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Results for irf10+irf3+irf8

Z-value: 1.71

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Transcription factors associated with irf10+irf3+irf8

Gene Symbol Gene ID Gene Info
ENSDARG00000027658 interferon regulatory factor 10
ENSDARG00000056407 interferon regulatory factor 8
ENSDARG00000076251 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf3dr10_dc_chr12_-_4563094_45631070.674.4e-03Click!

Activity profile of irf10+irf3+irf8 motif

Sorted Z-values of irf10+irf3+irf8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf3+irf8

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr23_+_43868027 7.38 ENSDART00000112598
ENSDART00000169576
OTU deubiquitinase 4
chr14_-_46980330 5.95 ENSDART00000043751
ENSDART00000141357
MACRO domain containing 1
chr18_-_38289370 4.26 ENSDART00000139519
cell cycle associated protein 1b
chr11_+_1558144 4.08 ENSDART00000154583
si:dkey-40c23.2
chr9_-_23954640 3.99 ENSDART00000027212
ENSDARG00000006848
chr13_-_37504883 3.95 ENSDART00000108855
si:dkey-188i13.7
chr21_+_22598805 3.65 ENSDART00000142495
ENSDARG00000089088
chr16_+_25370991 3.48 ENSDART00000154112
si:dkey-29h14.10
chr22_+_8856370 3.45 ENSDART00000178799
ENSDARG00000109049
chr10_-_35209022 3.28 ENSDART00000063434
receptor-interacting serine-threonine kinase 4
chr18_-_12889296 3.24 ENSDART00000130343
poly (ADP-ribose) polymerase family, member 12a
chr22_-_7431710 3.21 ENSDART00000170630
ENSDARG00000104176
chr24_+_32295105 3.09 ENSDART00000143570
ENSDARG00000092965
chr22_-_7780120 3.06 ENSDART00000097201
si:ch73-44m9.1
chr22_-_6062841 3.02

chr1_-_55072271 2.90 ENSDART00000142244
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr6_+_38898605 2.88 ENSDART00000029930
solute carrier family 48 (heme transporter), member 1b
chr5_-_29782745 2.86 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr22_-_8144696 2.84 ENSDART00000156571
si:ch73-44m9.3
chr18_-_12889369 2.83 ENSDART00000130343
poly (ADP-ribose) polymerase family, member 12a
chr20_-_22170411 2.80 ENSDART00000155568
ENSDARG00000097598
chr21_+_5027444 2.79 ENSDART00000139288
si:dkey-121h17.7
chr9_+_41658126 2.77 ENSDART00000100265
nuclear envelope integral membrane protein 2
chr4_+_16197 2.77 ENSDART00000166174
ENSDARG00000100660
chr16_+_25370955 2.58 ENSDART00000154112
si:dkey-29h14.10
chr10_-_210594 2.55 ENSDART00000059476
proteasome (prosome, macropain) assembly chaperone 1
chr16_+_29574449 2.50 ENSDART00000148450
cathepsin S, ortholog2, tandem duplicate 1
chr19_+_4135556 2.44 ENSDART00000162461
bloodthirsty-related gene family, member 26
chr9_-_23954690 2.44 ENSDART00000027212
ENSDARG00000006848
chr25_+_31979838 2.33 ENSDART00000012600
galactokinase 2
chr5_-_66982706 2.31 ENSDART00000013605
zinc finger and BTB domain containing 20
chr15_+_20416591 2.25 ENSDART00000161047
interleukin 15, like
chr14_-_25636795 2.22

chr10_+_35209025 2.18 ENSDART00000126105
NOP2/Sun domain family, member 5
chr9_+_23954807 2.15 ENSDART00000145120
ENSDARG00000040445
chr15_+_20054306 2.14 ENSDART00000155199
zgc:112083
chr22_-_8144599 2.12 ENSDART00000156571
si:ch73-44m9.3
chr9_-_23954761 2.11 ENSDART00000027212
ENSDARG00000006848
chr5_+_9579430 2.10 ENSDART00000109236
ENSDARG00000075416
chr3_+_32530476 2.01 ENSDART00000171556
si:dkey-16l2.16
chr11_+_36088518 2.01

chr9_+_41657971 2.01 ENSDART00000132501
nuclear envelope integral membrane protein 2
chr5_-_57053687 1.98 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr21_+_5027623 1.97 ENSDART00000139288
si:dkey-121h17.7
chr15_-_29229170 1.94 ENSDART00000138449
XIAP associated factor 1
chr5_-_29782945 1.93 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr15_+_20416518 1.92 ENSDART00000161047
interleukin 15, like
chr12_-_19030156 1.91 ENSDART00000057124
thyrotrophic embryonic factor a
chr19_-_3947422 1.90 ENSDART00000172271
thyroid hormone receptor associated protein 3b
chr7_-_69883542 1.87

chr24_+_32295150 1.86 ENSDART00000143570
ENSDARG00000092965
chr25_-_25455861 1.85 ENSDART00000150412
interferon regulatory factor 7
chr16_-_9911999 1.84 ENSDART00000154217
TAP binding protein (tapasin)-like
chr9_-_35824470 1.84 ENSDART00000140356
zona pellucida glycoprotein 2, like 1
chr5_-_38571198 1.82 ENSDART00000020808
progestin and adipoQ receptor family member IIIa
chr15_-_29229135 1.82 ENSDART00000138449
XIAP associated factor 1
chr10_-_45383207 1.81 ENSDART00000169845
poly (ADP-ribose) glycohydrolase, like
chr17_+_23710004 1.80 ENSDART00000034913
zgc:91976
chr11_-_36088336 1.79 ENSDART00000141477
proteasome subunit alpha 5
chr5_+_22076136 1.78 ENSDART00000080877
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr5_-_29782972 1.78 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr9_+_23954669 1.71 ENSDART00000145120
ENSDARG00000040445
chr7_-_69883581 1.69

chr15_-_16447990 1.69 ENSDART00000154504
family with sequence similarity 222, member Bb
chr12_-_13866903 1.69 ENSDART00000152400
DBF4 zinc finger B
chr5_-_45358634 1.68 ENSDART00000135072
POC5 centriolar protein homolog (Chlamydomonas)
chr4_-_765957 1.65 ENSDART00000128743
transmembrane protein 214
chr15_-_24653278 1.65 ENSDART00000123167
gem (nuclear organelle) associated protein 4
chr21_+_5027668 1.63 ENSDART00000139288
si:dkey-121h17.7
chr25_-_27222696 1.61 ENSDART00000123590
si:ch211-91p5.3
chr15_-_5636737 1.61 ENSDART00000114410
WD repeat domain 62
chr5_+_45295180 1.58 ENSDART00000083937
polymerase (DNA directed) kappa
chr22_+_17803309 1.58 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr17_+_23709781 1.54 ENSDART00000034913
zgc:91976
chr6_+_46307828 1.54 ENSDART00000154817
si:dkeyp-67f1.1
chr15_+_14442857 1.52 ENSDART00000160145
si:ch211-11n16.2
chr18_+_13280400 1.51 ENSDART00000080709
phospholipase C, gamma 2
chr12_-_93105 1.51 ENSDART00000105694
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr13_-_49886891 1.51 ENSDART00000074230
protein kinase containing Z-DNA binding domains
chr1_-_54570813 1.50 ENSDART00000098615
nanos homolog 3
chr6_+_12810986 1.49 ENSDART00000104757
ENSDART00000165896
caspase 8, apoptosis-related cysteine peptidase
chr15_+_43682831 1.49 ENSDART00000168589
cathepsin C
chr2_-_15380727 1.48

chr12_-_13866811 1.48 ENSDART00000152400
DBF4 zinc finger B
chr7_+_39810607 1.47 ENSDART00000173559
ENSDARG00000036489
chr22_-_36718623 1.47

chr6_-_51811024 1.46 ENSDART00000031597
proteasome inhibitor subunit 1
chr21_+_22599022 1.46 ENSDART00000142495
ENSDARG00000089088
chr13_+_2345595 1.44

chr2_-_6203659 1.44 ENSDART00000164269
peroxiredoxin 1
chr7_-_667841 1.43 ENSDART00000160644
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr3_+_32530071 1.43 ENSDART00000165562
si:dkey-16l2.16
chr21_-_30957555 1.43 ENSDART00000160224
post-GPI attachment to proteins 2
chr2_+_15380054 1.43 ENSDART00000058484
calponin 3, acidic b
KN150589v1_-_6303 1.42

chr10_-_25366450 1.41 ENSDART00000123820
transmembrane protein 135
chr3_-_31947991 1.40 ENSDART00000040900
bcl2-associated X protein, b
chr3_+_52745606 1.40 ENSDART00000104683
pre-B-cell leukemia transcription factor 4
chr4_+_17666992 1.39 ENSDART00000066999
coiled-coil domain containing 53
chr4_-_26106485 1.39 ENSDART00000100611
si:ch211-244b2.3
chr7_-_29956782 1.37 ENSDART00000173514
zinc finger protein 710b
chr22_+_17803347 1.37 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr22_-_7887341 1.36 ENSDART00000097198
sc:d217
chr2_-_38380883 1.36 ENSDART00000088026
protein arginine methyltransferase 5
chr4_-_17680826 1.35 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr1_-_44227583 1.31 ENSDART00000134635
si:dkey-9i23.15
chr2_-_37762426 1.29 ENSDART00000144807
myosin IXb
chr15_-_28852613 1.29 ENSDART00000152147
bleomycin hydrolase
chr6_+_41098443 1.29 ENSDART00000143741
FK506 binding protein 5
chr11_-_31012985 1.29 ENSDART00000162605
mannosidase, alpha, class 2B, member 1
chr6_+_48349630 1.28 ENSDART00000064826
Mov10 RISC complex RNA helicase a
chr2_+_16917097 1.25 ENSDART00000134135
si:dkeyp-13a3.10
chr21_+_5027576 1.25 ENSDART00000139288
si:dkey-121h17.7
chr3_+_35997687 1.25 ENSDART00000058605
serine carboxypeptidase 1
chr9_+_41658313 1.25 ENSDART00000100265
nuclear envelope integral membrane protein 2
chr19_-_7114660 1.24 ENSDART00000124094
death-domain associated protein
chr3_+_12087549 1.23

chr21_+_5027911 1.22 ENSDART00000139288
si:dkey-121h17.7
chr22_+_24576319 1.20 ENSDART00000164256
ENSDARG00000100186
chr10_+_9576840 1.20 ENSDART00000080843
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
chr19_-_7151715 1.20 ENSDART00000168755
TAP binding protein (tapasin), tandem duplicate 2
chr6_-_51811058 1.20 ENSDART00000031597
proteasome inhibitor subunit 1
chr22_-_36718745 1.18

chr15_-_1519615 1.17 ENSDART00000129356
si:dkeyp-97b10.3
chr9_+_23954607 1.17 ENSDART00000145120
ENSDARG00000040445
chr12_-_3018931 1.16 ENSDART00000139721
dicarbonyl/L-xylulose reductase
chr7_+_48025010 1.16 ENSDART00000052123
solute carrier family 25, member 44 b
chr20_+_27040570 1.15 ENSDART00000138369
cell division cycle associated 4
chr25_+_21417388 1.13

chr19_-_30265997 1.13 ENSDART00000024292
taxilin alpha
chr8_+_13757024 1.11

chr22_-_7688508 1.09

chr12_-_4563094 1.07 ENSDART00000152489
interferon regulatory factor 3
chr10_+_35208897 1.07 ENSDART00000063418
NOP2/Sun domain family, member 5
KN150200v1_-_6975 1.05

chr24_+_32295048 1.04 ENSDART00000143570
ENSDARG00000092965
chr15_+_43682994 1.04 ENSDART00000168589
cathepsin C
chr16_-_17793032 1.04 ENSDART00000108581
si:dkey-17m8.1
chr8_-_11164322 1.04 ENSDART00000147817
family with sequence similarity 208, member B
chr23_-_29431197 1.04 ENSDART00000156512
si:ch211-129o18.4
chr9_+_7829443 1.03

chr23_-_36350571 1.02 ENSDART00000110478
zgc:174906
chr13_-_26668719 1.02 ENSDART00000139264
vaccinia related kinase 2
chr18_-_38289008 1.01 ENSDART00000139519
cell cycle associated protein 1b
chr2_+_42077559 1.00 ENSDART00000023208
ENSDARG00000014209
chr8_-_11164125 1.00 ENSDART00000147817
family with sequence similarity 208, member B
chr22_-_10540917 0.99 ENSDART00000140736
si:dkey-42i9.6
chr24_-_34794463 0.98 ENSDART00000171009
ENSDART00000170046
catenin (cadherin-associated protein), alpha 1
chr3_+_40022244 0.97 ENSDART00000102526
growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
chr17_+_23709676 0.97 ENSDART00000179026
zgc:91976
chr21_-_36710989 0.96 ENSDART00000086060
mitochondrial ribosomal protein L22
chr15_-_24653336 0.95 ENSDART00000123167
gem (nuclear organelle) associated protein 4
chr18_+_13280519 0.94 ENSDART00000080709
phospholipase C, gamma 2
chr23_+_29431388 0.92 ENSDART00000027255
TAR DNA binding protein, like
chr2_+_16917277 0.90 ENSDART00000134135
si:dkeyp-13a3.10
chr14_-_16504730 0.90 ENSDART00000158396
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3b
chr8_+_13757180 0.88

chr7_-_667670 0.88 ENSDART00000159359
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr2_-_55584106 0.86 ENSDART00000169382
ENSDART00000097874
tropomyosin 4b
chr12_+_26970745 0.86 ENSDART00000153426
Snf2-related CREBBP activator protein
chr3_-_29557642 0.86 ENSDART00000151679
si:ch73-233k15.2
chr5_-_57053661 0.85 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr6_+_32849464 0.84 ENSDART00000157353
cylindromatosis (turban tumor syndrome), like
chr18_+_13280623 0.84 ENSDART00000080709
phospholipase C, gamma 2
chr19_+_4939999 0.84 ENSDART00000093402
cyclin-dependent kinase 12
chr25_+_31979756 0.83 ENSDART00000012600
galactokinase 2
chr22_-_37630428 0.83 ENSDART00000149482
fragile X mental retardation, autosomal homolog 1
chr7_-_73628049 0.81 ENSDART00000123136
Histone H2B 1/2
chr18_+_22285328 0.81

chr6_-_51810856 0.80 ENSDART00000031597
proteasome inhibitor subunit 1
chr15_-_5636514 0.79 ENSDART00000114410
WD repeat domain 62
chr19_+_27864350 0.79 ENSDART00000052352
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr2_+_52529869 0.78 ENSDART00000111266
theg spermatid protein
chr22_-_6723168 0.78

chr19_-_3947553 0.78 ENSDART00000172271
thyroid hormone receptor associated protein 3b
chr12_-_19029755 0.77 ENSDART00000057124
thyrotrophic embryonic factor a
chr18_-_17735227 0.77

chr4_-_1908065 0.77 ENSDART00000144074
transmembrane 7 superfamily member 3
chr22_-_7887401 0.74 ENSDART00000097198
sc:d217
chr22_-_6723094 0.74

chr14_+_21457220 0.73 ENSDART00000111839
lysine (K)-specific demethylase 2Ab
chr5_-_37220725 0.73 ENSDART00000165513
ENSDARG00000099693
chr8_-_11164610 0.73 ENSDART00000147817
family with sequence similarity 208, member B
chr24_+_12801404 0.72 ENSDART00000005105
proteasome activator subunit 1
chr25_-_19476079 0.71 ENSDART00000156811
si:ch211-59o9.10
chr12_-_26468261 0.71 ENSDART00000039510
si:dkey-57h18.2
chr15_+_20416637 0.66 ENSDART00000161047
interleukin 15, like
chr5_+_43772045 0.66 ENSDART00000144706
ENSDARG00000095282
chr22_-_8075916 0.66

chr9_+_56868126 0.64 ENSDART00000160107
ENSDARG00000100275
chr19_-_5946770 0.64

chr9_-_19084609 0.64 ENSDART00000131957
cytokine receptor family member b2
chr3_+_52746019 0.64

chr6_-_32849361 0.63 ENSDART00000129803
zinc finger CCCH-type containing 3
chr8_+_47197712 0.62 ENSDART00000137319
si:dkeyp-100a1.6
chr23_-_35297841 0.62 ENSDART00000145597
cap methyltransferase 1
chr5_+_32215942 0.62 ENSDART00000047377
carnitine O-acetyltransferase a
chr12_+_14111340 0.61 ENSDART00000123741
kelch repeat and BTB (POZ) domain containing 2
chr21_-_30957754 0.60 ENSDART00000065503
post-GPI attachment to proteins 2
chr1_+_31608918 0.60 ENSDART00000137156
pseudouridine 5'-phosphatase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.8 4.8 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.6 3.2 GO:0033262 positive regulation of nuclear cell cycle DNA replication(GO:0010571) regulation of nuclear cell cycle DNA replication(GO:0033262)
0.5 1.5 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903) interaction with host(GO:0051701)
0.5 2.9 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.5 1.8 GO:2000737 negative regulation of stem cell differentiation(GO:2000737)
0.4 1.8 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.4 3.2 GO:0006012 galactose metabolic process(GO:0006012)
0.3 1.6 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.3 2.9 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.3 2.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 1.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.3 GO:0016441 posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194)
0.2 1.4 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 3.2 GO:0070475 rRNA base methylation(GO:0070475)
0.2 1.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 1.3 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2 1.4 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.2 0.6 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 3.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 1.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 3.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.3 GO:0032475 otolith formation(GO:0032475)
0.1 0.6 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.5 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.1 2.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.4 GO:0032456 endocytic recycling(GO:0032456)
0.1 2.4 GO:0071482 cellular response to light stimulus(GO:0071482)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.9 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 7.6 GO:0017148 negative regulation of translation(GO:0017148)
0.1 1.6 GO:0043486 histone exchange(GO:0043486)
0.1 1.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.1 0.5 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.1 1.2 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 0.2 GO:0001715 ectodermal cell fate commitment(GO:0001712) ectodermal cell fate specification(GO:0001715) ectodermal cell differentiation(GO:0010668) regulation of ectodermal cell fate specification(GO:0042665) regulation of ectoderm development(GO:2000383)
0.1 2.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.7 GO:0007632 visual behavior(GO:0007632)
0.1 1.8 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.1 1.0 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 0.3 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 1.4 GO:0051607 defense response to virus(GO:0051607)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 1.3 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.8 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.7 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.7 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 5.9 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 7.9 GO:0042981 regulation of apoptotic process(GO:0042981)
0.0 1.0 GO:0042255 ribosome assembly(GO:0042255)
0.0 3.6 GO:0006915 apoptotic process(GO:0006915)
0.0 1.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 1.0 GO:0001894 tissue homeostasis(GO:0001894)
0.0 0.6 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0031431 Dbf4-dependent protein kinase complex(GO:0031431)
0.6 1.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.4 1.2 GO:0071159 NF-kappaB complex(GO:0071159)
0.4 2.6 GO:0032797 SMN complex(GO:0032797)
0.3 0.8 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.2 0.7 GO:0008537 proteasome activator complex(GO:0008537)
0.2 6.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.6 GO:0000812 Swr1 complex(GO:0000812)
0.1 2.8 GO:0043186 P granule(GO:0043186)
0.1 1.3 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 0.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.8 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 2.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.5 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 3.6 GO:0005774 vacuolar membrane(GO:0005774)
0.0 3.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 3.2 GO:0005730 nucleolus(GO:0005730)
0.0 9.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.4 GO:0005657 replication fork(GO:0005657)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.6 3.2 GO:0004335 galactokinase activity(GO:0004335)
0.6 15.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 1.8 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.4 1.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 2.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.3 1.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 1.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 2.9 GO:0015232 heme transporter activity(GO:0015232)
0.3 1.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 3.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.2 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.2 1.0 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972)
0.2 3.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.5 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.4 GO:0003896 DNA primase activity(GO:0003896)
0.1 3.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.3 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.3 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.9 GO:0051117 ATPase binding(GO:0051117)
0.1 1.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.6 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 4.8 GO:0005125 cytokine activity(GO:0005125)
0.1 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 2.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.8 GO:0045182 translation regulator activity(GO:0045182)
0.0 1.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 1.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.2 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 3.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 3.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 1.2 PID IL23 PATHWAY IL23-mediated signaling events
0.1 1.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 1.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 3.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 1.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 3.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 3.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 3.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 2.6 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation