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Results for nkx3-1

Z-value: 1.80

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Transcription factors associated with nkx3-1

Gene Symbol Gene ID Gene Info
nkx3-1
ENSDARG00000078280 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3-1dr10_dc_chr8_-_50270783_50270806-0.802.2e-04Click!

Activity profile of nkx3-1 motif

Sorted Z-values of nkx3-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_34971985 8.12 ENSDART00000141201
ccna1
cyclin A1
chr9_-_8318363 6.00 ENSDART00000139867
si:ch211-145c1.1
si:ch211-145c1.1
chr7_+_17695173 5.67 ENSDART00000101601
cth1
cysteine three histidine 1
chr16_+_54833107 5.10 ENSDART00000157641
fbxo43
F-box protein 43
chr4_-_1522439 4.99 ENSDART00000175566
CABZ01085702.1
ENSDARG00000106927
chr9_-_12916555 4.87 ENSDART00000140691
si:ch211-167j6.3
si:ch211-167j6.3
chr22_-_12738593 4.49 ENSDART00000143574
rqcd1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr11_-_30388949 4.11 ENSDART00000063775
ENSDARG00000043442
ENSDARG00000043442
chr10_-_34971926 3.93 ENSDART00000141201
ccna1
cyclin A1
chr15_+_29092022 3.89 ENSDART00000141164
si:ch211-137a8.2
si:ch211-137a8.2
chr16_-_41585481 3.65 ENSDART00000102662
rpp25l
ribonuclease P/MRP 25 subunit-like
chr19_+_33552393 3.60 ENSDART00000043039
fam84b
family with sequence similarity 84, member B
chr1_-_7160294 3.49 ENSDART00000174972
BX908756.2
ENSDARG00000108483
chr19_+_33551956 3.43 ENSDART00000043039
fam84b
family with sequence similarity 84, member B
chr5_+_36066651 3.40 ENSDART00000097686
zgc:153990
zgc:153990
chr22_-_7412566 3.25 ENSDART00000161615
ENSDART00000158210
BX511034.5
ENSDARG00000099295
chr15_+_29092224 3.21 ENSDART00000131755
si:ch211-137a8.2
si:ch211-137a8.2
chr5_+_36066758 3.19 ENSDART00000097686
zgc:153990
zgc:153990
chr19_-_10411573 3.08 ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr9_+_45193290 3.06 ENSDART00000176175
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr23_-_36178206 3.05 ENSDART00000153852
ENSDART00000153206
ENSDART00000155040
ENSDART00000156899
ENSDART00000157077
ENSDART00000155063
BX005254.1
ENSDARG00000093797
chr5_-_15971338 2.91 ENSDART00000110437
piwil2
piwi-like RNA-mediated gene silencing 2
chr5_-_55082078 2.87 ENSDART00000097424
kcmf1
potassium channel modulatory factor 1
chr14_+_24543399 2.84 ENSDART00000106039
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr1_-_54570813 2.74 ENSDART00000098615
nanos3
nanos homolog 3
chr19_+_41834452 2.71 ENSDART00000148732
ENSDART00000149799
dlx6a
distal-less homeobox 6a
chr17_-_43040958 2.69 ENSDART00000132754
npc2
Niemann-Pick disease, type C2
chr8_-_39825675 2.69 ENSDART00000130686
unc119.1
unc-119 homolog 1
chr22_-_12738445 2.68 ENSDART00000047464
rqcd1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr5_-_9577533 2.65 ENSDART00000036421
chek2
checkpoint kinase 2
chr12_-_25058837 2.59 ENSDART00000135368
rhoq
ras homolog family member Q
chr5_-_55081799 2.59 ENSDART00000158102
kcmf1
potassium channel modulatory factor 1
chr13_+_36554762 2.57 ENSDART00000136030
atp5s
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s
chr14_+_50010976 2.55 ENSDART00000171955
CR855307.1
ENSDARG00000099628
chr13_-_32595706 2.55 ENSDART00000012232
pdss2
prenyl (decaprenyl) diphosphate synthase, subunit 2
chr5_+_36067010 2.47 ENSDART00000097686
zgc:153990
zgc:153990
chr24_+_25872005 2.43 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr19_+_2942485 2.42 ENSDART00000177848
CABZ01066434.1
ENSDARG00000107451
chr11_+_36088518 2.42

chr3_-_18039574 2.40 ENSDART00000049240
tob1a
transducer of ERBB2, 1a
chr22_-_22234380 2.40 ENSDART00000020937
hdgfrp2
hepatoma-derived growth factor-related protein 2
chr10_+_33790718 2.38 ENSDART00000161430
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr12_-_10438255 2.37 ENSDART00000106172
rac1a
ras-related C3 botulinum toxin substrate 1a (rho family, small GTP binding protein Rac1)
chr12_-_31346300 2.32 ENSDART00000175929
acsl5
acyl-CoA synthetase long-chain family member 5
chr9_+_28329384 2.31 ENSDART00000046880
plekhm3
pleckstrin homology domain containing, family M, member 3
chr2_+_10858480 2.30 ENSDART00000091570
fam69aa
family with sequence similarity 69, member Aa
chr17_-_15487267 2.27

chr11_-_36088336 2.22 ENSDART00000141477
psma5
proteasome subunit alpha 5
chr7_+_34923319 2.20

chr11_-_22450582 2.17

chr5_+_40543392 2.16 ENSDART00000011229
sub1b
SUB1 homolog, transcriptional regulator b
chr12_-_31346234 2.14 ENSDART00000175929
acsl5
acyl-CoA synthetase long-chain family member 5
chr21_+_5027911 2.12 ENSDART00000139288
si:dkey-121h17.7
si:dkey-121h17.7
chr21_-_13654658 2.10 ENSDART00000111666
npdc1a
neural proliferation, differentiation and control, 1a
chr5_+_29996321 2.08 ENSDART00000124487
hinfp
histone H4 transcription factor
chr14_+_34673281 2.05 ENSDART00000164974
ebf1a
early B-cell factor 1a
chr17_+_52526741 2.04 ENSDART00000109891
angel1
angel homolog 1 (Drosophila)
chr16_+_16345914 2.03 ENSDART00000137672
setd2
SET domain containing 2
chr17_-_43632707 2.01 ENSDART00000136431
rtkn2a
rhotekin 2a
chr13_-_36554590 2.00 ENSDART00000085298
l2hgdh
L-2-hydroxyglutarate dehydrogenase
chr22_+_32274436 1.98 ENSDART00000092082
manf
mesencephalic astrocyte-derived neurotrophic factor
chr3_+_36093650 1.97 ENSDART00000150994
dus1l
dihydrouridine synthase 1-like (S. cerevisiae)
chr1_+_40776176 1.96

chr25_-_8026912 1.95

chr5_+_40543353 1.95 ENSDART00000011229
sub1b
SUB1 homolog, transcriptional regulator b
chr24_+_14451260 1.91 ENSDART00000137337
ENSDART00000091784
thtpa
thiamine triphosphatase
chr17_-_24684870 1.88 ENSDART00000156061
si:ch211-15d5.12
si:ch211-15d5.12
chr8_-_38284959 1.86 ENSDART00000125920
pdlim2
PDZ and LIM domain 2 (mystique)
chr21_+_18870471 1.86 ENSDART00000160185
smpd4
sphingomyelin phosphodiesterase 4
chr5_+_56896961 1.84

chr21_+_20439227 1.84

chr14_-_49798900 1.82 ENSDART00000169730
si:ch211-199b20.3
si:ch211-199b20.3
chr24_+_25871962 1.78 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr18_+_40481566 1.77 ENSDART00000098806
ugt5c3
UDP glucuronosyltransferase 5 family, polypeptide C3
chr1_+_40428827 1.76 ENSDART00000145272
lrpap1
low density lipoprotein receptor-related protein associated protein 1
chr5_+_32215942 1.75 ENSDART00000047377
crata
carnitine O-acetyltransferase a
chr12_-_7551118 1.75 ENSDART00000152556
FAM13C
family with sequence similarity 13 member C
chr20_-_13729816 1.74 ENSDART00000078893
ezrb
ezrin b
chr2_-_7959150 1.69 ENSDART00000136074
b3gnt5b
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr5_+_17508128 1.66 ENSDART00000048859
ascc2
activating signal cointegrator 1 complex subunit 2
chr25_-_13307171 1.66 ENSDART00000056723
gins3
GINS complex subunit 3
chr10_+_44456550 1.65 ENSDART00000157611
snrnp35
small nuclear ribonucleoprotein 35 (U11/U12)
chr8_-_39825792 1.63 ENSDART00000130686
unc119.1
unc-119 homolog 1
chr21_-_23873574 1.61

chr19_-_10411518 1.56 ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr9_-_46614763 1.56 ENSDART00000009790
cx43.4
connexin 43.4
chr15_+_24628191 1.55 ENSDART00000140658
dhrs13b
dehydrogenase/reductase (SDR family) member 13b
chr17_-_10657734 1.54 ENSDART00000153913
fbxo34
F-box protein 34
chr7_+_10669695 1.52 ENSDART00000170655
abhd17c
abhydrolase domain containing 17C
chr15_-_24741104 1.50 ENSDART00000100756
tmem199
transmembrane protein 199
chr16_-_41585555 1.49 ENSDART00000131706
rpp25l
ribonuclease P/MRP 25 subunit-like
chr17_-_43041254 1.49 ENSDART00000124663
npc2
Niemann-Pick disease, type C2
chr5_+_1461715 1.49 ENSDART00000054057
ddrgk1
DDRGK domain containing 1
chr5_+_62041556 1.48 ENSDART00000146879
zswim7
zinc finger, SWIM-type containing 7
chr3_-_23382550 1.47 ENSDART00000170200
BX682558.1
ENSDARG00000101975
chr3_+_25719002 1.47 ENSDART00000007119
mfsd6l
major facilitator superfamily domain containing 6-like
chr20_-_8847351 1.46 ENSDART00000141375
CR388209.1
ENSDARG00000091901
chr7_-_48394268 1.45 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr21_-_14719281 1.44 ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr16_+_43464824 1.43 ENSDART00000032778
rnf144b
ring finger protein 144B
chr3_+_16772351 1.43 ENSDART00000164895
atp6v0a1a
ATPase, H+ transporting, lysosomal V0 subunit a1a
chr7_-_60969349 1.42 ENSDART00000098610
rell1
RELT like 1
chr21_+_37405864 1.39 ENSDART00000148956
znf346
zinc finger protein 346
chr8_-_38284904 1.38 ENSDART00000125920
pdlim2
PDZ and LIM domain 2 (mystique)
chr22_+_24576319 1.38 ENSDART00000164256
ENSDARG00000100186
ENSDARG00000100186
chr15_+_25516764 1.37 ENSDART00000009545
pak4
p21 protein (Cdc42/Rac)-activated kinase 4
chr11_-_18112090 1.35 ENSDART00000019248
tmem110
transmembrane protein 110
chr6_-_46733412 1.33 ENSDART00000103455
tarbp2
TAR (HIV) RNA binding protein 2
chr5_+_36066523 1.32 ENSDART00000097686
zgc:153990
zgc:153990
chr17_+_25407766 1.31 ENSDART00000121848
srrm1
serine/arginine repetitive matrix 1
chr7_-_60969582 1.31 ENSDART00000098610
rell1
RELT like 1
chr21_+_19511167 1.28 ENSDART00000058487
rai14
retinoic acid induced 14
chr1_-_50626230 1.27

chr8_-_31044580 1.26 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr11_+_26138316 1.25 ENSDART00000175997
cpne1
copine I
chr3_-_20807407 1.24 ENSDART00000164601
ndufa4l
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4, like
chr22_-_10511906 1.24 ENSDART00000013933
si:dkey-42i9.4
si:dkey-42i9.4
chr17_-_18878230 1.23 ENSDART00000028044
galcb
galactosylceramidase b
chr24_-_32607801 1.22 ENSDART00000143781
EIF1B
eukaryotic translation initiation factor 1B
chr20_-_26003133 1.19 ENSDART00000142611
ENSDART00000024821
elmsan1a
ELM2 and Myb/SANT-like domain containing 1a
chr7_-_60969664 1.17 ENSDART00000098610
rell1
RELT like 1
chr7_-_26260802 1.16 ENSDART00000121698
senp3b
SUMO1/sentrin/SMT3 specific peptidase 3b
chr19_-_18689437 1.16 ENSDART00000016135
nfe2l3
nuclear factor, erythroid 2-like 3
chr6_-_46733353 1.15 ENSDART00000103455
tarbp2
TAR (HIV) RNA binding protein 2
chr6_-_29314529 1.15 ENSDART00000132456
bivm
basic, immunoglobulin-like variable motif containing
chr11_+_30389309 1.14 ENSDART00000087909
tmem246
transmembrane protein 246
chr11_-_23460219 1.13

chr3_-_35734943 1.11 ENSDART00000135957
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr24_-_6649190 1.11 ENSDART00000042478
enkur
enkurin, TRPC channel interacting protein
chr25_+_8585585 1.10 ENSDART00000154680
man2a2
mannosidase, alpha, class 2A, member 2
chr15_-_4424628 1.09 ENSDART00000062874
atp1b3b
ATPase, Na+/K+ transporting, beta 3b polypeptide
chr7_+_71766373 1.08 ENSDART00000011303
ywhae2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
chr10_+_33758581 1.07 ENSDART00000141650
b3glctb
beta 3-glucosyltransferase b
chr17_+_43633099 1.06 ENSDART00000154138
znf365
zinc finger protein 365
chr7_-_20212157 1.05 ENSDART00000078192
cnpy4
canopy4
chr1_+_5437488 1.04 ENSDART00000092324
abcb6a
ATP-binding cassette, sub-family B (MDR/TAP), member 6a
chr9_-_34459768 1.03 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr24_-_6649248 1.02 ENSDART00000042478
enkur
enkurin, TRPC channel interacting protein
chr9_-_53058151 1.02 ENSDART00000172534
ENSDART00000167922
ENSDART00000164924
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr16_+_51328478 1.02 ENSDART00000168162
FQ323156.1
ENSDARG00000100697
chr1_-_358810 1.01 ENSDART00000098627
pros1
protein S (alpha)
chr3_+_32519965 0.99 ENSDART00000131850
ENSDART00000055338
thoc6
THO complex 6
chr6_-_49802414 0.98 ENSDART00000008959
nelfcd
negative elongation factor complex member C/D
chr6_+_19933322 0.98 ENSDART00000143378
thumpd3
THUMP domain containing 3
chr24_+_15995931 0.97 ENSDART00000105955
TIMM21
translocase of inner mitochondrial membrane 21
chr19_-_10411878 0.97 ENSDART00000136653
ccdc106b
coiled-coil domain containing 106b
chr9_+_12917201 0.97 ENSDART00000102386
si:ch211-167j6.4
si:ch211-167j6.4
chr7_-_26355894 0.96 ENSDART00000159826
phf23b
PHD finger protein 23b
chr3_-_35735085 0.95 ENSDART00000135957
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr24_+_25872150 0.94 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr21_-_14719149 0.94 ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr11_+_30389137 0.94 ENSDART00000087909
tmem246
transmembrane protein 246
chr3_-_26675055 0.93 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr5_+_43455864 0.92

chr7_+_30454112 0.92 ENSDART00000085716
mtmr10
myotubularin related protein 10
chr1_+_40776542 0.91 ENSDART00000142967
dok1a
docking protein 1a
chr5_+_24378828 0.91 ENSDART00000111302
rhbdd3
rhomboid domain containing 3
chr9_+_2472639 0.90 ENSDART00000147034
gpr155a
G protein-coupled receptor 155a
chr11_-_7146819 0.88 ENSDART00000172879
smim7
small integral membrane protein 7
chr14_+_533611 0.87

KN149789v1_-_7443 0.86

chr17_+_43633129 0.86 ENSDART00000154138
znf365
zinc finger protein 365
chr11_-_25019165 0.85 ENSDART00000130477
ENSDART00000079578
snai1a
snail family zinc finger 1a
chr20_-_13244237 0.85 ENSDART00000124470
ints7
integrator complex subunit 7
chr20_+_31375136 0.85

chr19_+_7505348 0.83 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr12_+_31345948 0.83 ENSDART00000031154
gucy2g
guanylate cyclase 2g
chr15_+_17912538 0.81 ENSDART00000168940
zgc:113279
zgc:113279
chr18_-_15187432 0.81 ENSDART00000111333
mterf2
mitochondrial transcription termination factor 2
chr20_+_31375056 0.81

chr24_+_15996046 0.80 ENSDART00000105955
TIMM21
translocase of inner mitochondrial membrane 21
chr11_-_22450525 0.79

chr1_-_2309740 0.78 ENSDART00000103795
ggact.1
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr24_-_8217219 0.76 ENSDART00000106388
eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr5_+_56896748 0.76

chr1_+_40776703 0.76 ENSDART00000142967
dok1a
docking protein 1a
chr17_-_49197264 0.74 ENSDART00000169207
tfb1m
transcription factor B1, mitochondrial
chr4_-_7664508 0.74 ENSDART00000148973
lta4h
leukotriene A4 hydrolase
chr5_-_68935171 0.74 ENSDART00000149692
dguok
deoxyguanosine kinase
chr22_+_520271 0.74 ENSDART00000067638
med20
mediator complex subunit 20
chr2_-_37555425 0.73 ENSDART00000143496
arhgef18a
rho/rac guanine nucleotide exchange factor (GEF) 18a
chr18_-_48329076 0.72

chr14_+_51724531 0.72 ENSDART00000168437
b4galt1l
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr17_+_13654337 0.72 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr3_-_36277758 0.70 ENSDART00000173545
cog1
component of oligomeric golgi complex 1
chr21_+_1719308 0.70

chr2_-_56007484 0.70 ENSDART00000097755
jund
jun D proto-oncogene
chr23_+_7614867 0.69 ENSDART00000011554
tm9sf4
transmembrane 9 superfamily protein member 4
chr8_+_42968542 0.68

chr20_+_25652930 0.67 ENSDART00000162080
cyp2v1
cytochrome P450, family 2, subfamily V, polypeptide 1
chr19_+_46371192 0.67 ENSDART00000169710
utp23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr7_+_22386328 0.66 ENSDART00000141048
ponzr5
plac8 onzin related protein 5
chr3_+_25718973 0.66 ENSDART00000007119
mfsd6l
major facilitator superfamily domain containing 6-like
chr21_-_35291005 0.65 ENSDART00000134780
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr17_-_24684729 0.65

chr7_+_57877047 0.65 ENSDART00000123117
ggh
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr9_-_11683921 0.64 ENSDART00000044314
ENSDART00000124129
itgav
integrin, alpha V
chr23_-_15090815 0.64 ENSDART00000147636
ndrg3b
ndrg family member 3b
chr8_-_6782167 0.62 ENSDART00000135834
ENSDART00000172157
dock5
dedicator of cytokinesis 5
chr19_+_7839888 0.62

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0032890 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) regulation of anion transmembrane transport(GO:1903959) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
1.3 3.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
1.1 5.6 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
1.0 2.9 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.9 4.4 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.8 2.5 GO:0070922 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903) regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) small RNA loading onto RISC(GO:0070922) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.6 5.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.6 1.9 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.6 5.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.6 1.9 GO:0006772 thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357) thiamine-containing compound metabolic process(GO:0042723)
0.6 2.4 GO:0030801 positive regulation of cyclic nucleotide metabolic process(GO:0030801) positive regulation of cyclic nucleotide biosynthetic process(GO:0030804) positive regulation of nucleotide biosynthetic process(GO:0030810) positive regulation of cyclase activity(GO:0031281) positive regulation of lyase activity(GO:0051349) positive regulation of purine nucleotide biosynthetic process(GO:1900373)
0.5 1.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.4 1.8 GO:0010916 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916) regulation of lipoprotein particle clearance(GO:0010984) negative regulation of lipoprotein particle clearance(GO:0010985)
0.4 1.8 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.4 1.3 GO:1903894 regulation of endoplasmic reticulum unfolded protein response(GO:1900101) negative regulation of endoplasmic reticulum unfolded protein response(GO:1900102) regulation of IRE1-mediated unfolded protein response(GO:1903894) negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.4 1.2 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.4 1.2 GO:0019376 galactosylceramide catabolic process(GO:0006683) galactolipid catabolic process(GO:0019376)
0.4 4.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.3 1.0 GO:0042730 fibrinolysis(GO:0042730)
0.3 1.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 4.3 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.3 1.0 GO:0061072 iris morphogenesis(GO:0061072)
0.2 0.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 1.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 1.7 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 0.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 11.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 2.7 GO:0035141 medial fin morphogenesis(GO:0035141)
0.2 1.4 GO:0001845 phagolysosome assembly(GO:0001845)
0.2 1.0 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 0.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.2 1.0 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.7 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 2.6 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.1 0.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 2.7 GO:0019827 stem cell population maintenance(GO:0019827)
0.1 2.4 GO:0043652 engulfment of apoptotic cell(GO:0043652) regulation of neutrophil migration(GO:1902622)
0.1 1.5 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 2.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.7 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 2.3 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 2.6 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 1.2 GO:0016926 protein desumoylation(GO:0016926)
0.1 2.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.0 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.3 GO:0014807 regulation of somitogenesis(GO:0014807) regulation of heart looping(GO:1901207) positive regulation of feeding behavior(GO:2000253)
0.1 1.4 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.2 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 1.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.4 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.0 0.8 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.8 GO:0008078 mesodermal cell migration(GO:0008078)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.9 GO:0002573 myeloid leukocyte differentiation(GO:0002573)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.9 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 2.0 GO:0008033 tRNA processing(GO:0008033)
0.0 0.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 5.2 GO:0099536 synaptic signaling(GO:0099536)
0.0 0.6 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 9.3 GO:0006915 apoptotic process(GO:0006915)
0.0 0.3 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.5 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 3.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.5 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.7 5.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.5 7.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5 1.5 GO:0097196 Shu complex(GO:0097196)
0.4 2.9 GO:0071546 pi-body(GO:0071546)
0.4 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 1.7 GO:0000811 GINS complex(GO:0000811)
0.2 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 2.5 GO:1902555 endoribonuclease complex(GO:1902555)
0.2 2.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 1.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 2.7 GO:0043186 P granule(GO:0043186)
0.2 5.3 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.4 GO:0097361 CIA complex(GO:0097361)
0.1 2.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.1 GO:1904949 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.1 1.5 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:0032021 NELF complex(GO:0032021)
0.1 3.1 GO:0031941 filamentous actin(GO:0031941)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.1 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.1 2.4 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.6 GO:0045095 keratin filament(GO:0045095)
0.0 4.2 GO:0005764 lysosome(GO:0005764)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.9 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.7 2.9 GO:0034584 piRNA binding(GO:0034584)
0.6 2.4 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.6 1.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.5 1.9 GO:0003823 antigen binding(GO:0003823) lipid antigen binding(GO:0030882)
0.4 4.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.4 1.2 GO:0004336 galactosylceramidase activity(GO:0004336)
0.4 2.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.4 1.8 GO:0032184 SUMO polymer binding(GO:0032184)
0.4 2.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.4 1.8 GO:0048019 receptor antagonist activity(GO:0048019)
0.3 1.4 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.3 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 0.7 GO:0016803 ether hydrolase activity(GO:0016803)
0.2 0.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 11.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 1.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 1.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 2.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 4.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 2.6 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 1.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.7 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 2.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.1 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.4 GO:0001653 peptide receptor activity(GO:0001653) G-protein coupled peptide receptor activity(GO:0008528)
0.1 2.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 2.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.1 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 1.7 GO:0017069 snRNA binding(GO:0017069)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 5.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 2.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.0 4.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.0 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 1.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.9 GO:0032182 ubiquitin-like protein binding(GO:0032182)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.0 2.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID ATM PATHWAY ATM pathway
0.1 1.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 4.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4 2.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 7.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.3 1.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 1.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 1.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.5 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation