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Results for mtf1

Z-value: 1.16

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Transcription factors associated with mtf1

Gene Symbol Gene ID Gene Info
mtf1
ENSDARG00000102898 metal-regulatory transcription factor 1

Activity profile of mtf1 motif

Sorted Z-values of mtf1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of mtf1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_471166 7.12 ENSDART00000154888
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr1_-_35196892 6.20 ENSDART00000033566
smad1
SMAD family member 1
chr17_-_124685 4.49 ENSDART00000158825
actc1b
actin, alpha, cardiac muscle 1b
chr8_+_31426328 4.01 ENSDART00000135101
sepp1a
selenoprotein P, plasma, 1a
chr22_-_37414940 3.77 ENSDART00000104493
sox2
SRY (sex determining region Y)-box 2
chr3_+_23090476 2.70 ENSDART00000009393
col1a1a
collagen, type I, alpha 1a
chr23_+_23559246 2.60 ENSDART00000172214
agrn
agrin
chr1_+_44205158 2.59 ENSDART00000142820
wu:fc21g02
wu:fc21g02
chr22_-_11712371 2.59

chr11_+_7518953 2.41 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr22_-_38621100 2.35 ENSDART00000164609
si:ch211-126j24.1
si:ch211-126j24.1
chr20_+_13998066 2.34 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr7_+_25052543 2.27 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr7_+_49442972 2.22 ENSDART00000019446
ascl1b
achaete-scute family bHLH transcription factor 1b
chr2_+_33474083 2.22 ENSDART00000056657
zgc:113531
zgc:113531
chr4_-_28346021 2.14 ENSDART00000178149
celsr1a
cadherin EGF LAG seven-pass G-type receptor 1a
chr14_-_36037883 2.00 ENSDART00000173006
gpm6aa
glycoprotein M6Aa
chr17_-_53234493 1.96

chr14_+_22889826 1.95 ENSDART00000170356
enox2
ecto-NOX disulfide-thiol exchanger 2
chr23_+_36079624 1.94 ENSDART00000103131
hoxc1a
homeo box C1a
chr22_+_12327849 1.90 ENSDART00000178678
FO704572.1
ENSDARG00000106890
chr10_-_27035549 1.88 ENSDART00000146595
zgc:193742
zgc:193742
chr17_+_37268262 1.88 ENSDART00000104009
slc30a1b
solute carrier family 30 (zinc transporter), member 1b
chr1_+_49441608 1.83 ENSDART00000165973
ENSDART00000158988
ENSDART00000018469
npnt
nephronectin
chr20_-_158899 1.83 ENSDART00000131635
slc16a10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr12_+_24536857 1.78

chr12_-_17795448 1.78

chr20_+_54464026 1.72 ENSDART00000158810
ENSDART00000161631
ENSDART00000172631
ENSDART00000168924
fkbp3
FK506 binding protein 3
chr12_+_41016238 1.72 ENSDART00000170976
kif5bb
kinesin family member 5B, b
chr12_-_45714172 1.71 ENSDART00000149044
pax2b
paired box 2b
chr25_-_23428527 1.69 ENSDART00000062930
phlda2
pleckstrin homology-like domain, family A, member 2
chr7_-_38590391 1.65 ENSDART00000037361
ENSDART00000173629
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr24_-_4418454 1.59 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr8_+_22334642 1.52 ENSDART00000146457
ENSDART00000142883
zgc:153631
zgc:153631
chr8_+_999710 1.52 ENSDART00000081432
sprb
sepiapterin reductase b
chr10_+_24476213 1.52 ENSDART00000146370
slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr1_-_11591843 1.51 ENSDART00000003825
cplx2l
complexin 2, like
chr23_+_36079164 1.48 ENSDART00000103131
hoxc1a
homeo box C1a
chr1_-_54294303 1.40 ENSDART00000140016
khsrp
KH-type splicing regulatory protein
chr5_-_55477243 1.38

chr17_-_37040941 1.34 ENSDART00000126823
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr14_+_4810147 1.32 ENSDART00000114678
nanos1
nanos homolog 1
chr2_+_46428154 1.31 ENSDART00000128457
ephb1
EPH receptor B1
chr19_+_10912601 1.21 ENSDART00000053325
tomm40l
translocase of outer mitochondrial membrane 40 homolog, like
chr14_-_46407410 1.17 ENSDART00000173078
si:ch211-168f7.5
si:ch211-168f7.5
chr16_+_11138924 1.16 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr20_+_54463948 1.15 ENSDART00000158810
ENSDART00000161631
ENSDART00000172631
ENSDART00000168924
fkbp3
FK506 binding protein 3
chr20_-_46458839 1.04 ENSDART00000153087
bmf2
Bcl2 modifying factor 2
chr1_-_11591684 1.02 ENSDART00000003825
cplx2l
complexin 2, like
chr5_+_8741824 1.02 ENSDART00000081772
susd1
sushi domain containing 1
chr23_+_45876483 1.01 ENSDART00000169521
ENSDART00000162915
dclk2b
doublecortin-like kinase 2b
chr16_+_11138879 1.01 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr6_+_7395817 0.98 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr5_+_37113743 0.95

chr23_+_44137593 0.95 ENSDART00000148470
CU993818.1
ENSDARG00000095873
chr24_-_3445036 0.92 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr24_-_38496534 0.90 ENSDART00000140739
lrrc4bb
leucine rich repeat containing 4Bb
chr24_-_3445303 0.89 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr8_-_51537858 0.89 ENSDART00000167394
fgfr1a
fibroblast growth factor receptor 1a
chr21_-_22441376 0.83

chr11_+_7518748 0.74 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr20_-_1293519 0.73 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr23_+_23559198 0.73 ENSDART00000172214
agrn
agrin
chr17_+_25463178 0.72 ENSDART00000139451
aim1a
crystallin beta-gamma domain containing 1a
chr3_+_23090404 0.72 ENSDART00000009393
col1a1a
collagen, type I, alpha 1a
chr23_-_18131105 0.70 ENSDART00000173102
zgc:92287
zgc:92287
chr1_+_8320586 0.66 ENSDART00000006211
prkcba
protein kinase C, beta a
chr9_+_50609926 0.66 ENSDART00000098687
GRB14
growth factor receptor bound protein 14
chr8_+_8934762 0.64 ENSDART00000133137
bcap31
B-cell receptor-associated protein 31
chr2_+_54911012 0.63 ENSDART00000027313
ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr6_+_39056821 0.63

chr23_+_45876447 0.61 ENSDART00000169521
ENSDART00000162915
dclk2b
doublecortin-like kinase 2b
chr17_+_37268209 0.61 ENSDART00000104009
slc30a1b
solute carrier family 30 (zinc transporter), member 1b
chr4_+_47242957 0.60

chr11_-_11487856 0.59 ENSDART00000030103
krt94
keratin 94
chr5_+_36014029 0.58 ENSDART00000150574
nova1
neuro-oncological ventral antigen 1
chr17_-_37040694 0.53 ENSDART00000126823
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr9_+_25109928 0.53 ENSDART00000037025
slc39a10
solute carrier family 39 (zinc transporter), member 10
chr2_+_42027121 0.51 ENSDART00000138013
crlf1a
cytokine receptor-like factor 1a
chr9_-_53380782 0.46 ENSDART00000166906
trpm2
transient receptor potential cation channel, subfamily M, member 2
chr24_-_25021505 0.45 ENSDART00000141601
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr13_+_40377712 0.44 ENSDART00000114985
hpse2
heparanase 2
chr20_+_571020 0.41 ENSDART00000152149
si:dkey-121j17.6
si:dkey-121j17.6
chr7_-_69114789 0.41

chr3_+_14151127 0.41 ENSDART00000162023
plppr2a
phospholipid phosphatase related 2a
chr13_+_4040744 0.40

chr7_-_38590218 0.39 ENSDART00000133491
phf21aa
PHD finger protein 21Aa
chr17_-_12231165 0.37 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr24_-_37989964 0.34 ENSDART00000128574
tmem204
transmembrane protein 204
chr5_-_33611896 0.34

chr9_+_41910191 0.34

chr6_+_10214270 0.33 ENSDART00000090874
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr13_+_4040802 0.32

chr4_-_4698425 0.28 ENSDART00000093005
ENSDARG00000063578
ENSDARG00000063578
chr23_-_18131209 0.26 ENSDART00000173102
zgc:92287
zgc:92287
chr7_+_27420387 0.25 ENSDART00000079091
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr7_+_64897785 0.25 ENSDART00000113602
ENSDART00000167822
ipo7
importin 7
chr1_-_11591631 0.25 ENSDART00000142122
cplx2l
complexin 2, like
chr7_+_58866578 0.24 ENSDART00000167980
ostc
oligosaccharyltransferase complex subunit
chr19_+_43448344 0.22 ENSDART00000015632
nkain1
sodium/potassium transporting ATPase interacting 1
chr10_+_21477806 0.20 ENSDART00000142447
etf1b
eukaryotic translation termination factor 1b
chr11_-_3266080 0.20 ENSDART00000154314
prph
peripherin
chr3_+_38939974 0.18

chr25_-_23428563 0.15 ENSDART00000062930
phlda2
pleckstrin homology-like domain, family A, member 2
chr6_+_3120600 0.15 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr10_+_39142185 0.09

chr7_+_20595694 0.09 ENSDART00000174012
gigyf1a
GRB10 interacting GYF protein 1a
chr15_-_3024027 0.08

chr25_+_17217050 0.08 ENSDART00000125459
cnot1
CCR4-NOT transcription complex, subunit 1
chr23_-_18131038 0.08 ENSDART00000173385
zgc:92287
zgc:92287
chr3_+_14151244 0.07 ENSDART00000162023
plppr2a
phospholipid phosphatase related 2a
chr10_-_34122428 0.05

chr3_-_18606063 0.02 ENSDART00000130029
zgc:113333
zgc:113333
chr23_+_28472956 0.01 ENSDART00000135033
CT025585.1
ENSDARG00000093306
chr1_-_54294382 0.01 ENSDART00000038330
khsrp
KH-type splicing regulatory protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0010312 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
1.2 7.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
1.1 3.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.8 2.3 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.8 3.8 GO:0021982 pineal gland development(GO:0021982)
0.6 1.9 GO:0007624 ultradian rhythm(GO:0007624)
0.5 1.6 GO:0060898 radial glial cell differentiation(GO:0060019) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.5 1.8 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.4 1.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.4 3.4 GO:0070977 ossification involved in bone maturation(GO:0043931) bone maturation(GO:0070977)
0.3 0.9 GO:0043589 positive regulation of phospholipase C activity(GO:0010863) skin morphogenesis(GO:0043589) regulation of phospholipase C activity(GO:1900274)
0.3 1.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 0.5 GO:0050861 regulation of antigen receptor-mediated signaling pathway(GO:0050854) regulation of B cell receptor signaling pathway(GO:0050855) positive regulation of antigen receptor-mediated signaling pathway(GO:0050857) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.2 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.5 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 6.2 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 1.0 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 2.8 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 0.3 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.1 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.5 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 2.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 1.7 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 1.3 GO:0008354 germ cell migration(GO:0008354)
0.1 3.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 1.9 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.2 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.5 GO:0051289 protein homotetramerization(GO:0051289)
0.0 2.4 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 2.1 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 4.2 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.8 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 4.5 GO:0005869 dynactin complex(GO:0005869)
0.3 2.0 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.8 GO:0043195 terminal bouton(GO:0043195)
0.2 2.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.4 GO:0005581 collagen trimer(GO:0005581)
0.1 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.3 GO:0060293 germ plasm(GO:0060293)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 2.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 3.1 GO:0030424 axon(GO:0030424)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.6 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 2.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.4 6.2 GO:0070411 I-SMAD binding(GO:0070411)
0.4 1.8 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.3 1.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.2 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 8.4 GO:0045182 translation regulator activity(GO:0045182)
0.2 3.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.7 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 3.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.9 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.8 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 2.4 GO:0044325 ion channel binding(GO:0044325)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 3.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.2 GO:0022884 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.1 2.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 5.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.7 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.8 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.2 PID ALK2 PATHWAY ALK2 signaling events
0.2 5.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 3.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport