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Results for hsf2+si:dkey-18a10.3

Z-value: 1.72

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Transcription factors associated with hsf2+si:dkey-18a10.3

Gene Symbol Gene ID Gene Info
hsf2
ENSDARG00000053097 heat shock transcription factor 2
si_dkey-18a10.3
ENSDARG00000090814 si_dkey-18a10.3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hsf2dr10_dc_chr20_-_40589999_40590133-0.656.0e-03Click!

Activity profile of hsf2+si:dkey-18a10.3 motif

Sorted Z-values of hsf2+si:dkey-18a10.3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of hsf2+si:dkey-18a10.3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_-_54206610 8.82 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr15_+_37039861 7.17 ENSDART00000172664
kirrel3l
kin of IRRE like 3 like
chr23_-_31446156 6.05 ENSDART00000053367
hmgn3
high mobility group nucleosomal binding domain 3
chr9_-_11589126 4.86 ENSDART00000146832
cryba2b
crystallin, beta A2b
chr2_+_36634309 4.54 ENSDART00000169547
ENSDART00000098417
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr20_-_44598129 4.47 ENSDART00000012229
fkbp1b
FK506 binding protein 1b
chr7_-_50827308 4.26 ENSDART00000121574
col4a6
collagen, type IV, alpha 6
chr22_-_3661536 4.09 ENSDART00000153634
FP565432.1
ENSDARG00000097145
chr12_+_15235008 4.04

chr7_+_38479571 3.79 ENSDART00000170486
f2
coagulation factor II (thrombin)
chr3_-_23444371 3.76 ENSDART00000087726
igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chr20_+_15653121 3.76 ENSDART00000152702
jun
jun proto-oncogene
chr6_+_49096966 3.65 ENSDART00000141042
ENSDART00000143369
slc25a22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr11_-_41219340 3.45 ENSDART00000109204
megf6b
multiple EGF-like-domains 6b
chr4_-_17066886 3.43 ENSDART00000134595
sox5
SRY (sex determining region Y)-box 5
chr6_+_16279737 3.40 ENSDART00000040035
ccdc80l1
coiled-coil domain containing 80 like 1
chr25_+_33833810 3.30 ENSDART00000073440
ENSDARG00000051762
ENSDARG00000051762
chr8_-_1904720 3.24 ENSDART00000081563
si:dkey-178e17.3
si:dkey-178e17.3
chr13_+_24703802 3.19 ENSDART00000101274
zgc:153981
zgc:153981
chr23_+_36079164 3.13 ENSDART00000103131
hoxc1a
homeo box C1a
chr22_+_24362712 2.87 ENSDART00000157861
p3h2
prolyl 3-hydroxylase 2
chr2_-_58111727 2.85 ENSDART00000004431
ENSDART00000166845
ENSDART00000163999
epb41l3b
erythrocyte membrane protein band 4.1-like 3b
chr7_-_60525749 2.66 ENSDART00000136999
pcxb
pyruvate carboxylase b
chr23_+_36079624 2.65 ENSDART00000103131
hoxc1a
homeo box C1a
chr10_+_35478939 2.63 ENSDART00000147303
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr22_+_21997000 2.60 ENSDART00000046174
gna15.1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr19_-_18316039 2.59 ENSDART00000151133
top2b
topoisomerase (DNA) II beta
chr14_+_27936303 2.50 ENSDART00000003293
mid2
midline 2
chr23_-_24755654 2.39 ENSDART00000104035
ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr2_-_35584440 2.35 ENSDART00000125298
tnw
tenascin W
chr1_+_1953714 2.33 ENSDART00000164488
ENSDART00000167050
ENSDART00000122626
ENSDART00000128187
mbnl2
muscleblind-like splicing regulator 2
chr16_-_8481813 2.31 ENSDART00000051166
grb10b
growth factor receptor-bound protein 10b
chr6_-_30876091 2.28 ENSDART00000155330
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr16_+_34569479 2.26 ENSDART00000041007
stmn1b
stathmin 1b
chr16_-_44575942 2.20

chr22_-_14090538 2.15 ENSDART00000105717
aox5
aldehyde oxidase 5
chr1_+_9999842 2.10 ENSDART00000152438
ENSDARG00000037679
ENSDARG00000037679
chr16_-_17164459 2.05 ENSDART00000178443
tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr8_+_584353 2.04 ENSDART00000048498
CABZ01049925.1
ENSDARG00000079790
chr10_-_10906027 2.03 ENSDART00000122657
nrarpa
notch-regulated ankyrin repeat protein a
chr13_-_45338347 2.03 ENSDART00000043345
rsrp1
arginine/serine-rich protein 1
chr4_-_13394059 1.99 ENSDART00000175909
ENSDART00000174861
BX511038.1
ENSDARG00000108089
chr6_-_39311711 1.95

chr9_-_22507592 1.90 ENSDART00000132029
crygm2d2
crystallin, gamma M2d2
chr5_+_32191063 1.88 ENSDART00000077189
ier5l
immediate early response 5-like
chr20_+_23599157 1.86 ENSDART00000149922
palld
palladin, cytoskeletal associated protein
chr16_+_5466342 1.84 ENSDART00000160008
plecb
plectin b
chr20_+_34640435 1.83 ENSDART00000152073
ENSDARG00000054723
ENSDARG00000054723
chr5_-_20375703 1.73 ENSDART00000134697
pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr25_+_27829693 1.73 ENSDART00000010325
fezf1
FEZ family zinc finger 1
chr1_+_45961348 1.70 ENSDART00000053221
arl11
ADP-ribosylation factor-like 11
chr15_+_37040064 1.66 ENSDART00000172664
kirrel3l
kin of IRRE like 3 like
chr10_+_9575 1.63

chr17_+_15026344 1.63 ENSDART00000154987
samd4a
sterile alpha motif domain containing 4A
chr4_-_24298688 1.60 ENSDART00000077926
ENSDART00000128368
celf2
cugbp, Elav-like family member 2
chr22_+_24362832 1.59 ENSDART00000157861
p3h2
prolyl 3-hydroxylase 2
chr15_-_37949371 1.56 ENSDART00000031418
hsc70
heat shock cognate 70
chr4_-_72603830 1.56 ENSDART00000168547
si:cabz01071912.2
si:cabz01071912.2
chr3_+_33213672 1.56 ENSDART00000162870
mpp2a
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr9_+_32490721 1.53 ENSDART00000078608
hspe1
heat shock 10 protein 1
chr19_-_36009321 1.51 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr6_+_13099562 1.49 ENSDART00000038505
rprmb
reprimo, TP53 dependent G2 arrest mediator candidate b
chr6_-_60152594 1.47 ENSDART00000083453
slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr5_-_13184573 1.46 ENSDART00000018351
zgc:65851
zgc:65851
chr18_+_14725148 1.46 ENSDART00000146128
uri1
URI1, prefoldin-like chaperone
chr19_+_20194594 1.43 ENSDART00000169074
hoxa4a
homeobox A4a
chr11_+_29753417 1.42

chr5_+_41492032 1.39 ENSDART00000171678
ubb
ubiquitin B
chr24_-_39970858 1.37 ENSDART00000134251
slc12a7b
solute carrier family 12 (potassium/chloride transporter), member 7b
chr2_+_52561735 1.37 ENSDART00000175043
CABZ01040021.1
ENSDARG00000107973
chr10_+_29966381 1.36 ENSDART00000141549
hspa8
heat shock protein 8
chr23_+_45876483 1.36 ENSDART00000169521
ENSDART00000162915
dclk2b
doublecortin-like kinase 2b
chr17_+_41475052 1.33 ENSDART00000075331
insm1b
insulinoma-associated 1b
chr11_-_41219410 1.32 ENSDART00000109204
megf6b
multiple EGF-like-domains 6b
chr20_-_54206786 1.32 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr21_-_91068 1.30

chr3_-_53467621 1.26 ENSDART00000032788
rdh8a
retinol dehydrogenase 8a
chr6_+_43402753 1.25 ENSDART00000143374
mitfa
microphthalmia-associated transcription factor a
chr4_+_21091640 1.22 ENSDART00000005847
nav3
neuron navigator 3
chr13_+_25356184 1.21 ENSDART00000057689
bag3
BCL2-associated athanogene 3
chr13_+_25356121 1.20 ENSDART00000057689
bag3
BCL2-associated athanogene 3
chr2_+_36634251 1.16 ENSDART00000169547
ENSDART00000098417
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr25_+_34745872 1.15 ENSDART00000003494
slc17a6a
solute carrier family 17 (vesicular glutamate transporter), member 6a
chr2_+_31974269 1.14 ENSDART00000012413
ankhb
ANKH inorganic pyrophosphate transport regulator b
chr6_-_60152693 1.14 ENSDART00000083453
slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr5_+_19599323 1.12 ENSDART00000079424
si:rp71-1c23.3
si:rp71-1c23.3
chr10_+_29966252 1.11 ENSDART00000141549
hspa8
heat shock protein 8
chr3_-_5318206 1.10 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr2_-_24661477 1.09 ENSDART00000078975
ENSDART00000155677
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr19_+_20194656 1.09 ENSDART00000169074
hoxa4a
homeobox A4a
chr19_-_9793494 1.08 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr16_+_6693574 1.07

chr22_+_38028979 1.07 ENSDART00000165078
ENSDART00000159906
CU659306.1
ENSDARG00000100625
chr3_+_6557843 1.03 ENSDART00000169325
nup85
nucleoporin 85
chr6_-_39311594 0.99

chr10_-_36738730 0.97 ENSDART00000139097
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr21_+_20347283 0.96 ENSDART00000026430
hspb11
heat shock protein, alpha-crystallin-related, b11
chr10_+_35479226 0.96 ENSDART00000147303
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr1_-_30298698 0.96

chr9_-_47814390 0.95

chr6_-_24293008 0.95 ENSDART00000168355
brdt
bromodomain, testis-specific
chr15_-_177068 0.94 ENSDART00000115233
VSTM5
V-set and transmembrane domain containing 5
chr16_-_49282668 0.93

chr2_-_35120439 0.91 ENSDART00000111730
pappa2
pappalysin 2
chr19_-_9793444 0.90 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr8_+_28433869 0.85 ENSDART00000062716
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr11_-_16067646 0.85

chr10_-_42155790 0.84

chr4_-_30124515 0.83

chr21_-_661222 0.83

chr25_+_21735567 0.82 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr10_+_15398004 0.82

chr3_-_32409303 0.80 ENSDART00000151476
rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_-_42778156 0.77 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr10_+_29965951 0.76 ENSDART00000116893
SNORD14
Small nucleolar RNA SNORD14
chr14_+_49056502 0.76 ENSDART00000124773
ppid
peptidylprolyl isomerase D
chr13_+_49154065 0.73

chr25_-_14337158 0.72 ENSDART00000103957
exoc3l1
exocyst complex component 3-like 1
chr25_+_19901741 0.67 ENSDART00000026401
ENSDARG00000004577
ENSDARG00000004577
chr1_-_25369419 0.64 ENSDART00000168640
pdcd4a
programmed cell death 4a
chr16_-_6881218 0.64 ENSDART00000149070
mbpb
myelin basic protein b
chr22_-_570067 0.63 ENSDART00000145983
cdkn1a
cyclin-dependent kinase inhibitor 1A
chr23_+_35976073 0.63 ENSDART00000133760
hoxc11a
homeobox C11a
chr23_+_25005457 0.60 ENSDART00000136162
klhl21
kelch-like family member 21
chr25_+_29999307 0.59 ENSDART00000003346
pdcd2l
programmed cell death 2-like
chr10_+_17978994 0.58 ENSDART00000146489
prkab1a
protein kinase, AMP-activated, beta 1 non-catalytic subunit, a
chr21_-_25719352 0.56 ENSDART00000002341
cldnc
claudin c
chr8_+_28419432 0.55 ENSDART00000062706
tmem189
transmembrane protein 189
chr6_+_19623990 0.54 ENSDART00000057223
rhebl1
Ras homolog enriched in brain like 1
chr24_-_20987184 0.54 ENSDART00000010126
zdhhc23b
zinc finger, DHHC-type containing 23b
chr6_+_60152913 0.53

chr17_+_22050144 0.51

chr9_-_18727454 0.51 ENSDART00000143165
tsc22d1
TSC22 domain family, member 1
chr20_+_19879839 0.49 ENSDART00000132576
BX510657.1
ENSDARG00000093899
chr7_+_21006803 0.49 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr10_+_29964045 0.49 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr19_-_18315867 0.47 ENSDART00000151133
top2b
topoisomerase (DNA) II beta
chr18_+_8388897 0.47 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr7_-_6334156 0.45 ENSDART00000081359
zgc:110425
zgc:110425
chr22_+_10411257 0.45 ENSDART00000064805
cenpp
centromere protein P
chr23_+_17946933 0.42 ENSDART00000117743
SNORD59
Small nucleolar RNA SNORD59
chr9_+_6609374 0.41 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr1_-_58281796 0.41 ENSDART00000175765
CABZ01109030.1
ENSDARG00000108798
chr1_-_55072064 0.40 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr16_-_22394481 0.39

chr17_-_11264425 0.39 ENSDART00000151847
arid4a
AT rich interactive domain 4A (RBP1-like)
chr24_+_32635139 0.38 ENSDART00000175986
CU138525.1
ENSDARG00000105889
chr18_+_14509074 0.37 ENSDART00000146472
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr19_+_5054263 0.37

chr15_-_22212082 0.37 ENSDART00000159116
scn3b
sodium channel, voltage-gated, type III, beta
chr10_+_29963998 0.36 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr10_-_40904685 0.32

chr1_-_30298665 0.30

chr13_+_24703728 0.26 ENSDART00000101274
zgc:153981
zgc:153981
chr2_-_11720434 0.25 ENSDART00000019392
sdr16c5a
short chain dehydrogenase/reductase family 16C, member 5a
chr14_-_32485197 0.24

chr9_-_47814321 0.24

chr6_-_39312114 0.24

chr11_+_29753292 0.23

chr12_+_19745010 0.23 ENSDART00000045609
cpped1
calcineurin-like phosphoesterase domain containing 1
chr16_-_32267264 0.22 ENSDART00000112348
fam26e.1
family with sequence similarity 26, member E, tandem duplicate 1
chr10_+_29964164 0.22 ENSDART00000118838
SNORD14
Small nucleolar RNA SNORD14
chr8_-_23239664 0.22

chr7_-_23492042 0.22

chr12_+_44829938 0.21 ENSDART00000098932
wbp2
WW domain binding protein 2
chr25_-_17282337 0.19 ENSDART00000064586
cyp2x7
cytochrome P450, family 2, subfamily X, polypeptide 7
chr3_-_53467536 0.19 ENSDART00000032788
rdh8a
retinol dehydrogenase 8a
chr7_+_31066952 0.17

chr6_-_40700033 0.16 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr11_-_35778578 0.14 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr1_-_686007 0.13 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr6_+_19623749 0.13 ENSDART00000145564
rhebl1
Ras homolog enriched in brain like 1
chr7_-_6334242 0.13 ENSDART00000081359
zgc:110425
zgc:110425
chr5_-_55745987 0.13 ENSDART00000083079
acaca
acetyl-CoA carboxylase alpha
chr22_+_21996941 0.09 ENSDART00000149586
gna15.1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr13_-_9543393 0.07 ENSDART00000041609
tm9sf3
transmembrane 9 superfamily member 3
chr8_-_13327150 0.07 ENSDART00000063863
ccdc124
coiled-coil domain containing 124
chr5_+_31211445 0.07 ENSDART00000023463
uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1, like 1
chr4_+_18971779 0.06 ENSDART00000159160
impdh1b
IMP (inosine 5'-monophosphate) dehydrogenase 1b
chr23_+_17946764 0.03 ENSDART00000117743
SNORD59
Small nucleolar RNA SNORD59
chr5_-_24580478 0.01 ENSDART00000138209
dph7
diphthamide biosynthesis 7
chr2_+_41973443 0.01

chr4_-_12930797 0.00 ENSDART00000108552
lemd3
LEM domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.1 GO:0045428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
1.2 3.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
1.0 6.0 GO:0071326 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.9 3.8 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.8 3.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.6 2.4 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.5 8.8 GO:0032836 glomerular basement membrane development(GO:0032836)
0.5 3.4 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.4 1.7 GO:1903726 negative regulation of phospholipid metabolic process(GO:1903726)
0.3 4.2 GO:0046686 response to cadmium ion(GO:0046686)
0.3 2.9 GO:0007412 axon target recognition(GO:0007412)
0.3 2.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.3 3.0 GO:0042026 protein refolding(GO:0042026)
0.3 4.3 GO:0071711 basement membrane organization(GO:0071711)
0.3 0.8 GO:0008347 glial cell migration(GO:0008347)
0.2 2.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2 1.5 GO:0008210 estrogen biosynthetic process(GO:0006703) estrogen metabolic process(GO:0008210)
0.2 4.5 GO:0044259 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.2 2.3 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.2 2.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.4 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.7 GO:0051601 exocyst localization(GO:0051601)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.8 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 0.8 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 6.8 GO:0007601 visual perception(GO:0007601)
0.1 0.6 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 2.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.1 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.1 1.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 1.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 1.2 GO:0072576 liver morphogenesis(GO:0072576)
0.1 0.4 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.6 GO:0010165 response to X-ray(GO:0010165)
0.1 1.0 GO:0031033 myosin filament organization(GO:0031033)
0.1 2.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 1.1 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 1.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 5.3 GO:0032147 activation of protein kinase activity(GO:0032147)
0.1 0.6 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.0 2.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.2 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 3.8 GO:0003407 neural retina development(GO:0003407)
0.0 0.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 2.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.9 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.2 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 3.2 GO:0007411 axon guidance(GO:0007411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.9 10.8 GO:0043209 myelin sheath(GO:0043209)
0.6 2.9 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.5 3.8 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.4 3.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 8.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 2.8 GO:0030018 Z disc(GO:0030018)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 6.1 GO:0000785 chromatin(GO:0000785)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 2.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.0 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.9 2.6 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.6 2.4 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.6 2.9 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.5 2.2 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.4 2.1 GO:0005035 death receptor activity(GO:0005035)
0.4 1.1 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.4 1.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.3 2.7 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.3 1.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 6.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 3.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 2.3 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 2.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 6.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.3 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 0.8 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 5.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.6 GO:0030371 translation repressor activity(GO:0030371)
0.1 3.0 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.4 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 8.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 3.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 5.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 2.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421) ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 4.9 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 6.8 ST GA12 PATHWAY G alpha 12 Pathway
0.3 5.8 NABA COLLAGENS Genes encoding collagen proteins
0.2 2.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 2.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.4 3.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 4.1 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 5.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 5.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis