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Results for mef2d_mef2ca+mef2cb

Z-value: 3.04

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Transcription factors associated with mef2d_mef2ca+mef2cb

Gene Symbol Gene ID Gene Info
ENSDARG00000040237 myocyte enhancer factor 2d
ENSDARG00000009418 myocyte enhancer factor 2cb
ENSDARG00000029764 myocyte enhancer factor 2ca

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2cadr10_dc_chr10_-_43826919_438270490.961.9e-09Click!
mef2cbdr10_dc_chr5_-_47634182_476342330.802.2e-04Click!
mef2ddr10_dc_chr16_-_29229687_292297310.674.8e-03Click!

Activity profile of mef2d_mef2ca+mef2cb motif

Sorted Z-values of mef2d_mef2ca+mef2cb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2d_mef2ca+mef2cb

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_6862901 16.06 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr3_-_60973097 16.03 ENSDART00000055062
parvalbumin 1
chr12_-_4033069 15.84 ENSDART00000042200
aldolase a, fructose-bisphosphate, b
chr9_-_33296340 11.68 ENSDART00000013918
calsequestrin 2
chr5_-_71340996 9.97 ENSDART00000162526
SET and MYND domain containing 1a
chr6_+_52791515 9.81 ENSDART00000065682
matrilin 4
chr15_+_24064257 8.30 ENSDART00000156714
ENSDARG00000097097
chr7_-_57941497 8.13 ENSDART00000114008
un-named hu7910
chr6_+_3519697 8.04 ENSDART00000013588
kelch-like family member 41b
chr12_-_17590507 7.91 ENSDART00000010144
parvalbumin 2
chr4_+_10065500 7.90 ENSDART00000026492
filamin C, gamma b (actin binding protein 280)
chr9_+_41720118 7.34

chr23_+_44137593 7.12 ENSDART00000148470
ENSDARG00000095873
chr6_+_29420644 6.99 ENSDART00000065293
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr10_-_22834248 6.85 ENSDART00000079469
procollagen C-endopeptidase enhancer a
chr24_+_20430778 6.62 ENSDART00000010488
kelch-like family member 40b
chr10_-_8074713 6.57 ENSDART00000140476
ATPase, H+ transporting, lysosomal V0 subunit a2a
chr23_-_7283514 6.55 ENSDART00000156369
ENSDARG00000096997
chr5_+_66712197 6.52 ENSDART00000014822
early B-cell factor 2
chr24_+_36045759 6.05 ENSDART00000173322
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
chr9_-_34491458 5.88 ENSDART00000049805
immunoglobulin-like domain containing receptor 2
chr2_+_27005381 5.75

chr10_-_22875997 5.74 ENSDART00000079454
vesicle-associated membrane protein 2
chr20_-_9992898 5.73 ENSDART00000080664
zgc:86709
chr3_+_34064081 5.62

chr10_+_1954904 5.58 ENSDART00000177433
ENSDART00000178960
ENSDARG00000107761
chr23_+_20183765 5.56 ENSDART00000054664
troponin C type 1b (slow)
chr1_-_30772653 5.42 ENSDART00000087115
regulating synaptic membrane exocytosis 1b
chr11_+_18020191 5.27 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr7_-_23474701 5.20 ENSDART00000048050
integrin subunit beta 1 binding protein 2
chr16_+_5466342 5.19 ENSDART00000160008
plectin b
chr25_-_30818836 5.03 ENSDART00000156828
proline rich 33
chr21_+_19034242 5.02 ENSDART00000123309
NK6 homeobox 1
chr21_+_28408329 5.02 ENSDART00000077871
phosphorylase, glycogen, muscle A
chr23_+_25005457 4.95 ENSDART00000136162
kelch-like family member 21
chr11_+_11217547 4.84 ENSDART00000087105
myomesin 2a
chr4_-_9591451 4.73 ENSDART00000114060
cerebral dopamine neurotrophic factor
chr20_+_15653121 4.72 ENSDART00000152702
jun proto-oncogene
chr19_+_5156446 4.72 ENSDART00000151681
enolase 2
chr9_-_7695437 4.67 ENSDART00000102715
tubulin, alpha 8 like 3
chr7_-_57727148 4.64

chr12_-_17585587 4.63 ENSDART00000142427
parvalbumin 3
chr16_+_34569479 4.59 ENSDART00000041007
stathmin 1b
chr11_-_27455348 4.56 ENSDART00000045942
PHD finger protein 2
chr9_-_43340836 4.55 ENSDART00000059451
coiled-coil domain containing 141
chr23_+_18796386 4.53 ENSDART00000137438
myosin, heavy chain 7B, cardiac muscle, beta b
chr19_-_32900108 4.52 ENSDART00000050130
guanosine monophosphate reductase
chr12_+_18403055 4.49 ENSDART00000090332
neuralized E3 ubiquitin protein ligase 2
chr25_+_19992389 4.45 ENSDART00000143441
troponin I4b, tandem duplicate 2
chr16_-_31963977 4.43 ENSDART00000027364
RNA binding protein, fox-1 homolog (C. elegans) 1-like
chr19_-_41482388 4.43 ENSDART00000111982
sarcoglycan, epsilon
chr2_+_30932612 4.42 ENSDART00000132450
ENSDART00000137012
myomesin 1a (skelemin)
chr10_+_32160464 4.38 ENSDART00000099880
wingless-type MMTV integration site family, member 11, related
chr14_-_20766448 4.36 ENSDART00000164146
si:dkey-74k8.3
chr24_+_25326286 4.33 ENSDART00000066625
small muscle protein, X-linked
chr18_+_26737365 4.29 ENSDART00000141672
alpha-kinase 3a
chr23_-_38565787 4.28

chr24_-_23893617 4.26 ENSDART00000080549
lysozyme
chr3_+_28822408 4.25 ENSDART00000133528
lectin, galactoside-binding, soluble, 2a
chr19_+_41396014 4.23 ENSDART00000159444
ENSDART00000042990
ENSDART00000144544
collagen, type I, alpha 2
chr12_-_25973094 4.19 ENSDART00000171206
ENSDART00000171212
ENSDART00000170265
LIM domain binding 3b
chr9_-_37940101 4.19 ENSDART00000087663
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr18_-_25190648 4.17 ENSDART00000175178
solute carrier organic anion transporter family, member 3A1
chr21_+_11592175 4.16 ENSDART00000147473
proprotein convertase subtilisin/kexin type 1
chr21_+_25899113 4.16 ENSDART00000141149
calneuron 2
chr10_-_24401876 4.13 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr10_+_44364117 4.11

chr23_-_38565708 4.08

chr1_-_50066633 4.05

chr21_-_25649117 3.97 ENSDART00000101205
phosphorylase kinase, gamma 1b (muscle)
chr20_-_39200252 3.95 ENSDART00000037318
ENSDART00000143379
regulator of calcineurin 2
chr20_-_10131480 3.90 ENSDART00000033976
Meis homeobox 2b
chr7_+_31608828 3.90 ENSDART00000138491
myosin binding protein C, cardiac
chr17_+_38619041 3.87 ENSDART00000145147
spectrin, beta, erythrocytic
chr1_-_5796394 3.81 ENSDART00000109356
Kruppel-like factor 7a
chr21_-_22694225 3.72 ENSDART00000101797
F-box protein 40, tandem duplicate 1
chr18_+_20504980 3.69 ENSDART00000060295
receptor-associated protein of the synapse, 43kD
chr9_+_6600592 3.68 ENSDART00000061577
four and a half LIM domains 2a
chr11_-_27455242 3.68 ENSDART00000045942
PHD finger protein 2
chr15_-_9055873 3.67 ENSDART00000124998
reticulon 2a
chr24_+_25326233 3.59 ENSDART00000066625
small muscle protein, X-linked
chr1_-_43936717 3.59 ENSDART00000081835
solute carrier family 43 (amino acid system L transporter), member 1b
chr11_-_18306222 3.54 ENSDART00000155474
FYVE, RhoGEF and PH domain containing 5a
chr14_-_29542922 3.48

chr1_+_18272833 3.47 ENSDART00000132379
LIM and calponin homology domains 1a
chr13_+_22119569 3.43 ENSDART00000108472
synaptopodin 2-like a
chr15_+_40161311 3.43 ENSDART00000063783
integral membrane protein 2Ca
chr10_+_1812271 3.37

chr14_-_30025818 3.35 ENSDART00000007022
platelet-derived growth factor receptor-like
chr10_-_37098396 3.35 ENSDART00000155277
ENSDARG00000097288
chr6_-_42006033 3.33 ENSDART00000032527
caveolin 3
chr12_-_26339002 3.33 ENSDART00000153214
synaptopodin 2-like b
chr11_-_38940966 3.32 ENSDART00000105133
wingless-type MMTV integration site family, member 4a
chr5_-_28090077 3.32

chr18_+_40364675 3.31 ENSDART00000098791
ENSDART00000049171
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr5_-_22847399 3.27 ENSDART00000169258
neuroligin 3b
chr18_+_26102262 3.26 ENSDART00000164495
zinc finger protein 710a
chr15_+_19717045 3.23 ENSDART00000138680
lens intrinsic membrane protein 2.3
chr13_+_7575753 3.19

chr25_-_22821132 3.17

chr9_-_28588288 3.11 ENSDART00000104317
ENSDART00000064343
Kruppel-like factor 7b
chr12_+_22605268 3.09

chr1_+_13386937 3.07 ENSDART00000021693
ankyrin 2a, neuronal
chr3_-_39031305 3.06 ENSDART00000022393
si:dkeyp-57f11.2
chr4_+_19545842 3.05 ENSDART00000140028
leucine rich repeat containing 4.1
chr15_-_27778111 3.02 ENSDART00000134373
LIM homeobox 1a
chr3_+_18406137 2.96 ENSDART00000158791
chromobox homolog 4 (Pc class homolog, Drosophila)
chr23_+_24999817 2.96 ENSDART00000137486
kelch-like family member 21
chr2_+_2895642 2.93 ENSDART00000032459
aquaporin 1a (Colton blood group), tandem duplicate 1
chr24_+_16924647 2.89 ENSDART00000014787
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a
chr21_+_10769107 2.88

chr1_-_10391257 2.88 ENSDART00000102903
dystrophin
chr9_-_41982635 2.86 ENSDART00000144573
obscurin-like 1b
chr6_+_14822990 2.81 ENSDART00000149949
POU class 3 homeobox 3b
chr7_+_31608878 2.80 ENSDART00000099789
myosin binding protein C, cardiac
chr7_-_13128257 2.77 ENSDART00000164326
si:ch73-119p20.1
chr17_-_32913432 2.72 ENSDART00000077476
prospero homeobox 1a
chr3_-_49010673 2.72 ENSDART00000109544
si:ch1073-100f3.2
chr13_-_30807799 2.71

chr20_-_37673852 2.70

chr23_-_5751064 2.70 ENSDART00000067351
troponin T type 2a (cardiac)
chr24_+_26922969 2.66

chr21_-_32449627 2.66

chr15_-_14616083 2.64 ENSDART00000171169
numb homolog (Drosophila)-like
chr19_-_24859287 2.63 ENSDART00000163763
thrombospondin 3b
chr3_+_18249107 2.62 ENSDART00000141100
ENSDART00000138107
ribosomal protein S2
chr4_+_21996784 2.60 ENSDART00000040266
myogenic factor 6
chr4_-_2615160 2.58 ENSDART00000140760
E2F transcription factor 7
chr25_+_16849382 2.58 ENSDART00000016591
fibroblast growth factor 6a
chr15_+_7179382 2.57 ENSDART00000101578
hairy-related 8.2
chr25_+_33924376 2.56

chr1_-_43936611 2.55 ENSDART00000170912
solute carrier family 43 (amino acid system L transporter), member 1b
chr6_+_14823185 2.55 ENSDART00000149202
POU class 3 homeobox 3b
chr16_-_30698002 2.55 ENSDART00000146508
low density lipoprotein receptor class A domain containing 4b
chr3_+_59560881 2.54 ENSDART00000084738
protein phosphatase 1, regulatory subunit 27a
chr15_+_125263 2.54

chr12_+_3043444 2.50 ENSDART00000149427
sarcoglycan, alpha
chr8_-_11191783 2.48 ENSDART00000131171
unc-45 myosin chaperone B
chr16_+_34157866 2.46 ENSDART00000140552
transcription elongation factor A (SII), 3
chr8_+_10267246 2.45 ENSDART00000159312
ENSDART00000160766
Pim-1 proto-oncogene, serine/threonine kinase
chr7_-_29300448 2.42 ENSDART00000019140
RAR-related orphan receptor A, paralog b
chr13_+_22350043 2.42 ENSDART00000136863
LIM domain binding 3a
chr14_-_12001505 2.41 ENSDART00000171136
myotilin
chr16_-_7963894 2.38 ENSDART00000172836
ENSDARG00000105487
chr22_-_31110564 2.36 ENSDART00000022445
cullin-associated and neddylation-dissociated 2 (putative)
chr7_+_38735582 2.32 ENSDART00000173735
diacylglycerol kinase, zeta a
chr14_-_23784679 2.32 ENSDART00000158576
muscle segment homeobox 2a
chr12_+_25684420 2.30 ENSDART00000024415
endothelial PAS domain protein 1a
chr12_-_48758684 2.29 ENSDART00000130190
uroporphyrinogen III synthase
chr1_-_54319671 2.29 ENSDART00000074058
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23a
chr22_+_26423320 2.28 ENSDART00000044085
ENSDARG00000034211
chr7_-_39170016 2.27 ENSDART00000161191
ENSDARG00000101872
chr12_-_2905505 2.27 ENSDART00000157726
family with sequence similarity 20, member A
chr13_+_7974393 2.26 ENSDART00000163103
galactose mutarotase
chr1_-_21987718 2.26 ENSDART00000128918
fibroblast growth factor binding protein 1b
chr16_-_31517906 2.25 ENSDART00000145691
ENSDARG00000054814
chr5_+_38236956 2.24 ENSDART00000160236
Fraser extracellular matrix complex subunit 1
KN150425v1_+_103569 2.23 ENSDART00000169530
cytochrome P450, family 1, subfamily C, polypeptide 1
chr3_-_29992171 2.23 ENSDART00000153562
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr1_-_38097100 2.23 ENSDART00000148572
ankyrin repeat and SOCS box containing 5b
chr3_+_22774002 2.21

chr15_-_34987450 2.21 ENSDART00000009892
gamma-aminobutyric acid (GABA) B receptor, 1a
chr2_-_24113073 2.16 ENSDART00000148685
xin actin binding repeat containing 1
chr23_-_39956151 2.16 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_66982187 2.15

chr23_+_23559246 2.15 ENSDART00000172214
agrin
chr1_-_7417472 2.15 ENSDART00000161938
ENSDART00000163307
si:dkeyp-9d4.3
chr13_-_31246639 2.14 ENSDART00000026692
ubiquitin domain containing 1a
chr3_-_52419408 2.14 ENSDART00000154260
si:dkey-210j14.4
chr3_-_29768364 2.13 ENSDART00000020311
ribosomal protein L27
chr21_-_12179911 2.12 ENSDART00000081510
ENSDART00000151297
CUGBP, Elav-like family member 4
chr3_+_59491893 2.11 ENSDART00000084729
platelet/endothelial cell adhesion molecule 1
chr20_+_13279404 2.10 ENSDART00000025644
protein phosphatase 2, regulatory subunit B', alpha isoform
chr14_-_6822151 2.09 ENSDART00000171311
si:ch73-43g23.1
chr24_-_31772736 2.08

chr5_-_62592627 2.07 ENSDART00000131274
tubulin folding cofactor E-like b
chr21_+_10775209 2.07

chr25_-_26292712 2.04 ENSDART00000067114
F-box and leucine-rich repeat protein 22
chr22_+_16282153 2.03 ENSDART00000162685
ENSDART00000105678
leucine rich repeat containing 39
chr8_+_17148864 2.02 ENSDART00000140531
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr25_-_13057808 2.02 ENSDART00000172571
sphingomyelin phosphodiesterase 3, neutral
chr9_-_30073641 2.02

chr8_-_27667972 2.00 ENSDART00000086946
Moloney leukemia virus 10b, tandem duplicate 1
chr12_+_5969088 1.99 ENSDART00000114961
si:ch211-131k2.3
chr22_-_6977038 1.99 ENSDART00000133143
ENSDART00000146813
glycerol-3-phosphate dehydrogenase 1b
chr12_+_22605229 1.99

chr17_-_9869142 1.98 ENSDART00000008355
cofilin 2 (muscle)
chr1_+_9999665 1.97 ENSDART00000054879
ENSDARG00000037679
chr4_+_14659537 1.96

chr20_+_41652149 1.95 ENSDART00000135715
family with sequence similarity 184, member A
chr24_-_21750082 1.94

chr2_-_43318809 1.93 ENSDART00000132588
cAMP responsive element modulator a
chr6_+_27348529 1.93

chr11_+_44922098 1.93 ENSDART00000172999
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr20_+_40248154 1.93 ENSDART00000121818
triadin
chr24_+_9315953 1.92

chr1_+_51706536 1.91

chr9_+_17431036 1.90 ENSDART00000140852
regulator of cell cycle
chr1_+_11615117 1.89 ENSDART00000165733
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr1_-_41281418 1.88 ENSDART00000014678
adrenoceptor alpha 1D

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.7 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
2.7 8.2 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
2.7 8.1 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
2.2 6.6 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
1.7 6.7 GO:0003210 cardiac atrium formation(GO:0003210)
1.3 2.7 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
1.3 3.9 GO:1990092 calcium-dependent self proteolysis(GO:1990092)
1.2 3.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.2 4.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
1.1 4.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
1.1 3.3 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
1.1 5.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 5.3 GO:0035988 chondrocyte proliferation(GO:0035988)
1.0 3.0 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
1.0 3.0 GO:0097376 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
1.0 10.0 GO:0030240 skeletal muscle thin filament assembly(GO:0030240) skeletal muscle myosin thick filament assembly(GO:0030241)
1.0 13.9 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
1.0 2.9 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) carbon dioxide transport(GO:0015670)
1.0 5.7 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.9 2.6 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.8 15.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8 2.4 GO:0010265 SCF complex assembly(GO:0010265)
0.8 2.3 GO:0097186 enamel mineralization(GO:0070166) amelogenesis(GO:0097186)
0.7 4.2 GO:0050975 sensory perception of touch(GO:0050975)
0.7 3.4 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
0.7 7.9 GO:0034629 cellular protein complex localization(GO:0034629)
0.7 3.9 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.6 1.9 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.6 1.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.6 1.9 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.6 4.3 GO:0090303 positive regulation of wound healing(GO:0090303)
0.6 6.6 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.6 10.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.6 8.0 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.6 2.3 GO:0019320 hexose catabolic process(GO:0019320) galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.5 1.6 GO:0010712 regulation of collagen metabolic process(GO:0010712) regulation of granulocyte differentiation(GO:0030852) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246) regulation of neutrophil differentiation(GO:0045658)
0.5 2.7 GO:0015743 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.5 10.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.5 2.5 GO:0010991 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.5 1.5 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.5 2.0 GO:0030043 actin filament fragmentation(GO:0030043)
0.5 5.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.5 4.6 GO:0019226 transmission of nerve impulse(GO:0019226)
0.5 1.4 GO:0021563 glossopharyngeal nerve development(GO:0021563) abducens nucleus development(GO:0021742)
0.4 10.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.4 0.9 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.4 1.7 GO:0050687 negative regulation of response to biotic stimulus(GO:0002832) negative regulation of defense response to virus(GO:0050687)
0.4 2.0 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.4 1.2 GO:0042423 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.4 1.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 4.2 GO:0016486 peptide hormone processing(GO:0016486)
0.4 1.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.4 1.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 4.4 GO:0000272 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.4 1.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 2.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.3 5.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 3.8 GO:0046686 response to cadmium ion(GO:0046686)
0.3 2.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.3 1.2 GO:0031646 positive regulation of myelination(GO:0031643) positive regulation of neurological system process(GO:0031646)
0.3 6.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 2.9 GO:0007525 somatic muscle development(GO:0007525)
0.3 10.7 GO:0007416 synapse assembly(GO:0007416)
0.3 5.4 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.3 1.4 GO:0061337 cardiac conduction(GO:0061337)
0.3 4.7 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.3 2.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) regulation of synaptic transmission, glutamatergic(GO:0051966)
0.3 2.0 GO:0086003 cardiac muscle cell contraction(GO:0086003)
0.2 1.7 GO:0006108 malate metabolic process(GO:0006108)
0.2 4.5 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.2 2.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 4.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.2 2.7 GO:0021884 forebrain neuron development(GO:0021884)
0.2 1.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 3.4 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 0.6 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.2 4.2 GO:0009612 response to mechanical stimulus(GO:0009612)
0.2 1.3 GO:0036065 fucosylation(GO:0036065)
0.2 5.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.6 GO:0048512 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.2 1.1 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.2 4.0 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.2 0.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.5 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.2 1.1 GO:0048681 regulation of myelination(GO:0031641) negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 2.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.9 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 8.7 GO:0030239 myofibril assembly(GO:0030239)
0.1 2.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.0 GO:0044805 late nucleophagy(GO:0044805)
0.1 1.9 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 8.6 GO:0006936 muscle contraction(GO:0006936)
0.1 2.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 1.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 2.2 GO:0071711 basement membrane organization(GO:0071711)
0.1 0.1 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 4.0 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 4.1 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 3.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 2.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884) neurotransmitter receptor internalization(GO:0099590)
0.1 0.3 GO:0019323 pentose catabolic process(GO:0019323)
0.1 1.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 0.8 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.1 0.6 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.9 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1 3.3 GO:0043242 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) negative regulation of protein complex disassembly(GO:0043242) actin filament capping(GO:0051693) regulation of protein depolymerization(GO:1901879) negative regulation of protein depolymerization(GO:1901880)
0.1 4.6 GO:0042552 myelination(GO:0042552)
0.1 0.4 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.1 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 2.3 GO:0071456 cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.1 1.1 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.5 GO:0007634 optokinetic behavior(GO:0007634)
0.1 3.6 GO:0050808 synapse organization(GO:0050808)
0.1 1.8 GO:0048634 regulation of muscle organ development(GO:0048634)
0.1 1.9 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 4.3 GO:0048469 cell maturation(GO:0048469)
0.1 1.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.1 2.8 GO:0021549 cerebellum development(GO:0021549)
0.1 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.4 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.7 GO:0015780 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 1.8 GO:0003146 heart jogging(GO:0003146)
0.0 1.3 GO:0007586 digestion(GO:0007586)
0.0 2.7 GO:0006821 chloride transport(GO:0006821)
0.0 3.8 GO:0007492 endoderm development(GO:0007492)
0.0 1.3 GO:0031167 rRNA methylation(GO:0031167)
0.0 1.6 GO:0030901 midbrain development(GO:0030901)
0.0 2.6 GO:0044344 fibroblast growth factor receptor signaling pathway(GO:0008543) cellular response to fibroblast growth factor stimulus(GO:0044344) response to fibroblast growth factor(GO:0071774)
0.0 2.4 GO:0007626 locomotory behavior(GO:0007626)
0.0 1.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.3 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.6 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 0.2 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.0 1.6 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 3.0 GO:0006869 lipid transport(GO:0006869)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 0.7 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 1.0 GO:0001817 regulation of cytokine production(GO:0001817)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.1 GO:0033333 fin development(GO:0033333)
0.0 1.3 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.6 GO:0021782 glial cell development(GO:0021782)
0.0 0.6 GO:0006414 translational elongation(GO:0006414)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.8 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.0 0.8 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 35.2 GO:0031430 M band(GO:0031430)
2.3 11.7 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.5 4.5 GO:1902560 GMP reductase complex(GO:1902560)
1.4 4.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.2 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.2 6.9 GO:0016012 sarcoglycan complex(GO:0016012)
1.1 9.1 GO:0031672 A band(GO:0031672)
1.1 5.4 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.8 3.4 GO:0016460 myosin II complex(GO:0016460)
0.8 6.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.8 3.9 GO:0008091 spectrin(GO:0008091)
0.7 3.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.7 2.1 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
0.6 13.3 GO:0005861 troponin complex(GO:0005861)
0.5 10.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 5.2 GO:0030056 hemidesmosome(GO:0030056)
0.4 1.3 GO:0008352 katanin complex(GO:0008352)
0.4 2.2 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.4 4.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 1.4 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.3 2.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 7.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 17.2 GO:0030018 Z disc(GO:0030018)
0.3 1.4 GO:0031931 TORC1 complex(GO:0031931)
0.2 2.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 5.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 8.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 6.0 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 3.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 2.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.6 GO:0043204 perikaryon(GO:0043204)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.5 GO:0016459 myosin complex(GO:0016459)
0.1 2.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.0 GO:0043186 P granule(GO:0043186)
0.1 1.1 GO:0031209 SCAR complex(GO:0031209)
0.1 2.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.8 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 1.8 GO:0016342 catenin complex(GO:0016342)
0.1 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 11.6 GO:0045202 synapse(GO:0045202)
0.1 19.9 GO:0043005 neuron projection(GO:0043005)
0.0 2.2 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 17.6 GO:0005576 extracellular region(GO:0005576)
0.0 3.0 GO:0005874 microtubule(GO:0005874)
0.0 0.8 GO:0005769 early endosome(GO:0005769)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 15.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.5 4.5 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.4 4.3 GO:0003796 lysozyme activity(GO:0003796)
1.3 10.1 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 3.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
1.2 4.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.1 4.3 GO:0016936 galactoside binding(GO:0016936)
1.0 5.0 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
1.0 2.9 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.9 6.0 GO:0071253 connexin binding(GO:0071253)
0.8 4.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.8 4.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 6.6 GO:0051117 ATPase binding(GO:0051117)
0.6 2.5 GO:0070412 R-SMAD binding(GO:0070412)
0.6 8.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.5 2.7 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.5 3.7 GO:0043495 protein anchor(GO:0043495)
0.5 5.2 GO:0030506 ankyrin binding(GO:0030506)
0.5 1.9 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) alpha1-adrenergic receptor activity(GO:0004937)
0.5 1.9 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.5 6.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 1.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.4 2.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.4 1.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 2.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.4 4.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.4 2.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 3.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 2.7 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.3 1.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 1.0 GO:0070330 aromatase activity(GO:0070330)
0.3 6.6 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.3 1.6 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.3 5.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 4.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 0.8 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692) cGMP binding(GO:0030553)
0.3 5.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 2.6 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 1.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.2 3.0 GO:0043236 laminin binding(GO:0043236)
0.2 2.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 8.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 5.4 GO:0044325 ion channel binding(GO:0044325)
0.2 6.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 10.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 8.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.2 3.4 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.2 1.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.2 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 4.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 2.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 2.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 87.9 GO:0005509 calcium ion binding(GO:0005509)
0.2 2.9 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.2 0.5 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.2 3.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 2.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 2.6 GO:0016208 AMP binding(GO:0016208)
0.1 1.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 5.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 2.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 6.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.9 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 27.5 GO:0003779 actin binding(GO:0003779)
0.1 3.3 GO:0046332 SMAD binding(GO:0046332)
0.1 6.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 3.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 2.3 GO:0019838 growth factor binding(GO:0019838)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.0 5.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 2.0 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 5.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 8.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.7 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 1.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 15.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 6.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 15.3 PID CMYB PATHWAY C-MYB transcription factor network
0.2 14.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 1.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 4.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.5 PID INSULIN PATHWAY Insulin Pathway
0.1 2.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 1.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 4.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.6 PID E2F PATHWAY E2F transcription factor network
0.0 1.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.4 4.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.6 4.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 5.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.6 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.6 3.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 1.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.5 3.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 4.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 4.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 3.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 1.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 4.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 1.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 3.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex