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Results for meis3

Z-value: 0.70

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Transcription factors associated with meis3

Gene Symbol Gene ID Gene Info
meis3
ENSDARG00000002795 myeloid ecotropic viral integration site 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis3dr10_dc_chr15_-_6866486_68665350.775.5e-04Click!

Activity profile of meis3 motif

Sorted Z-values of meis3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of meis3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_26623251 2.22 ENSDART00000159264
sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr23_-_10242377 2.07 ENSDART00000129044
krt5
keratin 5
chr22_-_15567180 1.74 ENSDART00000123125
tpm4a
tropomyosin 4a
chr7_-_26035308 1.58 ENSDART00000131906
zgc:77439
zgc:77439
chr10_+_26705729 1.50 ENSDART00000147013
si:ch73-52f15.5
si:ch73-52f15.5
chr8_-_7425677 1.29 ENSDART00000149671
hdac6
histone deacetylase 6
chr23_+_21737142 1.20 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr8_-_11191783 1.17 ENSDART00000131171
unc45b
unc-45 myosin chaperone B
chr2_+_45228446 1.16 ENSDART00000123966
chrng
cholinergic receptor, nicotinic, gamma
chr5_-_46382728 1.04

chr7_+_40972616 0.99 ENSDART00000173814
scrib
scribbled planar cell polarity protein
chr1_-_40208544 0.96 ENSDART00000027463
hmx4
H6 family homeobox 4
chr1_-_40208469 0.95 ENSDART00000027463
hmx4
H6 family homeobox 4
chr8_+_53118919 0.92

chr16_-_26663643 0.88 ENSDART00000008152
sgk2b
serum/glucocorticoid regulated kinase 2b
chr12_-_45714172 0.86 ENSDART00000149044
pax2b
paired box 2b
chr15_+_24064257 0.86 ENSDART00000156714
CR394545.1
ENSDARG00000097097
chr16_-_16244210 0.83 ENSDART00000012718
fabp11b
fatty acid binding protein 11b
chr14_-_26138828 0.83 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr20_-_53560663 0.80 ENSDART00000146001
wasf1
WAS protein family, member 1
chr23_-_10242235 0.78 ENSDART00000081223
ENSDART00000144280
krt5
keratin 5
chr17_-_15659244 0.77 ENSDART00000142972
manea
mannosidase, endo-alpha
chr1_+_1657493 0.75 ENSDART00000103850
atp1a1a.3
ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 3
chr10_+_404464 0.70 ENSDART00000145124
ENSDART00000124319
dact3a
dishevelled-binding antagonist of beta-catenin 3a
chr7_-_26035541 0.70 ENSDART00000057288
zgc:77439
zgc:77439
chr20_-_26568204 0.69 ENSDART00000158213
akap12b
A kinase (PRKA) anchor protein 12b
chr22_-_10372023 0.68

chr15_-_25430003 0.66 ENSDART00000152651
cluha
clustered mitochondria (cluA/CLU1) homolog a
chr8_+_8252892 0.66 ENSDART00000170566
srpk3
SRSF protein kinase 3
chr15_-_34198725 0.62 ENSDART00000170130
ENSDARG00000101697
ENSDARG00000101697
chr3_+_55779906 0.60

chr2_-_44330405 0.60 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr21_-_45573799 0.59 ENSDART00000158489
zgc:77058
zgc:77058
chr23_-_38565787 0.58

chr15_-_34198695 0.57 ENSDART00000170130
ENSDARG00000101697
ENSDARG00000101697
chr22_+_10372455 0.57 ENSDART00000122403
wu:fb55g09
wu:fb55g09
chr14_-_6624878 0.56 ENSDART00000166439
si:ch211-266k2.1
si:ch211-266k2.1
chr2_-_32575527 0.55 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr23_-_10241885 0.54 ENSDART00000081223
ENSDART00000144280
krt5
keratin 5
chr18_-_19114558 0.54 ENSDART00000177621
dennd4a
DENN/MADD domain containing 4A
chr7_-_18629056 0.51 ENSDART00000021502
mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_45843528 0.51 ENSDART00000114225
ENSDART00000169279
CU467828.1
ENSDARG00000074082
KN150670v1_-_61400 0.47

chr8_-_27496134 0.47 ENSDART00000134879
si:ch211-254n4.3
si:ch211-254n4.3
chr23_-_38565708 0.46

chr22_-_22206778 0.44 ENSDART00000105580
ap3d1
adaptor-related protein complex 3, delta 1 subunit
chr9_-_28588288 0.42 ENSDART00000104317
ENSDART00000064343
klf7b
Kruppel-like factor 7b
chr20_+_51291139 0.42 ENSDART00000073981
eif2s1b
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr8_-_19166630 0.39

chr5_+_23741791 0.39 ENSDART00000049003
atp6v1aa
ATPase, H+ transporting, lysosomal, V1 subunit Aa
chr13_+_22165657 0.39

chr20_-_23272102 0.37 ENSDART00000167197
spata18
spermatogenesis associated 18
chr14_-_17000025 0.37 ENSDART00000168853
jakmip1
janus kinase and microtubule interacting protein 1
chr5_+_22613963 0.35 ENSDART00000128271
NEXMIF (1 of many)
si:dkey-114c15.7
chr16_-_7321943 0.35 ENSDART00000149260
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr13_+_22165699 0.33

chr11_-_17846665 0.33 ENSDART00000005999
twf2b
twinfilin actin-binding protein 2b
chr25_+_32114076 0.31 ENSDART00000156145
scaper
S-phase cyclin A-associated protein in the ER
chr22_+_21095535 0.31

chr16_-_26663608 0.27 ENSDART00000134908
sgk2b
serum/glucocorticoid regulated kinase 2b
chr11_-_27970634 0.27

chr6_+_33552572 0.27 ENSDART00000040334
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr19_-_36009321 0.27 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr16_-_12095302 0.27 ENSDART00000148666
ENSDART00000029121
usp5
ubiquitin specific peptidase 5 (isopeptidase T)
chr9_-_34410053 0.25 ENSDART00000111027
dcaf6
ddb1 and cul4 associated factor 6
chr8_-_4451417 0.25 ENSDART00000141915
si:ch211-166a6.5
si:ch211-166a6.5
chr4_+_27139902 0.24

chr3_+_44468134 0.24 ENSDART00000164561
ENSDARG00000098547
ENSDARG00000098547
chr7_-_71929355 0.24

chr20_-_26521700 0.24 ENSDART00000110883
akap12b
A kinase (PRKA) anchor protein 12b
chr9_+_50341397 0.22

chr4_+_21091640 0.21 ENSDART00000005847
nav3
neuron navigator 3
chr11_+_2437479 0.20 ENSDART00000130886
NABP2
nucleic acid binding protein 2
chr23_+_23255489 0.19 ENSDART00000137353
klhl17
kelch-like family member 17
chr6_+_15635696 0.19 ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr9_-_25370657 0.18 ENSDART00000166684
esd
esterase D/formylglutathione hydrolase
chr6_+_15635738 0.17 ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr2_+_26824005 0.15 ENSDART00000172669
ENSDART00000056795
ENSDART00000144837
hectd3
HECT domain containing 3
chr21_+_10693199 0.15

chr20_+_46969915 0.14 ENSDART00000158124
ENSDARG00000103380
ENSDARG00000103380
chr24_+_12845250 0.09 ENSDART00000126842
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr3_+_26603352 0.08 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr4_-_17033790 0.08

chr7_-_18629119 0.07 ENSDART00000021502
mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr17_-_11264425 0.07 ENSDART00000151847
arid4a
AT rich interactive domain 4A (RBP1-like)
chr6_+_8871439 0.07 ENSDART00000083820
vps16
vacuolar protein sorting protein 16
chr23_-_33753634 0.07 ENSDART00000138416
tfcp2
transcription factor CP2
chr9_-_25370467 0.04 ENSDART00000141837
esd
esterase D/formylglutathione hydrolase
chr7_-_33791033 0.04 ENSDART00000052404
map2k5
mitogen-activated protein kinase kinase 5
chr8_-_41511380 0.00 ENSDART00000019858
golga1
golgin A1
chr19_-_35155287 0.00 ENSDART00000175621
elp2
elongator acetyltransferase complex subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 1.0 GO:1902946 protein localization to early endosome(GO:1902946)
0.1 1.9 GO:0030656 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 0.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.2 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.4 GO:1904969 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.1 0.8 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.6 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.6 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.2 GO:0046292 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.0 2.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 3.4 GO:0031101 fin regeneration(GO:0031101)
0.0 1.2 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 2.3 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 1.3 GO:0006476 protein deacetylation(GO:0006476)
0.0 0.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0072576 liver morphogenesis(GO:0072576)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 GO:0045095 keratin filament(GO:0045095)
0.1 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.4 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 1.2 GO:0031672 A band(GO:0031672)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 1.3 GO:0047611 acetylspermidine deacetylase activity(GO:0047611)
0.2 1.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.2 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 1.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.8 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification