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Results for nfia
Z-value: 1.82
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Transcription factors associated with nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfia | dr10_dc_chr22_-_17026421_17026447 | 0.89 | 4.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfia
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_30673907 Show fit | 7.18 |
ENSDART00000053946
|
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) |
|
| chr21_-_11539798 Show fit | 5.93 |
ENSDART00000144770
|
calpastatin |
|
| chr15_-_29454583 Show fit | 5.82 |
ENSDART00000145976
|
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b |
|
| chr12_+_42281025 Show fit | 5.72 |
ENSDART00000167324
|
early B-cell factor 3a |
|
| chr12_-_17590507 Show fit | 5.07 |
ENSDART00000010144
|
parvalbumin 2 |
|
| chr2_+_2628865 Show fit | 4.62 |
ENSDART00000061955
|
myosin, light chain 13 |
|
| chr5_-_31692803 Show fit | 4.62 |
ENSDART00000131983
|
myosin, heavy polypeptide 1.2, skeletal muscle |
|
| chr9_-_42894582 Show fit | 4.58 |
ENSDART00000144744
|
collagen, type V, alpha 2a |
|
| chr3_+_23090476 Show fit | 4.38 |
ENSDART00000009393
|
collagen, type I, alpha 1a |
|
| chr22_-_27082972 Show fit | 4.31 |
ENSDART00000077411
|
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.4 | GO:0097535 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.1 | 10.1 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.3 | 7.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.3 | 6.6 | GO:0001757 | somite specification(GO:0001757) |
| 0.0 | 6.2 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter(GO:0045944) |
| 0.1 | 6.1 | GO:0021515 | cell differentiation in spinal cord(GO:0021515) |
| 0.1 | 6.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 5.9 | GO:0097340 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 0.3 | 5.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.4 | 5.1 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 11.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 10.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 7.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.4 | 7.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 6.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 5.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.5 | 4.6 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 4.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.0 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.2 | 14.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.1 | 11.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 8.8 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.1 | 8.5 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 6.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 5.9 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.6 | 5.4 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.3 | 5.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 4.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 1.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 1.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 5.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 2.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 2.2 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 2.2 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.1 | 2.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 2.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |