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Results for nfe2l3

Z-value: 0.99

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Transcription factors associated with nfe2l3

Gene Symbol Gene ID Gene Info
nfe2l3
ENSDARG00000019810 nuclear factor, erythroid 2-like 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfe2l3dr10_dc_chr19_-_18689571_186896920.811.4e-04Click!

Activity profile of nfe2l3 motif

Sorted Z-values of nfe2l3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nfe2l3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_39661423 2.56 ENSDART00000110380
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr14_+_26137608 2.43 ENSDART00000175459
gpr137
G protein-coupled receptor 137
chr20_-_17006936 2.15 ENSDART00000012859
psma6b
proteasome subunit alpha 6b
chr22_-_6977038 2.05 ENSDART00000133143
ENSDART00000146813
gpd1b
glycerol-3-phosphate dehydrogenase 1b
chr1_-_51862897 1.96 ENSDART00000136469
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr13_-_22877318 1.85 ENSDART00000057638
ENSDART00000171778
hk1
hexokinase 1
chr3_-_25886553 1.74 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr2_+_4366169 1.51 ENSDART00000157903
gata6
GATA binding protein 6
chr10_+_29378834 1.39 ENSDART00000155390
crebzf
CREB/ATF bZIP transcription factor
chr12_+_30591157 1.34 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr19_-_7235125 1.26

chr7_+_56807833 1.26 ENSDART00000055956
enosf1
enolase superfamily member 1
chr15_-_44260141 1.24 ENSDART00000121597
CU929391.2
ENSDARG00000090304
chr25_-_36876940 1.19

chr23_-_44729542 1.15 ENSDART00000024082
psmb6
proteasome subunit beta 6
chr10_+_31336284 1.13 ENSDART00000140988
tmem218
transmembrane protein 218
chr13_-_22901327 1.12 ENSDART00000056523
hkdc1
hexokinase domain containing 1
chr14_-_6901415 1.10 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr12_-_1931281 1.10 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr7_-_6273677 1.09 ENSDART00000173419
si:ch73-368j24.1
si:ch73-368j24.1
chr14_+_33727750 1.04 ENSDART00000135556
lonrf1
LON peptidase N-terminal domain and ring finger 1
chr19_+_43524098 1.03 ENSDART00000129362
eef1a1l2
eukaryotic translation elongation factor 1 alpha 1, like 2
chr6_+_9185750 1.02 ENSDART00000161036
kalrnb
kalirin RhoGEF kinase b
chr21_-_23074223 0.97 ENSDART00000147896
usp28
ubiquitin specific peptidase 28
chr6_-_39311711 0.96

chr21_+_8249235 0.94 ENSDART00000129749
psmb7
proteasome subunit beta 7
chr14_-_25688444 0.94 ENSDART00000172909
atox1
antioxidant 1 copper chaperone
chr18_+_1347470 0.93

chr5_-_66792947 0.90 ENSDART00000147009
si:dkey-251i10.2
si:dkey-251i10.2
chr19_-_6466494 0.90 ENSDART00000104950
atp1a3a
ATPase, Na+/K+ transporting, alpha 3a polypeptide
chr9_+_41301317 0.88 ENSDART00000000250
slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr20_-_48773402 0.88 ENSDART00000161769
mgst3a
microsomal glutathione S-transferase 3a
chr19_-_41819752 0.86 ENSDART00000167772
shfm1
split hand/foot malformation (ectrodactyly) type 1
chr5_-_30015572 0.86 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr8_+_39525254 0.84

chr8_+_21974863 0.81

chr11_-_2107054 0.78 ENSDART00000173031
hoxc6b
homeobox C6b
chr1_-_51863187 0.78 ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr2_-_25306278 0.75 ENSDART00000132050
hltf
helicase-like transcription factor
chr15_-_28744697 0.74 ENSDART00000060255
blmh
bleomycin hydrolase
chr14_+_34440699 0.72 ENSDART00000130469
sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr20_-_39200252 0.72 ENSDART00000037318
ENSDART00000143379
rcan2
regulator of calcineurin 2
chr2_-_26987186 0.69 ENSDART00000132854
u2surp
U2 snRNP-associated SURP domain containing
chr6_+_55413069 0.67

chr1_+_52365033 0.65 ENSDART00000133411
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr16_+_13993746 0.65 ENSDART00000101304
atg12
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr15_-_1625846 0.65 ENSDART00000081875
nnr
nanor
chr6_-_20625494 0.65

chr22_+_16509286 0.63 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr19_+_25288143 0.62 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr6_-_39312306 0.59

chr13_+_46487890 0.58

chr2_+_4366348 0.56 ENSDART00000166476
gata6
GATA binding protein 6
chr14_-_17282615 0.55 ENSDART00000006716
ENSDART00000136242
selt2
selenoprotein T, 2
chr14_-_3951077 0.54

chr21_-_45308592 0.53 ENSDART00000008454
skp1
S-phase kinase-associated protein 1
chr3_-_54884533 0.50 ENSDART00000115324
hbae1.3
hemoglobin, alpha embryonic 1.3
chr23_+_5632124 0.49 ENSDART00000059307
smpd2a
sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase)
chr4_+_5308883 0.49 ENSDART00000150366
si:ch211-214j24.10
si:ch211-214j24.10
chr17_-_12812747 0.48 ENSDART00000022874
ENSDART00000046025
psma6a
proteasome subunit alpha 6a
chr3_+_25933164 0.48 ENSDART00000143697
si:dkeyp-69e1.8
si:dkeyp-69e1.8
chr6_-_32362232 0.46 ENSDART00000140004
angptl3
angiopoietin-like 3
chr21_-_25719352 0.46 ENSDART00000002341
cldnc
claudin c
chr14_+_24543732 0.45 ENSDART00000106039
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr7_+_10346939 0.44

chr6_+_59749159 0.44

chr1_-_39509011 0.43 ENSDART00000146680
ENSDARG00000078251
ENSDARG00000078251
chr5_-_44243476 0.42 ENSDART00000161408
fbp1a
fructose-1,6-bisphosphatase 1a
chr2_-_31817355 0.42 ENSDART00000112763
retreg1
reticulophagy regulator 1
chr14_+_34440799 0.37 ENSDART00000173371
sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr14_-_38532216 0.36 ENSDART00000127479
gsr
glutathione reductase
chr25_-_34677352 0.36 ENSDART00000115210
ano9a
anoctamin 9a
chr23_+_9625994 0.32 ENSDART00000081433
adrm1
adhesion regulating molecule 1
chr7_+_890752 0.31 ENSDART00000111531
epdl1
ependymin-like 1
chr1_-_32647357 0.31 ENSDART00000136383
cd99
CD99 molecule
chr5_+_42312784 0.31 ENSDART00000039973
rufy3
RUN and FYVE domain containing 3
chr25_-_34540270 0.30 ENSDART00000156508
zgc:114046
zgc:114046
chr7_+_620117 0.30 ENSDART00000152224
zgc:63470
zgc:63470
chr23_+_44729796 0.30 ENSDART00000139088
ENSDART00000139547
trappc1
trafficking protein particle complex 1
chr25_-_1980943 0.29 ENSDART00000104915
wnt7bb
wingless-type MMTV integration site family, member 7Bb
chr4_+_1908127 0.29 ENSDART00000032460
med21
mediator complex subunit 21
chr2_+_4366568 0.29 ENSDART00000166476
gata6
GATA binding protein 6
chr24_-_3637123 0.29

chr9_+_6959065 0.28 ENSDART00000114323
mfsd9
major facilitator superfamily domain containing 9
chr11_+_30035395 0.27 ENSDART00000122756
si:dkey-163f14.6
si:dkey-163f14.6
chr3_+_15834458 0.26

chr9_-_33518171 0.26 ENSDART00000160534
ENSDART00000132973
rpl8
ribosomal protein L8
chr7_+_17740815 0.26 ENSDART00000173679
ehbp1l1a
EH domain binding protein 1-like 1a
chr10_+_26786051 0.25 ENSDART00000100329
f9b
coagulation factor IXb
chr14_-_6901783 0.24 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr3_-_25886604 0.23 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr3_-_21149752 0.23 ENSDART00000003939
syngr1a
synaptogyrin 1a
chr15_+_44260315 0.23 ENSDART00000128885
cwf19l2
CWF19-like 2, cell cycle control (S. pombe)
chr19_+_43537350 0.21

chr7_-_18791134 0.20 ENSDART00000158796
fcer1g
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr2_+_4366515 0.20 ENSDART00000166476
gata6
GATA binding protein 6
chr16_+_24806508 0.20 ENSDART00000109459
ENSDART00000155754
smg9
smg9 nonsense mediated mRNA decay factor
chr2_+_10023967 0.19 ENSDART00000148227
anxa13l
annexin A13, like
chr5_-_23179648 0.19

chr18_+_17548213 0.19 ENSDART00000144960
nup93
nucleoporin 93
chr18_-_20159345 0.19

chr1_+_13386937 0.17 ENSDART00000021693
ank2a
ankyrin 2a, neuronal
chr13_+_25266451 0.17 ENSDART00000041257
gsto2
glutathione S-transferase omega 2
chr13_-_41420815 0.17 ENSDART00000163331
ENSDART00000164732
pcdh15a
protocadherin-related 15a
chr8_+_17975195 0.16 ENSDART00000039887
ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr3_-_21149711 0.16 ENSDART00000003939
syngr1a
synaptogyrin 1a
chr22_-_35087752 0.15 ENSDART00000162211
ENSDART00000158158
zgc:63733
zgc:63733
chr21_+_27266000 0.14 ENSDART00000012855
sart1
squamous cell carcinoma antigen recognised by T cells
chr2_+_25622497 0.14 ENSDART00000131977
ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr17_-_11285631 0.13 ENSDART00000130105
psma3
proteasome subunit alpha 3
chr9_-_23442944 0.10 ENSDART00000143657
ENSDART00000169911
ENSDART00000167779
acmsd
aminocarboxymuconate semialdehyde decarboxylase
chr7_-_2308580 0.09 ENSDART00000098148
ENSDART00000173624
si:cabz01007802.1
si:cabz01007802.1
chr8_+_39478197 0.07

chr14_-_6680528 0.07 ENSDART00000060990
eif4ebp3l
eukaryotic translation initiation factor 4E binding protein 3, like
chr7_-_24337079 0.07

chr12_+_30591482 0.04 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr5_+_44205128 0.04 ENSDART00000136965
ctsla
cathepsin La
chr6_-_39312114 0.03

chr16_+_50355723 0.03 ENSDART00000166664
ENSDARG00000102916
ENSDARG00000102916
chr19_-_33013748 0.02 ENSDART00000134149
zgc:91944
zgc:91944
chr23_+_25365281 0.01 ENSDART00000016248
pa2g4b
proliferation-associated 2G4, b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.4 2.0 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 2.6 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.2 2.4 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.2 2.8 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.2 1.5 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.2 4.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.5 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.2 1.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 0.5 GO:0055091 negative regulation of phospholipase activity(GO:0010519) phospholipid homeostasis(GO:0055091)
0.1 1.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.9 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.3 GO:2000391 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.1 0.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.1 1.0 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 0.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.9 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.5 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805) quinolinate metabolic process(GO:0046874)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.3 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 2.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 2.1 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.5 GO:0005833 hemoglobin complex(GO:0005833) haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.4 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.4 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0004046 aminoacylase activity(GO:0004046)
0.5 2.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.5 2.8 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 2.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 0.9 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 1.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 2.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.9 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.7 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.4 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.5 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.4 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.8 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 1.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 0.9 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.3 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 2.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates