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Results for mycb
Z-value: 1.42
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Transcription factors associated with mycb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mycb | dr10_dc_chr2_+_32033176_32033202 | -0.54 | 3.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of mycb
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_24971633 Show fit | 6.72 |
ENSDART00000162801
|
polymerase (RNA) III (DNA directed) polypeptide G like a |
|
| chr20_-_23184142 Show fit | 4.64 |
ENSDART00000176282
|
ENSDARG00000108718 |
|
| chr15_+_19902697 Show fit | 3.04 |
ENSDART00000101204
|
activated leukocyte cell adhesion molecule b |
|
| chr16_+_24045774 Show fit | 3.03 |
ENSDART00000133484
|
apolipoprotein Eb |
|
| chr8_+_46378250 Show fit | 2.96 |
ENSDART00000129661
ENSDART00000084081 |
8-oxoguanine DNA glycosylase |
|
| chr24_+_23599223 Show fit | 2.53 |
|
|
|
| chr11_+_6446302 Show fit | 2.47 |
ENSDART00000140707
ENSDART00000036939 |
growth arrest and DNA-damage-inducible, beta a |
|
| chr23_-_28099284 Show fit | 2.22 |
ENSDART00000024283
|
Sp5 transcription factor-like |
|
| chr11_+_7139675 Show fit | 2.11 |
ENSDART00000155864
|
ENSDARG00000097452 |
|
| chr3_-_23444371 Show fit | 2.03 |
ENSDART00000087726
|
insulin-like growth factor 2 mRNA binding protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.2 | 6.2 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 1.7 | 5.1 | GO:0071830 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
| 0.4 | 4.1 | GO:0006285 | base-excision repair, AP site formation(GO:0006285) |
| 0.4 | 3.0 | GO:0021885 | forebrain cell migration(GO:0021885) |
| 0.2 | 2.9 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.0 | 2.9 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.8 | 2.5 | GO:1904019 | epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) |
| 0.2 | 2.2 | GO:0000467 | exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) |
| 0.1 | 2.0 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 7.7 | GO:0005730 | nucleolus(GO:0005730) |
| 1.3 | 5.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 2.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.2 | GO:0030424 | axon(GO:0030424) |
| 0.3 | 2.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 1.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.6 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.0 | 1.6 | GO:0030496 | midbody(GO:0030496) |
| 0.3 | 1.3 | GO:0032019 | mitochondrial cloud(GO:0032019) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 4.5 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 1.0 | 4.1 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.0 | 3.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.0 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.5 | 2.3 | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 0.0 | 2.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 1.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 1.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 1.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 1.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.1 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 3.0 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.1 | 2.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 2.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 1.8 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 1.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 1.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.4 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 1.2 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |