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Results for hsf1+hsf4

Z-value: 0.67

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Transcription factors associated with hsf1+hsf4

Gene Symbol Gene ID Gene Info
hsf1
ENSDARG00000008818 heat shock transcription factor 1
hsf4
ENSDARG00000013251 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hsf4dr10_dc_chr18_-_22764560_22764583-0.741.1e-03Click!
hsf1dr10_dc_chr19_+_3115685_31157240.601.5e-02Click!

Activity profile of hsf1+hsf4 motif

Sorted Z-values of hsf1+hsf4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hsf1+hsf4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_43749940 2.17 ENSDART00000133317
ENSDART00000140316
ENSDART00000142929
ENSDART00000133874
zgc:66313
zgc:66313
chr1_-_21961282 2.13 ENSDART00000171830
uchl1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_-_2419079 1.75 ENSDART00000065821
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr13_-_28480530 1.64 ENSDART00000043156
cyp17a1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr9_+_8418408 1.53 ENSDART00000043067
zgc:171776
zgc:171776
chr22_+_4145005 1.49 ENSDART00000171774
zgc:171566
zgc:171566
chr10_+_15066791 1.49 ENSDART00000140084
si:dkey-88l16.5
si:dkey-88l16.5
chr5_-_66145078 1.39 ENSDART00000041441
stip1
stress-induced phosphoprotein 1
chr9_+_28293831 1.31 ENSDART00000101338
idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr3_+_36093650 1.30 ENSDART00000150994
dus1l
dihydrouridine synthase 1-like (S. cerevisiae)
chr3_+_13450981 1.24 ENSDART00000162124
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_+_14295978 1.23 ENSDART00000168260
nudc
nudC nuclear distribution protein
chr2_-_57339717 1.23 ENSDART00000150034
pias4b
protein inhibitor of activated STAT, 4b
chr3_-_10044965 1.18 ENSDART00000154460
FP243382.1
ENSDARG00000097649
chr22_+_2014357 1.17 ENSDART00000165168
znf1157
zinc finger protein 1157
chr22_+_2014149 1.15 ENSDART00000165168
znf1157
zinc finger protein 1157
chr15_+_44168257 1.12 ENSDART00000176254
CU655961.7
ENSDARG00000106724
chr3_-_10045028 1.10 ENSDART00000154460
FP243382.1
ENSDARG00000097649
chr21_+_13291305 1.10 ENSDART00000134347
zgc:113162
zgc:113162
chr18_+_43039021 1.07

chr17_+_52526741 1.05 ENSDART00000109891
angel1
angel homolog 1 (Drosophila)
chr13_-_28480153 0.98 ENSDART00000043156
cyp17a1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr21_+_13291242 0.93 ENSDART00000134347
zgc:113162
zgc:113162
chr21_+_38685219 0.83 ENSDART00000076157
rab24
RAB24, member RAS oncogene family
chr7_-_2614300 0.82 ENSDART00000153548
BX323987.1
ENSDARG00000097745
chr2_-_21967353 0.82 ENSDART00000137169
zgc:55781
zgc:55781
chr2_+_19514886 0.81 ENSDART00000166073
elovl1a
ELOVL fatty acid elongase 1a
chr17_-_43749763 0.81 ENSDART00000167422
ahsa1b
AHA1, activator of heat shock protein ATPase homolog 1b
chr21_-_2261849 0.78 ENSDART00000172041
ENSDART00000161554
si:ch73-299h12.4
si:ch73-299h12.4
chr15_-_30247084 0.77 ENSDART00000154069
BX322555.4
ENSDARG00000097908
chr19_+_14295836 0.77 ENSDART00000170335
nudc
nudC nuclear distribution protein
chr15_+_44909293 0.74 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr23_+_2481946 0.72 ENSDART00000126038
tcp1
t-complex 1
chr6_-_52725402 0.71 ENSDART00000033949
oser1
oxidative stress responsive serine-rich 1
chr10_-_29945491 0.71 ENSDART00000063923
ENSDART00000136264
zpr1
ZPR1 zinc finger
chr13_-_44882023 0.71

chr13_-_28480365 0.70 ENSDART00000043156
cyp17a1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr10_+_15066654 0.67 ENSDART00000135667
si:dkey-88l16.5
si:dkey-88l16.5
chr21_+_13291347 0.65 ENSDART00000134347
zgc:113162
zgc:113162
chr22_-_31089831 0.65

chr22_+_2014232 0.65 ENSDART00000165168
znf1157
zinc finger protein 1157
chr17_+_14956899 0.64

chr14_-_6637670 0.64 ENSDART00000126279
clk4a
CDC-like kinase 4a
chr16_+_37716167 0.63

chr20_-_35601497 0.63

chr3_+_13450861 0.63 ENSDART00000162124
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr15_-_19396871 0.62

chr24_+_36430199 0.62

chr12_-_10384031 0.61 ENSDART00000052004
zgc:153595
zgc:153595
chr7_-_40359613 0.55 ENSDART00000173670
ube3c
ubiquitin protein ligase E3C
chr22_+_20686657 0.55

chr6_-_39633603 0.54 ENSDART00000104042
atf7b
activating transcription factor 7b
chr17_-_23201467 0.54 ENSDART00000156411
fam98a
family with sequence similarity 98, member A
chr17_+_19711077 0.53

chr12_-_10383960 0.52 ENSDART00000052004
zgc:153595
zgc:153595
chr12_-_18839743 0.52 ENSDART00000172574
ep300a
E1A binding protein p300 a
chr11_-_11641577 0.52 ENSDART00000161821
si:dkey-28e7.3
si:dkey-28e7.3
chr16_+_37716207 0.51

chr17_+_19711104 0.50

chr9_+_8418549 0.50 ENSDART00000043067
zgc:171776
zgc:171776
chr7_+_30011202 0.49 ENSDART00000108782
polr2m
RNA polymerase II subunit M
chr6_-_29169308 0.49 ENSDART00000110288
ENSDART00000008841
zbtb11
zinc finger and BTB domain containing 11
chr15_+_44909356 0.49 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr17_-_29005489 0.48 ENSDART00000157210
CR925802.1
ENSDARG00000097263
chr21_-_2261748 0.48 ENSDART00000172041
ENSDART00000161554
si:ch73-299h12.4
si:ch73-299h12.4
chr5_-_3255080 0.47 ENSDART00000152108
hspb1
heat shock protein, alpha-crystallin-related, 1
chr9_-_7676688 0.46 ENSDART00000102706
dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr8_+_9955720 0.45

chr14_+_533611 0.45

chr3_-_32158331 0.44 ENSDART00000055295
ENSDART00000156243
cpt1cb
carnitine palmitoyltransferase 1Cb
chr22_-_20925422 0.43 ENSDART00000002029
fkbp8
FK506 binding protein 8
chr10_+_29963102 0.43 ENSDART00000168898
hspa8
heat shock protein 8
chr8_+_13757024 0.42

chr15_+_44168674 0.42

chr24_+_32610430 0.42 ENSDART00000132417
yme1l1a
YME1-like 1a
chr14_-_36004835 0.42 ENSDART00000077823
lrit3a
info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a
chr15_-_46864317 0.41

chr11_-_18439280 0.39

chr10_+_29964045 0.39 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr8_+_13757180 0.39

chr3_-_43134137 0.38 ENSDART00000165592
rmi2
RecQ mediated genome instability 2
chr2_-_56632969 0.37 ENSDART00000089158
hmha1a
histocompatibility (minor) HA-1 a
chr16_-_22397159 0.37

chr7_+_73583860 0.36 ENSDART00000166244
si:ch73-252p3.1
si:ch73-252p3.1
chr4_+_74873994 0.35 ENSDART00000160218
ENSDART00000110144
zgc:113119
zgc:113119
chr18_+_37279099 0.35 ENSDART00000135444
tbcb
tubulin folding cofactor B
chr17_+_19711153 0.34

chr2_+_10209233 0.34 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr19_+_46667326 0.34 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr24_+_32610480 0.33 ENSDART00000132417
yme1l1a
YME1-like 1a
chr24_+_32635139 0.32 ENSDART00000175986
CU138525.1
ENSDARG00000105889
chr14_+_35552581 0.31 ENSDART00000135079
zgc:63568
zgc:63568
chr15_-_34732837 0.30 ENSDART00000003674
ankmy2a
ankyrin repeat and MYND domain containing 2a
chr10_+_44846631 0.30

chr8_-_6782167 0.28 ENSDART00000135834
ENSDART00000172157
dock5
dedicator of cytokinesis 5
chr5_-_3254995 0.28 ENSDART00000152108
hspb1
heat shock protein, alpha-crystallin-related, 1
chr17_+_4903106 0.28 ENSDART00000064313
ENSDART00000121806
cdc5l
CDC5 cell division cycle 5-like (S. pombe)
chr18_+_37279031 0.27 ENSDART00000135444
tbcb
tubulin folding cofactor B
chr22_-_36705684 0.27

chr5_+_32698516 0.26 ENSDART00000097945
usp20
ubiquitin specific peptidase 20
chr5_-_13278406 0.25 ENSDART00000051655
snrnp27
small nuclear ribonucleoprotein 27 (U4/U6.U5)
chr23_+_12427170 0.25 ENSDART00000143728
pigt
phosphatidylinositol glycan anchor biosynthesis, class T
chr5_+_41463969 0.24 ENSDART00000035235
UBB
si:ch211-202a12.4
chr1_-_53081805 0.23 ENSDART00000026409
cct4
chaperonin containing TCP1, subunit 4 (delta)
chr9_+_38233505 0.23 ENSDART00000022574
stam2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr2_-_56632913 0.21 ENSDART00000089158
hmha1a
histocompatibility (minor) HA-1 a
chr3_-_43134049 0.20 ENSDART00000165592
rmi2
RecQ mediated genome instability 2
chr8_-_985916 0.18 ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr22_-_37630428 0.18 ENSDART00000149482
fxr1
fragile X mental retardation, autosomal homolog 1
chr22_+_34726990 0.17 ENSDART00000082066
atpv0e2
ATPase, H+ transporting V0 subunit e2
chr10_+_29963998 0.17 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr21_-_2107554 0.16 ENSDART00000159378
AL627305.2
ENSDARG00000101832
chr18_+_37278733 0.16 ENSDART00000135444
tbcb
tubulin folding cofactor B
chr6_+_55835894 0.16 ENSDART00000108786
si:ch211-81n22.1
si:ch211-81n22.1
chr12_-_17029512 0.14

chr2_+_42286232 0.14 ENSDART00000008268
cyp7b1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr23_+_27957315 0.14

chr17_+_53209709 0.14 ENSDART00000158313
ddx24
DEAD (Asp-Glu-Ala-Asp) box helicase 24
chr1_+_43352429 0.13 ENSDART00000124873
si:ch73-109d9.4
si:ch73-109d9.4
chr18_+_27355569 0.11 ENSDART00000136172
si:dkey-29p10.4
si:dkey-29p10.4
chr2_-_39049391 0.10 ENSDART00000044331
copb2
coatomer protein complex, subunit beta 2
chr9_-_30752583 0.09

chr21_+_43490314 0.08 ENSDART00000026666
atg4a
autophagy related 4A, cysteine peptidase
chr20_-_33802212 0.07 ENSDART00000166573
rock2b
rho-associated, coiled-coil containing protein kinase 2b
chr6_+_7093685 0.07 ENSDART00000177226
dzip1
DAZ interacting zinc finger protein 1
chr10_+_29964164 0.06 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr5_-_13278451 0.05 ENSDART00000051655
snrnp27
small nuclear ribonucleoprotein 27 (U4/U6.U5)
chr6_-_13881001 0.04 ENSDART00000004656
ENSDARG00000020187
ENSDARG00000020187
chr13_-_50032548 0.03 ENSDART00000038120
cacul1
CDK2 associated cullin domain 1
chr14_-_220808 0.03

chr24_-_39970897 0.02 ENSDART00000134251
slc12a7b
solute carrier family 12 (potassium/chloride transporter), member 7b
chr22_-_8276968 0.01 ENSDART00000123982
CABZ01077218.1
ENSDARG00000089720
chr25_-_252714 0.01

chr3_-_32409303 0.01 ENSDART00000151476
rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr9_-_21427035 0.01 ENSDART00000146764
cox17
COX17 cytochrome c oxidase copper chaperone

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:1903449 male sex determination(GO:0030238) androst-4-ene-3,17-dione biosynthetic process(GO:1903449)
0.4 1.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 1.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.7 GO:0046685 regulation of myofibril size(GO:0014881) response to arsenic-containing substance(GO:0046685)
0.1 0.7 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 0.5 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.8 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:1902946 protein localization to early endosome(GO:1902946)
0.1 0.8 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 1.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.7 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.8 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 0.3 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.5 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 1.6 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 1.3 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.2 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 1.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.4 1.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 1.8 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 1.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 1.5 GO:0008242 omega peptidase activity(GO:0008242)
0.2 1.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 2.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.8 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.8 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 2.0 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation