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Results for lef1

Z-value: 2.96

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Transcription factors associated with lef1

Gene Symbol Gene ID Gene Info
lef1
ENSDARG00000031894 lymphoid enhancer-binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lef1dr10_dc_chr1_+_49170967_49170990-0.836.2e-05Click!

Activity profile of lef1 motif

Sorted Z-values of lef1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of lef1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_16683931 12.02 ENSDART00000103262
ENSDART00000145068
ENSDART00000169619
ENSDART00000010526
fat1a
FAT atypical cadherin 1a
chr16_-_45950530 11.68 ENSDART00000060822
afp4
antifreeze protein type IV
chr14_-_7774262 8.07 ENSDART00000045109
zgc:92242
zgc:92242
chr16_-_45943282 7.08 ENSDART00000133213
afp4
antifreeze protein type IV
chr4_-_11582061 6.53 ENSDART00000049066
net1
neuroepithelial cell transforming 1
chr21_-_37509454 6.24 ENSDART00000175126
fgfr4
fibroblast growth factor receptor 4
chr18_+_24935499 5.99

chr9_-_3700395 5.75 ENSDART00000102900
sp5a
Sp5 transcription factor a
chr12_+_6432058 5.51 ENSDART00000066477
dkk1b
dickkopf WNT signaling pathway inhibitor 1b
chr1_-_50066633 5.26

chr9_+_25520011 5.05 ENSDART00000167110
itm2bb
integral membrane protein 2Bb
chr2_-_8219329 5.01 ENSDART00000040209
ephb3a
eph receptor B3a
chr21_-_20291707 4.96 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr15_-_24987099 4.93

chr5_+_41680352 4.93 ENSDART00000142855
tbx6l
T-box 6, like
chr6_-_45903830 4.86 ENSDART00000025428
epha2a
eph receptor A2 a
chr24_-_37680649 4.74 ENSDART00000056286
h1f0
H1 histone family, member 0
chr11_-_5868257 4.69 ENSDART00000104360
gamt
guanidinoacetate N-methyltransferase
chr16_+_23999029 4.61 ENSDART00000129525
apoa4b.1
apolipoprotein A-IV b, tandem duplicate 1
chr19_+_5375413 4.51 ENSDART00000141237
si:dkeyp-113d7.10
si:dkeyp-113d7.10
chr1_+_35933511 4.50 ENSDART00000010632
ednraa
endothelin receptor type Aa
chr5_+_34857986 4.28 ENSDART00000141239
erlin2
ER lipid raft associated 2
chr7_+_44373815 4.27 ENSDART00000170721
si:dkey-56m19.5
si:dkey-56m19.5
chr25_-_22089794 4.25 ENSDART00000139110
pkp3a
plakophilin 3a
chr14_+_7626822 4.18 ENSDART00000109941
cxxc5b
CXXC finger protein 5b
chr10_+_32160464 4.16 ENSDART00000099880
wnt11r
wingless-type MMTV integration site family, member 11, related
chr21_-_28883441 4.13 ENSDART00000132884
cxxc5a
CXXC finger protein 5a
chr5_+_26925238 4.11 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr16_+_40610589 4.10 ENSDART00000038294
tp53inp1
tumor protein p53 inducible nuclear protein 1
chr2_-_28446615 4.09 ENSDART00000179495
cdh6
cadherin 6
chr5_+_49093250 3.99 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr23_+_19827551 3.98 ENSDART00000073442
flna
filamin A, alpha (actin binding protein 280)
chr17_+_52736192 3.97 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr6_-_32106882 3.92 ENSDART00000144772
BX664614.1
ENSDARG00000095311
chr13_+_11305781 3.91

chr6_-_43094573 3.90 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr22_-_22337268 3.90

chr20_-_22576513 3.84 ENSDART00000103510
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr5_+_49093134 3.60 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr16_-_29779166 3.54 ENSDART00000067854
tnfaip8l2b
tumor necrosis factor, alpha-induced protein 8-like 2b
chr12_+_6007990 3.45 ENSDART00000091868
g6pca.2
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 2
chr1_+_9426040 3.43 ENSDART00000080576
lratb
lecithin retinol acyltransferase b (phosphatidylcholine-retinol O-acyltransferase)
chr23_+_32573474 3.43 ENSDART00000134811
si:dkey-261h17.1
si:dkey-261h17.1
chr3_-_35928594 3.41

chr25_+_18866796 3.40 ENSDART00000017299
tdg.1
thymine DNA glycosylase, tandem duplicate 1
chr4_-_25075693 3.38 ENSDART00000025153
gata3
GATA binding protein 3
chr18_-_36291570 3.38

chr8_-_41194452 3.38 ENSDART00000165949
fahd2a
fumarylacetoacetate hydrolase domain containing 2A
chr3_-_29846530 3.35 ENSDART00000077111
hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr7_-_16776026 3.34 ENSDART00000022441
dbx1a
developing brain homeobox 1a
chr25_+_34135377 3.28 ENSDART00000157519
trpm1b
transient receptor potential cation channel, subfamily M, member 1b
chr12_-_9400344 3.27 ENSDART00000003932
erbb2
erb-b2 receptor tyrosine kinase 2
chr15_+_23849554 3.25 ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr9_-_14533551 3.25 ENSDART00000056103
nrp2b
neuropilin 2b
chr11_-_29891067 3.23 ENSDART00000172106
scml2
sex comb on midleg-like 2 (Drosophila)
chr6_+_30441419 3.23

chr4_+_57435 3.22 ENSDART00000169187
ptpro
protein tyrosine phosphatase, receptor type, O
chr8_-_16662185 3.21 ENSDART00000076542
rpe65b
retinal pigment epithelium-specific protein 65b
chr24_-_4418454 3.21 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr7_-_54407681 3.20 ENSDART00000162795
ccnd1
cyclin D1
chr1_-_50831155 3.19 ENSDART00000152719
spred2a
sprouty-related, EVH1 domain containing 2a
chr12_-_30988279 3.19 ENSDART00000122972
ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
tcf7l2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr25_-_352985 3.14 ENSDART00000165705
szl
sizzled
chr6_-_40101104 3.13 ENSDART00000017402
ip6k2b
inositol hexakisphosphate kinase 2b
chr21_-_37286942 3.12 ENSDART00000100310
dbn1
drebrin 1
chr11_+_7518953 3.10 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr4_-_25226680 3.07 ENSDART00000066932
ENSDART00000066933
ENSDART00000157714
itih2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_3302116 3.06 ENSDART00000123096
marcksa
myristoylated alanine-rich protein kinase C substrate a
chr1_-_7456961 3.04 ENSDART00000152295
FAM83G
family with sequence similarity 83 member G
chr4_+_18974767 3.04 ENSDART00000066973
impdh1b
IMP (inosine 5'-monophosphate) dehydrogenase 1b
chr6_-_13000193 3.04

chr6_+_54703206 3.03 ENSDART00000074605
pkp1b
plakophilin 1b
chr2_+_48448974 3.03 ENSDART00000023040
hes6
hes family bHLH transcription factor 6
chr9_-_11589126 3.02 ENSDART00000146832
cryba2b
crystallin, beta A2b
chr4_+_292818 3.02 ENSDART00000103659
msgn1
mesogenin 1
chr6_+_6967174 3.01 ENSDART00000151311
ENSDARG00000058903
ENSDARG00000058903
chr11_-_29316162 3.00 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr4_-_8610868 2.99 ENSDART00000067322
fbxl14b
F-box and leucine-rich repeat protein 14b
chr14_-_36523075 2.96 ENSDART00000109293
rnf130
ring finger protein 130
chr16_-_32022177 2.95 ENSDART00000139664
styk1
serine/threonine/tyrosine kinase 1
chr16_+_5625301 2.95

chr20_+_6640497 2.92 ENSDART00000138361
tns3.2
tensin 3, tandem duplicate 2
chr22_+_16471319 2.89 ENSDART00000014330
ier5
immediate early response 5
chr18_+_5899355 2.87

chr14_-_40918015 2.87 ENSDART00000147389
tmem35
transmembrane protein 35
chr13_-_31310439 2.87 ENSDART00000076571
rtn1a
reticulon 1a
chr6_-_23193752 2.85 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr16_-_24697750 2.82 ENSDART00000163305
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr25_+_30746445 2.80 ENSDART00000156916
lsp1
lymphocyte-specific protein 1
chr8_-_38357549 2.80 ENSDART00000129597
sorbs3
sorbin and SH3 domain containing 3
chr16_+_24697776 2.80

chr24_-_23175007 2.79 ENSDART00000112256
zfhx4
zinc finger homeobox 4
chr23_-_9924987 2.78 ENSDART00000005015
prkcbp1l
protein kinase C binding protein 1, like
chr8_-_51767046 2.78 ENSDART00000007090
tbx16
T-box 16
chr18_+_45199548 2.77

chr7_+_25466534 2.77

chr25_-_12691849 2.74 ENSDART00000158551
slc7a5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr15_-_15532980 2.74 ENSDART00000004220
ENSDART00000131259
rab34a
RAB34, member RAS oncogene family a
chr25_-_33670713 2.74 ENSDART00000125036
foxb1a
forkhead box B1a
chr11_-_17620732 2.73 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr21_-_25567978 2.73 ENSDART00000133134
efemp2b
EGF containing fibulin-like extracellular matrix protein 2b
chr16_-_39951493 2.72

chr6_+_29800606 2.70 ENSDART00000017424
ptmaa
prothymosin, alpha a
chr12_-_5628401 2.69 ENSDART00000105884
itga3b
integrin, alpha 3b
chr13_+_27102308 2.67 ENSDART00000145901
rin2
Ras and Rab interactor 2
chr24_-_33817169 2.66 ENSDART00000079292
cavin4b
caveolae associated protein 4b
chr23_+_6043862 2.64

chr2_-_43110857 2.64 ENSDART00000098303
oc90
otoconin 90
chr9_-_39190534 2.63

chr23_-_35595271 2.62 ENSDART00000164616
tuba1c
tubulin, alpha 1c
chr14_-_25879853 2.62 ENSDART00000014149
fat2
FAT atypical cadherin 2
chr4_+_12033088 2.61 ENSDART00000044154
tnnt2c
troponin T2c, cardiac
chr1_+_25662652 2.61 ENSDART00000113020
tet2
tet methylcytosine dioxygenase 2
chr22_-_16015935 2.60 ENSDART00000062633
s1pr1
sphingosine-1-phosphate receptor 1
chr5_+_48031920 2.60 ENSDART00000008043
ENSDART00000171438
adgrv1
adhesion G protein-coupled receptor V1
KN149932v1_+_27584 2.60

chr13_+_7575753 2.58

chr15_+_28435937 2.57 ENSDART00000142298
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a
chr3_+_22246697 2.56 ENSDART00000155597
arhgap27l
Rho GTPase activating protein 27, like
chr14_-_205130 2.56 ENSDART00000035581
ENSDART00000158725
ENSDART00000163549
OTOP1
otopetrin 1
chr8_+_7740132 2.55 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr14_+_21999898 2.54

chr7_-_54407461 2.50 ENSDART00000162795
ccnd1
cyclin D1
chr9_-_42682501 2.47 ENSDART00000048320
tfpia
tissue factor pathway inhibitor a
chr23_+_23730717 2.46

chr2_-_57244608 2.45 ENSDART00000149235
tcf3a
transcription factor 3a
chr13_-_39033893 2.44 ENSDART00000045434
col9a1b
collagen, type IX, alpha 1b
chr11_-_36853345 2.44 ENSDART00000172074
NINJ1
ninjurin 1
chr13_+_27102377 2.43 ENSDART00000138043
rin2
Ras and Rab interactor 2
chr3_+_23591228 2.43 ENSDART00000012470
hoxb4a
homeobox B4a
chr13_+_11305846 2.40

chr22_-_20101177 2.40 ENSDART00000138688
creb3l3a
cAMP responsive element binding protein 3-like 3a
chr1_+_27174549 2.39 ENSDART00000102337
dnajb14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr4_-_2187291 2.38 ENSDART00000150490
ENSDARG00000009262
ENSDARG00000009262
chr23_+_27985224 2.37 ENSDART00000171859
ENSDARG00000100606
ENSDARG00000100606
chr21_+_23916512 2.36 ENSDART00000145541
ENSDART00000065599
ENSDART00000112869
cadm1a
cell adhesion molecule 1a
chr18_-_23889256 2.35 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr15_-_11257445 2.35

chr12_-_37560192 2.34 ENSDART00000140353
sdk2b
sidekick cell adhesion molecule 2b
chr4_-_73485028 2.34 ENSDART00000122898
phf21b
PHD finger protein 21B
chr10_+_18994733 2.33 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr9_-_34068225 2.32 ENSDART00000088441
ENSDART00000150035
si:ch73-147f11.1
si:ch73-147f11.1
chr21_-_41286846 2.32 ENSDART00000167339
msx2b
muscle segment homeobox 2b
chr21_-_39900518 2.31 ENSDART00000175055
CABZ01065291.1
ENSDARG00000107374
chr24_+_4946542 2.30 ENSDART00000045813
zic4
zic family member 4
chr7_-_38590391 2.29 ENSDART00000037361
ENSDART00000173629
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr9_-_42894582 2.29 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr8_-_23591082 2.28 ENSDART00000025024
slc38a5b
solute carrier family 38, member 5b
chr4_-_73484546 2.28

chr21_+_45227200 2.27 ENSDART00000155681
ENSDART00000157136
tcf7
transcription factor 7 (T-cell specific, HMG-box)
chr5_+_42406222 2.26 ENSDART00000009182
aqp3a
aquaporin 3a
chr15_-_4154407 2.25 ENSDART00000090624
lpar6a
lysophosphatidic acid receptor 6a
chr7_+_48532749 2.25 ENSDART00000145375
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr11_-_42934175 2.24 ENSDART00000172929
sptbn1
spectrin, beta, non-erythrocytic 1
chr9_+_25117850 2.24

chr3_+_23587156 2.22

chr15_-_26703761 2.22 ENSDART00000087632
ENSDARG00000079340
ENSDARG00000079340
chr8_-_38168395 2.21 ENSDART00000155189
pdlim2
PDZ and LIM domain 2 (mystique)
chr12_-_30662709 2.21 ENSDART00000126466
entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr8_+_14120313 2.18 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr17_+_24613874 2.17 ENSDART00000093004
map4k3b
mitogen-activated protein kinase kinase kinase kinase 3b
chr1_-_35419335 2.17 ENSDART00000037516
znf827
zinc finger protein 827
chr7_-_52142689 2.16 ENSDART00000110265
myzap
myocardial zonula adherens protein
chr10_+_7125001 2.16 ENSDART00000157987
psd3l
pleckstrin and Sec7 domain containing 3, like
chr25_-_18855316 2.16 ENSDART00000155927
si:ch211-68a17.7
si:ch211-68a17.7
chr11_-_29586549 2.16 ENSDART00000079149
xk
X-linked Kx blood group (McLeod syndrome)
chr13_-_7434672 2.15 ENSDART00000159453
h2afy2
H2A histone family, member Y2
chr18_-_23888988 2.14 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_+_30048913 2.13

chr11_-_22966274 2.13 ENSDART00000003646
optc
opticin
chr21_+_10663517 2.13 ENSDART00000074833
rx3
retinal homeobox gene 3
chr7_-_72500748 2.11 ENSDART00000160523
CU929444.1
ENSDARG00000099109
chr24_+_18804086 2.11 ENSDART00000106186
prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr16_-_9785057 2.10 ENSDART00000113724
mal2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr18_+_40365208 2.09 ENSDART00000167134
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr6_-_43094926 2.09 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr17_-_12343975 2.09 ENSDART00000149551
emilin1b
elastin microfibril interfacer 1b
chr10_+_38582701 2.08 ENSDART00000144329
acer3
alkaline ceramidase 3
chr17_-_20877606 2.07 ENSDART00000088106
ank3a
ankyrin 3a
chr15_-_31687 2.04

chr25_-_5835981 2.03 ENSDART00000155751
nuak1b
NUAK family, SNF1-like kinase, 1b
chr9_-_23081250 2.03

chr2_+_38178934 2.02 ENSDART00000044264
mmp14b
matrix metallopeptidase 14b (membrane-inserted)
chr16_+_33041823 2.01 ENSDART00000170157
prss35
protease, serine, 35
chr25_+_19992389 2.01 ENSDART00000143441
tnni4b.2
troponin I4b, tandem duplicate 2
chr17_+_24830545 2.01 ENSDART00000062917
cx35.4
connexin 35.4
chr3_-_39287733 2.00

chr1_-_18709814 2.00 ENSDART00000145224
rbm47
RNA binding motif protein 47
chr21_-_26973987 1.99 ENSDART00000126542
ppp1r14ba
protein phosphatase 1, regulatory (inhibitor) subunit 14Ba
chr20_-_37587804 1.98 ENSDART00000166106
si:ch211-202p1.5
si:ch211-202p1.5
chr10_+_9716807 1.98 ENSDART00000064977
si:ch211-243g18.2
si:ch211-243g18.2
chr8_+_33010788 1.97 ENSDART00000172672
angptl2b
angiopoietin-like 2b
chr16_+_5625552 1.97

chr12_-_5628248 1.97 ENSDART00000105884
itga3b
integrin, alpha 3b
chr20_-_48677794 1.96 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr6_+_11594333 1.96 ENSDART00000109552
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr25_+_31547276 1.95 ENSDART00000090727
duox
dual oxidase
chr13_+_28601627 1.94 ENSDART00000015773
ldb1a
LIM domain binding 1a
chr18_-_23889025 1.94 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_+_54231519 1.94 ENSDART00000149542
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
1.9 5.8 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
1.8 5.5 GO:0061011 hepatic duct development(GO:0061011)
1.8 5.3 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
1.6 4.7 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
1.5 7.5 GO:0060845 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
1.3 3.8 GO:0048914 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
1.2 5.8 GO:1903019 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
1.1 4.5 GO:0019532 oxalate transport(GO:0019532)
1.1 3.3 GO:2000583 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
1.0 15.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.0 5.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) mitotic G1 DNA damage checkpoint(GO:0031571) positive regulation of cell cycle G2/M phase transition(GO:1902751)
1.0 5.1 GO:0045582 positive regulation of T cell differentiation(GO:0045582)
0.9 2.7 GO:0061378 associative learning(GO:0008306) visual learning(GO:0008542) mammillary axonal complex development(GO:0061373) mammillothalamic axonal tract development(GO:0061374) corpora quadrigemina development(GO:0061378) inferior colliculus development(GO:0061379) cell migration in diencephalon(GO:0061381)
0.9 2.6 GO:0051350 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.9 6.0 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.8 5.0 GO:0051963 regulation of synapse assembly(GO:0051963) positive regulation of synapse assembly(GO:0051965)
0.8 3.2 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.8 3.2 GO:0010226 response to lithium ion(GO:0010226)
0.8 3.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.8 9.2 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.7 4.1 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.7 2.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.7 8.8 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 7.3 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.7 2.0 GO:0014829 phasic smooth muscle contraction(GO:0014821) vascular smooth muscle contraction(GO:0014829) endocrine process(GO:0050886)
0.6 2.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.6 1.9 GO:0042554 superoxide anion generation(GO:0042554)
0.6 18.8 GO:0060030 dorsal convergence(GO:0060030)
0.6 4.5 GO:0042310 vasoconstriction(GO:0042310)
0.6 3.8 GO:0003315 heart rudiment formation(GO:0003315)
0.6 3.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 1.7 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.6 1.1 GO:0006699 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.6 3.3 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.5 2.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.5 2.6 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.5 2.6 GO:0006211 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.5 2.0 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.5 2.3 GO:0033151 V(D)J recombination(GO:0033151)
0.5 4.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.4 1.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.4 2.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.4 2.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.4 3.2 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.4 1.2 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.4 1.2 GO:1902024 serine transport(GO:0032329) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.4 2.0 GO:2000742 regulation of anterior head development(GO:2000742)
0.4 1.2 GO:1902893 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.4 1.1 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.4 1.1 GO:0042423 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.4 2.2 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.4 3.9 GO:0033292 T-tubule organization(GO:0033292)
0.3 2.1 GO:0045056 transcytosis(GO:0045056)
0.3 1.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 2.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.3 1.9 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.3 3.5 GO:0006183 GTP biosynthetic process(GO:0006183)
0.3 1.6 GO:0090317 negative regulation of intracellular protein transport(GO:0090317)
0.3 1.5 GO:0030316 osteoclast differentiation(GO:0030316)
0.3 1.7 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.3 6.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 2.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 1.7 GO:0007398 ectoderm development(GO:0007398)
0.2 1.2 GO:0090104 pancreatic epsilon cell differentiation(GO:0090104)
0.2 2.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.2 1.6 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 1.1 GO:0006833 water transport(GO:0006833)
0.2 0.8 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.2 1.5 GO:0021703 rhombomere 5 development(GO:0021571) rhombomere 6 development(GO:0021572) locus ceruleus development(GO:0021703)
0.2 0.6 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2 0.6 GO:0008347 glial cell migration(GO:0008347)
0.2 3.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 4.5 GO:0006937 regulation of muscle contraction(GO:0006937)
0.2 0.8 GO:0021547 midbrain-hindbrain boundary initiation(GO:0021547)
0.2 3.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 1.6 GO:0000729 DNA double-strand break processing(GO:0000729)
0.2 1.9 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.2 0.7 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 3.7 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.2 0.9 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.2 1.8 GO:0061099 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 1.8 GO:0046686 response to cadmium ion(GO:0046686)
0.2 2.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 0.6 GO:1901998 toxin transport(GO:1901998)
0.1 1.5 GO:0072576 liver morphogenesis(GO:0072576)
0.1 1.0 GO:1902534 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805) single-organism membrane invagination(GO:1902534)
0.1 2.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 3.3 GO:0060401 cytosolic calcium ion transport(GO:0060401) calcium ion transport into cytosol(GO:0060402)
0.1 1.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 2.3 GO:0015807 L-amino acid transport(GO:0015807)
0.1 2.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 3.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 3.2 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.1 0.9 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 6.6 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.1 0.9 GO:0008272 sulfate transport(GO:0008272)
0.1 1.5 GO:0001840 neural plate development(GO:0001840)
0.1 0.8 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 6.0 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.1 0.5 GO:0055062 regulation of fat cell differentiation(GO:0045598) phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.1 0.7 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.6 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012) ventricular cardiac muscle cell development(GO:0055015)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 2.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.9 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 1.6 GO:0032526 response to retinoic acid(GO:0032526)
0.1 1.1 GO:0043584 nose development(GO:0043584)
0.1 0.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 1.5 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 3.2 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) actin filament capping(GO:0051693)
0.1 1.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 2.5 GO:0060119 inner ear receptor cell development(GO:0060119)
0.1 2.7 GO:0007596 blood coagulation(GO:0007596) hemostasis(GO:0007599)
0.1 3.3 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 0.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.2 GO:0061056 sclerotome development(GO:0061056)
0.1 4.7 GO:0009880 embryonic pattern specification(GO:0009880)
0.1 0.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 8.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 4.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 0.5 GO:0051601 exocyst localization(GO:0051601)
0.1 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 1.8 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 2.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 0.4 GO:0043114 regulation of vascular permeability(GO:0043114)
0.1 0.5 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 3.5 GO:0007601 visual perception(GO:0007601)
0.1 0.6 GO:0010717 regulation of epithelial to mesenchymal transition(GO:0010717)
0.1 1.2 GO:0060349 bone morphogenesis(GO:0060349)
0.1 4.4 GO:0010721 negative regulation of cell development(GO:0010721)
0.1 0.2 GO:0060911 cardiac cell fate commitment(GO:0060911)
0.1 0.5 GO:0021654 rhombomere boundary formation(GO:0021654)
0.1 5.3 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 2.3 GO:0046148 pigment biosynthetic process(GO:0046148)
0.1 1.2 GO:0039021 pronephric glomerulus development(GO:0039021)
0.1 1.9 GO:0000460 maturation of 5.8S rRNA(GO:0000460) maturation of LSU-rRNA(GO:0000470)
0.1 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.1 0.6 GO:0042476 odontogenesis(GO:0042476)
0.1 3.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.2 GO:0051026 chiasma assembly(GO:0051026) meiotic metaphase plate congression(GO:0051311)
0.1 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.5 GO:0030901 midbrain development(GO:0030901)
0.0 5.6 GO:0045087 innate immune response(GO:0045087)
0.0 2.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.7 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 1.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.0 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 1.1 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.5 GO:0060974 cell migration involved in heart formation(GO:0060974)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 4.8 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 0.2 GO:0071938 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 4.5 GO:0006869 lipid transport(GO:0006869)
0.0 0.2 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.4 GO:0070509 calcium ion import(GO:0070509)
0.0 0.7 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.2 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.1 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.3 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.8 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 3.2 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 1.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.4 GO:0009408 response to heat(GO:0009408)
0.0 0.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.0 0.4 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.8 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.2 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.5 GO:0030641 regulation of cellular pH(GO:0030641)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.8 2.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 2.6 GO:0032420 photoreceptor inner segment(GO:0001917) stereocilium(GO:0032420)
0.4 2.2 GO:0008091 spectrin(GO:0008091)
0.4 8.2 GO:0005861 troponin complex(GO:0005861)
0.4 7.3 GO:0030057 desmosome(GO:0030057)
0.3 3.8 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.3 GO:0071818 BAT3 complex(GO:0071818)
0.3 1.2 GO:0032019 mitochondrial cloud(GO:0032019)
0.2 4.1 GO:0016342 catenin complex(GO:0016342)
0.2 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 2.9 GO:0045178 basal part of cell(GO:0045178) basal cortex(GO:0045180)
0.2 8.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 4.1 GO:0032587 ruffle membrane(GO:0032587)
0.2 3.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 4.8 GO:0008305 integrin complex(GO:0008305)
0.2 1.8 GO:0035060 brahma complex(GO:0035060)
0.2 1.2 GO:0089701 U2AF(GO:0089701)
0.1 2.1 GO:0030315 T-tubule(GO:0030315)
0.1 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:1902560 GMP reductase complex(GO:1902560)
0.1 3.9 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 0.9 GO:0071256 translocon complex(GO:0071256)
0.1 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.1 20.6 GO:0043235 receptor complex(GO:0043235)
0.1 0.7 GO:0014704 intercalated disc(GO:0014704)
0.1 4.1 GO:0005776 autophagosome(GO:0005776)
0.1 1.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.1 GO:0071564 npBAF complex(GO:0071564)
0.1 2.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 5.2 GO:0005882 intermediate filament(GO:0005882)
0.1 1.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 4.1 GO:0030018 Z disc(GO:0030018)
0.1 0.3 GO:0044304 main axon(GO:0044304)
0.1 0.6 GO:0005902 microvillus(GO:0005902)
0.1 2.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 1.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 6.5 GO:0009986 cell surface(GO:0009986)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.8 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 6.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 22.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 4.2 GO:0030425 dendrite(GO:0030425)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.7 GO:0071004 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 24.2 GO:0005576 extracellular region(GO:0005576)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.5 GO:0030175 filopodium(GO:0030175)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 11.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.8 GO:0005925 focal adhesion(GO:0005925)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.4 GO:0099513 supramolecular fiber(GO:0099512) polymeric cytoskeletal fiber(GO:0099513)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0039706 co-receptor binding(GO:0039706)
1.1 5.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
1.0 4.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.8 8.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 2.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.8 2.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.7 9.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.7 2.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.7 7.5 GO:0001972 retinoic acid binding(GO:0001972)
0.7 2.7 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.6 1.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174) superoxide-generating NADPH oxidase activity(GO:0016175)
0.6 3.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.6 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.6 4.5 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.5 2.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.5 1.9 GO:0030274 LIM domain binding(GO:0030274)
0.5 3.3 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.5 7.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 1.8 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.4 1.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.4 3.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.3 2.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.3 1.0 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.3 1.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 4.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 2.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 1.5 GO:0005035 death receptor activity(GO:0005035)
0.3 1.2 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.3 2.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 3.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.3 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 0.8 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.3 11.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 2.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 1.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 2.2 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 1.8 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.2 1.3 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.2 1.1 GO:0015250 water transmembrane transporter activity(GO:0005372) water channel activity(GO:0015250)
0.2 2.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 7.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 7.1 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.2 0.7 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.2 2.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.7 GO:0019215 intermediate filament binding(GO:0019215)
0.1 2.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.9 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 4.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 2.7 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.4 GO:0019960 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 1.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.9 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.6 GO:0030546 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.1 4.3 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.5 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.4 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 6.8 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 4.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 3.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 4.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 4.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.5 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 1.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.6 GO:0005518 collagen binding(GO:0005518)
0.1 1.6 GO:0044325 ion channel binding(GO:0044325)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.8 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.7 GO:0005179 hormone activity(GO:0005179)
0.1 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 30.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0034632 retinol binding(GO:0019841) retinol transporter activity(GO:0034632)
0.0 50.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.1 GO:0030215 semaphorin receptor binding(GO:0030215) chemorepellent activity(GO:0045499)
0.0 3.3 GO:0003678 DNA helicase activity(GO:0003678)
0.0 3.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 8.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 8.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 3.0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 0.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.0 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 5.1 PID IL27 PATHWAY IL27-mediated signaling events
0.3 3.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 2.6 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 2.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 2.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 6.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.9 PID AP1 PATHWAY AP-1 transcription factor network
0.1 0.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 1.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.8 4.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.7 1.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.4 2.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 3.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 6.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 5.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 2.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 1.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.2 5.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 0.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.6 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.1 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 6.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 0.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 3.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 2.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 0.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors