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Results for hoxc4a

Z-value: 1.06

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Transcription factors associated with hoxc4a

Gene Symbol Gene ID Gene Info
hoxc4a
ENSDARG00000070338 homeobox C4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc4adr10_dc_chr23_+_36032206_360322590.931.8e-07Click!

Activity profile of hoxc4a motif

Sorted Z-values of hoxc4a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxc4a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_23516127 4.63 ENSDART00000004679
icn
ictacalcin
chr3_-_32686790 4.48 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr16_-_42990753 3.84 ENSDART00000149317
hfe2
hemochromatosis type 2
chr8_+_21163236 3.54 ENSDART00000091307
col2a1a
collagen, type II, alpha 1a
chr20_-_9107294 3.37 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr19_+_10936229 3.24 ENSDART00000172219
apoea
apolipoprotein Ea
chr14_-_17257773 3.17 ENSDART00000082667
fgfrl1a
fibroblast growth factor receptor-like 1a
chr21_+_25199691 2.82 ENSDART00000168140
ENSDART00000112783
tmem45b
transmembrane protein 45B
chr18_-_782643 2.79 ENSDART00000161084
si:dkey-205h23.1
si:dkey-205h23.1
chr1_-_674449 2.66 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr15_-_14616083 2.55 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr16_+_46145286 2.53 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr19_+_43763483 2.26 ENSDART00000136695
yrk
Yes-related kinase
chr4_+_9668755 2.24 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr12_-_7902815 1.92 ENSDART00000088100
ank3b
ankyrin 3b
chr9_-_14533551 1.86 ENSDART00000056103
nrp2b
neuropilin 2b
chr19_+_5562107 1.74 ENSDART00000082080
jupb
junction plakoglobin b
chr18_-_3056732 1.74 ENSDART00000162657
rps3
ribosomal protein S3
chr24_-_14447773 1.62

chr25_-_5883620 1.57 ENSDART00000136054
snx22
sorting nexin 22
chr23_+_7537089 1.47 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr2_-_49114158 1.47

chr24_-_25546068 1.41 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr3_+_36155364 1.38 ENSDART00000059533
wipi1
WD repeat domain, phosphoinositide interacting 1
chr3_+_50511676 1.37 ENSDART00000102202
ppap2d
phosphatidic acid phosphatase type 2D
chr22_+_12746080 1.36 ENSDART00000044683
ftcd
formimidoyltransferase cyclodeaminase
chr7_+_25052687 1.35 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr13_+_516287 1.35 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr2_+_51087570 1.34

chr7_-_49322226 1.32 ENSDART00000174161
brsk2b
BR serine/threonine kinase 2b
chr23_-_7740845 1.32 ENSDART00000172451
plagl2
pleiomorphic adenoma gene-like 2
chr2_+_3370130 1.29 ENSDART00000098391
wnt9a
wingless-type MMTV integration site family, member 9A
chr24_+_21395671 1.23 ENSDART00000091529
wasf3b
WAS protein family, member 3b
chr14_+_2969679 1.22 ENSDART00000044678
ENSDARG00000034011
ENSDARG00000034011
chr17_-_26586506 1.20 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr21_+_26684617 1.18 ENSDART00000053797
slc3a2b
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr13_-_49983998 1.17

chr3_+_5665300 1.17 ENSDART00000101807
si:ch211-106h11.3
si:ch211-106h11.3
chr3_-_38642067 1.16 ENSDART00000155518
znf281a
zinc finger protein 281a
chr5_-_37850885 1.15 ENSDART00000136428
ENSDART00000112487
chrne
cholinergic receptor, nicotinic, epsilon
chr1_+_50395721 1.12 ENSDART00000134065
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr12_-_31679959 1.12 ENSDART00000153449
nat9
N-acetyltransferase 9 (GCN5-related, putative)
chr25_+_23326562 1.08

chr10_-_11303185 1.04 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr18_-_43890514 0.98 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr24_-_25545773 0.96 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr5_+_11340748 0.93 ENSDART00000159248
tesca
tescalcin a
chr10_+_21693418 0.92 ENSDART00000160754
pcdh1g1
protocadherin 1 gamma 1
chr1_-_30801520 0.89 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr11_-_40414239 0.88 ENSDART00000165163
si:ch211-222l21.1
si:ch211-222l21.1
chr20_+_1724609 0.87

chr25_+_23326630 0.82

chr1_-_18809429 0.81 ENSDART00000124260
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr19_-_5453469 0.81 ENSDART00000105004
krt17
keratin 17
chr20_+_29307142 0.78 ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr2_-_37061470 0.77 ENSDART00000056514
gng7
guanine nucleotide binding protein (G protein), gamma 7
chr25_+_32114076 0.75 ENSDART00000156145
scaper
S-phase cyclin A-associated protein in the ER
chr4_+_70768190 0.74

chr1_-_9256864 0.74 ENSDART00000041849
tmem8a
transmembrane protein 8A
chr8_+_29733109 0.73 ENSDART00000020621
mapk4
mitogen-activated protein kinase 4
chr5_+_45823481 0.71

chr15_+_46813538 0.71

chr3_-_15889742 0.70 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr8_-_12253026 0.68 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr17_+_42003279 0.68 ENSDART00000111537
kiz
kizuna centrosomal protein
chr22_+_699548 0.68 ENSDART00000017305
znf76
zinc finger protein 76
chr20_+_109649 0.67 ENSDART00000022725
si:ch1073-155h21.1
si:ch1073-155h21.1
chr24_-_28576494 0.66

chr8_+_30654835 0.63 ENSDART00000138750
adora2aa
adenosine A2a receptor a
chr3_-_4111993 0.63 ENSDART00000170535
gucy2c
guanylate cyclase 2C
chr2_-_17721575 0.61 ENSDART00000141188
ENSDART00000100201
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr20_+_1724656 0.59

chr24_+_35500964 0.59 ENSDART00000058571
snai2
snail family zinc finger 2
chr24_-_14447136 0.59

chr2_+_38390887 0.58 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr12_-_926641 0.58 ENSDART00000088351
SPAG9 (1 of many)
sperm associated antigen 9
chr20_+_29307039 0.58 ENSDART00000152949
katnbl1
katanin p80 subunit B-like 1
chr20_+_36098607 0.56 ENSDART00000021456
opn5
opsin 5
chr22_-_12130441 0.54 ENSDART00000146785
tmem163b
transmembrane protein 163b
chr10_+_11303321 0.54 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr17_+_25425967 0.53 ENSDART00000030691
clic4
chloride intracellular channel 4
chr2_+_51087643 0.52

chr2_-_37157969 0.52 ENSDART00000144220
tspan37
tetraspanin 37
chr24_+_24316486 0.52 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr17_+_44583892 0.52 ENSDART00000156625
pgfb
placental growth factor b
chr13_+_4040744 0.51

chr23_+_20714105 0.50 ENSDART00000054691
uba1
ubiquitin-like modifier activating enzyme 1
chr23_+_4773894 0.48 ENSDART00000172739
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a
chr8_+_30654957 0.48 ENSDART00000138750
adora2aa
adenosine A2a receptor a
chr3_+_3994248 0.47

chr3_-_13771322 0.46 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr3_+_27667194 0.44 ENSDART00000075100
carhsp1
calcium regulated heat stable protein 1
chr16_+_54350976 0.42 ENSDART00000172622
ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr7_+_21006803 0.41 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr2_+_50873893 0.38

chr20_+_47639141 0.38 ENSDART00000043938
tram2
translocation associated membrane protein 2
chr13_+_4040802 0.37

chr12_+_17498203 0.36 ENSDART00000073599
rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr8_+_30655100 0.35 ENSDART00000138750
adora2aa
adenosine A2a receptor a
chr22_+_1551406 0.35 ENSDART00000163223
si:ch211-255f4.9
si:ch211-255f4.9
chr12_-_26062065 0.35 ENSDART00000076051
opn4b
opsin 4b
chr9_-_32366320 0.31 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr24_+_192889 0.31 ENSDART00000067764
stk17a
serine/threonine kinase 17a
chr2_+_37157979 0.28 ENSDART00000045016
pex19
peroxisomal biogenesis factor 19
chr6_+_40924749 0.28 ENSDART00000133599
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr7_-_950176 0.27

chr13_+_516546 0.26 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr13_-_51743395 0.26

chr17_-_20538582 0.24

chr15_-_3024027 0.23

chr24_+_24316408 0.23 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr21_+_6858020 0.23 ENSDART00000139493
olfm1b
olfactomedin 1b
chr22_+_12306260 0.22

chr16_+_24818799 0.19 ENSDART00000155217
si:dkey-79d12.4
si:dkey-79d12.4
chr10_-_20545884 0.18

chr21_+_26684728 0.18 ENSDART00000053797
slc3a2b
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr12_+_1286911 0.17 ENSDART00000168225
ENSDART00000157467
pemt
phosphatidylethanolamine N-methyltransferase
chr20_-_43281081 0.16

chr6_-_8156520 0.15 ENSDART00000081561
ilf3a
interleukin enhancer binding factor 3a
chr12_+_35755300 0.15 ENSDART00000131300
unk
unkempt family zinc finger
chr13_+_32609784 0.15 ENSDART00000160138
sobpa
sine oculis binding protein homolog (Drosophila) a
chr14_-_33604914 0.15 ENSDART00000168546
zdhhc24
zinc finger, DHHC-type containing 24
chr2_-_37061049 0.14 ENSDART00000131834
gng7
guanine nucleotide binding protein (G protein), gamma 7
chr2_+_1881022 0.14 ENSDART00000101038
tmie
transmembrane inner ear
chr22_-_17571993 0.14

chr13_+_516496 0.13 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr17_-_16414629 0.10 ENSDART00000150149
tdp1
tyrosyl-DNA phosphodiesterase 1
chr11_-_23333850 0.10

chr24_+_24316346 0.10 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr16_+_40074850 0.10 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr7_-_52113622 0.08 ENSDART00000174186
wdr93
WD repeat domain 93
chr7_+_24787720 0.06

chr5_-_21015548 0.05 ENSDART00000040184
tenm1
teneurin transmembrane protein 1
chr15_+_32940372 0.04 ENSDART00000170098
spg20b
spastic paraplegia 20b (Troyer syndrome)
chr12_+_48497255 0.04 ENSDART00000168389
arhgap44
Rho GTPase activating protein 44
chr19_+_46567459 0.04 ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr5_+_57055662 0.04 ENSDART00000166545
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr18_-_15451738 0.03 ENSDART00000091466
polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr17_-_51804002 0.02 ENSDART00000103350
ENSDART00000017329
numb
numb homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0051000 regulation of nitric-oxide synthase activity(GO:0050999) positive regulation of nitric-oxide synthase activity(GO:0051000) beta-amyloid clearance(GO:0097242) regulation of beta-amyloid clearance(GO:1900221)
0.5 1.4 GO:0052805 imidazole-containing compound metabolic process(GO:0052803) imidazole-containing compound catabolic process(GO:0052805)
0.4 1.3 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.3 3.2 GO:0021592 fourth ventricle development(GO:0021592)
0.2 1.5 GO:0061469 regulation of cell proliferation involved in tissue homeostasis(GO:0060784) regulation of type B pancreatic cell proliferation(GO:0061469)
0.2 1.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 1.9 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.2 1.7 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.2 1.4 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.2 3.5 GO:0030199 collagen fibril organization(GO:0030199)
0.2 2.3 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 1.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.8 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.1 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.7 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 2.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.2 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.7 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.1 0.3 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 0.7 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.5 GO:0060753 mast cell chemotaxis(GO:0002551) positive regulation of leukocyte chemotaxis(GO:0002690) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.9 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 2.4 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 2.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.4 GO:0006284 base-excision repair(GO:0006284)
0.0 0.5 GO:0006821 chloride transport(GO:0006821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.4 3.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.2 GO:0031209 SCAR complex(GO:0031209)
0.1 0.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 3.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005542 folic acid binding(GO:0005542) ammonia-lyase activity(GO:0016841)
0.4 3.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 4.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 1.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 1.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 3.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.7 GO:0002039 p53 binding(GO:0002039)
0.1 0.6 GO:0016918 retinal binding(GO:0016918)
0.1 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 1.6 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.8 GO:0019955 cytokine binding(GO:0019955)
0.0 1.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.0 GO:0070042 rRNA (uridine-N3-)-methyltransferase activity(GO:0070042)
0.0 0.5 GO:0005254 chloride channel activity(GO:0005254)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 3.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC