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Results for nkx1.2la_rx1+rx2

Z-value: 0.26

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Transcription factors associated with nkx1.2la_rx1+rx2

Gene Symbol Gene ID Gene Info
nkx1.2la
ENSDARG00000006350 NK1 transcription factor related 2-like,a
rx2
ENSDARG00000040321 retinal homeobox gene 2
rx1
ENSDARG00000071684 retinal homeobox gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rx2dr10_dc_chr2_-_55737505_55737528-0.136.3e-01Click!
nkx1.2ladr10_dc_chr13_+_40644724_40644738-0.126.7e-01Click!
rx1dr10_dc_chr22_-_4622401_4622455-0.068.3e-01Click!

Activity profile of nkx1.2la_rx1+rx2 motif

Sorted Z-values of nkx1.2la_rx1+rx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2la_rx1+rx2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_37303599 0.46 ENSDART00000097754
ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr6_+_36862078 0.43 ENSDART00000104160
ENSDARG00000070746
ENSDARG00000070746
chr20_-_29961498 0.31 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr20_-_29961589 0.31 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr2_-_26941084 0.31 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr10_-_34058331 0.29 ENSDART00000046599
zar1l
zygote arrest 1-like
chr6_+_36861678 0.28 ENSDART00000104160
ENSDARG00000070746
ENSDARG00000070746
chr14_-_14353487 0.27 ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr13_-_36672424 0.27 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr20_-_29961621 0.23 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr20_+_29306677 0.22 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr13_-_36672285 0.20 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr15_+_35089305 0.18 ENSDART00000156515
zgc:55621
zgc:55621
chr7_-_29906486 0.17 ENSDART00000046689
tmed3
transmembrane p24 trafficking protein 3
chr16_+_23884575 0.17 ENSDART00000046922
rab13
RAB13, member RAS oncogene family
chr17_+_43041951 0.17 ENSDART00000154863
isca2
iron-sulfur cluster assembly 2
chr18_-_40718244 0.16 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr5_+_37303707 0.15 ENSDART00000097754
ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr21_-_2350090 0.15 ENSDART00000168946
si:ch211-241b2.4
si:ch211-241b2.4
chr7_-_73204361 0.15 ENSDART00000157500
AL929105.1
ENSDARG00000105194
chr25_+_10450395 0.14 ENSDART00000067678
zgc:110339
zgc:110339
chr24_-_14446593 0.14

chr20_+_29306945 0.13 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr21_+_10757086 0.13

chr1_+_35253862 0.12 ENSDART00000139636
zgc:152968
zgc:152968
chr17_-_36904594 0.12

chr14_+_30455165 0.12 ENSDART00000144817
cfl1
cofilin 1
chr16_-_55263338 0.11 ENSDART00000113358
wdtc1
WD and tetratricopeptide repeats 1
chr2_-_26940965 0.10 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr24_-_24999240 0.10 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr20_-_37910887 0.10 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr15_+_34734212 0.10 ENSDART00000099776
tspan13a
tetraspanin 13a
chr20_+_29306863 0.09 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr11_-_38856849 0.09 ENSDART00000113185
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr19_+_5562075 0.09 ENSDART00000148794
jupb
junction plakoglobin b
chr23_-_19299279 0.09 ENSDART00000080099
oard1
O-acyl-ADP-ribose deacylase 1
chr7_-_29906449 0.09 ENSDART00000046689
tmed3
transmembrane p24 trafficking protein 3
chr6_+_36862148 0.09 ENSDART00000104160
ENSDARG00000070746
ENSDARG00000070746
chr8_+_3364453 0.09 ENSDART00000164426
ctu1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr14_+_46362661 0.08 ENSDART00000025749
ttc9c
tetratricopeptide repeat domain 9C
chr2_+_25659945 0.08 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr18_-_43890836 0.08 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr13_-_18564182 0.08 ENSDART00000176809
sfxn3
sideroflexin 3
chr1_+_51087450 0.08 ENSDART00000040397
prdx2
peroxiredoxin 2
chr19_+_21783111 0.08 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr7_-_40359613 0.07 ENSDART00000173670
ube3c
ubiquitin protein ligase E3C
chr8_+_11287550 0.07 ENSDART00000115057
tjp2b
tight junction protein 2b (zona occludens 2)
chr11_-_2437396 0.07

chr13_-_8360779 0.07 ENSDART00000058107
mcfd2
multiple coagulation factor deficiency 2
chr24_+_24999138 0.07 ENSDART00000152095
ENSDART00000154988
ENSDART00000156098
CR383672.2
ENSDARG00000096452
chr1_+_14572155 0.07 ENSDART00000033018
pi4k2b
phosphatidylinositol 4-kinase type 2 beta
chr9_-_35127938 0.07 ENSDART00000077814
cdc16
cell division cycle 16 homolog (S. cerevisiae)
chr1_+_5464274 0.07 ENSDART00000144559
cnppd1
cyclin Pas1/PHO80 domain containing 1
chr18_+_49974874 0.07 ENSDART00000126916
mob2b
MOB kinase activator 2b
chr10_-_4641624 0.06 ENSDART00000163951
plppr1
phospholipid phosphatase related 1
chr13_-_36537892 0.06 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr17_+_16038358 0.06 ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr22_-_19986607 0.06 ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr20_+_36909452 0.06 ENSDART00000062931
abracl
ABRA C-terminal like
chr25_-_1243081 0.06 ENSDART00000156062
calml4b
calmodulin-like 4b
chr23_+_20779487 0.06 ENSDART00000079538
ccdc30
coiled-coil domain containing 30
chr23_-_33692244 0.05

chr11_+_16017857 0.05 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr10_-_28230992 0.05 ENSDART00000134491
med13a
mediator complex subunit 13a
chr14_+_22159893 0.05 ENSDART00000019296
gdf9
growth differentiation factor 9
chr10_-_4641512 0.05 ENSDART00000163951
plppr1
phospholipid phosphatase related 1
chr3_+_27667194 0.05 ENSDART00000075100
carhsp1
calcium regulated heat stable protein 1
chr20_+_35176069 0.05

chr13_-_36672606 0.05 ENSDART00000179242
sav1
salvador family WW domain containing protein 1
chr18_-_5749619 0.05 ENSDART00000161538
cyp1a
cytochrome P450, family 1, subfamily A
chr5_+_12894381 0.05 ENSDART00000051669
tctn2
tectonic family member 2
chr22_+_699477 0.05 ENSDART00000017305
znf76
zinc finger protein 76
chr24_+_16402587 0.05 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_+_1743359 0.05 ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr19_+_44185325 0.04 ENSDART00000063870
rpl11
ribosomal protein L11
chr16_+_13928376 0.04 ENSDART00000163251
flcn
folliculin
chr12_+_3632548 0.04

chr19_+_21783204 0.04 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr6_+_40924559 0.04 ENSDART00000133599
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr2_+_50873843 0.04

chr6_-_40924459 0.04 ENSDART00000076097
sfi1
SFI1 centrin binding protein
chr17_+_135261 0.04 ENSDART00000166339
klhdc2
kelch domain containing 2
chr10_-_2761480 0.04 ENSDART00000131749
ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
chr8_-_17692185 0.04

chr23_+_17220363 0.04 ENSDART00000143420
BX927275.2
ENSDARG00000095017
chr16_-_25653129 0.03 ENSDART00000149411
atxn1b
ataxin 1b
chr6_+_344760 0.03

chr10_+_40293111 0.03

chr2_+_8981028 0.03 ENSDART00000134308
zzz3
zinc finger, ZZ-type containing 3
chr21_-_30045669 0.03 ENSDART00000155188
ccnjl
cyclin J-like
chr24_-_24999290 0.03 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr12_+_22459177 0.03 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr17_-_135071 0.03

chr21_+_21158761 0.03 ENSDART00000058311
rictorb
RPTOR independent companion of MTOR, complex 2b
chr16_+_51597409 0.03

chr8_-_12253026 0.03 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr16_-_31393328 0.03 ENSDART00000178298
mroh1
maestro heat-like repeat family member 1
chr7_-_50137683 0.03 ENSDART00000083346
hypk
huntingtin interacting protein K
chr12_+_33257120 0.03

chr13_+_4743399 0.03 ENSDART00000092521
micu1
mitochondrial calcium uptake 1
chr20_+_29307283 0.02 ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr8_-_53165501 0.02 ENSDART00000135982
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr5_-_25133456 0.02 ENSDART00000051566
zgc:101016
zgc:101016
chr3_+_23561306 0.02 ENSDART00000078453
hoxb7a
homeobox B7a
chr22_-_19986461 0.02 ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr20_+_10502210 0.02 ENSDART00000155888
AL845550.1
ENSDARG00000097342
chr12_-_33256671 0.02 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr15_-_5827067 0.02 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr4_+_5246465 0.02 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr14_+_5078937 0.02 ENSDART00000031508
lbx2
ladybird homeobox 2
chr24_+_19270877 0.02

chr3_-_23442774 0.02

chr21_+_11742219 0.02 ENSDART00000081661
nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr9_-_32803650 0.01

chr18_+_44635321 0.01

chr24_+_37692365 0.01

chr5_+_51992974 0.01 ENSDART00000170341
apba1a
amyloid beta (A4) precursor protein-binding, family A, member 1a
chr25_+_34433321 0.01 ENSDART00000042678
ENSDART00000158092
vps4a
vacuolar protein sorting 4a homolog A (S. cerevisiae)
chr19_+_32679320 0.01

chr19_+_32679258 0.01

chr2_+_54267946 0.01 ENSDART00000015535
ctnnbl1
catenin, beta like 1
chr6_+_40925259 0.01 ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr12_-_33256934 0.01 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr9_+_41910191 0.01

chr7_-_57948889 0.01

chr9_+_33177527 0.01 ENSDART00000174533
vangl1
VANGL planar cell polarity protein 1
chr21_+_28441951 0.01 ENSDART00000077887
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr6_+_57544814 0.00 ENSDART00000157330
necab3
N-terminal EF-hand calcium binding protein 3
chr20_-_16553010 0.00

chr21_-_2316052 0.00 ENSDART00000158459
zgc:193790
zgc:193790
chr21_-_45323151 0.00 ENSDART00000151106
ENSDARG00000053404
ENSDARG00000053404
chr2_-_2800076 0.00 ENSDART00000124032
serbp1b
SERPINE1 mRNA binding protein 1b
chr1_+_53384116 0.00 ENSDART00000149760
triobpa
TRIO and F-actin binding protein a
chr20_+_28958586 0.00 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr24_-_14447136 0.00

chr1_+_35253821 0.00 ENSDART00000179634
zgc:152968
zgc:152968
chr8_-_25015215 0.00 ENSDART00000170511
nfyal
nuclear transcription factor Y, alpha, like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.1 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.9 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002144 cytosolic tRNA wobble base thiouridylase complex(GO:0002144)
0.0 0.2 GO:0016328 lateral plasma membrane(GO:0016328) insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.0 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0022889 serine transmembrane transporter activity(GO:0022889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis