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Results for klf15

Z-value: 0.79

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Transcription factors associated with klf15

Gene Symbol Gene ID Gene Info
klf15
ENSDARG00000091127 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf15dr10_dc_chr23_-_35096962_35097011-0.638.9e-03Click!

Activity profile of klf15 motif

Sorted Z-values of klf15 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_21563703 2.06 ENSDART00000045574
shisa2a
shisa family member 2a
chr21_-_13593659 1.87 ENSDART00000065817
pou5f3
POU domain, class 5, transcription factor 3
chr14_+_34154895 1.61 ENSDART00000147756
wnt8a
wingless-type MMTV integration site family, member 8a
chr5_+_26925392 1.47 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr24_-_4418454 1.44 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr5_+_26925238 1.31 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr3_-_18653909 1.27

KN149861v1_-_5655 1.25

chr22_-_20377970 1.18 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
KN149861v1_-_6089 1.17

chr5_+_26925663 1.00 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr16_+_9822930 0.98 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr8_+_17479651 0.89

chr23_+_31318844 0.82 ENSDART00000146510
irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr15_-_18087085 0.81 ENSDART00000155194
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr5_-_29480173 0.80 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr19_+_14132374 0.79 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr4_-_6443699 0.77

chr25_+_29631947 0.77 ENSDART00000154849
ENSDARG00000029431
ENSDARG00000029431
chr19_+_14490203 0.75 ENSDART00000164386
arid1ab
AT rich interactive domain 1Ab (SWI-like)
chr18_-_26876598 0.73

chr11_+_6012910 0.72 ENSDART00000161001
gtpbp3
GTP binding protein 3
chr19_+_14132473 0.71 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr3_-_22240424 0.70

chr14_+_46609215 0.69 ENSDART00000110429
zgc:194285
zgc:194285
chr5_+_26925957 0.69

chr5_-_56641212 0.67 ENSDART00000050957
fer
fer (fps/fes related) tyrosine kinase
chr18_+_46153484 0.61 ENSDART00000015034
blvrb
biliverdin reductase B
chr16_+_9823111 0.56 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr5_-_56641001 0.55 ENSDART00000149855
fer
fer (fps/fes related) tyrosine kinase
chr21_+_15505169 0.53 ENSDART00000011318
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr13_+_31586024 0.53 ENSDART00000034745
prkcha
protein kinase C, eta, a
chr2_-_56848527 0.52 ENSDART00000164330
CU634008.1
ENSDARG00000100430
chr12_+_10405904 0.52 ENSDART00000029133
snu13b
SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5)
chr5_-_56641061 0.49 ENSDART00000050957
fer
fer (fps/fes related) tyrosine kinase
chr9_-_18808049 0.48

chr7_-_71092598 0.47 ENSDART00000149682
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr8_-_52952141 0.47 ENSDART00000168185
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr19_-_17039269 0.47

chr10_-_25695574 0.47 ENSDART00000110751
tiam1a
T-cell lymphoma invasion and metastasis 1a
chr17_+_15527525 0.47 ENSDART00000159426
marcksb
myristoylated alanine-rich protein kinase C substrate b
chr22_-_5888816 0.47 ENSDART00000141373
si:rp71-36a1.1
si:rp71-36a1.1
chr17_-_2544896 0.45 ENSDART00000109582
spata7
spermatogenesis associated 7
chr16_+_9822879 0.43 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr5_+_21563654 0.43 ENSDART00000045574
shisa2a
shisa family member 2a
chr12_+_23300259 0.43

chr7_+_19300487 0.43 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr6_-_29386437 0.42 ENSDART00000168905
tmem131
transmembrane protein 131
chr9_-_18807868 0.40

chr3_+_35310412 0.39 ENSDART00000176700
BX511029.1
ENSDARG00000107881
chr22_-_20378023 0.38 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
chr6_+_36843778 0.38 ENSDART00000104157
tmem45a
transmembrane protein 45a
chr8_+_8908955 0.37 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr8_-_40231417 0.34 ENSDART00000162020
kdm2ba
lysine (K)-specific demethylase 2Ba
chr21_+_7627327 0.32 ENSDART00000172174
agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr9_+_23118780 0.32 ENSDART00000061299
tsn
translin
chr7_+_19300351 0.32 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr16_-_39527598 0.31 ENSDART00000102525
stt3b
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
chr16_+_51598269 0.31 ENSDART00000169443
SLC9A1
solute carrier family 9 member A1
KN149861v1_-_5543 0.31

chr8_-_52952226 0.31 ENSDART00000168185
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr6_-_10574082 0.30 ENSDART00000151661
wipf1b
WAS/WASL interacting protein family, member 1b
chr11_-_40239946 0.30 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr11_+_33154781 0.29

chr1_-_51862897 0.28 ENSDART00000136469
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr11_+_11735899 0.28 ENSDART00000003891
jupa
junction plakoglobin a
chr2_-_7374447 0.28

chr4_-_195110 0.27 ENSDART00000167885
lrp6
low density lipoprotein receptor-related protein 6
chr5_-_34664282 0.25 ENSDART00000114981
ENSDART00000051279
ptcd2
pentatricopeptide repeat domain 2
chr11_-_29891067 0.24 ENSDART00000172106
scml2
sex comb on midleg-like 2 (Drosophila)
chr3_-_25239180 0.24 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr2_+_25212281 0.23 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr12_+_10078043 0.22 ENSDART00000152369
si:dkeyp-118b1.2
si:dkeyp-118b1.2
chr3_-_51724440 0.22

chr12_-_14172962 0.22 ENSDART00000158399
avl9
AVL9 homolog (S. cerevisiase)
chr3_+_32293441 0.21 ENSDART00000156464
prr12b
proline rich 12b
chr2_-_44330306 0.21 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr7_+_23224924 0.20 ENSDART00000142401
zgc:109889
zgc:109889
chr18_-_26732762 0.20 ENSDART00000142043
malt3
MALT paracaspase 3
chr22_+_26840517 0.18 ENSDART00000158756
crebbpa
CREB binding protein a
chr7_+_23224800 0.17 ENSDART00000115299
ENSDART00000101423
zgc:109889
zgc:109889
chr9_-_32295031 0.15 ENSDART00000132448
BX530407.4
ENSDARG00000093950
chr4_-_194901 0.15 ENSDART00000166440
ENSDART00000168093
lrp6
low density lipoprotein receptor-related protein 6
chr17_-_2544927 0.14 ENSDART00000109582
spata7
spermatogenesis associated 7
chr17_-_52735527 0.13

chr17_+_8166308 0.12 ENSDART00000172443
cdc42bpaa
CDC42 binding protein kinase alpha (DMPK-like) a
chr25_+_65335 0.11 ENSDART00000170892
ENSDART00000158574
ENSDART00000008663
adam10b
ADAM metallopeptidase domain 10b
chr22_-_3134699 0.11 ENSDART00000159580
lmnb2
lamin B2
chr13_+_28601627 0.10 ENSDART00000015773
ldb1a
LIM domain binding 1a
chr5_-_14147868 0.08 ENSDART00000113037
sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr4_-_195193 0.08 ENSDART00000167885
lrp6
low density lipoprotein receptor-related protein 6
chr16_+_25845432 0.06

chr23_+_41295092 0.04 ENSDART00000109567
nhsa
Nance-Horan syndrome a (congenital cataracts and dental anomalies)
chr22_-_95158 0.04

chr14_-_23501428 0.03

chr7_-_68033162 0.02

chr18_-_14797284 0.02

chr3_+_23573053 0.02 ENSDART00000024256
hoxb6a
homeobox B6a
chr5_-_13844232 0.00

chr17_+_31346473 0.00 ENSDART00000062900
itpka
inositol-trisphosphate 3-kinase A
chr2_-_44330348 0.00 ENSDART00000111246
cadm3
cell adhesion molecule 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.4 1.6 GO:0021512 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.3 1.7 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 1.9 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.3 0.8 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.2 0.5 GO:2001284 epithelial cell morphogenesis involved in gastrulation(GO:0003381) BMP secretion(GO:0038055) positive regulation of BMP secretion(GO:1900144) regulation of BMP secretion(GO:2001284)
0.1 3.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 2.0 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 0.2 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 0.6 GO:0097499 protein localization to nonmotile primary cilium(GO:0097499)
0.0 1.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.5 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.8 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.5 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.8 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0097189 apoptotic body(GO:0097189)
0.1 1.3 GO:0035060 brahma complex(GO:0035060)
0.1 0.8 GO:0045180 basal cortex(GO:0045180)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0005930 axoneme(GO:0005930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 5.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.7 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA