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Results for nfat5a+nfat5b

Z-value: 0.74

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Transcription factors associated with nfat5a+nfat5b

Gene Symbol Gene ID Gene Info
nfat5a
ENSDARG00000020872 nuclear factor of activated T cells 5a
nfat5b
ENSDARG00000102556 nuclear factor of activated T cells 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfat5bdr10_dc_chr7_+_67102061_671020890.665.7e-03Click!
nfat5adr10_dc_chr25_-_36550392_365505160.312.5e-01Click!

Activity profile of nfat5a+nfat5b motif

Sorted Z-values of nfat5a+nfat5b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nfat5a+nfat5b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_30013086 1.24 ENSDART00000138050
rbm33b
RNA binding motif protein 33b
chr23_-_31719203 1.23 ENSDART00000148122
sgk1
serum/glucocorticoid regulated kinase 1
chr14_-_34293596 1.12 ENSDART00000128869
afap1l1a
actin filament associated protein 1-like 1a
chr15_-_25164321 1.10 ENSDART00000154628
fam101b
family with sequence similarity 101, member B
chr21_-_32747592 1.04

chr4_+_75515863 0.94 ENSDART00000163676
CU467646.6
ENSDARG00000104678
chr7_-_2614300 0.94 ENSDART00000153548
BX323987.1
ENSDARG00000097745
chr22_+_4035577 0.93 ENSDART00000170620
ctxn1
cortexin 1
chr21_+_21242470 0.93 ENSDART00000148346
itpkca
inositol-trisphosphate 3-kinase Ca
chr2_-_6203659 0.92 ENSDART00000164269
prdx1
peroxiredoxin 1
chr3_+_59972297 0.92

chr10_+_15296880 0.90 ENSDART00000023766
vldlr
very low density lipoprotein receptor
chr24_-_19574944 0.79 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr23_+_2786407 0.76 ENSDART00000066086
zgc:114123
zgc:114123
chr13_+_28785104 0.72

chr2_-_22631167 0.70 ENSDART00000168653
ENSDART00000158558
fam110b
BX927330.1
family with sequence similarity 110, member B
ENSDARG00000098356
chr3_+_31948579 0.69 ENSDART00000124943
aldh16a1
aldehyde dehydrogenase 16 family, member A1
chr1_-_44893257 0.68 ENSDART00000160961
atf7ip
activating transcription factor 7 interacting protein
chr19_+_30266913 0.67 ENSDART00000109729
si:ch73-130a3.4
si:ch73-130a3.4
chr21_-_32747544 0.66

chr22_+_1663690 0.65 ENSDART00000166672
si:dkey-1b17.6
si:dkey-1b17.6
chr12_+_30389706 0.65

chr7_+_31750514 0.64 ENSDART00000173976
mettl15
methyltransferase like 15
chr9_+_33334773 0.63 ENSDART00000005879
atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr16_-_21241981 0.62 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr14_-_30604897 0.61 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr20_-_22631007 0.60

chr5_-_56641212 0.59 ENSDART00000050957
fer
fer (fps/fes related) tyrosine kinase
chr1_-_53052062 0.58 ENSDART00000162751
xpo1a
exportin 1 (CRM1 homolog, yeast) a
chr15_-_18273640 0.56 ENSDART00000141508
btr16
bloodthirsty-related gene family, member 16
chr19_-_25564720 0.54 ENSDART00000148432
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr9_+_34510091 0.53 ENSDART00000035522
ENSDART00000170615
ENSDART00000146480
pou2f1b
POU class 2 homeobox 1b
chr1_-_7882397 0.51 ENSDART00000114613
ptcd1
pentatricopeptide repeat domain 1
chr22_-_8276968 0.51 ENSDART00000123982
CABZ01077218.1
ENSDARG00000089720
chr7_-_56472076 0.50

chr12_-_17481026 0.49 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr21_+_31216418 0.48 ENSDART00000178521
asl
argininosuccinate lyase
chr6_-_22910576 0.48 ENSDART00000164114
grb2a
growth factor receptor-bound protein 2a
chr9_-_32240567 0.47

chr3_-_32457708 0.46

chr7_+_28844711 0.45 ENSDART00000052345
tradd
tnfrsf1a-associated via death domain
chr25_-_34631252 0.44 ENSDART00000109751
zgc:173585
zgc:173585
chr24_-_19574666 0.42 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr6_-_12665211 0.41 ENSDART00000150887
ical1
islet cell autoantigen 1-like
chr22_-_20394671 0.40 ENSDART00000105520
pias4a
protein inhibitor of activated STAT, 4a
chr24_+_41409608 0.39 ENSDART00000176003
nub1
negative regulator of ubiquitin-like proteins 1
chr7_-_31749636 0.38 ENSDART00000023568
kif18a
kinesin family member 18A
chr4_+_10605257 0.38 ENSDART00000122636
ENSDART00000037140
ing3
inhibitor of growth family, member 3
chr17_+_43022709 0.35 ENSDART00000055541
gskip
gsk3b interacting protein
chr19_+_3115685 0.35 ENSDART00000127473
ENSDART00000126549
ENSDART00000024593
ENSDART00000082353
ENSDART00000141324
hsf1
heat shock transcription factor 1
chr3_-_40387858 0.35 ENSDART00000055194
actb2
actin, beta 2
chr5_+_1461715 0.35 ENSDART00000054057
ddrgk1
DDRGK domain containing 1
chr9_+_6277952 0.34 ENSDART00000078525
uxs1
UDP-glucuronate decarboxylase 1
chr7_+_55648832 0.34 ENSDART00000082780
ACSF3
acyl-CoA synthetase family member 3
chr5_-_9443859 0.34

chr19_-_8829701 0.34 ENSDART00000031173
rps27.1
ribosomal protein S27, isoform 1
chr14_+_23673635 0.33 ENSDART00000124944
kif3a
kinesin family member 3A
chr2_-_30012325 0.32 ENSDART00000020792
cnpy1
canopy1
chr24_-_19574761 0.32 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr19_+_41596472 0.30

chr3_+_21928413 0.29 ENSDART00000122782
kansl1b
KAT8 regulatory NSL complex subunit 1b
chr3_-_35425227 0.29 ENSDART00000010944
dctn5
dynactin 5
chr8_+_19472074 0.28 ENSDART00000158859
ENSDART00000157697
sec22bb
SEC22 homolog B, vesicle trafficking protein b
chr22_-_26231695 0.27 ENSDART00000142821
ccdc130
coiled-coil domain containing 130
chr11_-_12024136 0.27 ENSDART00000111919
sp2
sp2 transcription factor
chr6_-_22910388 0.26 ENSDART00000164114
grb2a
growth factor receptor-bound protein 2a
chr8_-_12631385 0.25 ENSDART00000143155
CU639468.1
ENSDARG00000093851
chr11_-_30364563 0.25 ENSDART00000165501
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr13_-_49826526 0.25 ENSDART00000099475
nid1a
nidogen 1a
chr3_-_5157662 0.25 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr7_-_48394268 0.23 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr17_+_12504341 0.23 ENSDART00000139918
gpn1
GPN-loop GTPase 1
chr19_+_33220009 0.23 ENSDART00000008698
stk3
serine/threonine kinase 3 (STE20 homolog, yeast)
chr12_-_17480978 0.22 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr23_-_3760604 0.22 ENSDART00000143731
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr8_-_4732671 0.21 ENSDART00000082256
ciao1
cytosolic iron-sulfur assembly component 1
chr7_+_71766373 0.21 ENSDART00000011303
ywhae2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
chr5_-_12853593 0.20 ENSDART00000099602
ube2l3b
ubiquitin-conjugating enzyme E2L 3b
chr5_+_41658782 0.20 ENSDART00000143738
eral1
Era-like 12S mitochondrial rRNA chaperone 1
chr7_+_24983985 0.18

chr1_+_18610282 0.18 ENSDART00000129970
si:dkeyp-118a3.2
si:dkeyp-118a3.2
chr1_-_44874299 0.17

chr16_+_43174128 0.17 ENSDART00000014140
rundc3b
RUN domain containing 3b
chr24_-_28150352 0.16 ENSDART00000145290
bcl2a
B-cell CLL/lymphoma 2a
chr9_-_46614949 0.16 ENSDART00000009790
cx43.4
connexin 43.4
chr12_-_10403738 0.16 ENSDART00000014379
uqcrc2b
ubiquinol-cytochrome c reductase core protein IIb
chr2_+_7127672 0.15 ENSDART00000050597
xpr1b
xenotropic and polytropic retrovirus receptor 1b
chr18_+_16726807 0.15 ENSDART00000166849
eif4g2b
eukaryotic translation initiation factor 4, gamma 2b
chr2_-_42643265 0.14 ENSDART00000009093
esyt2a
extended synaptotagmin-like protein 2a
chr18_+_5637539 0.14

chr1_+_44248486 0.14 ENSDART00000067621
vps37c
vacuolar protein sorting 37 homolog C (S. cerevisiae)
chr19_-_10295398 0.14 ENSDART00000148225
znf865
zinc finger protein 865
chr3_+_34063993 0.13

chr13_+_21973848 0.13 ENSDART00000115393
si:dkey-174i8.1
si:dkey-174i8.1
chr11_-_30364626 0.12 ENSDART00000089803
ENSDART00000046800
ENSDART00000172244
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr16_-_42857240 0.12

chr24_+_36478896 0.12

chr24_-_21529774 0.12 ENSDART00000123216
lnx2a
ligand of numb-protein X 2a
chr25_-_12236333 0.11 ENSDART00000174863
ENSDART00000179042
BX323452.1
ENSDARG00000107774
chr20_+_411845 0.11 ENSDART00000108872
ndufaf4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr4_-_12837406 0.11

chr18_+_5637588 0.10

chr6_-_36574848 0.10 ENSDART00000135413
her6
hairy-related 6
chr22_-_31602823 0.10

chr14_+_23673541 0.09 ENSDART00000124944
kif3a
kinesin family member 3A
chr17_+_43022617 0.09 ENSDART00000055541
gskip
gsk3b interacting protein
chr13_-_16127236 0.08 ENSDART00000079745
zgc:110045
zgc:110045
chr3_-_32457740 0.07

chr16_-_28901882 0.07 ENSDART00000142920
zgc:162150
zgc:162150
chr17_-_23947646 0.07

chr9_+_54185729 0.07 ENSDART00000165991
lect1
leukocyte cell derived chemotaxin 1
chr19_-_3115104 0.07 ENSDART00000093146
bop1
block of proliferation 1
chr7_-_29003965 0.06

chr23_-_36023579 0.06

chr19_-_10295122 0.06 ENSDART00000148225
znf865
zinc finger protein 865
chr8_+_31863748 0.06 ENSDART00000146933
c7a
complement component 7a
chr17_-_33462243 0.06 ENSDART00000131807
ccdc28a
coiled-coil domain containing 28A
chr19_-_42847112 0.05 ENSDART00000086961
vps45
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr7_+_39173765 0.04 ENSDART00000173748
tnnt3b
troponin T type 3b (skeletal, fast)
chr7_+_39353662 0.04 ENSDART00000173847
ENSDART00000173845
ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr16_+_21122024 0.04

chr8_+_50994889 0.04 ENSDART00000142061
si:dkey-32e23.4
si:dkey-32e23.4
chr7_-_56493164 0.03

chr18_+_16726839 0.03 ENSDART00000166849
eif4g2b
eukaryotic translation initiation factor 4, gamma 2b
chr9_-_11291927 0.03 ENSDART00000113847
chpfa
chondroitin polymerizing factor a
chr5_-_12213712 0.03 ENSDART00000099749
CLDN22
claudin 22
chr13_+_6990132 0.03 ENSDART00000140828
CU179758.1
ENSDARG00000094815
chr7_-_45747112 0.03 ENSDART00000172591
zgc:162297
zgc:162297
chr19_+_3115791 0.02 ENSDART00000127473
ENSDART00000126549
ENSDART00000024593
ENSDART00000082353
ENSDART00000141324
hsf1
heat shock transcription factor 1
chr18_-_1006445 0.02 ENSDART00000062654
parp6a
poly (ADP-ribose) polymerase family, member 6a
chr13_-_42630594 0.02 ENSDART00000111255
capn2a
calpain 2, (m/II) large subunit a
chr7_-_28844560 0.02 ENSDART00000076386
fbxl8
F-box and leucine-rich repeat protein 8
chr2_-_41669059 0.01 ENSDART00000130830
otomp
otolith matrix protein
chr15_+_11809276 0.01 ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr2_+_24135188 0.01 ENSDART00000041877
csrnp1a
cysteine-serine-rich nuclear protein 1a
chr2_-_41669008 0.01 ENSDART00000130830
otomp
otolith matrix protein
chr9_-_46615155 0.00 ENSDART00000009790
cx43.4
connexin 43.4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.1 0.4 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.1 0.9 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 0.4 GO:2000058 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.6 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.6 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.9 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.3 GO:0035264 multicellular organism growth(GO:0035264)
0.0 0.1 GO:0030002 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.5 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.0 0.6 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.4 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 1.5 GO:0030901 midbrain development(GO:0030901)
0.0 0.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101) negative regulation of endoplasmic reticulum unfolded protein response(GO:1900102) regulation of IRE1-mediated unfolded protein response(GO:1903894) negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.0 0.2 GO:1900006 membrane tubulation(GO:0097320) positive regulation of dendrite development(GO:1900006)
0.0 0.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.0 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.4 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.1 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.1 0.9 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.3 GO:0097433 dense body(GO:0097433)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.6 GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424)
0.1 0.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.9 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.1 0.3 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT