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Results for mbd2

Z-value: 1.02

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Transcription factors associated with mbd2

Gene Symbol Gene ID Gene Info
ENSDARG00000075952 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mbd2dr10_dc_chr5_-_1102450_1102556-0.087.7e-01Click!

Activity profile of mbd2 motif

Sorted Z-values of mbd2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of mbd2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_-_33816 3.81 ENSDART00000170044
apolipoprotein A-Ib
chr8_+_25880895 2.91 ENSDART00000124300
ras homolog gene family, member Ab
chr12_+_5673442 2.77 ENSDART00000017191
distal-less homeobox 3b
chr24_-_35811390 2.72 ENSDART00000167990
microtubule-associated protein, RP/EB family, member 2
chr18_+_62936 2.62 ENSDART00000052638
solute carrier family 27 (fatty acid transporter), member 2a
chr9_+_54185607 2.57 ENSDART00000165991
leukocyte cell derived chemotaxin 1
chr17_-_124685 2.37 ENSDART00000158825
actin, alpha, cardiac muscle 1b
chr5_-_34016383 2.30 ENSDART00000050271
ENSDART00000097975
hexosaminidase B (beta polypeptide)
chr3_-_25683205 2.24 ENSDART00000169706
netrin 1b
chr4_-_76594677 2.09 ENSDART00000049170
zgc:85975
chr14_-_23953804 2.07 ENSDART00000114169
BCL2/adenovirus E1B interacting protein 1a
chr4_+_16896821 1.99 ENSDART00000017726
ethanolamine kinase 1
chr2_-_816669 1.96 ENSDART00000122732
forkhead box C1a
chr24_+_4341242 1.75 ENSDART00000133360
cyclin Y
chr20_+_16843502 1.72 ENSDART00000050308
calmodulin 1b
chr12_+_27370834 1.63 ENSDART00000105661
mesenchyme homeobox 1
chr24_+_252774 1.58 ENSDART00000178656
ENSDART00000175867
ENSDARG00000107432
chr10_-_27037704 1.53 ENSDART00000146085
si:dkey-88p24.11
chr8_+_15987710 1.49 ENSDART00000165141
ELAV like neuron-specific RNA binding protein 4
chr9_+_44233139 1.47 ENSDART00000162406
integrin alpha 4
chr21_+_1117194 1.42 ENSDART00000178294
ENSDARG00000107408
chr12_+_25509394 1.42 ENSDART00000077157
SIX homeobox 3b
chr25_-_28054271 1.38

chr13_-_1278448 1.35 ENSDART00000049684
BCL2-associated athanogene 2
chr4_-_24298688 1.33 ENSDART00000077926
ENSDART00000128368
cugbp, Elav-like family member 2
chr1_+_46824595 1.32

chr6_-_23193752 1.32 ENSDART00000159749
ubiquitin specific peptidase 43a
chr16_+_5778650 1.29 ENSDART00000131575
zgc:158689
chr10_-_16268235 1.28

chr16_+_21109486 1.28 ENSDART00000079383
homeobox A9b
chr10_+_22566353 1.25 ENSDART00000079514
ephrin-B3a
chr21_+_22797283 1.24 ENSDART00000111150
baculoviral IAP repeat containing 2
chr8_+_2428689 1.20 ENSDART00000081325
dynein, light chain, LC8-type 1
chr10_+_24476213 1.18 ENSDART00000146370
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_+_35871754 1.12 ENSDART00000134918
DEAH (Asp-Glu-Ala-His) box helicase 9
chr19_+_14197118 1.11 ENSDART00000166230
trophoblast glycoprotein a
chr10_+_9575 1.09

chr19_+_5562107 1.08 ENSDART00000082080
junction plakoglobin b
chr7_+_53484981 1.07 ENSDART00000158160
ENSDART00000163261
neogenin 1a
chr25_-_13737344 1.04

chr13_+_25722545 0.99

chr23_-_7118314 0.97 ENSDART00000127702
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chr16_+_5778398 0.97 ENSDART00000011166
ENSDART00000126445
zgc:158689
chr14_+_150214 0.91 ENSDART00000162480
minichromosome maintenance complex component 7
chr1_-_29885008 0.83 ENSDART00000018827
dachshund c
chr14_+_51724430 0.79 ENSDART00000168437
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr5_+_71099904 0.78 ENSDART00000170215
nucleoporin 214
chr18_+_38768524 0.77 ENSDART00000143735
si:ch211-215d8.2
chr4_-_76594399 0.75 ENSDART00000049170
zgc:85975
chr11_+_40945681 0.75

chr2_-_28154388 0.73 ENSDART00000161864
zgc:123035
chr21_+_26660833 0.73 ENSDART00000004109
guanine nucleotide binding protein (G protein), gamma 3
chr22_-_2912805 0.73 ENSDART00000178290
p21 protein (Cdc42/Rac)-activated kinase 2b
chr4_-_24298620 0.72 ENSDART00000077926
ENSDART00000128368
cugbp, Elav-like family member 2
chr4_-_72132319 0.72 ENSDART00000159313
si:dkey-262g12.10
chr9_+_54185729 0.70 ENSDART00000165991
leukocyte cell derived chemotaxin 1
chr3_-_5318206 0.70 ENSDART00000137105
myosin, heavy chain 9b, non-muscle
chr22_+_39067567 0.67

chr7_+_53485273 0.66 ENSDART00000158160
ENSDART00000163261
neogenin 1a
chr14_+_9275853 0.63 ENSDART00000114563
transmembrane protein 129, E3 ubiquitin protein ligase
chr16_-_26072171 0.62 ENSDART00000177503
ENSDARG00000108060
chr4_-_25807510 0.61 ENSDART00000122881
transmembrane and coiled-coil domain family 3
chr21_+_45622590 0.60 ENSDART00000162422
secretion associated, Ras related GTPase 1B
chr22_+_10577516 0.59 ENSDART00000147975
RAD54-like 2 (S. cerevisiae)
chr25_+_386916 0.58

chr18_+_54352 0.57 ENSDART00000097163
solute carrier family 27 member 2
chr7_-_35042805 0.57 ENSDART00000005053
solute carrier family 12 (potassium/chloride transporter), member 4
chr14_+_51850006 0.56

chr1_+_31788994 0.55 ENSDART00000152580
neuroligin 4a
chr14_-_1080574 0.54 ENSDART00000169090
ENSDART00000158905
ENSDART00000159907
ENSDARG00000098694
chr5_+_13103316 0.53 ENSDART00000177946
ENSDARG00000108900
chr9_-_2416300 0.53

chr16_-_26083913 0.52 ENSDART00000166681
ferric-chelate reductase 1-like
chr25_+_21735567 0.52 ENSDART00000148299
creatine kinase, mitochondrial 1
KN149895v1_+_26398 0.51

chr14_+_51850213 0.49

KN150361v1_-_15974 0.48 ENSDART00000167588
ENSDARG00000099568
chr2_-_4277516 0.48

chr19_+_14197020 0.47 ENSDART00000166230
trophoblast glycoprotein a
chr12_-_4638371 0.47

chr22_+_10577272 0.46 ENSDART00000147975
RAD54-like 2 (S. cerevisiae)
chr2_+_42027121 0.44 ENSDART00000138013
cytokine receptor-like factor 1a
chr13_-_49546922 0.42

chr16_-_11028959 0.42

chr14_+_51849962 0.42

chr3_-_20972827 0.42 ENSDART00000129540
leucyl-tRNA synthetase a
chr24_+_36516320 0.41

chr7_+_7304079 0.41

chr20_-_22293402 0.40 ENSDART00000047624
transmembrane protein 165
chr19_+_43523303 0.40 ENSDART00000167847
eukaryotic translation elongation factor 1 alpha 1, like 2
chr14_-_223462 0.40

chr10_-_28307019 0.38 ENSDART00000019050
ribosomal protein S6 kinase b, polypeptide 1a
chr16_-_35634313 0.38 ENSDART00000162172
sex comb on midleg homolog 1 (Drosophila)
chr24_-_1014318 0.37 ENSDART00000114544
cyclin-dependent kinase 13
chr2_-_4277082 0.36

chr19_-_25843036 0.35 ENSDART00000036854
glucocorticoid induced 1
chr14_+_51850088 0.35

chr25_+_7359375 0.34

chr22_-_12837665 0.33 ENSDART00000145156
ENSDART00000137280
glutaminase a
chr15_-_47234665 0.32 ENSDART00000124474
ENSDARG00000089563
chr10_-_45134642 0.32 ENSDART00000166528
purine-rich element binding protein Bb
chr8_-_45752084 0.31 ENSDART00000025620
peptidylprolyl isomerase Aa (cyclophilin A)
chr12_-_89886 0.29 ENSDART00000113335
mitogen-activated protein kinase kinase 4b
chr10_-_28306847 0.29 ENSDART00000019050
ribosomal protein S6 kinase b, polypeptide 1a
chr5_-_54169374 0.29 ENSDART00000056213
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
KN150170v1_+_44642 0.29 ENSDART00000177674
ENSDARG00000109197
chr15_+_494813 0.29 ENSDART00000155682
nipsnap homolog 2
chr17_-_11312313 0.28 ENSDART00000091159
ADP-dependent glucokinase 2
chr11_-_27491564 0.26 ENSDART00000021949
family with sequence similarity 120A
chr15_+_11809276 0.24 ENSDART00000161930
striatin, calmodulin binding protein 4
chr14_-_40904826 0.24 ENSDART00000074438
centromere protein I
chr22_-_4715399 0.23 ENSDART00000122341
ENSDART00000161345
zinc finger RNA binding protein 2
chr7_+_7304047 0.23

chr2_-_57776634 0.22 ENSDART00000139948
ENSDARG00000027547
chr23_-_17524325 0.21 ENSDART00000104680
tumor protein D52-like 2b
chr22_+_39067994 0.19

chr12_-_11419332 0.18 ENSDART00000012318
HtrA serine peptidase 1b
chr5_+_56885728 0.18

chr6_+_39225133 0.15 ENSDART00000154991
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr21_+_8334453 0.15 ENSDART00000055336
DENN/MADD domain containing 1A
chr7_-_10318692 0.15 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr20_+_41123859 0.15 ENSDART00000146052
mannosidase, alpha, class 1A, member 1
chr14_+_6655894 0.14 ENSDART00000148394
heterogeneous nuclear ribonucleoprotein A/Ba
chr25_-_28054204 0.14

chr14_+_51724366 0.14 ENSDART00000168437
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr25_+_7359564 0.13

chr22_-_469154 0.12 ENSDART00000106645
ENSDART00000067637
dual serine/threonine and tyrosine protein kinase
chr17_-_49910160 0.12 ENSDART00000122747
transmembrane protein 30Aa
chr14_-_40905066 0.10 ENSDART00000074438
centromere protein I
chr9_+_712184 0.10 ENSDART00000136627
ybeY metallopeptidase
chr7_-_32708788 0.08 ENSDART00000113744
plakophilin 3b
chr1_-_22112384 0.08 ENSDART00000086867
transmembrane anterior posterior transformation 1b
chr18_-_50920374 0.06 ENSDART00000159287
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr16_+_38990622 0.02 ENSDART00000136215
enhancer of yellow 2 homolog (Drosophila)
chr13_+_51485138 0.02 ENSDART00000163741
PWWP domain containing 2B
chr19_+_14490092 0.02 ENSDART00000164386
AT rich interactive domain 1Ab (SWI-like)
chr13_+_20592002 0.02

chr19_-_47684478 0.01 ENSDART00000141437
syndecan 2
chr17_-_52550596 0.01 ENSDART00000084268
family with sequence similarity 98, member B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0034372 triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372) steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435) reverse cholesterol transport(GO:0043691) positive regulation of steroid metabolic process(GO:0045940)
0.7 2.8 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.7 2.0 GO:0014807 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) regulation of somitogenesis(GO:0014807) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.6 2.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.4 2.2 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.3 1.2 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.3 2.3 GO:2000251 regulation of actin cytoskeleton reorganization(GO:2000249) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.6 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.3 1.8 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 1.2 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 1.6 GO:0061056 sclerotome development(GO:0061056)
0.2 1.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.6 GO:0070861 regulation of COPII vesicle coating(GO:0003400) regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 1.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 1.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.4 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.6 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 2.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.9 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 1.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.5 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 0.3 GO:0043650 dicarboxylic acid biosynthetic process(GO:0043650)
0.0 2.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.6 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.8 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 1.5 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 1.3 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:1903010 positive regulation of cilium assembly(GO:0045724) regulation of bone development(GO:1903010)
0.0 1.1 GO:0009615 response to virus(GO:0009615)
0.0 0.3 GO:0034508 centromere complex assembly(GO:0034508)
0.0 0.3 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.1 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 0.1 GO:0035999 folic acid-containing compound biosynthetic process(GO:0009396) tetrahydrofolate interconversion(GO:0035999)
0.0 1.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.6 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.7 GO:0032147 activation of protein kinase activity(GO:0032147)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0042627 chylomicron(GO:0042627)
0.2 2.4 GO:0005869 dynactin complex(GO:0005869)
0.1 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 1.5 GO:0043204 perikaryon(GO:0043204)
0.0 1.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.9 GO:0042555 MCM complex(GO:0042555)
0.0 2.2 GO:0005604 basement membrane(GO:0005604)
0.0 1.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.3 0.9 GO:0004461 lactose synthase activity(GO:0004461)
0.2 0.9 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.2 2.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324) fatty acid transporter activity(GO:0015245)
0.1 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.1 3.8 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.2 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 1.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.6 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.7 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 4.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 2.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.4 GO:0046915 transition metal ion transmembrane transporter activity(GO:0046915)
0.0 0.4 GO:0019955 cytokine binding(GO:0019955)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 2.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing