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Results for hoxb5a+hoxb5b

Z-value: 0.35

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Transcription factors associated with hoxb5a+hoxb5b

Gene Symbol Gene ID Gene Info
hoxb5a
ENSDARG00000013057 homeobox B5a
hoxb5b
ENSDARG00000054030 homeobox B5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb5bdr10_dc_chr12_+_27038298_270383270.204.6e-01Click!
hoxb5adr10_dc_chr3_+_23577103_235771620.107.2e-01Click!

Activity profile of hoxb5a+hoxb5b motif

Sorted Z-values of hoxb5a+hoxb5b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb5a+hoxb5b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
KN149799v1_-_24611 1.31

KN149799v1_+_25349 0.37

chr8_-_17692185 0.23

chr16_+_53438473 0.21 ENSDART00000155940
CR848746.1
ENSDARG00000097164
chr9_+_16846294 0.20 ENSDART00000110866
cln5
ceroid-lipofuscinosis, neuronal 5
chr19_+_43745515 0.19 ENSDART00000145846
sesn2
sestrin 2
chr9_-_12063411 0.18 ENSDART00000038651
znf804a
zinc finger protein 804A
chr6_+_37881015 0.17 ENSDART00000087311
oca2
oculocutaneous albinism II
chr15_-_42327430 0.17 ENSDART00000144645
farsb
phenylalanyl-tRNA synthetase, beta subunit
chr5_+_31745031 0.15 ENSDART00000147132
c9
complement component 9
chr19_+_5562107 0.15 ENSDART00000082080
jupb
junction plakoglobin b
chr16_+_53438411 0.14 ENSDART00000155940
CR848746.1
ENSDARG00000097164
chr13_-_36008642 0.12 ENSDART00000015664
pcnx
pecanex homolog (Drosophila)
chr22_+_659157 0.11 ENSDART00000149712
gpr37l1a
G protein-coupled receptor 37 like 1a
chr18_-_616875 0.11 ENSDART00000169974
sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr23_-_624480 0.11 ENSDART00000132175
nadl1.1
neural adhesion molecule L1.1
chr8_-_17691889 0.11

chr23_-_624534 0.11 ENSDART00000132175
nadl1.1
neural adhesion molecule L1.1
chr2_-_5233961 0.11 ENSDART00000163728
dlg1l
discs, large (Drosophila) homolog 1, like
chr7_+_50828247 0.10 ENSDART00000174236
col4a5
collagen, type IV, alpha 5 (Alport syndrome)
chr23_+_20592121 0.10 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr24_-_42193714 0.09

chr20_+_51918693 0.09 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr7_-_50827308 0.09 ENSDART00000121574
col4a6
collagen, type IV, alpha 6
chr14_+_33382973 0.08 ENSDART00000132488
apln
apelin
chr15_-_723851 0.08

chr24_+_42193701 0.08 ENSDART00000067734
snx16
sorting nexin 16
chr3_+_39437497 0.08 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr22_+_1663690 0.08 ENSDART00000166672
si:dkey-1b17.6
si:dkey-1b17.6
chr8_+_166461 0.08

chr12_-_4638371 0.07

chr7_+_50828119 0.07 ENSDART00000108738
col4a5
collagen, type IV, alpha 5 (Alport syndrome)
chr23_+_3570270 0.07 ENSDART00000092258
spata2
spermatogenesis associated 2
chr13_-_36008571 0.07 ENSDART00000139593
pcnx
pecanex homolog (Drosophila)
chr3_+_28700619 0.06 ENSDART00000108973
flr
fleer
chr10_+_26982647 0.06 ENSDART00000135493
frmd8
FERM domain containing 8
chr19_+_43745687 0.06 ENSDART00000102384
sesn2
sestrin 2
chr9_-_32295031 0.06 ENSDART00000132448
BX530407.4
ENSDARG00000093950
chr14_+_27936303 0.06 ENSDART00000003293
mid2
midline 2
chr2_-_5233883 0.06 ENSDART00000163728
dlg1l
discs, large (Drosophila) homolog 1, like
chr5_-_33169062 0.06 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
KN149874v1_-_3544 0.06 ENSDART00000165981
CABZ01046348.1
ENSDARG00000099481
chr19_+_46667326 0.05 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr16_-_42202425 0.05 ENSDART00000038748
dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr7_+_33044157 0.05 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr19_-_23259063 0.05 ENSDART00000052503
nudcd1
NudC domain containing 1
KN149874v1_+_3898 0.05

KN150226v1_+_11579 0.04

chr2_+_24661778 0.04 ENSDART00000139339
mrpl34
mitochondrial ribosomal protein L34
chr11_+_24720206 0.04 ENSDART00000145647
sulf2a
sulfatase 2a
chr5_+_33807197 0.04 ENSDART00000145127
lamc3
laminin, gamma 3
chr3_+_1455242 0.03 ENSDART00000065922
wbp2nl
WBP2 N-terminal like
chr1_+_54403123 0.03 ENSDART00000152654
lgalsla
lectin, galactoside-binding-like a
chr11_+_24720057 0.03 ENSDART00000145647
sulf2a
sulfatase 2a
chr15_-_25164321 0.03 ENSDART00000154628
fam101b
family with sequence similarity 101, member B
chr23_+_35980812 0.03

chr19_+_43745546 0.03 ENSDART00000145846
sesn2
sestrin 2
chr3_-_2041373 0.02 ENSDART00000146552
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr19_+_31046291 0.02 ENSDART00000052124
fam49al
family with sequence similarity 49, member A-like
chr16_-_10089440 0.02 ENSDART00000066372
id4
inhibitor of DNA binding 4
chr19_+_40535249 0.01 ENSDART00000151276
si:ch211-173p18.3
si:ch211-173p18.3
chr17_+_20549925 0.01 ENSDART00000113936
ENSDARG00000074663
ENSDARG00000074663
chr24_+_37805069 0.01

chr5_-_29480173 0.01 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr1_-_9316038 0.01

chr23_+_3570243 0.01 ENSDART00000092258
spata2
spermatogenesis associated 2
chr12_+_46703637 0.00 ENSDART00000152928
exoc7
exocyst complex component 7
chr14_-_8779307 0.00 ENSDART00000054710
polr1d
polymerase (RNA) I polypeptide D
KN150563v1_-_10770 0.00

chr9_-_1954910 0.00 ENSDART00000140438
BX322661.1
ENSDARG00000094186

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.3 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.2 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0 0.1 GO:0042756 drinking behavior(GO:0042756)
0.0 0.2 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0060544 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0036372 opsin transport(GO:0036372)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.1 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0031704 apelin receptor binding(GO:0031704)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade