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Results for lef1
Z-value: 2.96
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Transcription factors associated with lef1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| lef1 | dr10_dc_chr1_+_49170967_49170990 | -0.83 | 6.2e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of lef1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_16683931 Show fit | 12.02 |
ENSDART00000103262
ENSDART00000145068 ENSDART00000169619 ENSDART00000010526 |
FAT atypical cadherin 1a |
|
| chr16_-_45950530 Show fit | 11.68 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr14_-_7774262 Show fit | 8.07 |
ENSDART00000045109
|
zgc:92242 |
|
| chr16_-_45943282 Show fit | 7.08 |
ENSDART00000133213
|
antifreeze protein type IV |
|
| chr4_-_11582061 Show fit | 6.53 |
ENSDART00000049066
|
neuroepithelial cell transforming 1 |
|
| chr21_-_37509454 Show fit | 6.24 |
ENSDART00000175126
|
fibroblast growth factor receptor 4 |
|
| chr18_+_24935499 Show fit | 5.99 |
|
|
|
| chr9_-_3700395 Show fit | 5.75 |
ENSDART00000102900
|
Sp5 transcription factor a |
|
| chr12_+_6432058 Show fit | 5.51 |
ENSDART00000066477
|
dickkopf WNT signaling pathway inhibitor 1b |
|
| chr1_-_50066633 Show fit | 5.26 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 18.8 | GO:0060030 | dorsal convergence(GO:0060030) |
| 1.0 | 15.6 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.8 | 9.2 | GO:0003209 | cardiac atrium morphogenesis(GO:0003209) |
| 0.7 | 8.8 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.1 | 8.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.5 | 7.6 | GO:0050810 | regulation of steroid biosynthetic process(GO:0050810) |
| 1.5 | 7.5 | GO:0060845 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.7 | 7.3 | GO:0006991 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.3 | 6.8 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 6.6 | GO:0021515 | cell differentiation in spinal cord(GO:0021515) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.2 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 22.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 20.6 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 11.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 8.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.4 | 8.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.4 | 7.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 6.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 6.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 5.2 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 50.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 30.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 11.5 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.7 | 9.9 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.8 | 8.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 8.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 8.2 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 7.7 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.5 | 7.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.7 | 7.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 6.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.5 | 5.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 5.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.3 | 3.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.4 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 3.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 3.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 2.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 7.6 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 6.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 5.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 5.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.8 | 4.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 3.8 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 3.8 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 3.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 2.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |