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Results for mef2aa
Z-value: 2.55
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Transcription factors associated with mef2aa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mef2aa | dr10_dc_chr18_+_23198330_23198352 | 0.96 | 2.0e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of mef2aa
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_60973097 Show fit | 10.23 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr17_-_124685 Show fit | 9.64 |
ENSDART00000158825
|
actin, alpha, cardiac muscle 1b |
|
| chr1_-_12584282 Show fit | 9.22 |
ENSDART00000127838
|
protocadherin 18a |
|
| chr3_-_32686790 Show fit | 8.67 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr7_+_6814828 Show fit | 8.64 |
ENSDART00000001649
|
actinin alpha 3b |
|
| chr12_-_17590507 Show fit | 8.04 |
ENSDART00000010144
|
parvalbumin 2 |
|
| chr19_+_2162466 Show fit | 7.44 |
|
|
|
| chr12_-_5085227 Show fit | 7.05 |
ENSDART00000160729
|
retinol binding protein 4, plasma |
|
| chr19_-_7531709 Show fit | 6.98 |
ENSDART00000104750
|
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 |
|
| chr1_-_12584179 Show fit | 6.86 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 20.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 1.1 | 11.6 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 1.9 | 9.5 | GO:0051899 | regulation of mitochondrial membrane potential(GO:0051881) membrane depolarization(GO:0051899) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.5 | 9.1 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 1.2 | 7.1 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
| 0.9 | 7.1 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) |
| 0.0 | 6.5 | GO:0001756 | somitogenesis(GO:0001756) |
| 0.3 | 5.8 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.2 | 5.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 5.3 | GO:0071456 | cellular response to hypoxia(GO:0071456) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.2 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 18.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 12.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.0 | 11.1 | GO:0031430 | M band(GO:0031430) |
| 0.7 | 9.6 | GO:0005869 | dynactin complex(GO:0005869) |
| 1.3 | 8.0 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.2 | 6.8 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 6.1 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.7 | 5.3 | GO:0031672 | A band(GO:0031672) |
| 0.2 | 5.3 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 72.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 12.6 | GO:0003779 | actin binding(GO:0003779) |
| 1.0 | 9.1 | GO:0052812 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 0.4 | 8.7 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 2.2 | 8.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.5 | 7.2 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 1.4 | 7.1 | GO:0034632 | retinol transporter activity(GO:0034632) |
| 0.4 | 7.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 6.8 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 6.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.6 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 5.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 4.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.5 | 4.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 3.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 2.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 6.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 5.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 3.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.5 | 3.2 | REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS | Genes involved in Acetylcholine Binding And Downstream Events |
| 1.0 | 3.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 2.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.4 | 2.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |