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Results for irf4a+irf4b

Z-value: 0.41

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Transcription factors associated with irf4a+irf4b

Gene Symbol Gene ID Gene Info
irf4a
ENSDARG00000006560 interferon regulatory factor 4a
irf4b
ENSDARG00000055374 interferon regulatory factor 4b

Activity profile of irf4a+irf4b motif

Sorted Z-values of irf4a+irf4b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of irf4a+irf4b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_-_23954640 0.94 ENSDART00000027212
ENSDARG00000006848
ENSDARG00000006848
chr1_-_54505112 0.75 ENSDART00000100619
ENSDART00000163796
LUC7L2
zgc:158803
chr1_-_54505313 0.73 ENSDART00000100619
ENSDART00000163796
LUC7L2
zgc:158803
chr25_+_15901398 0.66 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr16_+_19831573 0.53 ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr9_-_23954690 0.49 ENSDART00000027212
ENSDARG00000006848
ENSDARG00000006848
chr13_+_24132617 0.47 ENSDART00000135992
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr24_-_23793117 0.44

chr16_-_29451902 0.44

chr4_-_17680826 0.43 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr21_+_17265099 0.43 ENSDART00000145057
tsc1b
tuberous sclerosis 1b
chr7_-_69576406 0.43

chr6_-_10492724 0.40 ENSDART00000002247
sp3b
Sp3b transcription factor
chr21_+_20974216 0.39 ENSDART00000079692
ndr1
nodal-related 1
chr22_-_7748347 0.39 ENSDART00000097276
si:ch73-44m9.3
si:ch73-44m9.3
chr5_+_27659432 0.38 ENSDART00000087684
ncaph
non-SMC condensin I complex, subunit H
chr19_+_44073792 0.38 ENSDART00000051723
si:ch211-193k19.1
si:ch211-193k19.1
chr22_-_7431710 0.36 ENSDART00000170630
BX511034.7
ENSDARG00000104176
chr19_-_15516318 0.35 ENSDART00000151454
serinc2
serine incorporator 2
chr9_-_23954761 0.35 ENSDART00000027212
ENSDARG00000006848
ENSDARG00000006848
chr10_-_33435736 0.35 ENSDART00000023509
ska2
spindle and kinetochore associated complex subunit 2
chr9_+_23954669 0.35 ENSDART00000145120
ENSDARG00000040445
ENSDARG00000040445
chr18_+_44539099 0.34 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr7_-_69576628 0.34

chr6_-_1613994 0.34 ENSDART00000112118
trim107
tripartite motif containing 107
chr9_+_23954807 0.33 ENSDART00000145120
ENSDARG00000040445
ENSDARG00000040445
chr7_-_69576270 0.33

chr24_-_11326961 0.32 ENSDART00000082264
pxdc1b
PX domain containing 1b
chr20_+_35156812 0.32

chr12_+_26970745 0.31 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr25_+_16549708 0.31 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr1_-_36039634 0.30 ENSDART00000148386
prmt9
protein arginine methyltransferase 9
chr1_-_54504911 0.28 ENSDART00000100619
ENSDART00000163796
LUC7L2
zgc:158803
chr10_-_17593407 0.28 ENSDART00000145077
ska1
spindle and kinetochore associated complex subunit 1
chr19_+_44073707 0.27 ENSDART00000051723
si:ch211-193k19.1
si:ch211-193k19.1
chr18_+_44538877 0.27 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr6_+_9735186 0.27 ENSDART00000065471
abi2b
abl-interactor 2b
chr8_-_18193491 0.26 ENSDART00000143036
si:ch211-241d21.5
si:ch211-241d21.5
chr11_-_30261689 0.26 ENSDART00000101667
map4k3a
mitogen-activated protein kinase kinase kinase kinase 3a
chr13_+_17564330 0.26 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr3_-_26040846 0.26 ENSDART00000113890
rabep2
rabaptin, RAB GTPase binding effector protein 2
chr10_+_8143021 0.26 ENSDART00000138875
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr25_+_15901561 0.25 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr25_+_15901662 0.24 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr17_-_22532811 0.24 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr9_+_23954607 0.24 ENSDART00000145120
ENSDARG00000040445
ENSDARG00000040445
chr23_-_29627060 0.23 ENSDART00000166554
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr19_+_791656 0.23 ENSDART00000138406
tmem79a
transmembrane protein 79a
chr16_+_27449058 0.21 ENSDART00000132329
stx17
syntaxin 17
chr6_-_10492439 0.21 ENSDART00000002247
sp3b
Sp3b transcription factor
chr21_-_22507089 0.21 ENSDART00000177084
myo5b
myosin VB
chr6_-_1613740 0.21 ENSDART00000156305
trim107
tripartite motif containing 107
chr25_+_35540123 0.21 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr10_+_8142976 0.21 ENSDART00000123447
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr9_+_23192282 0.20 ENSDART00000021060
eaf2
ELL associated factor 2
chr15_-_41777233 0.19 ENSDART00000154230
ftr90
finTRIM family, member 90
chr4_-_29059042 0.19 ENSDART00000169971
CR387997.1
ENSDARG00000099486
chr13_-_24132195 0.19

chr18_-_44539130 0.19

chr2_+_2976602 0.18 ENSDART00000081976
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr6_-_1613915 0.18 ENSDART00000112118
trim107
tripartite motif containing 107
chr10_+_110941 0.18 ENSDART00000135572
pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr11_+_6209097 0.17 ENSDART00000156437
BX248501.1
ENSDARG00000074519
chr2_+_2976671 0.16 ENSDART00000081976
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr6_-_923389 0.16 ENSDART00000167390
zgc:113442
zgc:113442
chr16_-_41716834 0.15 ENSDART00000084528
atp2c1
ATPase, Ca++ transporting, type 2C, member 1
chr19_-_30265997 0.14 ENSDART00000024292
txlna
taxilin alpha
chr10_-_20524586 0.13

chr7_-_17129072 0.12

chr21_-_40025958 0.12 ENSDART00000124416
med31
mediator complex subunit 31
chr10_+_28273581 0.12 ENSDART00000131003
rnft1
ring finger protein, transmembrane 1
chr23_-_35297841 0.12 ENSDART00000145597
cmtr1
cap methyltransferase 1
chr3_-_26040615 0.12 ENSDART00000113890
rabep2
rabaptin, RAB GTPase binding effector protein 2
chr14_-_33245562 0.11 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr8_-_51354135 0.10 ENSDART00000170619
kansl3
KAT8 regulatory NSL complex subunit 3
chr2_+_2976973 0.10 ENSDART00000163587
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr15_+_34211736 0.09 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr7_+_19486714 0.08 ENSDART00000089333
tkfc
triokinase/FMN cyclase
chr11_-_30261559 0.06 ENSDART00000101667
map4k3a
mitogen-activated protein kinase kinase kinase kinase 3a
chr13_+_24132494 0.05 ENSDART00000135992
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr16_+_10666906 0.05 ENSDART00000091241
si:ch73-22o12.1
si:ch73-22o12.1
chr19_+_1743359 0.05 ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr19_+_44073507 0.04 ENSDART00000139151
si:ch211-193k19.1
si:ch211-193k19.1
chr19_-_30266029 0.04 ENSDART00000024292
txlna
taxilin alpha
chr22_+_748535 0.04 ENSDART00000125347
cry1bb
cryptochrome circadian clock 1bb
chr2_+_30506215 0.03 ENSDART00000115271
march6
membrane-associated ring finger (C3HC4) 6
chr6_+_15635738 0.03 ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr3_-_29557642 0.03 ENSDART00000151679
si:ch73-233k15.2
si:ch73-233k15.2
chr21_+_37985536 0.02 ENSDART00000085728
klf8
Kruppel-like factor 8
chr4_+_11465367 0.02 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr7_+_56171081 0.00 ENSDART00000073596
ENSDART00000123273
ist1
increased sodium tolerance 1 homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.1 0.2 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.4 GO:1900077 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.3 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.1 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.2 GO:1904103 regulation of convergent extension involved in gastrulation(GO:1904103)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.6 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.4 GO:0000796 condensin complex(GO:0000796)
0.1 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 1.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1 0.4 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.4 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0016849 phosphorus-oxygen lyase activity(GO:0016849)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases