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Results for lmx1a

Z-value: 0.54

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Transcription factors associated with lmx1a

Gene Symbol Gene ID Gene Info
lmx1a
ENSDARG00000020354 LIM homeobox transcription factor 1, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lmx1adr10_dc_chr20_+_34021116_34021138-0.774.3e-04Click!

Activity profile of lmx1a motif

Sorted Z-values of lmx1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of lmx1a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_-_782643 1.57 ENSDART00000161084
si:dkey-205h23.1
si:dkey-205h23.1
chr12_+_25509394 1.44 ENSDART00000077157
six3b
SIX homeobox 3b
chr8_-_26623251 1.42 ENSDART00000159264
sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr7_+_6814828 1.35 ENSDART00000001649
actn3b
actinin alpha 3b
chr20_-_45908435 1.32 ENSDART00000147637
fermt1
fermitin family member 1
chr14_-_17257773 1.26 ENSDART00000082667
fgfrl1a
fibroblast growth factor receptor-like 1a
chr20_-_9107294 1.09 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr3_+_49277125 1.03 ENSDART00000161724
gas7a
growth arrest-specific 7a
chr1_+_13779755 1.02

chr2_-_49114158 0.98

chr21_-_1716495 0.89 ENSDART00000151049
onecut2
one cut homeobox 2
chr7_+_25052687 0.79 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr6_+_8895437 0.79 ENSDART00000162588
rgn
regucalcin
chr18_+_46384462 0.75 ENSDART00000024202
daw1
dynein assembly factor with WDR repeat domains 1
chr17_+_30352361 0.75 ENSDART00000076611
greb1
growth regulation by estrogen in breast cancer 1
chr6_-_43679553 0.71 ENSDART00000150128
foxp1b
forkhead box P1b
chr16_-_16244210 0.64 ENSDART00000012718
fabp11b
fatty acid binding protein 11b
chr1_-_674449 0.62 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr19_+_5562107 0.62 ENSDART00000082080
jupb
junction plakoglobin b
chr5_-_31301280 0.61 ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr13_-_29290894 0.58 ENSDART00000150228
chata
choline O-acetyltransferase a
chr16_-_28921444 0.52 ENSDART00000078543
syt11b
synaptotagmin XIb
chr22_-_12130441 0.50 ENSDART00000146785
tmem163b
transmembrane protein 163b
chr9_+_34832049 0.50 ENSDART00000100735
ENSDART00000133996
shox
short stature homeobox
chr18_-_605558 0.49 ENSDART00000157564
wtip
WT1 interacting protein
chr2_-_30005139 0.49 ENSDART00000146968
cnpy1
canopy1
chr9_-_43736549 0.49 ENSDART00000140526
znf385b
zinc finger protein 385B
chr8_+_43334181 0.48 ENSDART00000038566
fam101a
family with sequence similarity 101, member A
chr4_-_20091845 0.47

chr10_+_11303321 0.45 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr12_+_18559530 0.44 ENSDART00000152948
rgs9b
regulator of G protein signaling 9b
chr24_+_24316486 0.44 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr7_+_21006803 0.43 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr22_-_12905648 0.43 ENSDART00000157820
mfsd6a
major facilitator superfamily domain containing 6a
chr18_-_43890514 0.42 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr14_-_14302241 0.41 ENSDART00000162322
rab9b
RAB9B, member RAS oncogene family
chr21_-_5692160 0.40 ENSDART00000075137
ENSDART00000151202
ccni
cyclin I
chr17_+_25425967 0.40 ENSDART00000030691
clic4
chloride intracellular channel 4
chr5_+_45823481 0.38

chr1_-_9256864 0.37 ENSDART00000041849
tmem8a
transmembrane protein 8A
chr8_-_12253026 0.35 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr8_-_14446883 0.32 ENSDART00000057644
lhx4
LIM homeobox 4
chr13_+_32609784 0.30 ENSDART00000160138
sobpa
sine oculis binding protein homolog (Drosophila) a
chr3_+_27667194 0.29 ENSDART00000075100
carhsp1
calcium regulated heat stable protein 1
chr15_+_32940372 0.24 ENSDART00000170098
spg20b
spastic paraplegia 20b (Troyer syndrome)
chr24_+_24316408 0.22 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr19_-_46058123 0.22

chr21_+_42893361 0.20

chr13_+_32609849 0.20 ENSDART00000160138
sobpa
sine oculis binding protein homolog (Drosophila) a
chr2_-_16548451 0.17 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr7_+_7463292 0.16 ENSDART00000091099
ino80b
INO80 complex subunit B
chr24_+_24316346 0.13 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr1_+_9634016 0.10 ENSDART00000029774
tmem55bb
transmembrane protein 55Bb
chr2_+_1881022 0.10 ENSDART00000101038
tmie
transmembrane inner ear
chr23_+_17952613 0.09 ENSDART00000156331
si:ch73-390p7.2
si:ch73-390p7.2
chr11_-_23333850 0.08

chr16_+_2582656 0.06 ENSDART00000092299
ENSDARG00000073784
ENSDARG00000073784
chr18_+_1353857 0.06 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr7_+_58427742 0.06 ENSDART00000073640
plag1
pleiomorphic adenoma gene 1
chr18_+_8362131 0.04 ENSDART00000092053
chkb
choline kinase beta
chr6_+_40924749 0.03 ENSDART00000133599
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr1_+_9633924 0.02 ENSDART00000029774
tmem55bb
transmembrane protein 55Bb

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 0.8 GO:0042364 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364) regulation of calcium-mediated signaling(GO:0050848)
0.1 0.4 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.3 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.6 GO:0008291 neuromuscular synaptic transmission(GO:0007274) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 1.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.2 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.7 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.3 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.7 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 1.4 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.5 GO:0030282 bone mineralization(GO:0030282)
0.0 0.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 1.0 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 1.4 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease