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Results for klf3+klf8

Z-value: 0.71

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Transcription factors associated with klf3+klf8

Gene Symbol Gene ID Gene Info
klf3
ENSDARG00000015495 Kruppel-like factor 3 (basic)
klf8
ENSDARG00000060661 Kruppel-like factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf3dr10_dc_chr1_-_17922028_179221720.783.4e-04Click!
klf8dr10_dc_chr21_+_37985816_379858800.683.6e-03Click!

Activity profile of klf3+klf8 motif

Sorted Z-values of klf3+klf8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of klf3+klf8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_29153215 3.02 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr16_+_24063849 2.39 ENSDART00000135084
apoa2
apolipoprotein A-II
chr14_+_13147115 2.32 ENSDART00000054849
pls3
plastin 3 (T isoform)
chr20_+_17840364 2.29 ENSDART00000024627
cdh2
cadherin 2, type 1, N-cadherin (neuronal)
chr15_+_46114986 1.92 ENSDART00000156366
si:ch1073-340i21.3
si:ch1073-340i21.3
chr3_-_32795866 1.80 ENSDART00000140117
aoc2
amine oxidase, copper containing 2
chr18_-_45750 1.58 ENSDART00000148821
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr2_-_35584440 1.57 ENSDART00000125298
tnw
tenascin W
chr16_-_17148579 1.34 ENSDART00000138715
plekhg6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr18_+_5456221 1.17

chr1_-_48790379 1.06 ENSDART00000150842
USMG5
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr18_-_45892 1.04 ENSDART00000052641
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_+_4874841 1.01 ENSDART00000165942
palm2
paralemmin 2
chr1_-_44239584 0.97 ENSDART00000137216
tmem176
transmembrane protein 176
chr21_+_17505748 0.97 ENSDART00000163238
stom
stomatin
chr6_-_23193752 0.92 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr5_-_68270398 0.89 ENSDART00000161561
ENSDARG00000059093
ENSDARG00000059093
chr13_+_1308683 0.87 ENSDART00000159047
si:ch211-165e15.1
si:ch211-165e15.1
chr22_-_11408859 0.86 ENSDART00000007649
mid1ip1b
MID1 interacting protein 1b
chr23_-_1008307 0.86 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr18_+_7350133 0.86 ENSDART00000172404
cers3b
ceramide synthase 3b
chr1_+_54460288 0.86 ENSDART00000138070
ENSDART00000150510
mb
myoglobin
chr8_-_21062262 0.85

KN149978v1_-_10669 0.78 ENSDART00000175723
CABZ01068178.1
ENSDARG00000105971
chr23_-_7889744 0.74 ENSDART00000164117
myt1b
myelin transcription factor 1b
chr21_+_13063614 0.73

chr25_-_36886647 0.72 ENSDART00000160688
psma1
proteasome subunit alpha 1
chr24_-_40968409 0.72 ENSDART00000169315
ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr5_-_71394207 0.70 ENSDART00000050971
rab14l
RAB14, member RAS oncogene family, like
chr15_-_9443120 0.66 ENSDART00000177158
sacs
sacsin molecular chaperone
chr12_-_48278273 0.66

chr6_+_170792 0.66

chr2_-_1753058 0.65 ENSDART00000126566
slc22a23
solute carrier family 22, member 23
chr21_+_44833070 0.59 ENSDART00000065083
ENSDART00000168217
fstl4
follistatin-like 4
chr24_-_14068113 0.59 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr18_+_9524247 0.59 ENSDART00000053125
sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr7_+_36267647 0.57 ENSDART00000173653
chd9
chromodomain helicase DNA binding protein 9
chr12_+_34662699 0.56 ENSDART00000153097
slc38a10
solute carrier family 38, member 10
chr19_-_35642440 0.55 ENSDART00000167853
ENSDART00000054274
macf1a
microtubule-actin crosslinking factor 1a
chr1_+_44239727 0.54 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr15_-_47264693 0.52

chr10_+_34372205 0.48 ENSDART00000110121
stard13a
StAR-related lipid transfer (START) domain containing 13a
chr6_-_39346614 0.44 ENSDART00000104074
zgc:158846
zgc:158846
chr10_+_36096599 0.44

chr7_-_6215188 0.39 ENSDART00000159542
zgc:112234
zgc:112234
chr8_-_30233570 0.39 ENSDART00000143809
zgc:162939
zgc:162939
chr5_-_63531729 0.39 ENSDART00000171711
gpsm1a
G protein signaling modulator 1a
chr16_-_12375204 0.39 ENSDART00000113345
leng8
leukocyte receptor cluster (LRC) member 8
chr2_-_17721575 0.36 ENSDART00000141188
ENSDART00000100201
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr6_-_60088120 0.35

chr21_+_45622590 0.35 ENSDART00000162422
sar1b
secretion associated, Ras related GTPase 1B
chr1_+_44239682 0.34 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr2_-_49060868 0.34

chr6_-_23193873 0.33 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr1_+_48790583 0.32 ENSDART00000124833
pdcd11
programmed cell death 11
chr21_+_11151424 0.31 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr15_-_47264619 0.29

chr2_-_54909304 0.28 ENSDART00000100103
acss2l
acyl-CoA synthetase short-chain family member 2 like
chr2_-_6351592 0.27

chr20_+_50091972 0.25 ENSDART00000097865
ints9
integrator complex subunit 9
chr18_+_54352 0.25 ENSDART00000097163
SLC27A2 (1 of many)
solute carrier family 27 member 2
chr7_-_6221053 0.23 ENSDART00000173426
zgc:112234
zgc:112234
chr23_-_1008468 0.22 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr3_-_1421391 0.20 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr14_-_2873620 0.18

chr10_+_4874800 0.18 ENSDART00000165942
palm2
paralemmin 2
chr25_-_35820568 0.17 ENSDART00000152766
CR354435.4
Histone H2B 1/2
chr25_+_25369539 0.17 ENSDART00000150537
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr4_-_44665935 0.15 ENSDART00000150524
si:ch211-162i8.4
si:ch211-162i8.4
chr19_-_1376498 0.14 ENSDART00000158429
tmem42b
transmembrane protein 42b
chr10_+_34372283 0.10 ENSDART00000110121
stard13a
StAR-related lipid transfer (START) domain containing 13a
chr3_+_15645543 0.10

chr7_+_5846555 0.07 ENSDART00000083397
hist1h4l
histone 1, H4, like
chr6_+_30449742 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.8 2.3 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.2 2.3 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.7 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 0.6 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.1 0.6 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.4 GO:0070861 regulation of COPII vesicle coating(GO:0003400) regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.7 GO:0006895 phagolysosome assembly(GO:0001845) Golgi to endosome transport(GO:0006895)
0.1 0.9 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.3 GO:0043542 endothelial cell migration(GO:0043542)
0.0 1.6 GO:0007601 visual perception(GO:0007601)
0.0 0.9 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 2.4 GO:0000280 nuclear division(GO:0000280)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0014704 intercalated disc(GO:0014704)
0.1 0.6 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.1 GO:0016342 catenin complex(GO:0016342)
0.0 2.3 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 1.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 2.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.4 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.1 0.9 GO:0005344 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 3.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.2 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 2.9 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives