(GO:0070695)
0.4 2.9 GO:0005899 insulin receptor complex(GO:0005899)
0.3 8.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.3 2.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 1.4 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.3 0.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 0.8 GO:0032302 MutSbeta complex(GO:0032302)
0.2 6.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.7 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 1.9 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.6 GO:0070209 ASTRA complex(GO:0070209)
0.2 2.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 3.1 GO:0071564 npBAF complex(GO:0071564)
0.2 1.1 GO:0001650 fibrillar center(GO:0001650)
0.2 4.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 0.5 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 3.7 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.7 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.1 0.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 4.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.5 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.2 GO:0015030 Cajal body(GO:0015030)
0.1 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 0.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 4.2 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 1.4 GO:0000145 exocyst(GO:0000145)
0.1 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.1 1.0 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 3.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 5.7 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 3.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.4 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 2.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 2.0 GO:0031941 filamentous actin(GO:0031941)
0.1 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.3 GO:0005811 lipid particle(GO:0005811)
0.1 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.0 GO:0005643 nuclear pore(GO:0005643)
0.0 1.5 GO:0030496 midbody(GO:0030496)
0.0 0.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.8 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 3.9 GO:0005815 microtubule organizing center(GO:0005815)
0.0 3.1 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.7 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 1.4 GO:0055037 recycling endosome(GO:0055037)
0.0 8.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.3 GO:0098794 postsynapse(GO:0098794)
0.0 1.0 GO:0030425 dendrite(GO:0030425)
0.0 0.0 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 2.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 7.3 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 10.1 GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA(GO:0070551)
1.1 17.0 GO:0051011 microtubule minus-end binding(GO:0051011)
1.1 8.6 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.0 6.0 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.8 4.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.8 2.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) CCR5 chemokine receptor binding(GO:0031730)
0.7 2.0 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.6 1.9 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.6 3.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.5 6.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 5.8 GO:0030552 cAMP binding(GO:0030552)
0.5 4.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.5 2.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 9.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.5 2.0 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.5 1.5 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.4 4.9 GO:0070697 activin receptor binding(GO:0070697)
0.4 1.7 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.4 1.3 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.4 1.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 1.1 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.4 2.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.4 2.9 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.4 1.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 4.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 3.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 1.9 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 0.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 1.6 GO:0004067 asparaginase activity(GO:0004067)
0.3 0.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 1.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 4.1 GO:0019894 kinesin binding(GO:0019894)
0.3 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 1.4 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.3 1.1 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.3 1.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 1.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.3 0.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 1.8 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.3 0.8 GO:0000406 double-strand/single-strand DNA junction binding(GO:0000406)
0.2 1.2 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.2 0.9 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 2.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 2.8 GO:0070411 I-SMAD binding(GO:0070411)
0.2 5.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 0.8 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.2 5.5 GO:0019003 GDP binding(GO:0019003)
0.2 0.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.2 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.6 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 3.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 2.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 7.0 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.2 1.0 GO:1901612 cardiolipin binding(GO:1901612)
0.2 0.9 GO:0034511 U3 snoRNA binding(GO:0034511)
0.2 0.5 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 5.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 0.7 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.0 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 4.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 4.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 1.8 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0030623 U5 snRNA binding(GO:0030623)
0.1 0.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 1.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.6 GO:0005537 mannose binding(GO:0005537)
0.1 1.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 0.3 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.1 0.3 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.1 0.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 2.7 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.2 GO:0002039 p53 binding(GO:0002039)
0.1 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 5.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.3 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 1.4 GO:0000149 SNARE binding(GO:0000149)
0.1 2.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 2.7 GO:0030215 semaphorin receptor binding(GO:0030215) chemorepellent activity(GO:0045499)
0.1 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 6.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.9 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 1.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985) neuropeptide binding(GO:0042923)
0.0 7.8 GO:0042393 histone binding(GO:0042393)
0.0 1.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 2.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.8 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0016504 peptidase activator activity(GO:0016504) endopeptidase activator activity(GO:0061133)
0.0 0.5 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0003874 6-pyruvoyltetrahydropterin synthase activity(GO:0003874)
0.0 2.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.8 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.7 GO:0008083 growth factor activity(GO:0008083)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 2.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 2.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 2.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.8 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 2.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0003724 RNA helicase activity(GO:0003724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 8.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 4.8 PID AURORA A PATHWAY Aurora A signaling
0.2 3.6 PID RAS PATHWAY Regulation of Ras family activation
0.2 2.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 1.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.9 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 0.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 0.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 1.3 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 1.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 2.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 7.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.4 8.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.4 3.9 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.4 5.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 2.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 0.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 2.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 0.6 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.2 2.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 1.6 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 2.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.7 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 3.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 2.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 2.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.2 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 4.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis