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Results for lhx1a+lhx1b

Z-value: 0.31

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Transcription factors associated with lhx1a+lhx1b

Gene Symbol Gene ID Gene Info
lhx1b
ENSDARG00000007944 LIM homeobox 1b
lhx1a
ENSDARG00000014018 LIM homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx1bdr10_dc_chr5_+_55598181_555982200.774.7e-04Click!
lhx1adr10_dc_chr15_-_27778111_277781610.683.7e-03Click!

Activity profile of lhx1a+lhx1b motif

Sorted Z-values of lhx1a+lhx1b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx1a+lhx1b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_32686790 0.96 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr1_+_13779755 0.87

chr20_-_45908435 0.67 ENSDART00000147637
fermt1
fermitin family member 1
chr12_-_17590507 0.66 ENSDART00000010144
pvalb2
parvalbumin 2
chr1_-_674449 0.66 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr21_-_1716495 0.58 ENSDART00000151049
onecut2
one cut homeobox 2
chr19_-_5851328 0.51 ENSDART00000133106
si:ch211-264f5.6
si:ch211-264f5.6
chr3_-_19218660 0.45 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr20_-_9107294 0.43 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr17_+_15425559 0.42 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr4_+_9668755 0.40 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr24_+_35500964 0.37 ENSDART00000058571
snai2
snail family zinc finger 2
chr4_+_16896821 0.37 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr9_-_14533551 0.34 ENSDART00000056103
nrp2b
neuropilin 2b
chr17_+_49198580 0.31 ENSDART00000059255
ENSDART00000155599
zgc:113176
zgc:113176
chr13_+_516287 0.30 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr2_+_20748431 0.30 ENSDART00000137848
palmda
palmdelphin a
chr15_-_14616083 0.30 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr3_+_47735048 0.28 ENSDART00000083024
gpr146
G protein-coupled receptor 146
chr2_+_38390887 0.26 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr24_+_21395671 0.26 ENSDART00000091529
wasf3b
WAS protein family, member 3b
chr8_+_21974863 0.26

chr12_-_7902815 0.25 ENSDART00000088100
ank3b
ankyrin 3b
chr19_+_5562107 0.25 ENSDART00000082080
jupb
junction plakoglobin b
chr3_-_15849644 0.24 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr1_+_50395721 0.24 ENSDART00000134065
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr5_-_31301280 0.23 ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr10_-_11303185 0.23 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr9_-_8035360 0.22

chr22_-_36561247 0.22 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr11_+_30416115 0.21 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr3_-_26657213 0.19

chr11_-_41241693 0.19 ENSDART00000002556
mrto4
MRT4 homolog, ribosome maturation factor
chr2_-_49114158 0.19

chr10_+_11303321 0.17 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr18_+_46384462 0.17 ENSDART00000024202
daw1
dynein assembly factor with WDR repeat domains 1
chr2_-_2782967 0.17 ENSDART00000057458
CABZ01088149.1
ENSDARG00000039322
chr16_-_28921444 0.17 ENSDART00000078543
syt11b
synaptotagmin XIb
chr7_+_25052687 0.17 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr23_-_32043229 0.16 ENSDART00000134550
ormdl2
ORMDL sphingolipid biosynthesis regulator 2
chr6_+_35069401 0.16 ENSDART00000082940
uhmk1
U2AF homology motif (UHM) kinase 1
chr2_+_51087570 0.16

chr20_-_28739099 0.16 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr14_-_33604914 0.16 ENSDART00000168546
zdhhc24
zinc finger, DHHC-type containing 24
chr9_+_34832049 0.15 ENSDART00000100735
ENSDART00000133996
shox
short stature homeobox
chr14_-_6901415 0.14 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr10_+_6120218 0.14 ENSDART00000166799
ENSDART00000157947
tln1
talin 1
chr8_+_43334181 0.14 ENSDART00000038566
fam101a
family with sequence similarity 101, member A
chr11_-_25017693 0.13

chr21_+_6046450 0.13 ENSDART00000131854
si:dkey-93m18.6
si:dkey-93m18.6
chr23_-_4470717 0.12 ENSDART00000081823
si:ch73-142c19.1
si:ch73-142c19.1
chr18_-_43890514 0.11 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr8_+_19471914 0.11 ENSDART00000159044
sec22bb
SEC22 homolog B, vesicle trafficking protein b
chr7_+_22539037 0.10 ENSDART00000020212
sf1
splicing factor 1
chr13_+_516496 0.10 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr17_+_25425967 0.10 ENSDART00000030691
clic4
chloride intracellular channel 4
chr17_-_32471070 0.10

chr13_+_516546 0.10 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr13_-_29290894 0.09 ENSDART00000150228
chata
choline O-acetyltransferase a
chr5_+_3721680 0.09 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr22_-_19527759 0.09 ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr5_+_18826505 0.09

chr4_+_5246465 0.09 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr10_-_20545884 0.08

chr3_+_3994248 0.08

chr23_+_20714105 0.08 ENSDART00000054691
uba1
ubiquitin-like modifier activating enzyme 1
chr22_-_12905648 0.08 ENSDART00000157820
mfsd6a
major facilitator superfamily domain containing 6a
chr3_+_50511676 0.08 ENSDART00000102202
ppap2d
phosphatidic acid phosphatase type 2D
chr22_-_12130441 0.08 ENSDART00000146785
tmem163b
transmembrane protein 163b
chr7_-_5366526 0.07

chr3_+_27667194 0.07 ENSDART00000075100
carhsp1
calcium regulated heat stable protein 1
chr5_+_45823481 0.07

chr7_+_22538681 0.07 ENSDART00000020212
sf1
splicing factor 1
chr2_+_1881022 0.07 ENSDART00000101038
tmie
transmembrane inner ear
chr14_-_1187074 0.06 ENSDART00000106672
arl9
ADP-ribosylation factor-like 9
chr2_-_16548451 0.06 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr5_-_37494209 0.06 ENSDART00000084890
si:ch211-284e13.4
si:ch211-284e13.4
chr6_-_50731538 0.06 ENSDART00000157153
pigu
phosphatidylinositol glycan anchor biosynthesis, class U
chr2_+_51087643 0.06

chr2_+_25659945 0.06 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr12_+_1286911 0.05 ENSDART00000168225
ENSDART00000157467
pemt
phosphatidylethanolamine N-methyltransferase
chr6_+_14854101 0.05 ENSDART00000087782
mrps9
mitochondrial ribosomal protein S9
chr11_+_11284030 0.04 ENSDART00000026814
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr8_-_45752084 0.04 ENSDART00000025620
ppiaa
peptidylprolyl isomerase Aa (cyclophilin A)
chr15_-_21003820 0.04 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr16_+_54350976 0.03 ENSDART00000172622
ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr13_-_51743395 0.03

chr14_-_14302241 0.03 ENSDART00000162322
rab9b
RAB9B, member RAS oncogene family
chr8_-_12253026 0.03 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr21_+_6858020 0.03 ENSDART00000139493
olfm1b
olfactomedin 1b
chr13_+_33138144 0.03 ENSDART00000002095
tmem39b
transmembrane protein 39B
chr15_-_36490729 0.03

chr6_-_35068708 0.02 ENSDART00000170116
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr21_-_13875945 0.02 ENSDART00000143874
akna
AT-hook transcription factor
chr24_+_16402613 0.02 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr12_+_48497255 0.02 ENSDART00000168389
arhgap44
Rho GTPase activating protein 44
chr22_-_4867538 0.02 ENSDART00000081801
ncl1
nicalin
chr1_+_9634016 0.02 ENSDART00000029774
tmem55bb
transmembrane protein 55Bb
chr24_+_26183653 0.01 ENSDART00000003884
mynn
myoneurin
chr7_-_52113622 0.01 ENSDART00000174186
wdr93
WD repeat domain 93
KN150706v1_+_7627 0.01

chr22_+_1691850 0.01 ENSDART00000170471
si:dkey-1b17.9
si:dkey-1b17.9
chr7_+_24787720 0.01

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 0.2 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.5 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.3 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.2 GO:0046822 regulation of nucleocytoplasmic transport(GO:0046822)
0.0 0.1 GO:0019884 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.3 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.7 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665) DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.2 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis