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Results for klf6a

Z-value: 0.85

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Transcription factors associated with klf6a

Gene Symbol Gene ID Gene Info
klf6a
ENSDARG00000029072 Kruppel-like factor 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf6adr10_dc_chr24_-_4117031_4117151-0.758.9e-04Click!

Activity profile of klf6a motif

Sorted Z-values of klf6a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of klf6a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_-_30256477 4.93 ENSDART00000137193
slbp2
stem-loop binding protein 2
chr9_-_55878791 2.50

chr19_-_48327666 2.07

KN149861v1_-_6661 1.61

chr7_+_24855467 1.49 ENSDART00000077217
zgc:101765
zgc:101765
chr22_-_111800 1.48 ENSDART00000163198
ENSDART00000168678
capzb
capping protein (actin filament) muscle Z-line, beta
chr7_+_45747622 1.47 ENSDART00000163991
ccne1
cyclin E1
KN149861v1_-_5655 1.47

chr12_+_23939657 1.40 ENSDART00000021298
asb3
ankyrin repeat and SOCS box containing 3
chr7_-_61373495 1.34 ENSDART00000098622
lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr23_-_43785497 1.26 ENSDART00000165963
ENSDARG00000102050
ENSDARG00000102050
chr7_-_45579815 1.25 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr6_-_6951460 1.21 ENSDART00000148879
nhej1
nonhomologous end-joining factor 1
KN149861v1_-_6916 1.19 ENSDART00000169003
5_8S_rRNA
5.8S ribosomal RNA
chr6_-_12268874 1.15

chr6_+_12268892 1.11 ENSDART00000171460
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr23_+_43785682 1.08 ENSDART00000172160
ENSDARG00000105093
ENSDARG00000105093
chr20_+_27041190 1.08 ENSDART00000164027
cdca4
cell division cycle associated 4
chr19_+_7717962 1.01 ENSDART00000112404
cgnb
cingulin b
KN149861v1_-_5543 0.99

chr2_+_25212281 0.99 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr6_+_27523853 0.96 ENSDART00000128985
ryk
receptor-like tyrosine kinase
chr7_-_61373339 0.93 ENSDART00000148270
lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr22_-_26537845 0.93

chr24_+_24581737 0.90 ENSDART00000137436
mtfr1
mitochondrial fission regulator 1
chr12_+_23939869 0.87 ENSDART00000021298
asb3
ankyrin repeat and SOCS box containing 3
chr20_+_27040570 0.86 ENSDART00000138369
cdca4
cell division cycle associated 4
chr4_-_1809690 0.78

chr21_-_2597788 0.73

chr24_+_36564831 0.70 ENSDART00000168060
zgc:114120
zgc:114120
chr13_-_11888896 0.70 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr17_+_6635602 0.70 ENSDART00000030773
foxo3a
forkhead box O3A
chr9_+_44921195 0.69 ENSDART00000145271
nckap1
NCK-associated protein 1
chr16_+_36118041 0.68 ENSDART00000166040
sh3bp5b
SH3-domain binding protein 5b (BTK-associated)
chr13_-_11888944 0.67 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr17_-_20264870 0.67

chr13_+_33578737 0.66 ENSDART00000161465
CABZ01087953.1
ENSDARG00000104106
chr6_+_27524145 0.61 ENSDART00000079397
ryk
receptor-like tyrosine kinase
chr22_+_10202801 0.61 ENSDART00000105900
si:dkeyp-87e7.4
si:dkeyp-87e7.4
chr17_-_20264762 0.60

chr13_-_33527029 0.59

chr6_-_60109646 0.56 ENSDART00000057463
ENSDART00000169188
pmepa1
prostate transmembrane protein, androgen induced 1
chr4_+_15007453 0.54 ENSDART00000146156
zc3hc1
zinc finger, C3HC-type containing 1
chr6_+_54568649 0.51 ENSDART00000157142
tead3b
TEA domain family member 3 b
chr15_-_45522055 0.45 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr19_-_24971920 0.38 ENSDART00000132660
polr3gla
polymerase (RNA) III (DNA directed) polypeptide G like a
chr16_-_7875908 0.36 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr4_+_344355 0.34 ENSDART00000142225
ENSDART00000163436
tmem181
transmembrane protein 181
chr7_-_23928945 0.31

chr17_+_6635649 0.29 ENSDART00000030773
foxo3a
forkhead box O3A
chr13_-_11888864 0.29 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr6_+_54568388 0.28 ENSDART00000093199
tead3b
TEA domain family member 3 b
chr5_-_43219303 0.28 ENSDART00000022481
mccc2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr21_+_43258389 0.28 ENSDART00000147026
shroom1
shroom family member 1
chr14_-_24304628 0.24

chr20_-_1248089 0.23 ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr16_+_34157948 0.23 ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr9_-_3524962 0.23 ENSDART00000136599
cybrd1
cytochrome b reductase 1
chr18_-_33832 0.22 ENSDART00000158957
ENSDART00000129125
pde8a
phosphodiesterase 8A
chr7_-_45747112 0.21 ENSDART00000172591
zgc:162297
zgc:162297
chr15_+_44514665 0.19

chr19_-_20522074 0.19 ENSDART00000043924
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr22_+_26840335 0.19 ENSDART00000158756
crebbpa
CREB binding protein a
chr7_-_45747162 0.18 ENSDART00000172591
zgc:162297
zgc:162297
chr14_-_32291093 0.12 ENSDART00000167282
ENSDART00000052938
atp11c
ATPase, Class VI, type 11C
chr3_-_30778523 0.07 ENSDART00000025046
ppp1caa
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr7_-_61373398 0.05 ENSDART00000098622
lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr9_+_8475950 0.03

chr20_+_54525614 0.03 ENSDART00000160409
arf6a
ADP-ribosylation factor 6a
chr6_-_18019342 0.02 ENSDART00000154941
ten1
TEN1 CST complex subunit
chr20_-_7186902 0.01 ENSDART00000012247
dhcr24
24-dehydrocholesterol reductase
chr3_-_15077819 0.00 ENSDART00000065807
kctd13
potassium channel tetramerization domain containing 13

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.9 GO:0040016 embryonic cleavage(GO:0040016)
0.2 1.0 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.2 1.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.0 GO:1902743 regulation of lamellipodium assembly(GO:0010591) regulation of lamellipodium organization(GO:1902743)
0.1 1.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 0.6 GO:0010991 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.7 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.2 GO:0070849 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 0.7 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 1.2 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.3 GO:0006552 leucine catabolic process(GO:0006552)
0.0 1.0 GO:0035329 hippo signaling(GO:0035329)
0.0 0.9 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.4 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.0 1.0 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 1.3 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 1.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.2 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.3 GO:1905202 methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.1 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.3 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0031526 brush border membrane(GO:0031526)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.2 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 1.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation