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Results for hoxb6a+hoxb6b
Z-value: 4.02
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Transcription factors associated with hoxb6a+hoxb6b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxb6b | dr10_dc_chr12_+_27035744_27035785 | 0.95 | 1.7e-08 | Click! |
| hoxb6a | dr10_dc_chr3_+_23573053_23573058 | 0.87 | 1.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxb6a+hoxb6b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_32686790 Show fit | 9.96 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr21_+_7844259 Show fit | 7.89 |
ENSDART00000027268
|
orthopedia homeobox a |
|
| chr1_+_9367672 Show fit | 7.54 |
ENSDART00000144756
|
fibrinogen beta chain |
|
| chr16_+_24069711 Show fit | 6.97 |
ENSDART00000142869
|
apolipoprotein C-II |
|
| chr20_-_22576513 Show fit | 6.81 |
ENSDART00000103510
|
platelet-derived growth factor receptor, alpha polypeptide |
|
| chr24_-_1307905 Show fit | 6.80 |
ENSDART00000159212
|
neuropilin 1a |
|
| chr22_-_35967525 Show fit | 6.80 |
ENSDART00000176971
|
ENSDARG00000106725 |
|
| chr10_+_39141022 Show fit | 6.75 |
ENSDART00000158245
|
si:ch73-1a9.3 |
|
| chr4_+_5498355 Show fit | 6.58 |
ENSDART00000150785
|
mitogen-activated protein kinase 11 |
|
| chr12_+_5673442 Show fit | 6.39 |
ENSDART00000017191
|
distal-less homeobox 3b |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.4 | 22.4 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.2 | 20.0 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.7 | 19.1 | GO:0043049 | otic placode formation(GO:0043049) |
| 1.5 | 14.7 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.9 | 14.2 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 1.2 | 13.9 | GO:0021767 | mammillary body development(GO:0021767) |
| 0.2 | 13.6 | GO:0099536 | synaptic signaling(GO:0099536) |
| 4.3 | 12.8 | GO:0007508 | larval development(GO:0002164) larval heart development(GO:0007508) |
| 1.1 | 12.6 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 62.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 47.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 45.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 31.0 | GO:0043235 | receptor complex(GO:0043235) |
| 0.1 | 24.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 18.5 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 16.4 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.4 | 15.2 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.2 | 15.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 13.4 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 240.7 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.1 | 37.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 26.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 24.6 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.4 | 23.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 14.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 14.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 14.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 13.8 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.1 | 12.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 14.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 14.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 13.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 10.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.4 | 8.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 8.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 8.0 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 7.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 7.3 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.6 | 12.8 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 2.1 | 12.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.4 | 12.1 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.7 | 8.9 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.4 | 8.7 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 7.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 7.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 7.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 7.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |