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Results for mef2b

Z-value: 0.51

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Transcription factors associated with mef2b

Gene Symbol Gene ID Gene Info
ENSDARG00000093170 myocyte enhancer factor 2b

Activity profile of mef2b motif

Sorted Z-values of mef2b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2b

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_60973097 2.19 ENSDART00000055062
parvalbumin 1
chr3_-_32686790 2.05 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr5_-_71340996 1.33 ENSDART00000162526
SET and MYND domain containing 1a
chr9_-_33296340 1.30 ENSDART00000013918
calsequestrin 2
chr15_-_27778111 1.29 ENSDART00000134373
LIM homeobox 1a
chr8_+_29953399 1.01 ENSDART00000149372
ENSDART00000007640
patched 1
patched 1
chr11_+_11217547 1.00 ENSDART00000087105
myomesin 2a
chr1_+_9999665 0.94 ENSDART00000054879
ENSDARG00000037679
chr6_-_42006033 0.91 ENSDART00000032527
caveolin 3
chr24_-_31772736 0.90

chr10_-_8074713 0.89 ENSDART00000140476
ATPase, H+ transporting, lysosomal V0 subunit a2a
chr17_-_9869142 0.86 ENSDART00000008355
cofilin 2 (muscle)
chr23_+_20183765 0.84 ENSDART00000054664
troponin C type 1b (slow)
chr12_-_34614931 0.83 ENSDART00000152876
BAH domain and coiled-coil containing 1b
chr10_-_22834248 0.80 ENSDART00000079469
procollagen C-endopeptidase enhancer a
chr2_-_34010299 0.80 ENSDART00000140910
patched 2
chr23_-_39956151 0.73 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr20_+_15653121 0.70 ENSDART00000152702
jun proto-oncogene
chr3_+_34064081 0.69

chr10_-_22875997 0.66 ENSDART00000079454
vesicle-associated membrane protein 2
chr13_+_9100463 0.66 ENSDART00000058064
ENSDARG00000039726
chr1_-_5796394 0.64 ENSDART00000109356
Kruppel-like factor 7a
chr2_+_20118917 0.63 ENSDART00000038648
polypyrimidine tract binding protein 2b
chr19_-_31448000 0.62 ENSDART00000147504
basic leucine zipper and W2 domains 2
chr1_-_16876855 0.61 ENSDART00000125125
acyl-CoA synthetase long-chain family member 1a
chr1_-_30772653 0.61 ENSDART00000087115
regulating synaptic membrane exocytosis 1b
chr1_-_416138 0.60 ENSDART00000092524
RAS p21 protein activator 3
chr6_-_40724581 0.60 ENSDART00000035101
kelch repeat and BTB (POZ) domain containing 12
chr10_-_24401876 0.58 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr14_+_23917724 0.58 ENSDART00000138082
ENSDART00000079215
stanniocalcin 2a
chr25_-_22821132 0.56

chr15_+_24064257 0.56 ENSDART00000156714
ENSDARG00000097097
chr23_-_7892862 0.55 ENSDART00000157612
ENSDART00000165427
myelin transcription factor 1b
chr15_-_14616083 0.54 ENSDART00000171169
numb homolog (Drosophila)-like
chr21_+_19034242 0.54 ENSDART00000123309
NK6 homeobox 1
chr12_+_34018417 0.53 ENSDART00000032821
cytohesin 1b
chr10_-_37098396 0.53 ENSDART00000155277
ENSDARG00000097288
chr6_-_14010044 0.52 ENSDART00000149177
ENSDART00000174839
ENSDART00000089577
calcium channel, voltage-dependent, beta 4b subunit
chr13_-_9737104 0.51 ENSDART00000158381
myomesin 2b
chr21_+_11592175 0.50 ENSDART00000147473
proprotein convertase subtilisin/kexin type 1
chr5_+_64411412 0.49 ENSDART00000158484
ENSDARG00000101163
chr24_+_25326286 0.49 ENSDART00000066625
small muscle protein, X-linked
chr17_-_14663139 0.48 ENSDART00000037371
protein phosphatase 1, regulatory subunit 13Ba
chr6_-_42006225 0.48 ENSDART00000032527
caveolin 3
chr24_+_25326233 0.48 ENSDART00000066625
small muscle protein, X-linked
chr20_+_41652149 0.47 ENSDART00000135715
family with sequence similarity 184, member A
chr18_+_26737365 0.45 ENSDART00000141672
alpha-kinase 3a
chr5_-_51172369 0.44 ENSDART00000164267
ENSDART00000157866
homer scaffolding protein 1b
chr7_-_23474701 0.44 ENSDART00000048050
integrin subunit beta 1 binding protein 2
chr22_+_26423320 0.43 ENSDART00000044085
ENSDARG00000034211
chr11_-_27455242 0.42 ENSDART00000045942
PHD finger protein 2
chr9_-_28588288 0.42 ENSDART00000104317
ENSDART00000064343
Kruppel-like factor 7b
chr11_-_27455348 0.41 ENSDART00000045942
PHD finger protein 2
chr10_-_4979688 0.41 ENSDART00000093228
methionine adenosyltransferase II, alpha-like
chr3_-_52419408 0.41 ENSDART00000154260
si:dkey-210j14.4
chr21_-_12179911 0.40 ENSDART00000081510
ENSDART00000151297
CUGBP, Elav-like family member 4
chr12_+_42244935 0.39 ENSDART00000166484
si:ch211-221j21.3
chr1_+_11541423 0.39 ENSDART00000170760
tropomodulin 1
chr23_-_32231333 0.38 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr24_-_27800234 0.38 ENSDART00000105778
heparan sulfate 6-O-sulfotransferase 1b
chr5_-_10445847 0.38 ENSDART00000163139
reticulon 4 receptor
chr11_-_38940966 0.37 ENSDART00000105133
wingless-type MMTV integration site family, member 4a
chr11_+_44922098 0.37 ENSDART00000172999
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr20_-_26102273 0.35 ENSDART00000063177
calpain 3b
chr5_+_64411584 0.35 ENSDART00000158484
ENSDARG00000101163
chr8_-_50270783 0.35 ENSDART00000146056
NK3 homeobox 1
chr23_-_38565787 0.34

chr1_-_24486146 0.34 ENSDART00000144711
transmembrane protein 154
chr20_-_26142897 0.34 ENSDART00000140255
si:dkey-12h9.6
chr12_+_30448812 0.33 ENSDART00000126064
si:ch211-28p3.4
chr10_+_1954904 0.32 ENSDART00000177433
ENSDART00000178960
ENSDARG00000107761
chr23_+_44137593 0.32 ENSDART00000148470
ENSDARG00000095873
chr21_+_10769107 0.32

chr16_-_30698002 0.32 ENSDART00000146508
low density lipoprotein receptor class A domain containing 4b
chr16_+_17061069 0.31 ENSDART00000111074
si:ch211-120k19.1
chr18_+_40364675 0.31 ENSDART00000098791
ENSDART00000049171
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr20_-_26102193 0.31 ENSDART00000136518
calpain 3b
chr13_+_18130206 0.30

chr17_-_12872503 0.29 ENSDART00000113713
family with sequence similarity 177, member A1
chr24_-_32115473 0.29 ENSDART00000168419
Ras suppressor protein 1
chr12_-_26339002 0.29 ENSDART00000153214
synaptopodin 2-like b
chr10_+_3461461 0.28

chr12_+_5969088 0.28 ENSDART00000114961
si:ch211-131k2.3
chr23_-_38565708 0.28

chr7_+_38735582 0.27 ENSDART00000173735
diacylglycerol kinase, zeta a
chr1_-_43936717 0.26 ENSDART00000081835
solute carrier family 43 (amino acid system L transporter), member 1b
chr3_-_8608620 0.26

chr1_-_54319671 0.26 ENSDART00000074058
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23a
chr3_+_22774002 0.25

chr20_-_31841557 0.23

chr6_+_36965023 0.23 ENSDART00000028895
neuronal growth regulator 1
chr15_-_12297979 0.22 ENSDART00000165159
Down syndrome cell adhesion molecule like 1
chr20_+_34552759 0.22 ENSDART00000135789
methyltransferase like 11B
chr8_+_7882144 0.21

chr9_+_24255064 0.21 ENSDART00000101577
ENSDART00000159324
ENSDART00000023196
ENSDART00000079689
ENSDART00000172743
ENSDART00000171577
leucine rich repeat (in FLII) interacting protein 1a
chr6_-_42005949 0.21 ENSDART00000032527
caveolin 3
chr4_+_13451169 0.20 ENSDART00000172552
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr13_+_18130077 0.19

chr1_-_43936611 0.19 ENSDART00000170912
solute carrier family 43 (amino acid system L transporter), member 1b
chr5_+_63687529 0.19 ENSDART00000162246
phospholipid phosphatase 7 (inactive)
chr25_+_33924376 0.19

chr6_+_27348529 0.19

chr12_+_28795950 0.18 ENSDART00000076572
ring finger protein 40
chr7_+_21593005 0.18 ENSDART00000159626
si:dkey-85k7.7
chr24_-_4418454 0.18 ENSDART00000066835
frizzled class receptor 8a
chr1_+_44379602 0.18 ENSDART00000129819
si:ch211-151p13.8
chr3_+_22724101 0.17 ENSDART00000167127
ENSDARG00000098353
chr5_+_3375612 0.17

chr7_-_7186964 0.16 ENSDART00000102620
SIX homeobox 7
chr24_+_8596066 0.16 ENSDART00000113493
transmembrane protein 14Ca
chr13_-_31246639 0.16 ENSDART00000026692
ubiquitin domain containing 1a
chr21_-_32449627 0.16

chr14_+_35560934 0.15 ENSDART00000105604
zgc:77938
chr20_-_37673852 0.15

chr12_+_6411166 0.15 ENSDART00000152616
protein kinase, cGMP-dependent, type Ib
chr23_-_38565866 0.14

chr11_-_26515468 0.14

chr2_+_37992682 0.14 ENSDART00000179233
ENSDARG00000108815
chr12_+_26930895 0.14 ENSDART00000152975
male-specific lethal 1 homolog b (Drosophila)
chr4_+_14659537 0.13

chr14_+_14541725 0.12 ENSDART00000169932
coiled-coil domain containing 142
chr9_+_30174202 0.12 ENSDART00000020743
cms1 ribosomal small subunit homolog (yeast)
chr15_+_20607816 0.11 ENSDART00000169941
small G protein signaling modulator 2
chr25_+_3551924 0.10 ENSDART00000154348
prion protein, related sequence 3
chr7_-_6222134 0.10 ENSDART00000173197
histone 1, H4, like
chr20_-_26102318 0.10 ENSDART00000063177
calpain 3b
chr6_-_6091628 0.09 ENSDART00000132350
reticulon 4a
chr1_-_33700550 0.09

chr15_+_14925920 0.09

chr7_-_29861232 0.09

chr3_+_34063993 0.09

chr8_+_30446599 0.08 ENSDART00000085894
phosphoglucomutase 5
chr9_+_50907029 0.08

chr25_-_27279272 0.07 ENSDART00000148121
zgc:153935
chr13_-_36456350 0.07 ENSDART00000143682
lectin, galactoside binding soluble 3a
chr4_+_75484112 0.07 ENSDART00000174393
si:dkey-240n22.8
chr11_-_22143133 0.06 ENSDART00000159681
transcription factor EB
chr12_+_26931140 0.06 ENSDART00000152975
male-specific lethal 1 homolog b (Drosophila)
chr5_+_36348848 0.05

chr9_+_29860757 0.04 ENSDART00000015377
ribonuclease H2, subunit B
chr4_+_11465367 0.04 ENSDART00000008584
GDP dissociation inhibitor 2
chr10_+_4979788 0.02

chr12_-_34614903 0.01 ENSDART00000152876
BAH domain and coiled-coil containing 1b
chr7_+_33186069 0.01 ENSDART00000164921
progestin and adipoQ receptor family member Vb
chr8_-_23250112 0.01

chr16_-_20084901 0.00 ENSDART00000103586
ENSDART00000079159
histone deacetylase 9b
chr3_+_30962542 0.00 ENSDART00000153074
si:dkey-66i24.9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.4 1.8 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.3 1.3 GO:0014808 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.3 0.8 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 0.8 GO:1990092 calcium-dependent self proteolysis(GO:1990092)
0.2 0.9 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 1.6 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 0.5 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.3 GO:0030241 skeletal muscle thin filament assembly(GO:0030240) skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.9 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0060394 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.2 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.5 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.6 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.5 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.5 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.2 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.6 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.2 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.5 GO:0007416 synapse assembly(GO:0007416)
0.0 0.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.1 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 GO:0031430 M band(GO:0031430)
0.3 1.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.6 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 1.6 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.4 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.2 1.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.9 GO:0051117 ATPase binding(GO:0051117)
0.1 0.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.4 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.6 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692) cGMP binding(GO:0030553)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling