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Results for hoxb10a+hoxc10a

Z-value: 0.47

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Transcription factors associated with hoxb10a+hoxc10a

Gene Symbol Gene ID Gene Info
ENSDARG00000011579 homeobox B10a
ENSDARG00000070348 homeobox C10a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc10adr10_dc_chr23_+_35984969_359849910.775.5e-04Click!
hoxb10adr10_dc_chr3_+_23538277_235382830.683.5e-03Click!

Activity profile of hoxb10a+hoxc10a motif

Sorted Z-values of hoxb10a+hoxc10a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb10a+hoxc10a

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr16_-_45950530 1.89 ENSDART00000060822
antifreeze protein type IV
chr23_+_10211543 1.35 ENSDART00000048073
zgc:171775
chr1_-_37475807 1.19 ENSDART00000020409
heart and neural crest derivatives expressed 2
chr14_-_24463906 1.06 ENSDART00000126199
slit homolog 3 (Drosophila)
chr25_-_13518274 0.97 ENSDART00000165510
fatty acid 2-hydroxylase
chr23_+_27141681 0.96 ENSDART00000054238
major intrinsic protein of lens fiber a
chr8_+_2428689 0.96 ENSDART00000081325
dynein, light chain, LC8-type 1
chr23_+_39713307 0.90 ENSDART00000109464
G0/G1 switch 2
chr19_+_22478256 0.84 ENSDART00000100181
spalt-like transcription factor 3b
chr12_+_13080209 0.84 ENSDART00000127870
calymmin
chr2_-_35584440 0.83 ENSDART00000125298
tenascin W
chr25_-_30845998 0.83 ENSDART00000027661
myogenic differentiation 1
chr17_-_20267580 0.83 ENSDART00000078703
adducin 3 (gamma) b
chr19_+_17926983 0.79 ENSDART00000141397
ubiquitin-conjugating enzyme E2E 1
chr25_+_19992389 0.76 ENSDART00000143441
troponin I4b, tandem duplicate 2
chr16_-_33105847 0.75

chr23_+_25428372 0.75 ENSDART00000147440
formin-like 3
chr3_-_31672763 0.73 ENSDART00000028270
glial fibrillary acidic protein
chr6_+_52791515 0.72 ENSDART00000065682
matrilin 4
chr23_+_22977031 0.71

chr20_+_26639029 0.71 ENSDART00000045397
syntaxin 11b, tandem duplicate 1
chr23_+_7445760 0.67 ENSDART00000012194
GATA binding protein 5
chr5_+_36010448 0.66 ENSDART00000097684
neuro-oncological ventral antigen 1
chr25_+_30701751 0.66

chr19_-_39048324 0.65 ENSDART00000086717
collagen, type XVI, alpha 1
chr6_+_35378839 0.64 ENSDART00000102483
ENSDART00000133783
regulator of G protein signaling 4
chr19_+_42899678 0.62 ENSDART00000076915
si:dkey-166k12.1
chr14_+_45895103 0.60

chr6_-_28231995 0.59 ENSDART00000131126
B-cell CLL/lymphoma 6a (zinc finger protein 51)
chr18_+_22617072 0.59 ENSDART00000128965
breast cancer anti-estrogen resistance 1
chr23_-_27645138 0.57 ENSDART00000008174
phosphofructokinase, muscle a
chr16_+_28819826 0.57 ENSDART00000103340
S100 calcium binding protein V1
chr25_+_34069931 0.56

chr23_+_24711233 0.56

chr8_+_18552850 0.56 ENSDART00000177476
proline rich Gla (G-carboxyglutamic acid) 1
chr2_+_53253623 0.55 ENSDART00000121980
cAMP responsive element binding protein 3-like 3b
chr6_-_60152693 0.54 ENSDART00000083453
solute carrier family 32 (GABA vesicular transporter), member 1
chr6_-_60152594 0.53 ENSDART00000083453
solute carrier family 32 (GABA vesicular transporter), member 1
chr2_+_20748431 0.53 ENSDART00000137848
palmdelphin a
chr22_+_4791383 0.52 ENSDART00000160927
ceramide synthase 1
chr9_-_32942783 0.52 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr10_-_30016761 0.51 ENSDART00000078800
lens intrinsic membrane protein 2.1
chr1_-_50215233 0.50 ENSDART00000137648
si:dkeyp-123h10.2
chr19_-_17926919 0.49 ENSDART00000167592
ENSDART00000162383
NFKB inhibitor interacting Ras-like 1
chr21_-_20291707 0.49 ENSDART00000079593
solute carrier family 26 (anion exchanger), member 1
chr5_-_20441931 0.48

chr12_+_27026112 0.47 ENSDART00000076154
homeobox B8b
chr19_-_15951003 0.47 ENSDART00000133059
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr7_+_31608878 0.44 ENSDART00000099789
myosin binding protein C, cardiac
chr13_+_22134507 0.43 ENSDART00000060576
myozenin 1a
chr23_-_18203680 0.42 ENSDART00000016976
nuclear casein kinase and cyclin-dependent kinase substrate 1b
chr23_-_29138952 0.41 ENSDART00000002812
castor zinc finger 1
chr20_+_9776103 0.39 ENSDART00000053834
proteasome 26S subunit, ATPase 6
chr19_-_10962536 0.38 ENSDART00000160438
proteasome 26S subunit, non-ATPase 4a
chr2_+_1881022 0.38 ENSDART00000101038
transmembrane inner ear
chr22_-_22696091 0.34

chr10_+_22876094 0.34

chr10_+_2559774 0.33 ENSDART00000126937
wu:fb59d01
chr20_+_32646617 0.33

chr5_+_26312951 0.33 ENSDART00000126609
T-box 3b
chr13_+_12257610 0.33 ENSDART00000086525
ATPase, class V, type 10D
chr19_-_39048402 0.32 ENSDART00000086717
collagen, type XVI, alpha 1
chr21_+_10663517 0.32 ENSDART00000074833
retinal homeobox gene 3
chr19_-_46058895 0.30 ENSDART00000163504
trichorhinophalangeal syndrome I
chr19_-_46058954 0.30 ENSDART00000163504
trichorhinophalangeal syndrome I
chr17_-_2513630 0.30 ENSDART00000135374
protein tyrosine phosphatase, non-receptor type 21
chr6_+_60152913 0.30

chr19_+_20189224 0.29 ENSDART00000163611
homeobox A4a
chr24_-_8592157 0.29 ENSDART00000082351
transcription factor AP-2 alpha
chr23_-_35997065 0.28 ENSDART00000153910
ENSDARG00000097150
chr25_-_13579869 0.27 ENSDART00000090226
zinc finger protein 319b
chr6_-_47386720 0.27 ENSDART00000058736
glutamate receptor, metabotropic 4
chr2_-_6127811 0.26 ENSDART00000013079
sterol carrier protein 2a
chr13_+_36459706 0.25 ENSDART00000138940
glia maturation factor, beta
chr6_+_30716955 0.24 ENSDART00000104628
insulin-like 5a
chr10_-_22875997 0.24 ENSDART00000079454
vesicle-associated membrane protein 2
chr10_+_9762039 0.24

chr10_-_38206060 0.24 ENSDART00000174882
ENSDARG00000107804
chr11_+_35896325 0.24 ENSDART00000163330
glutamate receptor, metabotropic 2b
chr23_+_11734349 0.23 ENSDART00000091416
contactin 3a, tandem duplicate 1
chr3_+_54506912 0.23 ENSDART00000135913
si:ch211-74m13.1
chr25_+_5567388 0.23

chr12_-_20251183 0.23 ENSDART00000066382
aquaporin 8a, tandem duplicate 1
chr1_+_50763649 0.22 ENSDART00000074294
ARP2 actin related protein 2a homolog
chr11_-_18166056 0.22 ENSDART00000155752
Scm-like with four mbt domains 1
chr3_+_26015378 0.22

chr11_+_25495396 0.22

chr23_+_22858531 0.22 ENSDART00000111345
arginine-glutamic acid dipeptide (RE) repeats a
chr14_+_20862466 0.20 ENSDART00000059796
ENSDARG00000019213
chr24_-_8592102 0.19 ENSDART00000082351
transcription factor AP-2 alpha
chr16_+_13993746 0.19 ENSDART00000101304
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr9_+_30909382 0.19 ENSDART00000146115
Kruppel-like factor 12b
chr2_+_33907298 0.19

chr20_+_52740555 0.19 ENSDART00000110777
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr11_+_7570097 0.18 ENSDART00000091550
adhesion G protein-coupled receptor L2a
chr9_+_30909291 0.18 ENSDART00000146115
Kruppel-like factor 12b
chr3_+_24003840 0.18 ENSDART00000156204
si:ch211-246i5.5
chr4_+_28452948 0.18 ENSDART00000150879
zinc finger protein 1067
chr11_+_18020191 0.17 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr18_-_15361133 0.17 ENSDART00000019818
RIC8 guanine nucleotide exchange factor B
chr11_+_7570027 0.17 ENSDART00000091550
adhesion G protein-coupled receptor L2a
chr5_+_45823481 0.17

chr18_+_41242498 0.16 ENSDART00000138552
ENSDART00000145863
thyroid hormone receptor interactor 12
chr5_+_14701877 0.16 ENSDART00000144915
T-box 1
chr21_-_25719352 0.16 ENSDART00000002341
claudin c
chr2_+_16928379 0.16 ENSDART00000160641
ENSDART00000125413
5'-3' exoribonuclease 1
chr14_-_2342593 0.15

chr14_+_45895037 0.15

chr21_+_17509116 0.15

chr5_+_22632707 0.14 ENSDART00000003428
phosphoribosyl pyrophosphate synthetase 1A
chr23_+_22858773 0.13 ENSDART00000142085
arginine-glutamic acid dipeptide (RE) repeats a
chr9_+_41223155 0.13 ENSDART00000014660
ORMDL sphingolipid biosynthesis regulator 1
chr11_+_2630587 0.13 ENSDART00000082512
transmembrane protein 167B
chr4_-_29488075 0.13 ENSDART00000167636
ENSDARG00000101492
chr15_-_1880375 0.12 ENSDART00000102410
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_23741791 0.11 ENSDART00000049003
ATPase, H+ transporting, lysosomal, V1 subunit Aa
chr14_-_47226179 0.10 ENSDART00000056734
ENSDART00000143158
SET domain containing (lysine methyltransferase) 7
chr18_+_20836320 0.10 ENSDART00000090100
tetratricopeptide repeat domain 23
chr1_+_33510660 0.10 ENSDART00000147201
solute carrier family 5 (sodium/choline cotransporter), member 7a
chr2_-_26160882 0.09 ENSDART00000133163
ENSDARG00000094803
chr9_+_1968455 0.09

chr4_-_16461748 0.08 ENSDART00000128835
wu:fc23c09
chr23_-_10906094 0.08

chr4_-_16887296 0.07 ENSDART00000044005
ENSDART00000042874
ENSDART00000016690
thymopoietin a
chr8_+_8822226 0.07 ENSDART00000081999
OTU deubiquitinase 5a
chr23_+_22858361 0.07 ENSDART00000111345
arginine-glutamic acid dipeptide (RE) repeats a
chr11_-_27970634 0.06

chr6_+_12849629 0.06 ENSDART00000172158
trans-L-3-hydroxyproline dehydratase
chr16_+_25749018 0.06 ENSDART00000154024
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
chr8_+_23172960 0.06 ENSDART00000028946
tumor protein D52-like 2a
chr10_+_39142185 0.06

chr23_+_36607999 0.06 ENSDART00000113179
tetraspanin 31
chr25_+_19992328 0.06 ENSDART00000143441
troponin I4b, tandem duplicate 2
chr10_+_18921391 0.06 ENSDART00000024127
protein phosphatase 2, regulatory subunit B, alpha b
chr12_+_31523317 0.05 ENSDART00000153129
dynamin binding protein
chr5_-_49724579 0.05 ENSDART00000157800
si:ch73-280o22.2
chr1_-_51658383 0.05 ENSDART00000132638
ENSDARG00000059948
chr19_+_20189194 0.04 ENSDART00000163611
homeobox A4a
chr17_-_48833163 0.04 ENSDART00000054781
galectin 8b
chr21_+_15637884 0.04 ENSDART00000149371
isocitrate dehydrogenase 3 (NAD+) beta
chr21_-_11877525 0.03 ENSDART00000145194
NOP56 ribonucleoprotein homolog
chr19_+_2659309 0.02 ENSDART00000162293
si:ch73-345f18.3
chr13_+_24453943 0.02 ENSDART00000057599
fucose mutarotase
chr3_+_24004141 0.02 ENSDART00000155216
si:ch211-246i5.5
chr14_+_23419894 0.01 ENSDART00000006373
Nedd4 family interacting protein 1
chr17_-_43896998 0.01 ENSDART00000156513
ENSDARG00000097825
chr1_-_17073539 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.2 1.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 0.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 1.0 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 0.5 GO:0021742 abducens nucleus development(GO:0021742)
0.2 0.7 GO:0009886 post-embryonic morphogenesis(GO:0009886) post-embryonic foregut morphogenesis(GO:0048618)
0.1 1.0 GO:0006833 water transport(GO:0006833)
0.1 0.4 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 0.3 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.6 GO:0061718 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.2 GO:0043282 pharyngeal muscle development(GO:0043282)
0.1 1.9 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.4 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.2 GO:2001032 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.3 GO:0032367 intracellular cholesterol transport(GO:0032367) positive regulation of lipid transport(GO:0032370)
0.0 0.5 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 1.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.7 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.1 GO:0070285 pigment cell development(GO:0070285)
0.0 0.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.8 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.5 GO:0050935 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036) iridophore differentiation(GO:0050935)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.2 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.2 1.2 GO:0015250 water channel activity(GO:0015250)
0.2 0.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.1 0.8 GO:0070888 E-box binding(GO:0070888)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.4 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.1 1.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.4 GO:0031593 polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression