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Results for mecom+sinhcafl

Z-value: 2.59

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Transcription factors associated with mecom+sinhcafl

Gene Symbol Gene ID Gene Info
ENSDARG00000060808 MDS1 and EVI1 complex locus
ENSDARG00000095007 SIN3-HDAC complex associated factor, like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fam60aldr10_dc_chr7_+_28782292_28782387-0.581.9e-02Click!

Activity profile of mecom+sinhcafl motif

Sorted Z-values of mecom+sinhcafl motif

Network of associatons between targets according to the STRING database.

First level regulatory network of mecom+sinhcafl

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr23_+_20496283 13.99 ENSDART00000144047
ENSDART00000104336
troponin C type 2 (fast)
chr17_-_124685 10.37 ENSDART00000158825
actin, alpha, cardiac muscle 1b
chr7_-_24093289 7.71 ENSDART00000064789
thioredoxin
chr13_+_13550656 7.35 ENSDART00000057825
complement factor D (adipsin)
chr15_-_23711689 7.11 ENSDART00000128644
creatine kinase, muscle b
chr16_-_42040346 7.05 ENSDART00000169313
PYD and CARD domain containing
chr25_+_18467217 6.79 ENSDART00000170841
caveolin 1
chr14_+_35351559 6.61 ENSDART00000074685
glycine receptor, beta b
chr13_-_33696425 6.43 ENSDART00000143703
fibronectin leucine rich transmembrane 3
chr15_+_19902697 6.38 ENSDART00000101204
activated leukocyte cell adhesion molecule b
chr23_+_23730717 6.15

chr25_-_2485276 5.95 ENSDART00000154889
ENSDART00000155027
ENSDARG00000096850
chr14_-_46651359 5.90 ENSDART00000163316
ENSDARG00000099970
chr21_-_36338514 5.57 ENSDART00000157826
membrane protein, palmitoylated 1
chr3_+_26896869 4.86 ENSDART00000065495
epithelial membrane protein 2
chr7_-_8128948 4.69 ENSDART00000057101
aerolysin-like protein
chr9_+_16437408 4.69 ENSDART00000006787
eph receptor A3
chr21_+_7844259 4.66 ENSDART00000027268
orthopedia homeobox a
chr19_+_16318256 4.58 ENSDART00000137189
protein tyrosine phosphatase, receptor type, U, a
chr7_+_38479571 4.40 ENSDART00000170486
coagulation factor II (thrombin)
chr7_-_16776026 4.39 ENSDART00000022441
developing brain homeobox 1a
chr10_-_8029671 4.23 ENSDART00000141445
EWS RNA-binding protein 1a
chr5_+_49093250 4.22 ENSDART00000133384
nuclear receptor subfamily 2, group F, member 1a
chr23_+_20183765 4.19 ENSDART00000054664
troponin C type 1b (slow)
chr4_+_10722966 4.15 ENSDART00000102534
ENSDART00000067253
ENSDART00000136000
stabilin 2
chr6_-_9964616 4.15

chr15_+_46189096 4.08

chr2_-_21265803 4.05 ENSDART00000006870
prostaglandin-endoperoxide synthase 2a
chr6_-_34024063 3.99 ENSDART00000003701
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr5_+_49093134 3.98 ENSDART00000133384
nuclear receptor subfamily 2, group F, member 1a
chr10_+_22759607 3.98

chr8_-_14142049 3.91 ENSDART00000126432
ras homolog gene family, member Aa
chr11_+_41401893 3.89 ENSDART00000171655
ENSDARG00000103982
chr19_-_35739239 3.87

chr22_+_37944019 3.86

chr21_-_36338704 3.85 ENSDART00000157826
membrane protein, palmitoylated 1
chr11_-_22966274 3.85 ENSDART00000003646
opticin
chr6_-_21894941 3.77 ENSDART00000160679
si:dkey-31g6.6
chr20_+_23599157 3.76 ENSDART00000149922
palladin, cytoskeletal associated protein
chr15_+_42329269 3.76 ENSDART00000099234
ENSDART00000152731
SR-related CTD-associated factor 4b
chr6_-_7281412 3.74 ENSDART00000053776
FK506 binding protein 11
chr25_+_18467835 3.70 ENSDART00000172338
caveolin 1
chr6_+_3519697 3.69 ENSDART00000013588
kelch-like family member 41b
chr25_-_31218193 3.68 ENSDART00000170673
ENSDART00000166930
laminin, beta 1a
chr19_+_1814994 3.64

chr18_+_16257606 3.64 ENSDART00000142584
ALX homeobox 1
chr14_-_46650724 3.56

chr11_-_3275255 3.53 ENSDART00000066177
tubulin, alpha 2
chr17_+_27706409 3.49 ENSDART00000123588
ENSDART00000170462
ENSDART00000169708
QKI, KH domain containing, RNA binding a
chr21_-_15578808 3.47 ENSDART00000136666
matrix metallopeptidase 11b
chr22_-_3134876 3.45 ENSDART00000159580
lamin B2
chr18_-_6494014 3.43 ENSDART00000062423
troponin I, skeletal, slow c
chr25_+_18467034 3.39 ENSDART00000170841
caveolin 1
chr23_-_24755654 3.37 ENSDART00000104035
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr6_-_39278328 3.36 ENSDART00000148531
Rho guanine nucleotide exchange factor (GEF) 25b
chr3_-_30554400 3.34 ENSDART00000151097
si:ch211-51c14.1
chr9_-_34068225 3.34 ENSDART00000088441
ENSDART00000150035
si:ch73-147f11.1
chr1_+_21309690 3.33 ENSDART00000141317
dynein, axonemal, heavy chain 6
chr23_-_32378111 3.31 ENSDART00000143772
diacylglycerol kinase, alpha a
chr10_+_33462953 3.31 ENSDART00000137089
ryanodine receptor 1a (skeletal)
chr23_+_9285446 3.31 ENSDART00000033663
ribosomal protein S21
chr1_+_25662910 3.29 ENSDART00000113020
tet methylcytosine dioxygenase 2
chr20_-_34898276 3.21 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr10_+_9325719 3.16 ENSDART00000064968
RasGEF domain family, member 1Bb
chr7_+_16615075 3.14

chr17_+_53162459 3.02

chr20_+_34942798 3.02 ENSDART00000128895
elastin microfibril interfacer 1a
chr11_-_9479592 2.98 ENSDART00000175829
ENSDARG00000086489
chr24_+_24924379 2.96 ENSDART00000115165
APC membrane recruitment protein 2
chr16_-_42063851 2.96 ENSDART00000045403
ets variant 2
chr22_-_28840467 2.92

chr7_+_13753344 2.90

chr20_+_26639029 2.89 ENSDART00000045397
syntaxin 11b, tandem duplicate 1
chr3_-_18426055 2.87 ENSDART00000122968
aquaporin 8b
chr8_+_2428689 2.85 ENSDART00000081325
dynein, light chain, LC8-type 1
chr11_+_18020191 2.72 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr13_+_33378267 2.71 ENSDART00000025007
jagged 2a
chr16_-_14463682 2.71 ENSDART00000011224
integrin, alpha 10
chr1_+_25928481 2.70 ENSDART00000158193
coronin, actin binding protein, 2A
chr14_+_51848088 2.67 ENSDART00000168874
ribosomal protein L26
chr16_+_46902372 2.67 ENSDART00000177679
thrombospondin, type I, domain containing 7Ab
chr7_+_38123920 2.63 ENSDART00000138669
centrosomal protein 89
chr23_-_30114528 2.63 ENSDART00000131209
coiled-coil domain containing 187
chr8_-_34077387 2.63 ENSDART00000159208
ENSDART00000040126
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr14_-_16791447 2.60 ENSDART00000158002
ENSDARG00000103278
chr2_+_29992879 2.60 ENSDART00000056748
engrailed homeobox 2b
chr19_+_38033219 2.59 ENSDART00000158960
thrombospondin, type I, domain containing 7Aa
chr9_-_19154264 2.59 ENSDART00000081878
POU class 1 homeobox 1
chr8_+_3391493 2.59 ENSDART00000085993
paxillin b
chr11_-_13069266 2.57 ENSDART00000169052
ELOVL fatty acid elongase 1b
chr11_-_3846064 2.54 ENSDART00000161426
GATA binding protein 2a
chr15_+_46141934 2.53 ENSDART00000154388
wu:fb18f06
chr23_+_2101659 2.48

chr5_+_50379968 2.48 ENSDART00000050988
glucosaminyl (N-acetyl) transferase 4, core 2, a
chr8_-_38444845 2.45 ENSDART00000075989
inositol polyphosphate-5-phosphatase L
chr1_+_19376127 2.45 ENSDART00000088653
protease, serine, 12 (neurotrypsin, motopsin)
chr9_-_9370003 2.43 ENSDART00000132257
zgc:113337
chr17_-_30685367 2.43 ENSDART00000114358
zgc:194392
chr8_-_38308535 2.41

chr8_+_25060320 2.38 ENSDART00000000744
synaptophysin-like 2b
chr10_-_44527708 2.38

chr13_+_10100146 2.34 ENSDART00000080805
SIX homeobox 2a
chr7_-_58751849 2.30 ENSDART00000165390
charged multivesicular body protein 5b
chr10_-_42157835 2.29 ENSDART00000141500
ENSDART00000156626
ENSDARG00000093535
chr2_-_25325686 2.26 ENSDART00000111212
NCK adaptor protein 1a
chr4_-_19992951 2.26 ENSDART00000169248
dopamine receptor D4 related sequence
chr20_+_48971948 2.22 ENSDART00000164006
NK2 homeobox 4b
chr6_-_7281346 2.22 ENSDART00000133096
FK506 binding protein 11
chr12_-_7820226 2.20 ENSDART00000149594
ENSDART00000148866
ankyrin 3b
chr3_-_18642744 2.18 ENSDART00000134208
hydroxyacylglutathione hydrolase
chr6_+_23611854 2.15 ENSDART00000167795
phosphoinositide-3-kinase, regulatory subunit 6a
chr20_-_51746555 2.15 ENSDART00000065231
dispatched homolog 1 (Drosophila)
chr18_-_17527321 2.13

chr16_+_7745309 2.11 ENSDART00000081418
ENSDART00000149404
blood vessel epicardial substance
chr14_-_31748733 2.07 ENSDART00000158014
si:ch211-69b22.5
chr11_-_9479689 2.04 ENSDART00000175829
ENSDARG00000086489
chr14_-_31522323 2.03 ENSDART00000172870
RNA binding motif protein, X-linked
chr13_+_28382422 2.01 ENSDART00000043117
F-box and WD repeat domain containing 4
chr20_+_19175518 2.01

chr8_-_31359923 1.96 ENSDART00000019937
growth arrest and DNA-damage-inducible, gamma a
chr14_-_31748697 1.96 ENSDART00000158014
si:ch211-69b22.5
chr6_-_50205020 1.94 ENSDART00000083999
ENSDART00000125950
ENSDART00000143050
RALY heterogeneous nuclear ribonucleoprotein
chr22_-_15254208 1.92 ENSDART00000063008
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr24_-_16993914 1.92

chr7_+_9726412 1.91 ENSDART00000173155
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr22_+_11505448 1.91 ENSDART00000113930
neuropeptide B
chr8_+_1122000 1.91 ENSDART00000127252
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr2_+_47885551 1.91

chr16_-_9075915 1.84

chr5_-_41345192 1.82

chr3_+_23600462 1.81 ENSDART00000131410
homeobox B3a
chr8_+_25060389 1.79 ENSDART00000000744
synaptophysin-like 2b
chr18_+_45564871 1.79

chr24_+_25326286 1.74 ENSDART00000066625
small muscle protein, X-linked
chr20_+_38129564 1.74 ENSDART00000032161
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr7_+_59806180 1.71 ENSDART00000131442
heat shock protein 12B
chr8_-_52729505 1.66 ENSDART00000168241
tubulin, beta 2b
chr8_+_48812632 1.62 ENSDART00000098363
tumor protein p63 regulated 1-like
chr14_+_33382672 1.61 ENSDART00000075312
apelin
chr15_-_9616877 1.61 ENSDART00000168668
GRB2-associated binding protein 2
chr4_-_671973 1.61 ENSDART00000164735
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr3_-_11409342 1.59

chr21_-_15578885 1.59 ENSDART00000136666
matrix metallopeptidase 11b
chr2_-_55673404 1.58 ENSDART00000158147
calreticulin 3b
chr9_+_30909291 1.58 ENSDART00000146115
Kruppel-like factor 12b
chr17_-_12772433 1.57 ENSDART00000044126
ENSDARG00000020655
chr14_-_33483075 1.56 ENSDART00000158870
si:dkey-76i15.1
chr25_+_35796086 1.54 ENSDART00000112196
zgc:163040
chr12_+_30448812 1.54 ENSDART00000126064
si:ch211-28p3.4
chr9_+_30909382 1.52 ENSDART00000146115
Kruppel-like factor 12b
chr6_-_10728582 1.52 ENSDART00000151102
notum pectinacetylesterase 2
chr14_-_2268924 1.51 ENSDART00000160205
protocadherin 2 alpha b 12
chr3_-_2010512 1.49

chr24_+_25326233 1.49 ENSDART00000066625
small muscle protein, X-linked
chr7_+_44106327 1.48 ENSDART00000108766
ENSDART00000111441
cadherin 5
chr8_+_27724171 1.47 ENSDART00000046004
wingless-type MMTV integration site family, member 2Bb
chr5_-_19691538 1.45 ENSDART00000139675
D-amino-acid oxidase, tandem duplicate 1
chr2_-_52202004 1.43 ENSDART00000165350
ENSDARG00000098957
chr2_+_26161204 1.39 ENSDART00000078639
solute carrier family 2 (facilitated glucose transporter), member 2
chr18_-_39340435 1.38 ENSDART00000077694
LEO1 homolog, Paf1/RNA polymerase II complex component
chr11_-_26583383 1.37

chr6_-_20625494 1.35

chr3_-_22098046 1.30 ENSDART00000017750
myosin, light chain 4, alkali; atrial, embryonic
chr13_-_11873376 1.29 ENSDART00000111438
meningioma expressed antigen 5 (hyaluronidase)
chr1_+_25928586 1.29 ENSDART00000152643
coronin, actin binding protein, 2A
chr13_-_39704878 1.29 ENSDART00000138981
zgc:171482
chr4_+_40119702 1.23

chr20_+_33272248 1.23 ENSDART00000023963
DEAD (Asp-Glu-Ala-Asp) box helicase 1
chr22_-_12905648 1.22 ENSDART00000157820
major facilitator superfamily domain containing 6a
chr23_-_29138719 1.18 ENSDART00000002812
castor zinc finger 1
chr6_+_27348529 1.16

chr7_-_38340949 1.16 ENSDART00000173678
C1q and TNF related 4
chr5_-_17542077 1.15 ENSDART00000144898
ring finger protein 215
chr5_+_22204129 1.15

chr2_-_43318809 1.13 ENSDART00000132588
cAMP responsive element modulator a
chr10_+_22043094 1.13 ENSDART00000035188
Kv channel interacting protein 1 b
chr14_-_46650551 1.10

chr11_-_26583342 1.09

chr15_+_19358079 1.09 ENSDART00000123815
junctional adhesion molecule 3a
chr14_-_10311677 1.09 ENSDART00000133723
si:dkey-92i17.2
chr20_-_5324678 1.06 ENSDART00000114316
serine palmitoyltransferase, long chain base subunit 2b
chr21_+_21158761 1.05 ENSDART00000058311
RPTOR independent companion of MTOR, complex 2b
chr19_+_17355544 1.04 ENSDART00000078951
mannosidase endo-alpha like
chr8_+_39478197 1.04

chr11_-_41512092 1.04 ENSDART00000173147
ENSDARG00000105426
chr18_+_8388897 1.03 ENSDART00000083421
carnitine palmitoyltransferase 1B (muscle)
chr15_-_31236277 1.02

chr14_-_46650640 1.00

KN149797v1_-_70680 0.99 ENSDART00000170785
uncharacterized protein LOC795664 precursor
chr10_-_22988906 0.98

chr3_-_55278137 0.95 ENSDART00000123544
testis expressed 2
chr17_-_15141309 0.94 ENSDART00000103405
GTP cyclohydrolase 1
chr23_+_37535830 0.93

chr5_-_32674787 0.93 ENSDART00000145222
cysteine conjugate-beta lyase, cytoplasmic
chr6_-_40700033 0.91 ENSDART00000113196
si:ch211-157b11.14
chr1_+_37033111 0.91 ENSDART00000139448
polypeptide N-acetylgalactosaminyltransferase like 6
chr11_+_38449192 0.89 ENSDART00000041800
eph receptor A8
chr25_+_25343112 0.87 ENSDART00000161369
si:ch211-103e16.5
chr7_+_16615154 0.85

chr12_-_19160315 0.82 ENSDART00000152832
si:ch211-141o9.10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.9 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
1.4 4.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.3 7.7 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
1.2 3.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.2 4.7 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
1.1 4.4 GO:0050820 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
1.0 4.2 GO:1901490 regulation of lymphangiogenesis(GO:1901490) positive regulation of lymphangiogenesis(GO:1901492)
0.9 24.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.9 3.7 GO:0055016 hypochord development(GO:0055016)
0.9 6.4 GO:0021885 forebrain cell migration(GO:0021885)
0.9 7.1 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.8 2.5 GO:1902895 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.8 3.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.8 2.3 GO:0030800 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.7 8.2 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.7 7.3 GO:0006956 complement activation(GO:0006956)
0.7 6.6 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.7 3.3 GO:0006211 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.6 4.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 6.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.6 3.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.5 2.7 GO:0035988 chondrocyte proliferation(GO:0035988)
0.5 4.7 GO:0021767 mammillary body development(GO:0021767)
0.5 1.5 GO:0042756 drinking behavior(GO:0042756)
0.5 2.0 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.5 1.5 GO:0001955 blood vessel maturation(GO:0001955)
0.5 1.5 GO:0061011 hepatic duct development(GO:0061011)
0.4 5.8 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.4 2.2 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.4 4.2 GO:0000022 mitotic spindle elongation(GO:0000022) regulation of chondrocyte differentiation(GO:0032330) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.4 1.2 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.4 3.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.4 1.5 GO:0046416 D-amino acid catabolic process(GO:0019478) D-serine catabolic process(GO:0036088) D-amino acid metabolic process(GO:0046416) D-serine metabolic process(GO:0070178)
0.4 2.1 GO:0042694 muscle cell fate specification(GO:0042694)
0.3 1.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 3.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 2.6 GO:0061055 myotome development(GO:0061055)
0.3 6.0 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.3 1.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529)
0.3 0.8 GO:0051031 tRNA transport(GO:0051031)
0.3 3.3 GO:0097320 membrane tubulation(GO:0097320)
0.3 11.7 GO:0042742 defense response to bacterium(GO:0042742)
0.2 2.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 0.9 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 0.6 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.2 2.5 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.2 3.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.2 3.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 1.1 GO:0038203 TORC2 signaling(GO:0038203)
0.2 1.9 GO:0007631 feeding behavior(GO:0007631)
0.2 1.4 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 5.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.2 3.0 GO:0007398 ectoderm development(GO:0007398)
0.1 1.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.1 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 2.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 2.2 GO:0030878 thyroid gland development(GO:0030878)
0.1 5.0 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.1 3.2 GO:1902749 regulation of cell cycle G2/M phase transition(GO:1902749)
0.1 2.6 GO:0048794 swim bladder development(GO:0048794)
0.1 1.9 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.3 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 3.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.0 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 1.1 GO:0035675 neuromast hair cell development(GO:0035675)
0.1 2.4 GO:0031638 zymogen activation(GO:0031638)
0.1 0.9 GO:0014823 response to activity(GO:0014823)
0.1 0.7 GO:0007020 microtubule nucleation(GO:0007020)
0.1 5.2 GO:0001708 cell fate specification(GO:0001708)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 2.2 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 2.7 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 4.6 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 1.2 GO:0006623 protein targeting to vacuole(GO:0006623)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.0 2.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 3.6 GO:0048793 pronephros development(GO:0048793)
0.0 0.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.8 GO:0006284 base-excision repair(GO:0006284)
0.0 0.3 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 4.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 4.2 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 1.7 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 2.6 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.0 2.0 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 0.3 GO:0048840 otolith development(GO:0048840)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:0061702 inflammasome complex(GO:0061702)
1.0 21.6 GO:0005861 troponin complex(GO:0005861)
0.8 10.4 GO:0005869 dynactin complex(GO:0005869)
0.6 3.2 GO:0043034 costamere(GO:0043034)
0.6 2.4 GO:0043083 synaptic cleft(GO:0043083)
0.6 3.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.5 4.7 GO:0046930 pore complex(GO:0046930)
0.5 2.0 GO:0070062 extracellular exosome(GO:0070062)
0.5 16.0 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.3 3.7 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.3 2.2 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.3 3.3 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.3 3.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 2.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 0.7 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.2 2.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 2.2 GO:0030286 dynein complex(GO:0030286)
0.2 1.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 4.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.7 GO:0008305 integrin complex(GO:0008305)
0.1 0.5 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 3.7 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 6.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 2.6 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 0.6 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 9.0 GO:0043235 receptor complex(GO:0043235)
0.1 0.7 GO:0045180 basal cortex(GO:0045180)
0.1 1.5 GO:0016342 catenin complex(GO:0016342)
0.1 25.8 GO:0005615 extracellular space(GO:0005615)
0.1 0.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 5.6 GO:0030425 dendrite(GO:0030425)
0.0 7.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 6.6 GO:0005938 cell cortex(GO:0005938)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 3.3 GO:0043005 neuron projection(GO:0043005)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.1 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0032090 Pyrin domain binding(GO:0032090)
1.4 4.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.2 18.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.1 6.6 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.9 4.7 GO:0070492 oligosaccharide binding(GO:0070492)
0.9 7.1 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.7 3.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.7 3.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.6 1.9 GO:0005463 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.6 2.3 GO:0099528 G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.6 3.3 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.5 13.9 GO:0044325 ion channel binding(GO:0044325)
0.5 1.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.5 2.9 GO:0015250 water channel activity(GO:0015250)
0.4 2.5 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.3 4.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 3.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 4.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 7.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.3 3.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 1.5 GO:0031704 apelin receptor binding(GO:0031704)
0.2 0.7 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.2 1.6 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 1.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 1.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.2 2.1 GO:0030552 cAMP binding(GO:0030552)
0.2 1.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 4.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 0.8 GO:0008097 5S rRNA binding(GO:0008097)
0.2 2.7 GO:0005112 Notch binding(GO:0005112)
0.1 14.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.4 GO:0045309 protein phosphorylated amino acid binding(GO:0045309) phosphoprotein binding(GO:0051219)
0.1 6.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 0.9 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.3 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 3.7 GO:0005178 integrin binding(GO:0005178)
0.1 5.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 8.2 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 3.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.8 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 2.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 2.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 5.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.2 GO:0005109 frizzled binding(GO:0005109)
0.1 4.0 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.2 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 2.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.0 6.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 3.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.5 GO:0045296 cadherin binding(GO:0045296)
0.0 1.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:0000049 tRNA binding(GO:0000049)
0.0 20.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.9 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.2 GO:0004527 exonuclease activity(GO:0004527)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.4 GO:0042802 identical protein binding(GO:0042802)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.8 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 4.2 GO:0003682 chromatin binding(GO:0003682)
0.0 0.0 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.9 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.6 4.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 8.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 3.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 3.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 2.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 1.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 1.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 7.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.2 PID P73PATHWAY p73 transcription factor network
0.0 1.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 2.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 14.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.8 7.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.4 11.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.9 4.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.8 15.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 4.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 2.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 1.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 3.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.0 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism