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Results for nkx2.1

Z-value: 0.24

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Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
nkx2.1
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr10_dc_chr17_+_38314814_38314876-0.504.9e-02Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_22450582 0.65

chr19_-_33264349 0.38

chr20_+_9141086 0.35 ENSDART00000064144
ENSDART00000144396
bpnt1
bisphosphate nucleotidase 1
chr6_+_38882608 0.31 ENSDART00000019939
bin2b
bridging integrator 2b
chr3_+_17783319 0.28 ENSDART00000104299
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr3_+_17783868 0.26 ENSDART00000165644
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr23_-_18105560 0.23

chr14_+_10351071 0.20 ENSDART00000061932
atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr2_-_11335644 0.20 ENSDART00000135450
cryz
crystallin, zeta (quinone reductase)
chr15_-_16137131 0.20

chr4_-_5786680 0.19 ENSDART00000039987
pgm3
phosphoglucomutase 3
chr7_+_34235297 0.19 ENSDART00000173957
rfx7
regulatory factor X, 7
chr20_-_53123015 0.19 ENSDART00000162812
fdft1
farnesyl-diphosphate farnesyltransferase 1
chr17_-_49256667 0.18 ENSDART00000112806
orc3
origin recognition complex, subunit 3
chr22_-_20899539 0.17 ENSDART00000100642
ell
elongation factor RNA polymerase II
chr3_+_22204475 0.17 ENSDART00000055676
ENSDARG00000038186
ENSDARG00000038186
chr11_+_25358353 0.16 ENSDART00000140856
ccdc120
coiled-coil domain containing 120
chr21_-_2322963 0.16 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr14_+_15778201 0.14 ENSDART00000168462
rnf103
ring finger protein 103
chr23_+_37364185 0.14 ENSDART00000006436
pink1
PTEN induced putative kinase 1
chr15_-_29079613 0.13 ENSDART00000060018
dharma
dharma
chr1_+_15928362 0.13 ENSDART00000149026
ENSDART00000159785
ENSDART00000164899
pcm1
pericentriolar material 1
chr1_+_13333864 0.12 ENSDART00000079716
hpf1
histone PARylation factor 1
chr3_-_30757570 0.12 ENSDART00000124458
suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr17_-_12095723 0.11 ENSDART00000115321
ahctf1
AT hook containing transcription factor 1
chr6_+_38882803 0.11 ENSDART00000132798
bin2b
bridging integrator 2b
chr19_-_25842574 0.11 ENSDART00000036854
glcci1
glucocorticoid induced 1
chr19_-_38832985 0.11

chr22_+_15872131 0.11 ENSDART00000062587
klf2a
Kruppel-like factor 2a
chr9_-_30692223 0.10

chr7_+_25554355 0.10 ENSDART00000149835
mtm1
myotubularin 1
chr9_-_27581087 0.10 ENSDART00000135221
nepro
nucleolus and neural progenitor protein
chr23_-_33753484 0.10 ENSDART00000138416
tfcp2
transcription factor CP2
chr8_-_51380776 0.10 ENSDART00000060628
chmp7
charged multivesicular body protein 7
chr11_+_23807915 0.10 ENSDART00000006703
maf1
MAF1 homolog, negative regulator of RNA polymerase III
chr19_+_7373519 0.09 ENSDART00000026634
ccdc127b
coiled-coil domain containing 127b
chr11_+_25358389 0.09 ENSDART00000140856
ccdc120
coiled-coil domain containing 120
chr8_+_45339021 0.09

chr2_-_11335695 0.09 ENSDART00000135450
cryz
crystallin, zeta (quinone reductase)
chr3_+_22204569 0.09 ENSDART00000055676
ENSDARG00000038186
ENSDARG00000038186
chr12_+_31379514 0.08 ENSDART00000153390
gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr6_-_22060441 0.08 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr7_-_24778185 0.07 ENSDART00000135179
arl2
ADP-ribosylation factor-like 2
chr3_-_23331479 0.07 ENSDART00000040065
casc3
cancer susceptibility candidate 3
chr25_-_20593345 0.07 ENSDART00000158130
edc3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr2_-_37419017 0.07 ENSDART00000015723
prkci
protein kinase C, iota
chr5_-_34856057 0.06 ENSDART00000051312
ttc33
tetratricopeptide repeat domain 33
chr18_-_7488960 0.05 ENSDART00000052803
si:dkey-30c15.10
si:dkey-30c15.10
chr20_+_31375056 0.04

chr1_-_22603959 0.04 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr18_-_321265 0.04 ENSDART00000136693
tm2d3
TM2 domain containing 3
chr22_-_20695416 0.04 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr1_+_50348973 0.04

chr24_-_8637129 0.04 ENSDART00000082362
mak
male germ cell-associated kinase
chr11_-_35778578 0.02 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr12_+_34851952 0.02 ENSDART00000123988
qki2
QKI, KH domain containing, RNA binding 2
chr7_+_48402923 0.02 ENSDART00000174084
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr18_-_895821 0.02 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr18_+_29166912 0.01 ENSDART00000089031
ppfibp2a
PTPRF interacting protein, binding protein 2a (liprin beta 2)
chr7_-_15781823 0.01 ENSDART00000002498
elp4
elongator acetyltransferase complex subunit 4
chr3_-_23331363 0.01 ENSDART00000040065
casc3
cancer susceptibility candidate 3
chr7_-_28300008 0.01

chr2_-_22692538 0.00

chr6_-_6091628 0.00 ENSDART00000132350
rtn4a
reticulon 4a
chr13_+_46637827 0.00 ENSDART00000167931
mtrf1l
mitochondrial translational release factor 1-like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071800 podosome assembly(GO:0071800)
0.0 0.5 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
0.0 0.2 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.0 0.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349)
0.0 0.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 0.2 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.3 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.1 GO:0072572 poly-ADP-D-ribose binding(GO:0072572)
0.0 0.5 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.0 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation