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Results for irx6a

Z-value: 0.86

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Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr25_-_30818836 4.16 ENSDART00000156828
prr33
proline rich 33
chr4_+_9027862 2.55 ENSDART00000102893
aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr1_-_58580939 2.38 ENSDART00000158011
col5a3b
collagen, type V, alpha 3b
chr12_+_36716775 2.03 ENSDART00000048927
cox10
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr13_+_2774422 2.00 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr15_-_23587330 1.94 ENSDART00000167246
hmbsb
hydroxymethylbilane synthase, b
chr16_+_25401922 1.85 ENSDART00000172514
ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr19_+_3713027 1.78 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr22_+_2921305 1.66 ENSDART00000143258
cep19
centrosomal protein 19
chr21_+_25597814 1.65 ENSDART00000110705
tmem151a
transmembrane protein 151A
chr7_-_44332679 1.59 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr24_+_3931981 1.50 ENSDART00000167043
pfkpa
phosphofructokinase, platelet a
chr8_+_28240085 1.41 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr23_-_45266310 1.33

chr20_-_47680305 1.29 ENSDART00000023058
efhc1
EF-hand domain (C-terminal) containing 1
chr2_+_33343287 1.28 ENSDART00000056655
klf17
Kruppel-like factor 17
chr6_-_113401 1.24 ENSDART00000151251
LRRC8E
leucine rich repeat containing 8 VRAC subunit E
chr24_-_14447773 1.16

chr20_+_35479511 1.05 ENSDART00000135284
vsnl1a
visinin-like 1a
chr3_-_12818954 1.00 ENSDART00000158747
ENSDART00000158815
pdgfab
platelet-derived growth factor alpha polypeptide b
chr7_-_44332885 0.98 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr3_-_18642744 0.96 ENSDART00000134208
hagh
hydroxyacylglutathione hydrolase
chr21_-_11943446 0.95 ENSDART00000142644
tpgs2
tubulin polyglutamylase complex subunit 2
chr23_+_157661 0.87

chr18_-_40893823 0.81 ENSDART00000059194
snrpd2
small nuclear ribonucleoprotein D2 polypeptide
chr19_-_5453469 0.80 ENSDART00000105004
krt17
keratin 17
chr24_-_15118619 0.78 ENSDART00000006930
rttn
rotatin
chr20_+_35479428 0.76 ENSDART00000159483
ENSDART00000031091
BX511024.1
vsnl1a
ENSDARG00000104812
visinin-like 1a
chr24_-_28150352 0.74 ENSDART00000145290
bcl2a
B-cell CLL/lymphoma 2a
chr14_-_32838287 0.73

chr9_-_14137664 0.70 ENSDART00000132747
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr7_+_10460031 0.67 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr5_+_19599323 0.62 ENSDART00000079424
si:rp71-1c23.3
si:rp71-1c23.3
chr1_+_966385 0.61 ENSDART00000051919
n6amt1
N-6 adenine-specific DNA methyltransferase 1 (putative)
chr4_-_29059042 0.61 ENSDART00000169971
CR387997.1
ENSDARG00000099486
chr9_-_2938937 0.58

chr15_-_14439483 0.57 ENSDART00000160675
dpf1
D4, zinc and double PHD fingers family 1
chr18_+_20001243 0.55 ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr22_-_2921219 0.54 ENSDART00000092991
pigx
phosphatidylinositol glycan anchor biosynthesis, class X
chr18_+_8388897 0.53 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr5_-_32861219 0.53 ENSDART00000162290
ENSDARG00000060631
ENSDARG00000060631
chr8_-_6899611 0.51 ENSDART00000139545
wdr13
WD repeat domain 13
chr15_+_2894254 0.51 ENSDART00000163434
mre11a
MRE11 homolog A, double strand break repair nuclease
chr12_+_34615991 0.50

chr21_-_45833527 0.46 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr5_-_41646616 0.39

chr9_+_1964320 0.32

chr4_-_18851997 0.32 ENSDART00000140722
cbll1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr10_-_15686739 0.31 ENSDART00000101191
smc5
structural maintenance of chromosomes 5
chr2_-_2971242 0.31 ENSDART00000032540
usp14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr11_+_11809234 0.30 ENSDART00000168346
CR848705.1
ENSDARG00000102054
chr21_+_43887079 0.30 ENSDART00000075672
sra1
steroid receptor RNA activator 1
chr3_-_3589844 0.29 ENSDART00000140482
ENSDARG00000079723
ENSDARG00000079723
chr13_-_12257253 0.25 ENSDART00000141606
commd8
COMM domain containing 8
chr7_-_31559772 0.24 ENSDART00000052514
cars
cysteinyl-tRNA synthetase
chr7_+_10460159 0.19 ENSDART00000158162
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr15_-_2894111 0.17 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr14_+_46484340 0.16 ENSDART00000173261
ENSDART00000126979
ubxn1
UBX domain protein 1
chr8_-_1154004 0.16 ENSDART00000149969
ENSDART00000016800
znf367
zinc finger protein 367
chr5_-_32860888 0.14 ENSDART00000085636
ENSDARG00000060631
ENSDARG00000060631
chr12_+_36716838 0.13 ENSDART00000048927
cox10
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr19_+_27339056 0.12 ENSDART00000148439
nelfe
negative elongation factor complex member E
chr3_+_17900924 0.12 ENSDART00000035531
mettl26
methyltransferase like 26
chr6_+_6645326 0.09 ENSDART00000138283
dtd1
D-tyrosyl-tRNA deacylase 1
chr5_-_32861134 0.08 ENSDART00000162290
ENSDARG00000060631
ENSDARG00000060631
chr17_-_27247516 0.08 ENSDART00000110903
E2F2
E2F transcription factor 2
chr7_+_10459899 0.06 ENSDART00000171385
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr17_-_14697094 0.02 ENSDART00000154281
ptp4a2a
protein tyrosine phosphatase type IVA, member 2a
chr7_-_31559907 0.01 ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr10_+_8670564 0.00 ENSDART00000129643
aplnrb
apelin receptor b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.4 2.5 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.4 1.8 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.3 GO:0048785 hatching gland development(GO:0048785)
0.3 1.9 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.2 1.5 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 0.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.0 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.1 1.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.9 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 2.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 1.0 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.9 GO:0010970 establishment of localization by movement along microtubule(GO:0010970)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.4 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.2 1.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.8 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 1.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0045503 dynein light chain binding(GO:0045503)
0.4 2.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.4 2.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.3 1.9 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.2 1.5 GO:0003872 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.1 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 1.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.7 GO:0016208 AMP binding(GO:0016208)
0.0 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.1 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 1.0 PID P73PATHWAY p73 transcription factor network
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway