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Results for hoxc8a

Z-value: 0.65

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Transcription factors associated with hoxc8a

Gene Symbol Gene ID Gene Info
hoxc8a
ENSDARG00000070346 homeobox C8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc8adr10_dc_chr23_+_36002332_360024310.504.8e-02Click!

Activity profile of hoxc8a motif

Sorted Z-values of hoxc8a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxc8a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_57300743 1.82 ENSDART00000081122
COLGALT1 (1 of many)
collagen beta(1-O)galactosyltransferase 1
chr2_+_4366169 1.41 ENSDART00000157903
gata6
GATA binding protein 6
chr13_+_35213326 1.35 ENSDART00000019323
jag1b
jagged 1b
chr4_-_5325164 1.30 ENSDART00000067375
osgep
O-sialoglycoprotein endopeptidase
chr20_-_45908435 1.28 ENSDART00000147637
fermt1
fermitin family member 1
chr13_-_33574216 1.25 ENSDART00000065435
cst3
cystatin C (amyloid angiopathy and cerebral hemorrhage)
chr17_+_23278879 1.16 ENSDART00000153652
zgc:165461
zgc:165461
chr5_+_27897765 1.06 ENSDART00000166737
ENSDART00000164418
nfr
notochord formation related
chr12_-_4497094 1.04 ENSDART00000163651
trpm4b.2
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr18_-_3056732 1.02 ENSDART00000162657
rps3
ribosomal protein S3
chr21_-_22510751 1.00 ENSDART00000169870
myo5b
myosin VB
chr4_-_22751641 0.97 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
kmt2e
lysine (K)-specific methyltransferase 2E
chr10_+_42530040 0.89 ENSDART00000025691
dbnla
drebrin-like a
chr15_+_880573 0.86 ENSDART00000115077
zgc:174573
zgc:174573
chr16_+_51316772 0.85 ENSDART00000169022
hmgn2
high mobility group nucleosomal binding domain 2
chr1_-_40208544 0.80 ENSDART00000027463
hmx4
H6 family homeobox 4
chr20_-_9107294 0.77 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr15_-_15421065 0.74 ENSDART00000106120
ywhag2
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr23_+_36032206 0.69 ENSDART00000103132
hoxc4a
homeobox C4a
chr15_-_14616083 0.68 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr10_+_38582701 0.67 ENSDART00000144329
acer3
alkaline ceramidase 3
chr9_-_47833777 0.62

chr16_-_13733759 0.61 ENSDART00000164344
si:dkeyp-69b9.6
si:dkeyp-69b9.6
chr1_-_40208469 0.59 ENSDART00000027463
hmx4
H6 family homeobox 4
chr2_+_4366568 0.58 ENSDART00000166476
gata6
GATA binding protein 6
chr8_-_13026629 0.57 ENSDART00000129168
si:dkey-208b23.5
si:dkey-208b23.5
chr17_+_30352361 0.57 ENSDART00000076611
greb1
growth regulation by estrogen in breast cancer 1
chr8_-_31098193 0.57 ENSDART00000098925
vgll4l
vestigial like 4 like
chr2_-_17564676 0.55 ENSDART00000144251
artnb
artemin b
chr15_-_35394535 0.55 ENSDART00000144153
mff
mitochondrial fission factor
chr19_-_39048324 0.54 ENSDART00000086717
col16a1
collagen, type XVI, alpha 1
chr15_-_1858350 0.53 ENSDART00000082026
mmp28
matrix metallopeptidase 28
chr4_-_76594399 0.51 ENSDART00000049170
zgc:85975
zgc:85975
chr4_+_14728248 0.50 ENSDART00000124189
cmasa
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr8_+_18593622 0.50 ENSDART00000089141
fsd1
fibronectin type III and SPRY domain containing 1
chr16_-_13734068 0.50 ENSDART00000164344
si:dkeyp-69b9.6
si:dkeyp-69b9.6
chr25_+_4918339 0.48 ENSDART00000153980
parvb
parvin, beta
chr21_-_26453406 0.48 ENSDART00000009889
zgc:110540
zgc:110540
chr11_-_40464213 0.47 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr1_-_57301027 0.46 ENSDART00000081122
COLGALT1 (1 of many)
collagen beta(1-O)galactosyltransferase 1
chr7_-_26331734 0.45

chr6_+_24299180 0.45 ENSDART00000167482
tgfbr3
transforming growth factor, beta receptor III
chr23_-_7740845 0.44 ENSDART00000172451
plagl2
pleiomorphic adenoma gene-like 2
chr15_-_34987450 0.44 ENSDART00000009892
gabbr1a
gamma-aminobutyric acid (GABA) B receptor, 1a
chr6_-_53227526 0.44 ENSDART00000160955
slc38a3b
solute carrier family 38, member 3b
chr8_-_19166630 0.42

chr5_-_27958815 0.42 ENSDART00000177313
si:ch73-195i19.3
si:ch73-195i19.3
chr19_-_39048402 0.41 ENSDART00000086717
col16a1
collagen, type XVI, alpha 1
chr20_+_38298755 0.40 ENSDART00000022694
ehd3
EH-domain containing 3
chr2_+_4366348 0.39 ENSDART00000166476
gata6
GATA binding protein 6
chr1_-_518543 0.39 ENSDART00000138032
trmt10c
tRNA methyltransferase 10C, mitochondrial RNase P subunit
chr2_-_28687065 0.38 ENSDART00000164657
dhcr7
7-dehydrocholesterol reductase
chr24_-_25283218 0.37 ENSDART00000090010
phex
phosphate regulating endopeptidase homolog, X-linked
chr5_+_65754237 0.36 ENSDART00000170757
kntc1
kinetochore associated 1
chr4_-_802415 0.35 ENSDART00000067455
dpysl5b
dihydropyrimidinase-like 5b
chr7_-_45726932 0.35 ENSDART00000158603
si:ch211-260e23.8
si:ch211-260e23.8
chr12_+_18622682 0.34 ENSDART00000153456
mkl1b
megakaryoblastic leukemia (translocation) 1b
chr5_+_62987426 0.34 ENSDART00000178937
dnm1b
dynamin 1b
chr20_+_38298893 0.34 ENSDART00000022694
ehd3
EH-domain containing 3
chr2_-_53156364 0.33

chr5_+_29071526 0.33 ENSDART00000043096
ak8
adenylate kinase 8
chr1_+_22000499 0.33 ENSDART00000017413
zmynd10
zinc finger, MYND-type containing 10
chr7_-_23775835 0.32 ENSDART00000144616
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr10_-_5016472 0.31 ENSDART00000101414
hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr20_+_41123859 0.31 ENSDART00000146052
man1a1
mannosidase, alpha, class 1A, member 1
chr2_+_4366515 0.31 ENSDART00000166476
gata6
GATA binding protein 6
chr7_-_45726974 0.31 ENSDART00000158603
si:ch211-260e23.8
si:ch211-260e23.8
chr6_-_8075384 0.30 ENSDART00000129674
slc44a2
solute carrier family 44 (choline transporter), member 2
chr8_-_12365342 0.29 ENSDART00000113286
phf19
PHD finger protein 19
chr3_+_27667194 0.28 ENSDART00000075100
carhsp1
calcium regulated heat stable protein 1
chr13_+_13562712 0.28 ENSDART00000110509
ENSDART00000169265
si:ch211-194c3.5
si:ch211-194c3.5
chr10_+_22065010 0.28 ENSDART00000133304
npm1a
nucleophosmin 1a (nucleolar phosphoprotein B23, numatrin)
chr15_-_5911548 0.28

chr23_+_36016450 0.27 ENSDART00000103035
hoxc6a
homeobox C6a
chr8_-_7548976 0.27 ENSDART00000132536
hcfc1b
host cell factor C1b
chr1_+_18610282 0.27 ENSDART00000129970
si:dkeyp-118a3.2
si:dkeyp-118a3.2
chr21_+_35292807 0.27 ENSDART00000130626
rars
arginyl-tRNA synthetase
chr6_+_33896684 0.26 ENSDART00000165710
gpbp1l1
GC-rich promoter binding protein 1-like 1
chr18_-_510172 0.25 ENSDART00000164374
si:ch211-79l17.1
si:ch211-79l17.1
chr21_-_11561978 0.25 ENSDART00000132699
cast
calpastatin
chr25_+_29690047 0.25

chr11_-_40464253 0.24 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr17_+_25500291 0.24 ENSDART00000041721
aim1a
crystallin beta-gamma domain containing 1a
chr21_-_5692160 0.24 ENSDART00000075137
ENSDART00000151202
ccni
cyclin I
chr19_+_5562107 0.23 ENSDART00000082080
jupb
junction plakoglobin b
chr10_-_20545884 0.23

chr8_-_12365285 0.23 ENSDART00000142150
phf19
PHD finger protein 19
chr19_-_34263023 0.22 ENSDART00000160719
otud6b
OTU domain containing 6B
chr14_-_3836967 0.20 ENSDART00000055817
ENSDARG00000038270
ENSDARG00000038270
chr9_+_41278246 0.19 ENSDART00000141179
zgc:136439
zgc:136439
chr20_+_13507202 0.19 ENSDART00000127350
enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_+_50873893 0.18

chr20_-_15029379 0.18 ENSDART00000152641
dnm3a
dynamin 3a
chr15_-_5911817 0.16

chr20_-_16553010 0.16

chr15_-_18130992 0.16 ENSDART00000113142
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr15_-_5912105 0.15

chr9_+_4708975 0.14 ENSDART00000081326
prpf40a
PRP40 pre-mRNA processing factor 40 homolog A
chr2_-_32842678 0.13 ENSDART00000098834
prpf4ba
pre-mRNA processing factor 4Ba
chr15_-_37202518 0.13 ENSDART00000165867
zmp:0000001114
zmp:0000001114
chr20_-_9474672 0.12 ENSDART00000152674
ENSDARG00000033201
ENSDARG00000033201
chr2_+_4366022 0.12 ENSDART00000157903
gata6
GATA binding protein 6
chr11_+_11284030 0.11 ENSDART00000026814
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr22_-_16128314 0.11 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr9_+_32367808 0.11 ENSDART00000078576
coq10b
coenzyme Q10B
chr3_+_19548039 0.10

chr23_-_35691396 0.10 ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr4_+_5325362 0.09 ENSDART00000150306
apex1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_28362311 0.09 ENSDART00000062682
adipor1b
adiponectin receptor 1b
chr10_+_11397605 0.08 ENSDART00000064215
cops4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr10_+_6925975 0.08

chr12_-_36303384 0.08 ENSDART00000168538
oxld1
oxidoreductase-like domain containing 1
chr15_-_36072087 0.07 ENSDART00000076229
irs1
insulin receptor substrate 1
chr25_-_3345176 0.06 ENSDART00000029067
hbp1
HMG-box transcription factor 1
chr5_-_42304154 0.06 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr15_-_5911297 0.06

chr17_-_14621328 0.05

chr15_+_22331719 0.05 ENSDART00000110665
nrgnb
neurogranin (protein kinase C substrate, RC3) b
chr13_+_6091028 0.05 ENSDART00000025910
apmap
adipocyte plasma membrane associated protein
chr3_-_40407003 0.03

chr21_+_29040831 0.02 ENSDART00000166403
ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr20_-_49901709 0.01 ENSDART00000129214
COX7A2 (1 of many)
cytochrome c oxidase subunit 7A2
chr2_-_33703921 0.01 ENSDART00000147439
atp6v0b
ATPase, H+ transporting, lysosomal V0 subunit b
chr23_+_29431734 0.01 ENSDART00000027255
tardbpl
TAR DNA binding protein, like
chr15_-_37202326 0.01 ENSDART00000165867
zmp:0000001114
zmp:0000001114
chr3_+_22312446 0.00 ENSDART00000156450
wnk4b
WNK lysine deficient protein kinase 4b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.4 2.8 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.3 1.0 GO:0002706 regulation of lymphocyte mediated immunity(GO:0002706)
0.3 1.0 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 0.9 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.2 1.4 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.6 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 1.4 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.4 GO:0015817 histidine transport(GO:0015817)
0.1 0.7 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.1 0.3 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.4 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 1.0 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.2 GO:0055062 regulation of fat cell differentiation(GO:0045598) phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.3 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.6 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.4 GO:0042446 hormone biosynthetic process(GO:0042446)
0.0 0.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0015696 ammonium transport(GO:0015696)
0.0 0.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.4 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.1 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.9 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.4 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 0.6 GO:0044447 axoneme part(GO:0044447)
0.1 0.7 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.4 GO:0030677 nucleoid(GO:0009295) ribonuclease P complex(GO:0030677) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.8 GO:0005925 focal adhesion(GO:0005925)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.4 GO:0015182 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
0.1 0.4 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 0.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.3 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.4 GO:0005112 Notch binding(GO:0005112)
0.1 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 1.2 GO:0019838 growth factor binding(GO:0019838)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation