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Results for nkx2.3+nkx2.7

Z-value: 1.40

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol Gene ID Gene Info
nkx2.7
ENSDARG00000021232 NK2 transcription factor related 7
nkx2.3
ENSDARG00000039095 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.3dr10_dc_chr13_-_40286013_402860320.886.3e-06Click!
nkx2.7dr10_dc_chr8_-_50299273_502993280.656.0e-03Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_24221087 3.95 ENSDART00000088178
nrxn1a
neurexin 1a
chr24_+_30343717 3.26 ENSDART00000162377
FP085414.1
ENSDARG00000100270
chr13_-_36265504 3.15 ENSDART00000140243
actn1
actinin, alpha 1
chr1_+_21037251 3.11

chr23_+_19827551 2.96 ENSDART00000073442
flna
filamin A, alpha (actin binding protein 280)
chr17_-_29102320 2.87 ENSDART00000104204
foxg1a
forkhead box G1a
chr12_+_14970278 2.87 ENSDART00000003847
mylpfb
myosin light chain, phosphorylatable, fast skeletal muscle b
chr17_+_23278879 2.75 ENSDART00000153652
zgc:165461
zgc:165461
chr1_-_58580939 2.73 ENSDART00000158011
col5a3b
collagen, type V, alpha 3b
chr1_+_43738350 2.70 ENSDART00000127087
ENSDART00000100309
crybb1l2
crystallin, beta B1, like 2
chr21_+_28441951 2.65 ENSDART00000077887
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr5_+_31606213 2.64 ENSDART00000126873
myhz2
myosin, heavy polypeptide 2, fast muscle specific
chr13_+_24148599 2.56 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr3_-_27516974 2.48 ENSDART00000151675
si:ch211-157c3.4
si:ch211-157c3.4
chr22_-_4264838 2.45 ENSDART00000125302
fbn2b
fibrillin 2b
chr16_-_42040346 2.38 ENSDART00000169313
pycard
PYD and CARD domain containing
chr7_+_58718614 2.37 ENSDART00000157873
hacd1
3-hydroxyacyl-CoA dehydratase 1
chr17_-_31642673 2.35 ENSDART00000030448
vsx2
visual system homeobox 2
chr25_+_19992389 2.32 ENSDART00000143441
tnni4b.2
troponin I4b, tandem duplicate 2
chr23_+_32007035 2.28 ENSDART00000132981
si:dkey-126g1.9
si:dkey-126g1.9
chr13_-_13163676 2.28 ENSDART00000125883
ENSDART00000013534
fgfr3
fibroblast growth factor receptor 3
chr10_-_17527124 2.28 ENSDART00000137905
nt5c2l1
5'-nucleotidase, cytosolic II, like 1
chr24_+_2523708 2.27 ENSDART00000106619
nrn1a
neuritin 1a
chr8_-_23172938 2.13 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr4_+_12932838 2.12 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr15_-_35563367 2.11

chr2_-_20941256 2.07 ENSDART00000114199
si:ch211-267e7.3
si:ch211-267e7.3
chr1_-_35419335 2.05 ENSDART00000037516
znf827
zinc finger protein 827
chr24_+_30343687 1.97 ENSDART00000162377
FP085414.1
ENSDARG00000100270
chr14_+_20045365 1.97 ENSDART00000167637
aff2
AF4/FMR2 family, member 2
chr17_-_52735250 1.96

chr20_+_2443682 1.91 ENSDART00000131642
akap7
A kinase (PRKA) anchor protein 7
chr6_-_23455346 1.90 ENSDART00000157527
ENSDART00000168882
ENSDART00000171384
ntn1a
netrin 1a
chr11_+_41401893 1.89 ENSDART00000171655
AL929185.1
ENSDARG00000103982
chr21_+_7844259 1.89 ENSDART00000027268
otpa
orthopedia homeobox a
chr13_+_22350043 1.86 ENSDART00000136863
ldb3a
LIM domain binding 3a
chr1_-_37475807 1.86 ENSDART00000020409
hand2
heart and neural crest derivatives expressed 2
chr2_-_30675594 1.85 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr5_-_41672394 1.84 ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr15_-_15421065 1.81 ENSDART00000106120
ywhag2
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr5_-_15774816 1.78 ENSDART00000090684
kremen1
kringle containing transmembrane protein 1
chr22_-_37417903 1.77 ENSDART00000149948
FP102167.1
ENSDARG00000095844
chr18_-_3056732 1.76 ENSDART00000162657
rps3
ribosomal protein S3
chr1_-_37990863 1.75 ENSDART00000132402
gpm6ab
glycoprotein M6Ab
chr19_-_29205158 1.75 ENSDART00000026992
sox4a
SRY (sex determining region Y)-box 4a
chr24_+_9605832 1.74 ENSDART00000131891
tmem108
transmembrane protein 108
chr13_-_36265476 1.73 ENSDART00000133740
ENSDART00000100217
actn1
actinin, alpha 1
chr6_+_23787804 1.69 ENSDART00000163188
znf648
zinc finger protein 648
chr6_-_8075384 1.68 ENSDART00000129674
slc44a2
solute carrier family 44 (choline transporter), member 2
chr22_-_22846670 1.68 ENSDART00000176355
CABZ01039424.2
ENSDARG00000108442
chr5_-_58269742 1.67 ENSDART00000122413
mcama
melanoma cell adhesion molecule a
chr21_-_43020159 1.65 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr20_+_28958586 1.63 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr16_-_17439735 1.63 ENSDART00000144392
zyx
zyxin
chr4_+_8531280 1.61 ENSDART00000162065
wnt5b
wingless-type MMTV integration site family, member 5b
chr2_+_25363717 1.61 ENSDART00000142601
stag1a
stromal antigen 1a
chr18_+_48426375 1.57

chr1_-_4757890 1.56 ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chr6_+_28886741 1.55 ENSDART00000065137
tp63
tumor protein p63
chr5_+_37254520 1.53 ENSDART00000051222
ins
preproinsulin
chr16_+_14817718 1.53 ENSDART00000027982
col14a1a
collagen, type XIV, alpha 1a
chr2_-_36058327 1.51 ENSDART00000003550
nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr14_-_5371581 1.51 ENSDART00000012116
tlx2
T-cell leukemia, homeobox 2
chr12_+_34852049 1.50 ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr13_-_13163801 1.49 ENSDART00000156968
fgfr3
fibroblast growth factor receptor 3
chr5_-_47523737 1.48 ENSDART00000153239
BX465834.1
ENSDARG00000095715
chr13_-_44492897 1.48

chr3_+_23557320 1.48 ENSDART00000046638
hoxb8a
homeobox B8a
chr9_-_33584190 1.47 ENSDART00000138844
caska
calcium/calmodulin-dependent serine protein kinase a
chr7_+_34018862 1.46 ENSDART00000123498
fibinb
fin bud initiation factor b
chr25_-_18855316 1.46 ENSDART00000155927
si:ch211-68a17.7
si:ch211-68a17.7
chr12_-_6144233 1.45 ENSDART00000152292
a1cf
apobec1 complementation factor
chr19_-_8829565 1.44 ENSDART00000031173
rps27.1
ribosomal protein S27, isoform 1
chr17_+_52736192 1.43 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr1_+_10036098 1.42 ENSDART00000139387
atp1b1b
ATPase, Na+/K+ transporting, beta 1b polypeptide
chr2_+_21067708 1.42 ENSDART00000148400
ENSDART00000021168
rxrga
retinoid x receptor, gamma a
chr2_-_32370176 1.41 ENSDART00000077151
asap1a
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
chr2_-_59019569 1.40

chr3_-_13942505 1.40

chr10_-_8074713 1.39 ENSDART00000140476
atp6v0a2a
ATPase, H+ transporting, lysosomal V0 subunit a2a
chr13_+_30781652 1.39 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr8_-_31065717 1.38 ENSDART00000163407
slc20a1a
solute carrier family 20, member 1a
chr14_+_14262816 1.38 ENSDART00000164749
pcdh20
protocadherin 20
chr3_+_23638277 1.38 ENSDART00000110682
hoxb1a
homeobox B1a
chr9_+_21911860 1.38 ENSDART00000102021
sox1a
SRY (sex determining region Y)-box 1a
chr1_-_10391257 1.37 ENSDART00000102903
dmd
dystrophin
chr9_-_14533551 1.34 ENSDART00000056103
nrp2b
neuropilin 2b
chr13_+_24531753 1.34 ENSDART00000014176
msx3
muscle segment homeobox 3
chr5_+_44407763 1.34 ENSDART00000010786
dmrt2a
doublesex and mab-3 related transcription factor 2a
chr16_-_36022327 1.31 ENSDART00000172252
eva1ba
eva-1 homolog Ba (C. elegans)
chr9_+_48717490 1.30 ENSDART00000163353
lrp2a
low density lipoprotein receptor-related protein 2a
chr3_-_32464649 1.30 ENSDART00000103239
tspan4b
tetraspanin 4b
chr2_-_10555152 1.30 ENSDART00000150166
gng12a
guanine nucleotide binding protein (G protein), gamma 12a
chr2_+_32036450 1.29 ENSDART00000140776
CR391940.1
ENSDARG00000091946
chr18_+_48959401 1.27 ENSDART00000158104
SHKBP1
SH3KBP1 binding protein 1
chr12_+_25684420 1.27 ENSDART00000024415
epas1a
endothelial PAS domain protein 1a
chr12_+_32936230 1.27 ENSDART00000153146
rbfox3a
RNA binding protein, fox-1 homolog (C. elegans) 3a
chr9_+_30767182 1.27 ENSDART00000139811
commd6
COMM domain containing 6
chr13_+_23065500 1.25 ENSDART00000158370
sorbs1
sorbin and SH3 domain containing 1
chr19_-_2486568 1.25 ENSDART00000012791
sp8a
sp8 transcription factor a
KN149858v1_-_12281 1.25 ENSDART00000157456
CABZ01056637.1
ENSDARG00000100203
chr12_-_30897542 1.24 ENSDART00000145967
tcf7l2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr2_+_25659945 1.24 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr21_-_9863186 1.24 ENSDART00000170710
arhgap24
Rho GTPase activating protein 24
chr12_-_37921731 1.23

chr17_-_52735615 1.22

chr7_+_32451041 1.22 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr13_+_28689749 1.22 ENSDART00000101653
CU639469.1
ENSDARG00000062790
chr8_-_22945616 1.22

chr2_-_20490037 1.22 ENSDART00000160388
FQ377605.1
ENSDARG00000101927
chr8_-_50159285 1.21 ENSDART00000149010
hp
haptoglobin
chr7_+_47014195 1.21 ENSDART00000114669
dpy19l3
dpy-19-like 3 (C. elegans)
chr12_-_25825072 1.21

chr14_-_24113324 1.20 ENSDART00000125923
cxcl14
chemokine (C-X-C motif) ligand 14
chr5_+_36431824 1.18 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr24_-_16994956 1.17 ENSDART00000111079
CR376737.1
ENSDARG00000077318
chr1_-_11286438 1.16 ENSDART00000159981
ENSDART00000066638
grk4
G protein-coupled receptor kinase 4
chr3_-_61104221 1.16 ENSDART00000155414
tecpr1b
tectonin beta-propeller repeat containing 1b
chr1_-_12584282 1.16 ENSDART00000127838
pcdh18a
protocadherin 18a
chr18_+_23891068 1.16 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr6_+_3771586 1.15

chr21_-_20305406 1.15 ENSDART00000065659
rbp4l
retinol binding protein 4, like
chr25_+_30701751 1.15

chr5_+_62987426 1.14 ENSDART00000178937
dnm1b
dynamin 1b
chr8_-_15091823 1.14 ENSDART00000142358
bcar3
breast cancer anti-estrogen resistance 3
chr20_-_23272102 1.13 ENSDART00000167197
spata18
spermatogenesis associated 18
chr14_-_9216303 1.12 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr8_+_23716843 1.12 ENSDART00000136547
rpl10a
ribosomal protein L10a
chr3_+_3955069 1.12 ENSDART00000092393
plbd1
phospholipase B domain containing 1
chr21_+_28921734 1.11 ENSDART00000166575
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_-_32942783 1.11 ENSDART00000060006
olig2
oligodendrocyte lineage transcription factor 2
chr8_+_14120313 1.11 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr22_+_16279764 1.11

chr13_+_19191645 1.10 ENSDART00000058036
emx2
empty spiracles homeobox 2
chr15_+_43714699 1.10 ENSDART00000168191
ENSDARG00000102235
ENSDARG00000102235
chr16_+_21104310 1.10 ENSDART00000046766
hoxa10b
homeobox A10b
chr3_-_39554155 1.09 ENSDART00000015393
b9d1
B9 protein domain 1
chr14_-_40918015 1.08 ENSDART00000147389
tmem35
transmembrane protein 35
chr9_+_51733862 1.08 ENSDART00000137426
gcgb
glucagon b
chr6_+_8895437 1.08 ENSDART00000162588
rgn
regucalcin
chr5_-_67233396 1.07 ENSDART00000051833
ENSDART00000124890
gsx1
GS homeobox 1
chr11_-_1409262 1.07 ENSDART00000155269
phactr3b
phosphatase and actin regulator 3b
chr1_+_529491 1.07 ENSDART00000102421
mrpl16
mitochondrial ribosomal protein L16
chr17_+_24613874 1.06 ENSDART00000093004
map4k3b
mitogen-activated protein kinase kinase kinase kinase 3b
chr19_+_41488385 1.05 ENSDART00000138687
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr19_-_6856033 1.05 ENSDART00000170952
pvrl2l
poliovirus receptor-related 2 like
chr16_-_6450531 1.05 ENSDART00000060550
ENSDART00000145663
ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr24_-_8589270 1.04 ENSDART00000082346
tfap2a
transcription factor AP-2 alpha
chr10_-_43466392 1.04 ENSDART00000062631
hapln1b
hyaluronan and proteoglycan link protein 1b
chr18_-_41384938 1.04 ENSDART00000098673
ptx3a
pentraxin 3, long a
chr7_-_25816549 1.03 ENSDART00000052989
ENSDART00000047951
ache
acetylcholinesterase
chr13_+_30781718 1.03 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr3_-_27517052 1.03 ENSDART00000151625
si:ch211-157c3.4
si:ch211-157c3.4
chr17_-_44133941 1.02 ENSDART00000126097
otx2
orthodenticle homeobox 2
chr16_+_26576242 1.02 ENSDART00000039746
epb41b
erythrocyte membrane protein band 4.1b
chr11_-_27253835 1.02 ENSDART00000065889
wnt7aa
wingless-type MMTV integration site family, member 7Aa
chr13_+_28286826 0.99 ENSDART00000043658
slc2a15a
solute carrier family 2 (facilitated glucose transporter), member 15a
chr10_-_43466478 0.98 ENSDART00000062631
hapln1b
hyaluronan and proteoglycan link protein 1b
chr19_-_42821964 0.98 ENSDART00000087002
plekho1a
pleckstrin homology domain containing, family O member 1a
chr7_-_71638662 0.98 ENSDART00000162984
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr5_-_31301280 0.98 ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr5_-_10445847 0.97 ENSDART00000163139
rtn4r
reticulon 4 receptor
chr20_+_33972327 0.97 ENSDART00000170930
rxrgb
retinoid X receptor, gamma b
chr9_+_25964868 0.97 ENSDART00000147229
ENSDART00000127834
zeb2a
zinc finger E-box binding homeobox 2a
chr13_-_44492701 0.97

chr10_+_17494274 0.96

chr21_+_35181329 0.96 ENSDART00000135256
ubtd2
ubiquitin domain containing 2
chr7_-_39170016 0.95 ENSDART00000161191
BX842701.1
ENSDARG00000101872
chr17_+_29259577 0.95 ENSDART00000049399
ankrd9
ankyrin repeat domain 9
chr4_+_12932950 0.95 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr15_-_34354293 0.95

chr2_+_3370130 0.95 ENSDART00000098391
wnt9a
wingless-type MMTV integration site family, member 9A
chr24_+_24924379 0.93 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr19_+_2754903 0.93 ENSDART00000160533
tomm7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr17_-_21046246 0.92 ENSDART00000078763
vsx1
visual system homeobox 1 homolog, chx10-like
chr15_-_20088439 0.92 ENSDART00000161379
auts2b
autism susceptibility candidate 2b
chr1_+_30992553 0.91 ENSDART00000112333
cnnm2b
cyclin and CBS domain divalent metal cation transport mediator 2b
chr9_-_37940101 0.90 ENSDART00000087663
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr4_-_2549493 0.90

chr24_-_6048914 0.90 ENSDART00000146830
ENSDART00000021981
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_-_7563110 0.90 ENSDART00000135945
rpsa
ribosomal protein SA
chr13_+_24703802 0.90 ENSDART00000101274
zgc:153981
zgc:153981
chr16_-_37461878 0.89 ENSDART00000142916
si:ch211-208k15.1
si:ch211-208k15.1
chr1_-_50215233 0.88 ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr16_+_10531926 0.88 ENSDART00000161568
ino80e
INO80 complex subunit E
chr12_+_5046825 0.88 ENSDART00000164178
prrt2
proline-rich transmembrane protein 2
chr6_-_23455458 0.88 ENSDART00000157527
ENSDART00000168882
ENSDART00000171384
ntn1a
netrin 1a
chr9_-_23307419 0.88 ENSDART00000020884
lypd6
LY6/PLAUR domain containing 6
chr24_-_6129575 0.87 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr18_+_23891152 0.87 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr6_+_45493396 0.87 ENSDART00000159863
cntn4
contactin 4
chr19_-_4079427 0.87 ENSDART00000170325
map7d1b
MAP7 domain containing 1b
chr5_-_13826859 0.86 ENSDART00000137355
tet3
tet methylcytosine dioxygenase 3
chr20_-_37587804 0.86 ENSDART00000166106
si:ch211-202p1.5
si:ch211-202p1.5
chr23_+_2193582 0.85 ENSDART00000106336
cpeb2
cytoplasmic polyadenylation element binding protein 2
chr24_-_16995194 0.85 ENSDART00000111079
CR376737.1
ENSDARG00000077318
chr8_+_20456215 0.85 ENSDART00000036630
zgc:101100
zgc:101100
chr21_-_7617151 0.85 ENSDART00000170166
fam69b
family with sequence similarity 69, member B
chr21_-_19293600 0.84 ENSDART00000101462
mrps18c
mitochondrial ribosomal protein S18C
chr15_+_4079643 0.84

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:2000136 cell proliferation involved in heart morphogenesis(GO:0061323) regulation of cell proliferation involved in heart morphogenesis(GO:2000136)
0.8 3.4 GO:0035908 ventral aorta development(GO:0035908) pharyngeal arch artery morphogenesis(GO:0061626)
0.8 2.3 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.6 1.9 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.6 1.7 GO:0097484 dendrite extension(GO:0097484)
0.5 1.5 GO:0006581 response to amphetamine(GO:0001975) acetylcholine catabolic process(GO:0006581) response to amine(GO:0014075)
0.5 1.4 GO:0032616 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.4 0.9 GO:0050886 endocrine process(GO:0050886)
0.4 1.2 GO:0051701 interaction with host(GO:0051701)
0.4 1.5 GO:0060259 positive regulation of epithelial cell differentiation(GO:0030858) regulation of feeding behavior(GO:0060259)
0.4 7.1 GO:0051764 actin crosslink formation(GO:0051764)
0.4 1.1 GO:0021742 abducens nucleus development(GO:0021742)
0.4 1.8 GO:0048903 anterior lateral line neuromast development(GO:0048901) anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.3 1.7 GO:0035313 negative regulation of Rac protein signal transduction(GO:0035021) wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.3 1.4 GO:0021561 facial nerve development(GO:0021561)
0.3 1.2 GO:0010226 response to lithium ion(GO:0010226)
0.3 0.9 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.3 1.2 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.3 1.2 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.3 0.6 GO:0097378 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.3 3.6 GO:0043584 nose development(GO:0043584)
0.3 4.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.3 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 1.1 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.3 1.3 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.3 1.0 GO:0019343 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.2 1.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 0.7 GO:0030818 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.2 0.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 1.1 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 1.3 GO:0070293 renal absorption(GO:0070293)
0.2 0.8 GO:1901207 regulation of heart looping(GO:1901207)
0.2 0.6 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 0.8 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 2.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 0.6 GO:0009713 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.2 2.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 0.6 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2 1.8 GO:0048730 epidermis morphogenesis(GO:0048730)
0.2 0.5 GO:0061550 cranial ganglion development(GO:0061550)
0.2 1.0 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.2 0.6 GO:1901389 transforming growth factor beta activation(GO:0036363) transforming growth factor beta production(GO:0071604) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635) regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.2 1.9 GO:0021767 mammillary body development(GO:0021767)
0.2 3.0 GO:0014823 response to activity(GO:0014823)
0.2 1.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 1.4 GO:0007525 somatic muscle development(GO:0007525)
0.2 0.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 0.9 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.8 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.1 0.4 GO:0042554 superoxide anion generation(GO:0042554)
0.1 1.5 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.8 GO:0032371 regulation of sterol transport(GO:0032371) regulation of cholesterol transport(GO:0032374)
0.1 0.9 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.4 GO:0008347 glial cell migration(GO:0008347)
0.1 2.4 GO:0032526 response to retinoic acid(GO:0032526)
0.1 0.4 GO:0048913 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.1 1.5 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.5 GO:0001881 receptor recycling(GO:0001881)
0.1 1.4 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.1 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 0.4 GO:0070640 vitamin D3 metabolic process(GO:0070640)
0.1 1.5 GO:0016556 mRNA modification(GO:0016556)
0.1 4.0 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 2.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 2.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.3 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.9 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 2.4 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.9 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 2.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.3 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 2.7 GO:0048794 swim bladder development(GO:0048794)
0.1 1.0 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 2.9 GO:0043049 otic placode formation(GO:0043049)
0.1 1.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.3 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.4 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.5 GO:0032096 regulation of response to food(GO:0032095) negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 2.4 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 0.2 GO:0010259 multicellular organism aging(GO:0010259)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.7 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1 0.5 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.7 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.7 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1 0.2 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.1 0.6 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.7 GO:0015696 ammonium transport(GO:0015696)
0.1 0.3 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.2 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 1.7 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.1 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.5 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.1 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.5 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 2.6 GO:0048741 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.2 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 5.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 3.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 4.4 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.4 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.3 GO:0007613 memory(GO:0007613)
0.0 1.2 GO:0060326 cell chemotaxis(GO:0060326)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0060347 trabecula formation(GO:0060343) heart trabecula formation(GO:0060347)
0.0 0.3 GO:0090148 membrane fission(GO:0090148)
0.0 0.1 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of DNA-templated transcription in response to stress(GO:0043620)
0.0 0.4 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0045682 regulation of epidermis development(GO:0045682)
0.0 1.1 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.4 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.0 1.0 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.2 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 1.1 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 1.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.6 GO:0097581 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.0 0.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.8 GO:0021761 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.0 1.6 GO:0071559 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 1.9 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.3 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.6 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.7 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.1 GO:0042594 response to starvation(GO:0042594)
0.0 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.2 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.7 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.4 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.8 GO:0060215 primitive hemopoiesis(GO:0060215)
0.0 0.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.5 GO:0016358 dendrite development(GO:0016358)
0.0 4.1 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 0.1 GO:0006611 protein export from nucleus(GO:0006611)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0061702 inflammasome complex(GO:0061702)
0.4 2.5 GO:0044295 axonal growth cone(GO:0044295)
0.3 1.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 1.1 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 0.7 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 2.6 GO:0005869 dynactin complex(GO:0005869)
0.2 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.4 GO:0098533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.2 1.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.1 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 6.7 GO:0005604 basement membrane(GO:0005604)
0.1 1.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 2.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.1 GO:0014069 postsynaptic density(GO:0014069)
0.1 5.2 GO:0001726 ruffle(GO:0001726)
0.1 1.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 4.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.6 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.6 GO:0030426 growth cone(GO:0030426)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 2.6 GO:0016459 myosin complex(GO:0016459)
0.1 0.6 GO:0042645 nucleoid(GO:0009295) ribonuclease P complex(GO:0030677) mitochondrial nucleoid(GO:0042645)
0.1 2.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.0 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.6 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 4.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 1.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 4.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.8 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 4.7 GO:0043235 receptor complex(GO:0043235)
0.0 0.3 GO:0045178 basal part of cell(GO:0045178) basal cortex(GO:0045180)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 8.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0030424 axon(GO:0030424)
0.0 10.4 GO:0005576 extracellular region(GO:0005576)
0.0 2.0 GO:0005912 adherens junction(GO:0005912)
0.0 0.7 GO:0005840 ribosome(GO:0005840)
0.0 0.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0032090 Pyrin domain binding(GO:0032090)
0.8 2.4 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.5 1.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.5 1.5 GO:0004104 acetylcholinesterase activity(GO:0003990) cholinesterase activity(GO:0004104)
0.5 2.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 2.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.3 1.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 0.9 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.3 1.4 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.3 2.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 1.4 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.3 4.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.7 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 1.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.2 GO:0034632 retinol transporter activity(GO:0034632)
0.2 0.8 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.2 1.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 0.7 GO:0099528 G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.2 1.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.6 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 1.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.6 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.4 GO:0016175 NAD(P)H oxidase activity(GO:0016174) superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.4 GO:0051117 ATPase binding(GO:0051117)
0.1 1.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 1.0 GO:0042379 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.1 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 5.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.9 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 3.8 GO:0005179 hormone activity(GO:0005179)
0.1 1.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.7 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 1.3 GO:0042562 hormone binding(GO:0042562)
0.1 0.4 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.5 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 2.8 GO:0019838 growth factor binding(GO:0019838)
0.1 0.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.2 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.2 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.3 GO:0015145 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 2.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 7.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0031386 protein tag(GO:0031386)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.2 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 6.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 4.0 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 2.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 22.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 3.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.6 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 PID ALK2 PATHWAY ALK2 signaling events
0.3 5.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 4.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 3.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.2 PID FGF PATHWAY FGF signaling pathway
0.1 3.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.2 ST GA13 PATHWAY G alpha 13 Pathway
0.0 1.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.4 3.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 4.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 3.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 2.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 1.6 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.1 0.9 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.5 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 0.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors