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Results for irx5a+irx5b_irx3b
Z-value: 2.75
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Transcription factors associated with irx5a+irx5b_irx3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irx5a | dr10_dc_chr7_-_35438739_35438853 | -0.90 | 2.0e-06 | Click! |
| irx5b | dr10_dc_chr25_+_35602451_35602500 | -0.88 | 7.2e-06 | Click! |
| irx3b | dr10_dc_chr25_+_35901081_35901148 | -0.86 | 1.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of irx5a+irx5b_irx3b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_33264349 Show fit | 8.64 |
|
|
|
| chr21_+_11943637 Show fit | 7.68 |
ENSDART00000141306
|
zgc:162344 |
|
| chr17_+_24791024 Show fit | 7.02 |
ENSDART00000130871
|
speedy/RINGO cell cycle regulator family member A |
|
| chr23_+_46000362 Show fit | 6.61 |
ENSDART00000023944
|
lamin L3 |
|
| chr2_+_216779 Show fit | 6.44 |
ENSDART00000101071
|
zgc:113293 |
|
| chr6_+_51713264 Show fit | 6.38 |
ENSDART00000146281
|
family with sequence similarity 65, member C |
|
| chr17_+_24790812 Show fit | 6.25 |
ENSDART00000082251
|
speedy/RINGO cell cycle regulator family member A |
|
| chr2_+_216931 Show fit | 5.83 |
ENSDART00000101071
|
zgc:113293 |
|
| chr16_-_47446494 Show fit | 5.58 |
ENSDART00000032188
|
si:dkey-256h2.1 |
|
| chr19_+_32670271 Show fit | 5.33 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0043413 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 0.5 | 6.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.4 | 5.7 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.8 | 5.5 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 1.4 | 5.4 | GO:0043622 | cortical microtubule organization(GO:0043622) |
| 0.1 | 5.4 | GO:0007596 | blood coagulation(GO:0007596) hemostasis(GO:0007599) |
| 0.3 | 5.2 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.2 | 5.2 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.1 | 5.0 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 5.0 | GO:0051169 | nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 7.4 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 7.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 6.0 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.1 | 5.9 | GO:0016605 | PML body(GO:0016605) |
| 1.4 | 5.5 | GO:0002144 | cytosolic tRNA wobble base thiouridylase complex(GO:0002144) |
| 0.1 | 5.2 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.7 | 4.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 4.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 4.3 | GO:0005813 | centrosome(GO:0005813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.0 | 9.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.5 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 7.9 | GO:0016757 | transferase activity, transferring glycosyl groups(GO:0016757) |
| 0.2 | 7.0 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.3 | 6.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.5 | 6.0 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 5.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 5.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 1.4 | 5.6 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 6.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 4.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 3.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 2.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 2.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 2.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 2.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.3 | 5.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 4.5 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.3 | 4.3 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 3.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.5 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.4 | 3.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.2 | 3.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 3.0 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 3.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |