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Results for nkx1.2lb

Z-value: 0.30

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Transcription factors associated with nkx1.2lb

Gene Symbol Gene ID Gene Info
nkx1.2lb
ENSDARG00000099427 NK1 transcription factor related 2-like,b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2lbdr10_dc_chr14_+_14759314_14759320-0.486.1e-02Click!

Activity profile of nkx1.2lb motif

Sorted Z-values of nkx1.2lb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2lb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_34058331 1.29 ENSDART00000046599
zar1l
zygote arrest 1-like
chr8_-_23759076 1.06 ENSDART00000145894
zgc:195245
zgc:195245
chr20_-_14218080 0.93 ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
KN150266v1_-_68652 0.75

chr20_+_14218237 0.63 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
KN150663v1_-_3381 0.60

chr13_-_18564182 0.52 ENSDART00000176809
sfxn3
sideroflexin 3
chr2_-_26941084 0.51 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr2_+_6341404 0.45 ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr13_-_36672424 0.39 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr20_-_14218236 0.35 ENSDART00000168434
si:ch211-223m11.2
si:ch211-223m11.2
KN150266v1_-_68620 0.35

chr23_-_33692244 0.34

chr18_-_43890836 0.34 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr8_-_3974320 0.33 ENSDART00000159895
mtmr3
myotubularin related protein 3
chr16_+_25693878 0.32 ENSDART00000077484
zhx2a
zinc fingers and homeoboxes 2a
chr12_-_4212149 0.30 ENSDART00000059298
zgc:92313
zgc:92313
chr13_+_12629211 0.29 ENSDART00000015127
zgc:100846
zgc:100846
chr6_+_31381325 0.27 ENSDART00000038990
jak1
Janus kinase 1
chr5_-_32698092 0.26 ENSDART00000015076
zgc:103692
zgc:103692
chr14_+_46362661 0.26 ENSDART00000025749
ttc9c
tetratricopeptide repeat domain 9C
chr7_+_20132424 0.25 ENSDART00000173809
si:dkey-33c9.6
si:dkey-33c9.6
chr20_-_37910887 0.24 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr6_+_31381039 0.24 ENSDART00000038990
jak1
Janus kinase 1
chr13_-_30011574 0.24 ENSDART00000110157
tysnd1
trypsin domain containing 1
chr11_+_12754166 0.24 ENSDART00000123445
ENSDART00000163364
ENSDART00000066122
rtel1
regulator of telomere elongation helicase 1
chr10_-_34969570 0.22

chr12_-_4212095 0.22 ENSDART00000059298
zgc:92313
zgc:92313
chr14_-_30604897 0.22 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr13_-_36537892 0.21 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr11_+_16017857 0.20 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr21_+_10757086 0.19

chr5_+_32698516 0.19 ENSDART00000097945
usp20
ubiquitin specific peptidase 20
chr2_-_26940965 0.19 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr23_+_34120812 0.18 ENSDART00000143933
chchd6a
coiled-coil-helix-coiled-coil-helix domain containing 6a
chr12_-_7201660 0.18 ENSDART00000152450
ipmkb
inositol polyphosphate multikinase b
chr12_-_18997267 0.17 ENSDART00000149180
aco2
aconitase 2, mitochondrial
chr17_+_5454020 0.16 ENSDART00000097455
fam167aa
family with sequence similarity 167, member Aa
chr14_+_30073402 0.16 ENSDART00000136009
cnot7
CCR4-NOT transcription complex, subunit 7
chr22_-_6972182 0.16

chr13_-_6151100 0.16 ENSDART00000092105
agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr16_+_32097505 0.16 ENSDART00000039109
leng1
leukocyte receptor cluster (LRC) member 1
chr13_-_30011613 0.15 ENSDART00000110157
tysnd1
trypsin domain containing 1
chr23_+_29431388 0.14 ENSDART00000027255
tardbpl
TAR DNA binding protein, like
chr7_-_40359613 0.14 ENSDART00000173670
ube3c
ubiquitin protein ligase E3C
chr14_+_8288174 0.14 ENSDART00000037749
stx5a
syntaxin 5A
KN150703v1_+_15225 0.13

chr2_+_10209233 0.13 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr13_-_36672285 0.12 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr2_+_6341345 0.12 ENSDART00000058256
zp3b
zona pellucida glycoprotein 3b
chr17_-_36904594 0.12

chr5_+_60774642 0.12 ENSDART00000050902
polr2j
polymerase (RNA) II (DNA directed) polypeptide J
chr18_+_13267740 0.11 ENSDART00000091560
tldc1
TBC/LysM-associated domain containing 1
chr21_-_30977021 0.10 ENSDART00000065504
ncbp3
nuclear cap binding subunit 3
chr2_-_48203102 0.10

chr13_-_36538099 0.09

chr21_-_29995378 0.08 ENSDART00000178201
pwwp2a
PWWP domain containing 2A
chr13_+_12629243 0.07 ENSDART00000015127
zgc:100846
zgc:100846
chr22_+_39110524 0.07 ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr6_+_17928720 0.07 ENSDART00000124948
srp68
signal recognition particle 68
chr14_+_46318771 0.06 ENSDART00000034606
ENSDART00000173301
sfxn5b
sideroflexin 5b
chr2_+_50873843 0.06

chr6_+_3313515 0.06 ENSDART00000011785
rad54l
RAD54-like (S. cerevisiae)
chr7_-_73624022 0.05 ENSDART00000111049
HIST2H2AB (1 of many)
histone cluster 2 H2A family member b
chr3_+_52373536 0.05

chr5_-_21548930 0.04 ENSDART00000002938
mtmr8
myotubularin related protein 8
chr20_+_36909452 0.04 ENSDART00000062931
abracl
ABRA C-terminal like
chr3_+_32700750 0.04 ENSDART00000139410
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr8_-_23759198 0.03 ENSDART00000145894
zgc:195245
zgc:195245
chr13_-_36672606 0.03 ENSDART00000179242
sav1
salvador family WW domain containing protein 1
chr3_+_32700882 0.03 ENSDART00000139410
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr5_-_13267041 0.02

chr9_+_26218474 0.02 ENSDART00000177394
CR391949.1
ENSDARG00000107108
chr16_+_10950751 0.01 ENSDART00000128762
dedd1
death effector domain-containing 1
chr18_+_13267658 0.01 ENSDART00000091560
tldc1
TBC/LysM-associated domain containing 1
chr4_+_63623569 0.01 ENSDART00000170824
znf1108
zinc finger protein 1108
chr4_-_47142181 0.00 ENSDART00000150426
znf1064
zinc finger protein 1064
chr17_-_15181427 0.00 ENSDART00000002176
ENSDART00000138764
wdhd1
WD repeat and HMG-box DNA binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0090656 t-circle formation(GO:0090656)
0.1 0.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 0.5 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.4 GO:0036268 swimming(GO:0036268)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.6 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.2 GO:1900153 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.2 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.6 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
0.1 0.5 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.1 0.6 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease