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Results for nkx2.2a

Z-value: 0.80

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Transcription factors associated with nkx2.2a

Gene Symbol Gene ID Gene Info
ENSDARG00000053298 NK2 homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.2adr10_dc_chr17_-_42778156_427782390.844.6e-05Click!

Activity profile of nkx2.2a motif

Sorted Z-values of nkx2.2a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.2a

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr7_-_69399273 2.14 ENSDART00000159823
ENSDART00000075178
ENSDART00000168942
ENSDART00000126739
tetraspanin 5a
chr1_+_51925783 1.87 ENSDART00000167514
ATP-binding cassette, sub-family A (ABC1), member 1A
chr8_-_9081109 1.74 ENSDART00000176850
solute carrier family 6 (neurotransmitter transporter), member 8
chr14_-_26238386 1.63 ENSDART00000105933
transforming growth factor, beta-induced
chr20_-_54206610 1.55 ENSDART00000004756
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr8_+_23464087 1.54 ENSDART00000026316
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr5_+_37053530 1.41 ENSDART00000161051
spectrin, beta, non-erythrocytic 2
chr23_+_22763861 1.38

chr6_+_4712785 1.37 ENSDART00000151674
protocadherin 9
chr10_-_10059864 1.35 ENSDART00000132375
spermatid perinuclear RNA binding protein
chr9_-_22347397 1.33 ENSDART00000146188
crystallin, gamma M2d16
chr10_+_4094568 1.31 ENSDART00000114533
meningioma 1a
chr2_+_49358871 1.31 ENSDART00000179089
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr13_-_18506153 1.29 ENSDART00000057869
methionine adenosyltransferase I, alpha
chr15_-_29454583 1.29 ENSDART00000145976
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr19_+_38834972 1.27 ENSDART00000140198
ENSDART00000033037
ENSDART00000035093
procollagen, type IX, alpha 2
chr10_+_21850059 1.24 ENSDART00000164634
ENSDART00000172513
protocadherin 1 gamma 32
chr4_-_24152926 1.21 ENSDART00000123199
USP6 N-terminal like
chr19_+_1626598 1.21 ENSDART00000163539
scratch family zinc finger 1a
chr16_+_737615 1.21 ENSDART00000161774
iroquois homeobox 1a
chr8_+_29953399 1.19 ENSDART00000149372
ENSDART00000007640
patched 1
patched 1
chr6_-_10593395 1.19 ENSDART00000020261
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr9_-_11589126 1.18 ENSDART00000146832
crystallin, beta A2b
chr16_+_23172295 1.18 ENSDART00000167518
ENSDART00000161087
ephrin-A3b
chr23_+_19887319 1.16 ENSDART00000139192
emerin (Emery-Dreifuss muscular dystrophy)
chr16_+_21109486 1.14 ENSDART00000079383
homeobox A9b
chr21_-_40694583 1.13 ENSDART00000045124
proteasome maturation protein
chr19_+_38834765 1.08 ENSDART00000140198
ENSDART00000033037
ENSDART00000035093
procollagen, type IX, alpha 2
chr9_+_21911860 1.07 ENSDART00000102021
SRY (sex determining region Y)-box 1a
chr2_-_24614261 1.06 ENSDART00000099532
ventricular myosin heavy chain
chr1_+_14451504 1.05 ENSDART00000111475
protocadherin 7a
chr5_-_58269742 1.04 ENSDART00000122413
melanoma cell adhesion molecule a
chr6_+_18588827 1.03

chr16_+_14817799 1.01 ENSDART00000137912
collagen, type XIV, alpha 1a
chr6_+_40631517 1.00 ENSDART00000103757
solute carrier family 6 (neurotransmitter transporter), member 11a
chr23_+_6861489 0.99 ENSDART00000092131
si:ch211-117c9.5
chr6_+_3771586 0.98

chr25_+_30746445 0.97 ENSDART00000156916
lymphocyte-specific protein 1
chr15_-_4537178 0.97 ENSDART00000155619
ENSDART00000128602
transcription factor Dp-2
chr5_+_29578638 0.95 ENSDART00000134624
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
chr6_+_19167652 0.94 ENSDART00000086619
protein kinase C, alpha
chr8_-_2447758 0.93 ENSDART00000101125
ribosomal protein L6
chr23_+_25428372 0.92 ENSDART00000147440
formin-like 3
chr13_-_14978365 0.92

chr12_-_8780098 0.92 ENSDART00000113148
jumonji domain containing 1Cb
chr23_+_26995808 0.92

chr14_+_4810147 0.92 ENSDART00000114678
nanos homolog 1
chr9_+_6684835 0.91

chr22_+_20695983 0.90 ENSDART00000171321
si:dkey-211f22.5
chr2_-_55737505 0.90 ENSDART00000059003
retinal homeobox gene 2
chr9_+_24198112 0.88 ENSDART00000148226
melanophilin b
chr25_+_3232912 0.88 ENSDART00000104877
ENSDART00000170765
ENSDART00000158571
coiled-coil-helix-coiled-coil-helix domain containing 3b
chr14_-_425659 0.87

chr23_-_31585883 0.87 ENSDART00000157511
EYA transcriptional coactivator and phosphatase 4
chr7_-_37816600 0.86 ENSDART00000052366
CCAAT/enhancer binding protein (C/EBP), alpha
chr7_-_32604392 0.86 ENSDART00000132504
anoctamin 5b
chr20_-_25652576 0.84 ENSDART00000003666
ENSDART00000122351
ENSDART00000063081
ENSDART00000153282
cytochrome P450, family 2, subfamily AD, polypeptide 3
chr24_+_5906087 0.84 ENSDART00000131768
abl-interactor 1a
chr7_-_29300402 0.82 ENSDART00000099477
RAR-related orphan receptor A, paralog b
chr11_+_42821961 0.81 ENSDART00000013642
forkhead box G1b
chr5_-_47106694 0.81 ENSDART00000165249
cytochrome c oxidase, subunit VIIc
chr16_+_19926776 0.80 ENSDART00000149901
ENSDART00000052927
twist family bHLH transcription factor 1b
chr22_+_38096040 0.80 ENSDART00000097533
WW domain containing transcription regulator 1
chr3_-_27516974 0.79 ENSDART00000151675
si:ch211-157c3.4
chr24_+_3931981 0.78 ENSDART00000167043
phosphofructokinase, platelet a
chr23_-_7892862 0.78 ENSDART00000157612
ENSDART00000165427
myelin transcription factor 1b
chr16_+_14817718 0.77 ENSDART00000027982
collagen, type XIV, alpha 1a
chr7_-_29300448 0.77 ENSDART00000019140
RAR-related orphan receptor A, paralog b
chr3_-_58161663 0.77 ENSDART00000178787
ENSDARG00000108952
chr17_+_7438152 0.77 ENSDART00000130625
si:dkeyp-110a12.4
chr16_-_41994015 0.77

chr15_-_12484651 0.76 ENSDART00000162258
ENSDARG00000098363
chr7_+_19857885 0.76 ENSDART00000146335
zgc:114045
chr24_-_35897257 0.76

KN150683v1_+_13359 0.74

chr3_-_15849644 0.74 ENSDART00000160668
NME/NM23 nucleoside diphosphate kinase 3
chr1_+_25662910 0.73 ENSDART00000113020
tet methylcytosine dioxygenase 2
chr12_-_10001043 0.73 ENSDART00000152250
nerve growth factor receptor b
chr25_+_18467835 0.73 ENSDART00000172338
caveolin 1
chr13_-_29294141 0.73 ENSDART00000026765
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr14_+_21563827 0.73 ENSDART00000032141
spondin 2a, extracellular matrix protein
chr22_+_28496424 0.72 ENSDART00000089546
ABI family, member 3 (NESH) binding protein b
chr13_+_17333810 0.71 ENSDART00000134181
ENSDARG00000093577
chr4_+_2215426 0.70 ENSDART00000168370
fibroblast growth factor receptor substrate 2a
chr4_-_12915292 0.70 ENSDART00000067135
methionine sulfoxide reductase B3
chr3_+_48362748 0.69 ENSDART00000157199
MKL/myocardin-like 2b
chr3_+_12432686 0.69

chr12_+_48761772 0.68 ENSDART00000007202
zgc:92749
chr22_+_21221777 0.68 ENSDART00000079046
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr12_-_9256949 0.67 ENSDART00000003805
parathyroid hormone 1 receptor b
chr23_-_31419805 0.67 ENSDART00000138106
pleckstrin homology domain interacting protein
chr5_-_54954988 0.67 ENSDART00000142912
heterogeneous nuclear ribonucleoprotein K, like
chr11_+_25266623 0.67 ENSDART00000154213
transcription factor binding to IGHM enhancer 3b
chr7_+_19857748 0.66 ENSDART00000146335
zgc:114045
chr25_-_16658906 0.66 ENSDART00000124729
ENSDART00000110859
RIB43A domain with coiled-coils 2
chr9_+_24089828 0.66 ENSDART00000127859
tripartite motif containing 63b
chr8_-_25055160 0.65 ENSDART00000134190
sortilin 1b
chr17_-_20124053 0.65 ENSDART00000133327
actinin, alpha 2b
chr12_-_27032151 0.65 ENSDART00000153365
ENSDARG00000096750
chr6_-_47507750 0.64 ENSDART00000128700
im:7151449
chr8_-_25055333 0.64 ENSDART00000134190
sortilin 1b
chr18_-_8697347 0.64 ENSDART00000093131
FERM domain containing 4A
chr23_+_24778062 0.64

chr3_+_45375639 0.63 ENSDART00000162799
crumbs homolog 3a
chr1_+_21309690 0.63 ENSDART00000141317
dynein, axonemal, heavy chain 6
chr17_+_25659010 0.63 ENSDART00000029703
potassium voltage-gated channel, subfamily H (eag-related), member 1a
chr21_-_44610563 0.63 ENSDART00000099528
sprouty homolog 4 (Drosophila)
chr4_-_25847471 0.62 ENSDART00000142491
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr9_-_46272322 0.62 ENSDART00000169682
histone deacetylase 4
chr18_-_14723138 0.61 ENSDART00000010129
peptide deformylase (mitochondrial)
chr6_+_49096966 0.61 ENSDART00000141042
ENSDART00000143369
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr3_-_12432661 0.60

chr13_-_40600924 0.60 ENSDART00000099847
ENSDART00000057046
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr12_+_30053414 0.60 ENSDART00000138252
actin binding LIM protein 1b
chr21_-_41445163 0.59 ENSDART00000170457
HMP19 protein
chr8_+_51061523 0.58 ENSDART00000166249
dispatched RND transporter family member 3
chr7_-_28278286 0.56 ENSDART00000113313
suppression of tumorigenicity 5
chr25_+_35602451 0.56 ENSDART00000036147
iroquois homeobox 5b
chr9_-_23346038 0.55 ENSDART00000135461
LY6/PLAUR domain containing 6B
chr2_+_2374651 0.55 ENSDART00000132500
complement component 8, alpha polypeptide
chr16_+_10531926 0.55 ENSDART00000161568
INO80 complex subunit E
chr20_+_14591802 0.54

chr12_-_45714172 0.54 ENSDART00000149044
paired box 2b
chr22_-_17026124 0.53 ENSDART00000138382
nuclear factor I/A
chr10_-_39210658 0.53 ENSDART00000150193
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr23_+_22763789 0.53

chr23_+_4423579 0.53 ENSDART00000039829
zgc:112175
chr7_+_20215723 0.52 ENSDART00000173724
ENSDART00000173773
si:dkey-33c9.8
chr14_-_25688444 0.52 ENSDART00000172909
antioxidant 1 copper chaperone
chr19_+_21140010 0.52 ENSDART00000090757
K(lysine) acetyltransferase 2B
chr2_+_20814144 0.52 ENSDART00000177709
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a
chr7_-_41209891 0.52 ENSDART00000174300
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr4_-_75675696 0.52 ENSDART00000111941
zgc:174310
chr15_+_6789662 0.51 ENSDART00000013278
sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
chr22_-_15576473 0.51 ENSDART00000036075
tropomyosin 4a
chr21_+_29190291 0.51 ENSDART00000013641
adrenoceptor alpha 1Ba
chr21_-_36338704 0.50 ENSDART00000157826
membrane protein, palmitoylated 1
chr7_-_38427334 0.50 ENSDART00000173900
CD59 molecule (CD59 blood group)
chr8_+_20592039 0.50 ENSDART00000160421
nuclear factor I/C
chr12_+_33261056 0.50 ENSDART00000124982
coiled-coil domain containing 57
chr2_+_22875548 0.49 ENSDART00000157884
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr20_+_27121126 0.49 ENSDART00000126919
ENSDART00000016014
chromogranin A
chr8_-_45752084 0.49 ENSDART00000025620
peptidylprolyl isomerase Aa (cyclophilin A)
chr13_-_49695322 0.49

chr2_-_11879076 0.49 ENSDART00000145108
ENSDARG00000039203
chr22_-_17026421 0.48 ENSDART00000138382
nuclear factor I/A
chr23_-_24468191 0.48 ENSDART00000044918
eph receptor A2 b
chr6_-_9933233 0.48 ENSDART00000151016
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1a
chr4_-_7803189 0.48 ENSDART00000103070
cyclin-dependent kinase 17
chr8_-_14446883 0.47 ENSDART00000057644
LIM homeobox 4
chr11_-_16067646 0.47

chr13_+_44720106 0.47 ENSDART00000017770
zinc finger and BTB domain containing 8 opposite strand
chr9_+_22953351 0.47 ENSDART00000090875
tumor necrosis factor, alpha-induced protein 6
chr23_-_36812319 0.47 ENSDART00000109976
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr24_+_16924647 0.47 ENSDART00000014787
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a
chr3_-_15850290 0.45 ENSDART00000160628
NME/NM23 nucleoside diphosphate kinase 3
chr20_+_53310252 0.45 ENSDART00000175125
ENSDARG00000106770
chr13_-_24248675 0.45 ENSDART00000046360
ras homolog family member Ua
chr22_-_17561082 0.45 ENSDART00000060786
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a
chr23_+_31420174 0.45

chr11_-_11534819 0.45 ENSDART00000104254
keratin 15
chr16_+_34574302 0.45 ENSDART00000144718
progestin and adipoQ receptor family member VII, b
chr1_+_23664646 0.45 ENSDART00000143428
ribosomal protein S3A
chr9_-_41982635 0.44 ENSDART00000144573
obscurin-like 1b
chr16_+_11138924 0.44 ENSDART00000091183
Ets2 repressor factor like 3
chr5_+_35198499 0.44

chr5_-_63521649 0.44 ENSDART00000029364
adenylate kinase 5, like
chr19_+_24455545 0.44 ENSDART00000144541
Ras-like without CAAX 1
chr4_-_16461748 0.43 ENSDART00000128835
wu:fc23c09
chr16_+_11138879 0.43 ENSDART00000091183
Ets2 repressor factor like 3
chr7_-_33678058 0.42 ENSDART00000173513
protein inhibitor of activated STAT, 1a
chr10_+_36710393 0.42

chr10_-_8029671 0.42 ENSDART00000141445
EWS RNA-binding protein 1a
chr3_+_24003840 0.42 ENSDART00000156204
si:ch211-246i5.5
chr13_-_22641001 0.42

chr12_-_36415239 0.41

chr14_+_23917724 0.41 ENSDART00000138082
ENSDART00000079215
stanniocalcin 2a
chr11_-_9479592 0.41 ENSDART00000175829
ENSDARG00000086489
chr21_-_27164751 0.41 ENSDART00000065402
zgc:77262
chr11_-_3846064 0.41 ENSDART00000161426
GATA binding protein 2a
chr11_-_25181234 0.40 ENSDART00000013714
GATA binding protein 1a
chr24_-_21844170 0.40 ENSDART00000032963
apolipoprotein O, b
chr14_+_20614087 0.40 ENSDART00000160318
lysozyme g-like 2
chr15_+_28173909 0.40 ENSDART00000041707
unc-119 homolog a (C. elegans)
chr5_-_44243476 0.39 ENSDART00000161408
fructose-1,6-bisphosphatase 1a
chr3_-_32795866 0.39 ENSDART00000140117
amine oxidase, copper containing 2
chr2_-_56321500 0.39

chr14_-_45887648 0.39 ENSDART00000074208
clathrin, light chain B
chr6_-_41087828 0.39 ENSDART00000028217
serine/arginine-rich splicing factor 3a
chr18_+_20236794 0.38 ENSDART00000045679
transducin-like enhancer of split 3a
chr23_+_24778090 0.38

chr7_-_26246473 0.37 ENSDART00000140694
eukaryotic translation initiation factor 4A1A
chr14_+_36529003 0.37 ENSDART00000111674
F2R like thrombin or trypsin receptor 3
chr9_-_33972623 0.37 ENSDART00000008737
EF-hand domain (C-terminal) containing 2
chr9_-_18903879 0.37 ENSDART00000138785
si:dkey-239h2.3
chr10_-_39211281 0.37 ENSDART00000148825
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr3_-_7220340 0.37

chr14_+_16632329 0.37 ENSDART00000163013
LIM and calponin homology domains 1b
chr10_-_5135388 0.36 ENSDART00000108587
SEC31 homolog A, COPII coat complex component
chr4_+_71392976 0.36 ENSDART00000167082
zgc:152938

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0032374 regulation of sterol transport(GO:0032371) regulation of cholesterol transport(GO:0032374)
0.3 0.9 GO:0035058 nonmotile primary cilium assembly(GO:0035058) regulation of nonmotile primary cilium assembly(GO:1902855)
0.3 1.7 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.2 0.7 GO:0042908 xenobiotic transport(GO:0042908)
0.2 1.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.2 1.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 1.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 0.6 GO:0036073 perichondral ossification(GO:0036073)
0.2 0.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 0.7 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 0.5 GO:1903010 regulation of bone development(GO:1903010)
0.2 0.5 GO:2000378 regulation of DNA binding(GO:0051101) regulation of oligodendrocyte progenitor proliferation(GO:0070445) negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.2 1.2 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.2 0.5 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.2 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 1.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.5 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.1 1.8 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.7 GO:0019857 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.1 0.9 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.4 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 0.4 GO:0044036 cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.1 0.6 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.1 0.5 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.1 0.2 GO:0014807 regulation of somitogenesis(GO:0014807) positive regulation of behavior(GO:0048520) positive regulation of feeding behavior(GO:2000253)
0.1 0.8 GO:0061621 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.6 GO:0021576 hindbrain formation(GO:0021576)
0.1 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.4 GO:0030224 monocyte differentiation(GO:0030224)
0.1 0.3 GO:0055004 atrial cardiac myofibril assembly(GO:0055004)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0030643 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.6 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.9 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 1.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.3 GO:0010226 response to lithium ion(GO:0010226)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 0.4 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 0.5 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.3 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.4 GO:0002063 chondrocyte development(GO:0002063)
0.1 0.3 GO:0061469 regulation of cell proliferation involved in tissue homeostasis(GO:0060784) regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.4 GO:0061056 sclerotome development(GO:0061056)
0.1 2.9 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.2 GO:0045905 positive regulation of translational termination(GO:0045905)
0.1 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 1.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 3.7 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.1 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.7 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.5 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.2 GO:0090104 pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.5 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.4 GO:0090109 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.8 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 1.3 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.5 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 5.1 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.9 GO:0008354 germ cell migration(GO:0008354)
0.0 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 2.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.9 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.9 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 1.2 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 1.4 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) actin filament capping(GO:0051693)
0.0 0.6 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.6 GO:0097581 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.0 0.1 GO:0035676 anterior lateral line neuromast hair cell development(GO:0035676)
0.0 0.4 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.0 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.7 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.8 GO:1990266 neutrophil migration(GO:1990266)
0.0 0.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.1 GO:0051604 protein maturation(GO:0051604)
0.0 0.4 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.3 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.3 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.5 GO:0048634 regulation of muscle organ development(GO:0048634)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.6 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.2 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008091 spectrin(GO:0008091)
0.2 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.3 GO:0043209 myelin sheath(GO:0043209)
0.1 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.4 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.3 GO:0061617 MICOS complex(GO:0061617)
0.1 0.4 GO:0016460 myosin II complex(GO:0016460)
0.1 0.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 1.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0030175 filopodium(GO:0030175)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 12.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0022626 cytosolic ribosome(GO:0022626)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 1.2 GO:0008158 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.2 0.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 1.3 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.2 0.6 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.2 0.6 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2 0.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 0.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 0.5 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 2.9 GO:0005518 collagen binding(GO:0005518)
0.1 1.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.5 GO:0004937 alpha-adrenergic receptor activity(GO:0004936) alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.4 GO:0005521 lamin binding(GO:0005521)
0.1 0.8 GO:0070095 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.1 1.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.5 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 0.4 GO:0032028 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.1 0.5 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.9 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 1.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 2.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.1 GO:0004407 histone deacetylase activity(GO:0004407) NAD-dependent histone deacetylase activity(GO:0017136)
0.1 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.7 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.1 2.9 GO:0030215 semaphorin receptor binding(GO:0030215) chemorepellent activity(GO:0045499)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0016918 retinal binding(GO:0016918)
0.0 4.0 GO:0015293 symporter activity(GO:0015293)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0030580 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity(GO:0008425) quinone cofactor methyltransferase activity(GO:0030580)
0.0 0.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.7 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 1.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.5 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.3 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 0.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.4 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.2 PID AURORA A PATHWAY Aurora A signaling
0.0 1.0 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 1.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.7 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation