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Results for nfil3-5+nfil3-6+si:dkey-60d5.3

Z-value: 1.33

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Transcription factors associated with nfil3-5+nfil3-6+si:dkey-60d5.3

Gene Symbol Gene ID Gene Info
ENSDARG00000087188 nuclear factor, interleukin 3 regulated, member 6
ENSDARG00000094965 nuclear factor, interleukin 3 regulated, member 5
ENSDARG00000097088 si_dkey-60d5.3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfil3-5dr10_dc_chr6_+_7936632_7936769-0.656.7e-03Click!

Activity profile of nfil3-5+nfil3-6+si:dkey-60d5.3 motif

Sorted Z-values of nfil3-5+nfil3-6+si:dkey-60d5.3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nfil3-5+nfil3-6+si:dkey-60d5.3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr21_-_32747592 6.70

chr9_-_12916555 6.51 ENSDART00000140691
si:ch211-167j6.3
chr2_+_28199458 3.16 ENSDART00000150330
bucky ball
chr11_+_24583090 2.75 ENSDART00000135443
lysine (K)-specific demethylase 5Ba
chr8_-_37989930 2.73

chr19_-_35411993 2.73 ENSDART00000051751
zgc:113424
chr21_+_5027444 2.62 ENSDART00000139288
si:dkey-121h17.7
chr22_+_748767 2.53 ENSDART00000125347
cryptochrome circadian clock 1bb
chr14_+_3399943 2.45 ENSDART00000159326
glutathione S-transferase pi 1
chr21_+_43183522 2.41 ENSDART00000151350
AF4/FMR2 family, member 4
chr23_+_19663746 2.38 ENSDART00000170149
sarcolemma associated protein b
chr24_-_23639325 2.32 ENSDART00000090368
serum/glucocorticoid regulated kinase family, member 3
chr17_-_23689233 2.32 ENSDART00000124661
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr24_-_23639458 2.14 ENSDART00000090368
serum/glucocorticoid regulated kinase family, member 3
chr12_-_24711074 2.13 ENSDART00000066317
forkhead box N2b
chr22_-_29740737 2.13 ENSDART00000009223
programmed cell death 4b
chr22_-_11817587 2.11 ENSDART00000000192
protein tyrosine phosphatase, non-receptor type 4b
chr11_-_40383013 2.06 ENSDART00000112140
family with sequence similarity 213, member B
chr13_-_50940551 2.04

chr25_+_30627892 2.04

chr2_+_46210971 2.03

chr2_+_34984631 2.01 ENSDART00000141796
astrotactin 1
chr2_+_46210909 1.97

chr7_-_37283707 1.94 ENSDART00000148905
ENSDART00000150229
cylindromatosis (turban tumor syndrome), a
chr4_-_14981572 1.92

chr20_-_44678938 1.91 ENSDART00000148639
UBX domain protein 2A
chr3_+_22204475 1.90 ENSDART00000055676
ENSDARG00000038186
chr16_-_31834830 1.90

chr22_-_26537845 1.88

chr21_-_32747544 1.86

chr18_-_14910497 1.84 ENSDART00000099701
selenoprotein O
chr13_-_50940520 1.84

chr5_-_47610384 1.82

chr19_+_24398149 1.80 ENSDART00000080673
synaptotagmin XIa
chr1_+_34763140 1.76 ENSDART00000053806
GRB2-associated binding protein 1
chr4_-_27109874 1.75 ENSDART00000146459
cysteine-rich with EGF-like domains 2
chr10_+_18953548 1.73 ENSDART00000030205
BCL2/adenovirus E1B interacting protein 3-like b
chr23_-_32239909 1.73

chr11_-_10001506 1.71 ENSDART00000123359
neuroligin 1
chr1_+_34763197 1.70 ENSDART00000053806
GRB2-associated binding protein 1
chr21_+_5027623 1.67 ENSDART00000139288
si:dkey-121h17.7
chr3_-_26052785 1.63 ENSDART00000147517
si:ch211-11k18.4
chr19_+_8693855 1.62 ENSDART00000144925
sorting nexin family member 27a
chr24_-_26866824 1.62

chr25_-_13394261 1.60 ENSDART00000056721
lactate dehydrogenase D
chr23_-_32267833 1.60

chr8_-_21071108 1.58 ENSDART00000137838
aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1
chr25_+_30627755 1.58

chr5_+_22470117 1.53 ENSDART00000020434
bromodomain and WD repeat domain containing 3
chr6_-_19556029 1.52 ENSDART00000136019
protein phosphatase 1, regulatory subunit 12C
chr16_+_41004372 1.51 ENSDART00000058587
glycogen synthase kinase binding protein
chr10_+_16914003 1.48 ENSDART00000177906
unc-13 homolog B
chr4_-_14916491 1.46 ENSDART00000067040
si:dkey-180p18.9
chr3_-_29760552 1.45 ENSDART00000014021
solute carrier family 25, member 39
chr12_-_24711169 1.41 ENSDART00000066317
forkhead box N2b
chr15_+_24802510 1.40 ENSDART00000078024
v-crk avian sarcoma virus CT10 oncogene homolog
chr21_+_26486084 1.40 ENSDART00000134617
adenylosuccinate synthase, like
chr20_-_36714338 1.40 ENSDART00000172395
ENSDART00000152856
enabled homolog (Drosophila)
chr12_-_28679813 1.39 ENSDART00000020667
oxysterol binding protein-like 7
chr1_-_26088792 1.37 ENSDART00000152406
SH3 domain containing GRB2 like 2a, endophilin A1
chr16_-_40633986 1.37 ENSDART00000170815
ENSDARG00000100586
chr23_+_37364185 1.36 ENSDART00000006436
PTEN induced putative kinase 1
chr21_+_5854755 1.35 ENSDART00000149689
MOB kinase activator 1Bb
chr8_-_29842489 1.35 ENSDART00000149297
solute carrier family 20 (phosphate transporter), member 2
chr20_+_1100809 1.35 ENSDART00000064472
proline-rich nuclear receptor coactivator 1
chr22_-_29740663 1.35 ENSDART00000009223
programmed cell death 4b
chr19_-_17306473 1.34 ENSDART00000007906
stathmin 1a
chr18_+_21962395 1.33 ENSDART00000089507
RAN binding protein 10
chr18_+_6396038 1.32 ENSDART00000024576
FK506 binding protein 4
chr3_+_22204569 1.30 ENSDART00000055676
ENSDARG00000038186
chr15_+_27000467 1.30 ENSDART00000023842
protein phosphatase, Mg2+/Mn2+ dependent, 1Da
chr9_-_34700736 1.29 ENSDART00000169114
protein phosphatase 2, regulatory subunit B'', beta
chr14_-_21320696 1.28 ENSDART00000043162
receptor accessory protein 2
chr16_-_31835007 1.28

chr21_+_5027668 1.28 ENSDART00000139288
si:dkey-121h17.7
chr3_+_7877162 1.27 ENSDART00000057434
ENSDART00000170291
hook microtubule-tethering protein 2
chr12_-_13511174 1.27 ENSDART00000133895
GH3 domain containing
chr16_-_33151404 1.26 ENSDART00000145055
proline-rich nuclear receptor coactivator 2
chr6_-_19556328 1.25 ENSDART00000074256
protein phosphatase 1, regulatory subunit 12C
chr19_+_20404995 1.24 ENSDART00000142841
oxysterol binding protein-like 3a
chr10_-_39362315 1.24 ENSDART00000023831
cryptochrome circadian clock 5
chr18_+_6396115 1.22 ENSDART00000149350
FK506 binding protein 4
chr10_+_18953503 1.20 ENSDART00000030205
BCL2/adenovirus E1B interacting protein 3-like b
chr6_-_39634534 1.19 ENSDART00000077839
activating transcription factor 7b
chr8_-_21071331 1.19 ENSDART00000171771
aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1
chr24_-_10756995 1.18 ENSDART00000145593
family with sequence similarity 49, member Bb
chr21_+_15660646 1.18 ENSDART00000101956
ENSDART00000026903
protein tyrosine phosphatase, receptor type, A
chr24_-_23639592 1.18 ENSDART00000090368
serum/glucocorticoid regulated kinase family, member 3
chr20_-_20370397 1.18 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr4_-_14916416 1.17 ENSDART00000067040
si:dkey-180p18.9
chr5_-_11471707 1.17 ENSDART00000166285
si:ch73-47f2.1
chr4_+_5325823 1.16 ENSDART00000163850
APEX nuclease (multifunctional DNA repair enzyme) 1
chr17_-_23689380 1.16 ENSDART00000124661
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr15_-_28547372 1.15 ENSDART00000057696
G protein-coupled receptor kinase interacting ArfGAP 1
chr16_+_41004516 1.14 ENSDART00000058587
glycogen synthase kinase binding protein
chr6_-_32424559 1.13 ENSDART00000151002
ubiquitin specific peptidase 1
chr13_+_29904913 1.12 ENSDART00000057525
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr3_-_26052601 1.12 ENSDART00000147517
si:ch211-11k18.4
chr24_-_9153339 1.11 ENSDART00000082434
TGFB-induced factor homeobox 1
chr11_+_5638359 1.11

chr13_+_29904945 1.10 ENSDART00000057525
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr23_-_29952020 1.09 ENSDART00000058407
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr22_+_818795 1.09 ENSDART00000003325
DENN/MADD domain containing 2Db
chr8_-_22537415 1.08 ENSDART00000165640
porcupine homolog like
chr5_-_13945310 1.08 ENSDART00000157675
K(lysine) acetyltransferase 6A
chr16_-_31834774 1.08

chr9_-_9754243 1.05 ENSDART00000092884
leucine rich repeat containing 58b
chr12_+_23939869 1.05 ENSDART00000021298
ankyrin repeat and SOCS box containing 3
chr11_+_40847576 1.05 ENSDART00000041531
parkinson protein 7
chr21_-_39521698 1.04 ENSDART00000020174
dynein, light chain, LC8-type 2b
chr17_-_23689317 1.04 ENSDART00000124661
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr6_-_19556121 1.02 ENSDART00000136019
protein phosphatase 1, regulatory subunit 12C
chr19_+_20405107 1.01 ENSDART00000151066
oxysterol binding protein-like 3a
chr17_+_39794317 0.98 ENSDART00000154996
si:dkey-229e3.2
chr2_-_38380883 0.98 ENSDART00000088026
protein arginine methyltransferase 5
chr21_+_1622040 0.98 ENSDART00000148540
ferrochelatase
chr15_-_41732606 0.97 ENSDART00000059327
splA/ryanodine receptor domain and SOCS box containing 4b
chr14_+_27811681 0.96

chr12_+_4651222 0.96 ENSDART00000128145
KAT8 regulatory NSL complex subunit 1a
chr21_+_5027911 0.95 ENSDART00000139288
si:dkey-121h17.7
chr21_+_5027576 0.94 ENSDART00000139288
si:dkey-121h17.7
chr16_-_25765512 0.94 ENSDART00000132693
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr21_+_43183835 0.94 ENSDART00000175107
AF4/FMR2 family, member 4
chr8_-_21071055 0.93 ENSDART00000131322
aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1
chr19_-_17306333 0.93 ENSDART00000132662
stathmin 1a
chr5_+_22470177 0.93 ENSDART00000020434
bromodomain and WD repeat domain containing 3
chr5_-_37648047 0.92 ENSDART00000139479
solute carrier family 12, member 9
chr10_-_27047692 0.92 ENSDART00000139942
ENSDART00000146983
ubiquinol-cytochrome c reductase complex assembly factor 3
chr20_+_1100589 0.90 ENSDART00000064472
proline-rich nuclear receptor coactivator 1
chr18_-_14910429 0.90 ENSDART00000099701
selenoprotein O
chr24_+_32610430 0.88 ENSDART00000132417
YME1-like 1a
chr14_+_21401897 0.88 ENSDART00000073707
syntaxin 3A
chr8_-_11286437 0.87 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr19_+_8693695 0.87 ENSDART00000144925
sorting nexin family member 27a
chr16_-_21241981 0.87 ENSDART00000131582
chromobox homolog 3b
chr19_-_35411924 0.86 ENSDART00000051751
zgc:113424
chr21_-_32748287 0.86 ENSDART00000031028
CCR4-NOT transcription complex, subunit 6a
chr20_-_20921480 0.85 ENSDART00000152781
creatine kinase, brain b
chr16_-_35474091 0.85 ENSDART00000172294
ENSDART00000162733
CTP synthase 1b
chr20_+_54404987 0.84 ENSDART00000099338
ARP10 actin related protein 10 homolog
chr16_+_28335377 0.84 ENSDART00000059035
family with sequence similarity 188, member A
chr24_-_9153377 0.84 ENSDART00000082434
TGFB-induced factor homeobox 1
chr2_+_21698627 0.84 ENSDART00000133228
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b
chr19_-_31223752 0.83 ENSDART00000103524
MYCL proto-oncogene, bHLH transcription factor b
chr23_+_32095225 0.83 ENSDART00000012963
trafficking protein particle complex 6b
chr14_-_30564987 0.82 ENSDART00000173451
si:ch211-126c2.4
chr12_-_24710877 0.81 ENSDART00000066317
forkhead box N2b
chr8_-_11286308 0.80 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr20_-_36714401 0.79 ENSDART00000165176
enabled homolog (Drosophila)
chr16_-_25765322 0.79 ENSDART00000132693
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr25_+_2968769 0.79

chr23_-_21607742 0.78 ENSDART00000139092
regulator of chromosome condensation 2
chr16_-_25765396 0.78 ENSDART00000132693
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr16_-_12206435 0.78 ENSDART00000103944
peroxisomal biogenesis factor 5
chr11_+_16017857 0.77 ENSDART00000081054
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr22_+_33180599 0.77 ENSDART00000004504
dystroglycan 1
chr6_+_48349630 0.77 ENSDART00000064826
Mov10 RISC complex RNA helicase a
chr14_+_23419864 0.77 ENSDART00000006373
Nedd4 family interacting protein 1
chr7_+_48025010 0.77 ENSDART00000052123
solute carrier family 25, member 44 b
chr7_+_17464608 0.77 ENSDART00000173792
reticulon 3
chr21_-_22320879 0.76 ENSDART00000134320
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr1_-_358810 0.76 ENSDART00000098627
protein S (alpha)
chr15_-_41732430 0.75 ENSDART00000059327
splA/ryanodine receptor domain and SOCS box containing 4b
chr2_-_32502787 0.75 ENSDART00000110821
tetratricopeptide repeat domain 19
chr1_-_19072200 0.75

chr3_+_16401508 0.75 ENSDART00000080771
solute carrier family 6, member 16a
chr8_-_11286377 0.74 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr3_+_16514376 0.73 ENSDART00000013816
ENSDARG00000013161
chr7_-_68114465 0.73

chr17_+_25815708 0.72 ENSDART00000164160
acyl-CoA synthetase short-chain family member 1
chr16_-_25765542 0.72 ENSDART00000132693
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr8_+_18509772 0.72 ENSDART00000089274
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr12_+_4651511 0.71 ENSDART00000128145
KAT8 regulatory NSL complex subunit 1a
chr17_+_17745119 0.69 ENSDART00000138189
ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr10_+_36718872 0.69 ENSDART00000063359
uncoupling protein 3
chr13_-_36486255 0.69 ENSDART00000160250
ENSDARG00000103360
chr3_+_23963926 0.68 ENSDART00000138270
coatomer protein complex, subunit zeta 2
chr13_-_36440277 0.68 ENSDART00000030133
synaptojanin 2 binding protein
chr12_+_25341625 0.68 ENSDART00000011662
protein phosphatase, Mg2+/Mn2+ dependent, 1Bb
chr7_-_21620707 0.68 ENSDART00000019699
methyltransferase like 3
chr5_-_37648291 0.67 ENSDART00000139479
solute carrier family 12, member 9
chr9_+_27909662 0.67 ENSDART00000112415
leucine carboxyl methyltransferase 2
chr19_+_1148544 0.66 ENSDART00000166088
zgc:63863
chr7_+_22127173 0.65

chr13_+_13799208 0.65 ENSDART00000079154
ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)
chr3_-_33127793 0.65 ENSDART00000151070
retinoic acid receptor, alpha b
chr15_-_16137131 0.64

chr1_+_51087450 0.64 ENSDART00000040397
peroxiredoxin 2
chr6_-_39634666 0.62 ENSDART00000077839
activating transcription factor 7b
chr11_-_16018729 0.62

chr18_-_2580747 0.62

chr1_+_15907685 0.62 ENSDART00000171166
microtubule associated tumor suppressor 1b
chr10_+_26982647 0.61 ENSDART00000135493
FERM domain containing 8
chr20_+_15264912 0.61 ENSDART00000063877
peroxiredoxin 6
chr16_-_25765583 0.60 ENSDART00000132693
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_-_32424706 0.59 ENSDART00000078908
ubiquitin specific peptidase 1
chr22_+_2313616 0.59

chr18_-_21961658 0.58 ENSDART00000043452
translin-associated factor X interacting protein 1
chr7_-_32511365 0.58 ENSDART00000052497
growth arrest-specific 2b
chr1_+_23778514 0.58 ENSDART00000176581
family with sequence similarity 160, member A1a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.9 2.7 GO:1903523 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.8 4.5 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.6 2.5 GO:0030521 androgen receptor signaling pathway(GO:0030521) regulation of androgen receptor signaling pathway(GO:0060765)
0.6 3.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.6 3.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.5 2.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.5 1.1 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.5 2.4 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.5 1.4 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.4 1.3 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.4 1.3 GO:0060853 forebrain radial glial cell differentiation(GO:0021861) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) regulation of mRNA modification(GO:0090365)
0.3 1.0 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.3 1.4 GO:0006828 manganese ion transport(GO:0006828)
0.3 1.9 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.3 1.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.3 1.1 GO:0061355 Wnt protein secretion(GO:0061355)
0.3 1.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.3 0.8 GO:0042730 fibrinolysis(GO:0042730)
0.2 1.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 0.7 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded DNA demethylation(GO:0035552)
0.2 2.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 1.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.2 1.0 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 1.3 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 0.7 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 4.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 2.2 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 1.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.4 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.1 3.5 GO:0003171 atrioventricular valve development(GO:0003171)
0.1 1.3 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 1.1 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 1.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 2.0 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.1 1.6 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 1.0 GO:0080111 DNA demethylation(GO:0080111)
0.1 1.8 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.2 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.1 2.2 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 0.6 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 0.4 GO:1900373 positive regulation of cyclic nucleotide metabolic process(GO:0030801) positive regulation of cyclic nucleotide biosynthetic process(GO:0030804) positive regulation of nucleotide biosynthetic process(GO:0030810) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) positive regulation of cyclase activity(GO:0031281) regulation of adenylate cyclase activity(GO:0045761) positive regulation of lyase activity(GO:0051349) positive regulation of purine nucleotide biosynthetic process(GO:1900373)
0.1 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.5 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 2.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.7 GO:0003139 secondary heart field specification(GO:0003139)
0.1 2.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.4 GO:0032655 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 2.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 1.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.8 GO:0007525 somatic muscle development(GO:0007525) T-tubule organization(GO:0033292)
0.1 0.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.5 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 1.2 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) actin filament debranching(GO:0071846)
0.1 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 1.2 GO:0050870 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 0.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.7 GO:0009409 response to cold(GO:0009409)
0.0 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.3 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 5.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 2.9 GO:0008360 regulation of cell shape(GO:0008360)
0.0 3.5 GO:0090504 epiboly(GO:0090504)
0.0 1.5 GO:0006282 regulation of DNA repair(GO:0006282)
0.0 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 1.7 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 2.4 GO:0006936 muscle contraction(GO:0006936)
0.0 0.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.8 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086) cell cycle G2/M phase transition(GO:0044839)
0.0 0.2 GO:0090316 positive regulation of intracellular protein transport(GO:0090316)
0.0 0.5 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.8 GO:0035194 posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194)
0.0 2.6 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 0.2 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 1.9 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.3 GO:0048821 erythrocyte development(GO:0048821)
0.0 1.7 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0032019 mitochondrial cloud(GO:0032019)
0.4 3.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 3.9 GO:0032783 ELL-EAF complex(GO:0032783)
0.3 4.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 1.3 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.2 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.1 1.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 1.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.5 GO:0044545 NSL complex(GO:0044545)
0.1 1.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.2 GO:0005869 dynactin complex(GO:0005869)
0.1 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.5 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.8 GO:0016011 dystroglycan complex(GO:0016011)
0.1 1.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.9 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.0 GO:0030126 COPI vesicle coat(GO:0030126) COPI-coated vesicle membrane(GO:0030663)
0.1 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.8 GO:0043186 P granule(GO:0043186)
0.0 3.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.1 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 3.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.7 GO:0005819 spindle(GO:0005819)
0.0 1.4 GO:0016607 nuclear speck(GO:0016607)
0.0 1.7 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0019145 aminobutyraldehyde dehydrogenase activity(GO:0019145) glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.8 4.5 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.6 2.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 2.4 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.5 1.6 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.4 1.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.4 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.4 1.1 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.4 2.5 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.3 1.0 GO:0008311 double-stranded DNA exodeoxyribonuclease activity(GO:0008309) double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.3 5.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.3 2.2 GO:0005522 profilin binding(GO:0005522)
0.3 1.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.3 1.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 0.7 GO:0035514 DNA demethylase activity(GO:0035514) oxidative RNA demethylase activity(GO:0035515)
0.2 1.3 GO:1901612 cardiolipin binding(GO:1901612)
0.2 1.2 GO:0051920 peroxiredoxin activity(GO:0051920)
0.2 4.0 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.2 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 4.1 GO:0022884 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.2 1.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 2.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 0.5 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.6 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 1.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 2.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.4 GO:0016530 metallochaperone activity(GO:0016530)
0.1 1.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 2.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 0.3 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 2.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.2 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.8 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.6 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.8 GO:0043236 laminin binding(GO:0043236)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 4.2 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 2.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.4 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 2.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.0 GO:0016829 lyase activity(GO:0016829)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526) tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.3 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.7 GO:0003724 RNA helicase activity(GO:0003724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 3.9 PID EPO PATHWAY EPO signaling pathway
0.2 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.8 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 4.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 0.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 2.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 2.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 2.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 3.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.2 0.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.0 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 0.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 5.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.0 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling