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Results for nfkb2

Z-value: 0.73

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Transcription factors associated with nfkb2

Gene Symbol Gene ID Gene Info
nfkb2
ENSDARG00000038687 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfkb2dr10_dc_chr13_+_22589282_225893680.647.3e-03Click!

Activity profile of nfkb2 motif

Sorted Z-values of nfkb2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_28680035 2.20 ENSDART00000020667
osbpl7
oxysterol binding protein-like 7
chr6_-_8468819 2.10 ENSDART00000064149
nabp1b
nucleic acid binding protein 1b
chr6_+_3174047 1.73 ENSDART00000160290
st3gal3a
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr6_-_8468961 1.64 ENSDART00000064149
nabp1b
nucleic acid binding protein 1b
chr3_-_31487744 1.56 ENSDART00000124559
moto
minamoto
chr9_+_188749 1.40 ENSDART00000172946
rrp1
ribosomal RNA processing 1
chr12_-_28679813 1.38 ENSDART00000020667
osbpl7
oxysterol binding protein-like 7
chr6_+_38629054 1.28 ENSDART00000086533
atp10a
ATPase, class V, type 10A
chr19_-_3547196 1.23 ENSDART00000166107
hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr13_+_36832090 1.19 ENSDART00000024386
frmd6
FERM domain containing 6
chr5_+_23582676 1.17 ENSDART00000139520
tp53
tumor protein p53
chr12_-_28680442 1.15 ENSDART00000178777
osbpl7
oxysterol binding protein-like 7
chr20_+_39145226 1.08 ENSDART00000142778
BX569784.1
ENSDARG00000092980
chr21_-_23873574 0.97

chr5_+_23582805 0.96 ENSDART00000137298
tp53
tumor protein p53
chr1_+_48770997 0.92 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_-_20743808 0.89

chr23_+_25952958 0.87 ENSDART00000124963
pkig
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr21_+_36938203 0.85 ENSDART00000027459
grk6
G protein-coupled receptor kinase 6
chr21_+_36938230 0.84 ENSDART00000027459
grk6
G protein-coupled receptor kinase 6
chr8_-_40149223 0.84 ENSDART00000005118
gpx8
glutathione peroxidase 8 (putative)
chr8_-_12394688 0.83 ENSDART00000133350
traf1
TNF receptor-associated factor 1
chr5_-_31089598 0.80 ENSDART00000098172
sh3glb2b
SH3-domain GRB2-like endophilin B2b
chr10_+_21487458 0.77 ENSDART00000147215
ENSDART00000019252
fbxw11b
F-box and WD repeat domain containing 11b
chr14_+_27984076 0.75 ENSDART00000173237
mid2
midline 2
chr9_+_20743219 0.71 ENSDART00000147435
man1a2
mannosidase, alpha, class 1A, member 2
chr9_+_20743866 0.65 ENSDART00000144248
man1a2
mannosidase, alpha, class 1A, member 2
chr10_+_31357862 0.63 ENSDART00000145562
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr20_+_2625619 0.63 ENSDART00000058775
zgc:101562
zgc:101562
chr13_-_14798134 0.62 ENSDART00000020576
cdc25b
cell division cycle 25B
chr8_-_40149140 0.61 ENSDART00000005118
gpx8
glutathione peroxidase 8 (putative)
chr10_+_21487218 0.60 ENSDART00000147215
ENSDART00000019252
fbxw11b
F-box and WD repeat domain containing 11b
chr23_+_25953162 0.56 ENSDART00000138731
pkig
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr13_-_999570 0.54 ENSDART00000121970
pno1
partner of NOB1 homolog
chr8_+_53734037 0.53 ENSDART00000179055
ENSDARG00000106018
ENSDARG00000106018
chr8_-_12394639 0.50 ENSDART00000133350
traf1
TNF receptor-associated factor 1
chr11_-_13295436 0.50

chr8_-_12394879 0.50 ENSDART00000101174
traf1
TNF receptor-associated factor 1
chr23_-_27663219 0.50 ENSDART00000138381
si:ch211-156j22.4
si:ch211-156j22.4
chr21_-_21604542 0.44 ENSDART00000010282
cbr1l
carbonyl reductase 1-like
chr13_+_6061419 0.44

chr13_+_36831946 0.41 ENSDART00000024386
frmd6
FERM domain containing 6
chr13_+_36832145 0.40 ENSDART00000024386
frmd6
FERM domain containing 6
chr23_-_20592068 0.37 ENSDART00000153767
CR352228.1
ENSDARG00000097895
chr9_-_34145854 0.36

chr9_+_188598 0.36 ENSDART00000162764
rrp1
ribosomal RNA processing 1
chr9_-_52033978 0.35 ENSDART00000148918
tank
TRAF family member-associated NFKB activator
chr5_-_31306608 0.34

chr1_+_54059634 0.34 ENSDART00000162075
pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr23_+_20592121 0.31 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr10_-_26263954 0.29 ENSDART00000079194
arfip2b
ADP-ribosylation factor interacting protein 2b
chr7_-_23928945 0.29

chr16_-_13927947 0.29 ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr1_+_48770878 0.28 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr16_-_13927684 0.27 ENSDART00000146719
leng9
leukocyte receptor cluster (LRC) member 9
chr21_-_41804961 0.26 ENSDART00000046076
ENSDARG00000030665
ENSDARG00000030665
chr7_+_56171081 0.25 ENSDART00000073596
ENSDART00000123273
ist1
increased sodium tolerance 1 homolog (yeast)
chr10_+_31358110 0.25 ENSDART00000145562
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr11_+_269859 0.24 ENSDART00000109091
mettl1
methyltransferase like 1
chr5_+_23582396 0.22 ENSDART00000051549
ENSDART00000135934
tp53
tumor protein p53
chr13_-_25689369 0.19 ENSDART00000077612
rel
v-rel avian reticuloendotheliosis viral oncogene homolog
chr13_+_28545221 0.17 ENSDART00000027213
inaa
internexin neuronal intermediate filament protein, alpha a
chr9_+_32496059 0.16 ENSDART00000078513
mob4
MOB family member 4, phocein
chr5_+_29988157 0.12 ENSDART00000086661
dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr2_+_25107108 0.11 ENSDART00000136072
ifi30
interferon, gamma-inducible protein 30
chr9_-_28464146 0.09 ENSDART00000137582
creb1b
cAMP responsive element binding protein 1b
chr3_+_23587109 0.08

chr20_-_35173500 0.08 ENSDART00000019196
lft1
lefty1
chr9_+_20743306 0.05 ENSDART00000147435
man1a2
mannosidase, alpha, class 1A, member 2
chr17_+_8018808 0.04 ENSDART00000131200
myct1b
myc target 1b
chr17_+_9918253 0.02 ENSDART00000169892
srp54
signal recognition particle 54
chr25_-_21058792 0.01 ENSDART00000156257
wnk1a
WNK lysine deficient protein kinase 1a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0032197 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.3 1.6 GO:0007141 male meiosis I(GO:0007141)
0.2 1.4 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.6 GO:1902751 regulation of mitotic cell cycle, embryonic(GO:0009794) positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) mitotic cell cycle, embryonic(GO:0045448) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 3.7 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.8 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 0.2 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.6 GO:0007032 endosome organization(GO:0007032)
0.0 1.2 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 4.7 GO:0006869 lipid transport(GO:0006869)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.4 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 2.0 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0070876 SOSS complex(GO:0070876)
0.5 4.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.8 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.3 1.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 4.7 GO:0015248 sterol transporter activity(GO:0015248)
0.2 1.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.2 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.1 2.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.8 PID CD40 PATHWAY CD40/CD40L signaling
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.7 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane